Researchers Database

TANOUE, Rumi

    Center for Marine Environmental Studies Assistant Professor
Last Updated :2021/03/06

Researcher Information

Degree

  • Ph.D. in Science(Ehime University)

Research funding number

  • 60767226

ORCID ID

Researcher ID

  • D-7274-2014

J-Global ID

Profile

  • My study focuses on the examination of ecological risk and human health risk posed by organic chemical contaminants in the natural environment and our living environment.


    ORCID

    https://orcid.org/0000-0003-2354-0694

Research Interests

  • 環境汚染物質   環境汚染   LC-MS/MS   Environmental Science   Environmental Chemistry   Wildlife   Fish   Uptake and Depuration   生物移行・残留性   Species difference   Biomonitoring   Human Health Risk   Aquatic Environment   Endocrine Disrupting Chemicals   Toxicokinetics   Aquatic organisms   Pharmaceuticals and Personal Care Products   Environmental Analytical Chemistry   

Research Areas

  • Environmental science/Agricultural science / Environmental load/risk assessment
  • Environmental science/Agricultural science / Environmental impact assessment
  • Environmental science/Agricultural science / Environmental effects of chemicals
  • Environmental science/Agricultural science / Environmental effects of radiation

Academic & Professional Experience

  • 2019/04 - Today  Ehime UniversityCenter for Marine Environmental Studies (CMES)Assistant Professor
  • 2019/04 - Today  Ehime UniversityCenter for Marine Environmental Studies助教(特定教員)
  • 2016/04 - 2019/03  Ehime UniversityCenter for Marine Environmental Studies (CMES)Researcher
  • 2016/04 - 2019/03  Ehime UniversityCenter for Marine Environmental Studies特定研究員
  • 2015/04 - 2016/03  Japan Society for the Promotion of SciencePostdoctoral researcher
  • 2015/04 - 2016/03  日本学術振興会特別研究員(PD)
  • 2014/04 - 2015/03  日本学術振興会特別研究員(DC2)
  • 2012/04 - 2014/03  Ehime UniversityCenter for Marine Environmental Studies特別研究員

Education

  • 2012/04 - 2015/03  Ehime University  Graduate School of Science and Engineering  Doctor's course, Chemistry and Biology
  • 2010/04 - 2012/03  Prefectural University of Kumamoto  Graduate School of Environmental & Symbiotic Sciences  Master's course
  • 2006/04 - 2010/03  Prefectural University of Kumamoto  環境共生学部  Faculty of Environmental & Symbiotic Sciences

Association Memberships

  • JAPAN SOCIETY ON WATER ENVIRONMENT   JAPAN SOCIETY FOR ENVIRONMENTAL CHEMISTRY   

Published Papers

  • Hoang Quoc Anh, Thi Phuong Quynh Le, Nhu Da Le, Xi Xi Lu, Thi Thuy Duong, Josette Garnier, Emma Rochelle-Newall, Shurong Zhang, Neung-Hwan Oh, Chantha Oeurng, Chaiwat Ekkawatpanit, Tien Dat Nguyen, Quang Trung Nguyen, Tran Dung Nguyen, Trong Nghia Nguyen, Thi Lieu Tran, Tatsuya Kunisue, Rumi Tanoue, Shin Takahashi, Tu Binh Minh, Huu Tuyen Le, Thi Ngoc Mai Pham, Thi Anh Huong Nguyen
    The Science of the total environment 764 142865 - 142865 2021/04 [Peer-reviewed]
     Scientific journal 
    This review provides focused insights into the contamination status, sources, and ecological risks associated with multiple classes of antibiotics in surface water from the East and Southeast Asia based on publications over the period 2007 to 2020. Antibiotics are ubiquitous in surface water of these countries with concentrations ranging from <1 ng/L to hundreds μg/L and median values from 10 to 100 ng/L. Wider ranges and higher maximum concentrations of certain antibiotics were found in surface water of the East Asian countries like China and South Korea than in the Southeast Asian nations. Environmental behavior and fate of antibiotics in surface water is discussed. The reviewed occurrence of antibiotics in their sources suggests that effluent from wastewater treatment plants, wastewater from aquaculture and livestock production activities, and untreated urban sewage are principal sources of antibiotics in surface water. Ecological risks associated with antibiotic residues were estimated for aquatic organisms and the prevalence of antibiotic resistance genes and antibiotic-resistant bacteria were reviewed. Such findings underline the need for synergistic efforts from scientists, engineers, policy makers, government managers, entrepreneurs, and communities to manage and reduce the burden of antibiotics and antibiotic resistance in water bodies of East and Southeast Asian countries.
  • Rumi Tanoue, Kazusa Nozaki, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe
    Journal of Chromatography A 1631 461586 - 461586 2020/11 [Peer-reviewed]
     Scientific journal
  • Kohki Takaguchi, Hiroyuki Nishikawa, Hazuki Mizukawa, Rumi Tanoue, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Tatsuya Kunisue, Mayumi Ishizuka, Shinsuke Tanabe, Hisato Iwata, Kei Nomiyama
    Science of the Total Environment 688 1172 - 1183 0048-9697 2019/10 [Peer-reviewed]
     Scientific journal 
    © 2019 Elsevier B.V. Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) might disrupt thyroid function. However, there is no clear evidence of PCB exposure disrupting thyroid hormone (TH) homeostasis in dogs and cats. The present study conducted in vivo experiments to evaluate the effects of a mixture of 12 PCB congeners (CB18, 28, 70, 77, 99, 101, 118, 138, 153, 180, 187 and 202, each congener 0.5 mg/kg BW, i.p. administration) on serum TH levels in male dogs (Canis lupus familiaris) and male cats (Felis silvestris catus). In PCB-exposed dogs, the time courses of higher-chlorinated PCBs and L-thyroxine (T4)-like OH-PCBs (4-OH-CB107 and 4-OH-CB202) concentrations were unchanged or tended to increase, whereas those of lower-chlorinated PCBs and OH-PCBs tended to decrease after 24 h. In PCB-exposed cats, concentrations of PCBs increased until 6 h and then remained unchanged. The levels of lower-chlorinated OH-PCBs including 4′-OH-CB18 increased until 96 h and then decreased. In PCB-exposed dogs, free T4 concentrations were higher than those in the control group at 48 and 96 h after PCB administration and positively correlated with the levels of T4-like OH-PCBs, suggesting competitive binding of T4 and T4-like OH-PCBs to a TH transporter, transthyretin. Serum levels of total T4 and total 3,3′,5-triiodo-L-thyronine (T3) in PCB-exposed dogs were lower than in the control group at 24 and 48 h and negatively correlated with PCB concentrations, implying that PCB exposure enhanced TH excretion by increasing TH uptake and TH conjugation enzyme activities in the dog liver. In contrast, no obvious changes in TH levels were observed in PCB-exposed cats. This could be explained by the lower levels of T4-like OH-PCBs and lower hepatic conjugation enzyme activities in cats compared with dogs. Different effects on serum TH levels in PCB-exposed dogs and cats are likely to be attributable to species-specific PCB and TH metabolism.
  • Guruge KS, Goswami P, Tanoue R, Nomiyama K, Wijesekara RGS, Dharmaratne TS
    The Science of the total environment 690 683 - 695 0048-9697 2019/07 [Peer-reviewed]
  • Tanoue R, Margiotta-Casaluci L, Huerta B, Runnalls TJ, Eguchi A, Nomiyama K, Kunisue T, Tanabe S, Sumpter JP
    The Science of the total environment 664 915 - 926 0048-9697 2019/05 [Peer-reviewed]
  • Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Rumi Tanoue, Tatsuya Kunisue, Hisato Iwata
    Toxicology and Applied Pharmacology 347 23 - 32 1096-0333 2018/05 [Peer-reviewed]
     Scientific journal 
    Triclosan (TCS), a commonly used antimicrobial compound, has recently been detected in the eggs of wild avian species. Exposure to TCS in rodents is known to interfere with thyroid hormone (TH), disrupt immune responses and cause liver disease. However, no attempt has been made to clarify the effects of TCS in avian species. The aim of this study is therefore to evaluate the toxic effects of in ovo exposure to TCS and explore the molecular mechanism by transcriptome analysis in the embryonic liver of a model avian species, chicken (Gallus gallus). Embryos were treated with graded concentration of TCS (0.1, 1 and 10 μg/g egg) at Hamburger Hamilton Stage (HHS) 1 (1st day), followed by 20 days of incubation to HHS 46. At the administration of 10 μg TCS/g egg, embryo mortality increased from 20% in control to 37% accompanied with 8% attenuation in tarsus length. While liver somatic index (LSI) in TCS treatments was enhanced, statistical difference was only observed at the treatment of 0.1 μg TCS/g egg in females. The up-regulation of several crucial differentially expressed genes (DEGs) in transcriptome analysis suggested that TCS induced xenobiotic metabolism (e.g. CYP2C23a, CYP2C45 and CYP3A37 in males CYP2C45 in females) and activated the thyroid hormone receptor (THR) - mediated downstream signaling (e.g. THRSPB and DIO2 in males THRSPB in females). In females, TCS may further activate the lipogenesis signaling (e.g. ACSL5, ELOVL2) and repress the lipolysis signaling (e.g. ABHD5, ACAT2). A battery of enriched transcription factors in relation to these TCS-induced signaling and phenotypes were found, including activated SREBF1, PPARa, LXRa, and LXRb in males and activated GLI2 in females COUP-TFII was predicted to be suppressed in both genders. Finally, we developed adverse outcome pathways (AOPs) that provide insights into the molecular mechanisms underlying the alteration of phenotypes.
  • Rumi Tanoue, Imari Kume, Yasuo Yamamoto, Kohki Takaguchi, Kei Nomiyama, Shinsuke Tanabe, Tatsuya Kunisue
    Journal of Chromatography A 1539 30 - 40 1873-3778 2018/03 [Peer-reviewed]
     Scientific journal 
    Thyroid hormones (THs), which mainly consist of 3, 3′ 5-triiodo-L-thyronine (T3) and L-thyroxine (T4), play a critical role in regulating biological processes such as growth and metabolism in various animal species. Thus, accurate measurement of T3 and T4, especially physiologically active free (protein-unbound) forms, in serum/plasma is needed for the evaluation of TH homeostasis. However, such high-precision determination of free THs is lacking for non-human species. The present study aimed to develop a highly sensitive and reliable liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the determination of six free THs in serum/plasma, which is applicable to not only humans but also non-human species. Two different physical separation steps, ultrafiltration (UF) and equilibrium dialysis (ED), were examined to obtain the free TH fraction. Several experimental conditions were carefully optimized and validated for UF or ED using the commercially available bovine serum. As a result, UF at 1100 × g and 37 °C for 30 min with a 30 kDa ultrafiltration device (Centrifree YM-30, Millipore) yielded excellent precision (CV: < 10%). The optimized ED step also yielded high precision (CV: < 10%) and the measurement values were approximately equal to those of UF, but at least 16 h were required to reach equilibrium. Thus, UF combined with LC–MS/MS was finally chosen, in terms of the time needed for the measurement. Acceptable accuracy (recovery: 70%–110%) and intra- and inter-day precision (CV: < 10% and < 12%, respectively) were obtained, when triplicate analyses in three different days were conducted using the bovine serum. The developed analytical method was successfully applied to the determination of free THs in serum/plasma samples of humans, cats, and dogs. Furthermore, comparison with free T4 concentrations measured by a common immunoassay method evidently indicated that the ultrafiltration-LC–MS/MS method developed in this study can increase the specificity and accuracy of TH measurement.
  • Rumi Tanoue, Luigi Margiotta-Casaluci, Belinda Huerta, Tamsin J. Runnalls, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe, John P. Sumpter
    ENVIRONMENTAL SCIENCE & TECHNOLOGY 51 (21) 12825 - 12835 0013-936X 2017/11 [Peer-reviewed]
     Scientific journal 
    Recent species-extrapolation approaches to the prediction of the potential effects of pharmaceuticals present in the environment on wild fish are based on the assumption that pharmacokinetics and metabolism in humans and fish are comparable. To test this hypothesis, we exposed fathead minnows to the opiate pro-drug tramadol and examined uptake from the water into the blood and brain and the metabolism of the drug into its main metabolites. We found that plasma concentrations could be predicted reasonably accurately based on the lipophilicity of the drug once the pH of the water was taken into account. The concentrations of the drug and its main metabolites were higher in the brain than in the plasma, and the observed brain and plasma concentration ratios were within the range of values reported in mammalian species. This fish species was able to metabolize the pro-drug tramadol into the highly active metabolite O-desmethyl tramadol and the inactive metabolite N-desmethyl tramadol in a similar manner to that of mammals. However, we found that concentration ratios of O-desmethyl tramadol to tramadol were lower in the fish than values in most humans administered the drug. Our pharmacokinetic data of tramadol in fish help bridge the gap between widely available mammalian pharmacological data and potential effects on aquatic organisms and highlight the importance of understanding drug uptake and metabolism in fish to enable the full implementation of predictive toxicology approaches.
  • Rumi Tanoue, Kei Nomiyama, Haruna Nakamura, Joon-Woo Kim, Tomohiko Isobe, Ryota Shinohara, Tatsuya Kunisue, Shinsuke Tanabe
    ENVIRONMENTAL SCIENCE & TECHNOLOGY 49 (19) 11649 - 11658 0013-936X 2015/10 [Peer-reviewed]
     Scientific journal 
    A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals to wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, and biological risk of 20 pharmaceutical and personal care product (PPCP) residues in wild cyprinoid fish inhabiting treated-wastewater-impacted streams. In order to clarify the uncertainty of the FPM for PPCPs, we compared the plasma bioaccumulation factor in the field (BAF(plasma) = measured fish plasma/ambient water concentration ratio) with the predicted plasma bioconcentration factor (BCFplasma = fish plasma predicted by use of theoretical partition coefficients/ambient water concentration ratio) in the actual environment. As a result, the measured maximum BAF(plasma) of inflammatory agents was up to 17 times higher than theoretical BCFplasma values, leading to possible underestimation of toxicological risk on wild fish. When the tissue blood partition coefficients (tissue/blood concentration ratios) of PPCPs were estimated, higher transportability into tissues, especially the brain, was found for psychotropic agents, but brain/plasma ratios widely varied among individual fish (up to 28-fold). In the present study, we provide a valuable data set on the intraspecies variability of PPCP pharmacokinetics, and our results emphasize the importance of determining PPCP concentrations in possible target organs as well as in the blood to assess the risk of PPCPs on wild fish.
  • Kim, Joon-Woo, Isobe, Tomohiko, Tanoue, Rumi, Chang, Kwang-Hyeon, Tanabe, Shinsuke
    Current Analytical Chemistry 11 (2) 138 - 149 1573-4110 2015 [Peer-reviewed]
     Scientific journal
  • Rumi Tanoue, Kei Nomiyama, Haruna Nakamura, Terutake Hayashi, Joon-Woo Kim, Tomohiko Isobe, Ryota Shinohara, Shinsuke Tanabe
    JOURNAL OF CHROMATOGRAPHY A 1355 193 - 205 0021-9673 2014/08 [Peer-reviewed]
     Scientific journal 
    In the present study, a sensitive and accurate isotope dilution method was developed for the simultaneous determination of 17 polar pharmaceutical and personal care product (PPCP) residues (logK(ow) = 1.40-5.74), including 14 pharmaceuticals and 3 personal care products, in biological organs and tissues. The proposed method involved enzymatic hydrolysis, followed by sequential clean-up using silica gel chromatography and gel permeation chromatography, and analysis via ultra-high-performance liquid chromatography with tandem mass spectrometry. This method yielded acceptable absolute recoveries (48-88%) and internal standard-corrected recoveries (90-130%) for 17 PPCPs. Method detection limits were between 0.0092 and 3.2 ng g(-1) wet weight, and the limits of quantification were between 0.020 and 8.7 ng g(-1) wet weight. The method can be used to readily detect the target compounds at trace levels while minimizing the required sample volume. The developed method was applied to the determination of 17 PPCPs in the liver and kidney of 17 birds collected from Japan and also in the plasma, liver, and brain of 7 cyprinoid fish from an effluent-dominated stream in Japan. Triclosan was detected in 5 of 11 fish-eating birds but not in non-fish-eating birds, suggesting the contamination of prey fish by the chemical. Non-steroidal anti-inflammatory drugs, antibacterial agents, and psychotropic agents were frequently detected in the fish tissues. In addition, 7 of the target compounds were found in fish brain. The median brain/plasma ratios of the psychotropic agents ranged from 1.6 (carbamazepine) to 12 (diphenhydramine), indicating high transportability to fish brain. (C) 2014 Elsevier B.V. All rights reserved.
  • Rumi Tanoue, Yuri Sato, Mild Motoyama, Shuhei Nakagawa, Ryota Shinohara, Kei Nomiyama
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60 (41) 10203 - 10211 0021-8561 2012/10 [Peer-reviewed]
     Scientific journal 
    Land application of recycled manure produced from biosolids and reclaimed wastewater can transfer pharmaceutical chemicals to terrestrial environments, giving rise to potential accumulation of these residues in edible plants. In this study, the potential for plant uptake of 13 pharmaceutical chemicals, and the relation between the accumulation features within the plant and the physicochemical properties were examined by exposing pea and cucumber to an aqueous solution containing pharmaceutical chemicals. Ten of 13 compounds tested were detected in plant leaves and stems. Comparison of the plant uptake characteristics and the octanol water partition coefficient of pharmaceutical chemicals showed that compounds with an intermediate polarity such as carbamazepine and crotamiton could be easily transported to plant shoots. Moreover, these results suggest the possibility of highly hydrophilic pharmaceutical chemicals such as trimethoprim and sulfonamides to be accumulated in plant roots owing to their low permeability in root cell membranes.
  • 生活関連化学物質による、水環境汚染: 医薬品類による河川の汚染実態
    野見山桂, 田上瑠美, 篠原亮太
    産業と環境 8 37 - 41 2012 [Invited]
     Scientific journal 
    総説
  • Miki Motoyama, Shuhei Nakagawa, Rumi Tanoue, Yuri Sato, Kei Nomiyama, Ryota Shinohara
    CHEMOSPHERE 84 (4) 432 - 438 0045-6535 2011/07 [Peer-reviewed]
     Scientific journal 
    In recent years, sludge generated in sewage treatment plants (STPs) and solid waste from livestock being utilized is useful for circulation of nourishment in farmlands as recycled organic manure (ROM). In this study, we determined the residue levels and patterns of 12 pharmaceutical products generated by human activity in the ROMs produced from human waste sludge (HWS), sewage sludge (SS), cattle manure (CM), poultry manure (PM), swine manure (SM) and horse manure (HM). The kind and number of pharmaceutical products detected in ROMs were different. Fluoroquinolones (FQs) were detected at high levels in HWS and SS samples. In addition, the detection frequency and concentration levels of sulfonamides (SAs) in PM and SM were high. Moreover, high concentrations of chlortetracycline (CTC) were found in only SM. These differences reflect specific adherence adsorption of the pharmaceutical products to different livestock and humans. Moreover, it was found that the concentrations of pharmaceutical products and fermentation levels of ROMs had significant positive correlation (r = 0.41, p = 0.024). When the fermentation test of ROM was conducted in a rotary fermentor in a lab scale test, the residue levels of pharmaceutical products decreased effectively except carbamazepine (CBZ). The rates of decrease were in the case of tetracyclines (TCs): 85-92%, FQs: 81-100%, erythromycine: 67%, SAs: 79-95%, trimethoprim: 86% and CBZ: 37% by 30 d. Pharmaceutical products that can be decomposed by fermentation process at the lowest impact of residual antibiotic activities may therefore be considered as environmentally friendly medicines. (C) 2011 Elsevier Ltd. All rights reserved.

MISC

Awards & Honors

  • 2017/06 第26回環境化学討論会 優秀発表賞(35歳以下の若手研究者の部)
     
    受賞者: 田上 瑠美
  • 2016/09 平成28年度日本水環境学会 博士研究奨励賞(オルガノ賞)
     
    受賞者: 田上 瑠美
  • 2016/09 第22回日本環境毒性学会研究発表会 若手研究奨励賞
     
    受賞者: 田上 瑠美
  • 2013/08 第22回環境化学討論会 最優秀学生賞(博士後期課程の部)
     
    受賞者: 田上 瑠美
  • 2012/07 第21回環境化学討論会 優秀学生賞(博士後期課程の部)
     
    受賞者: 田上 瑠美
  • 2011/07 第20回環境化学討論会 優秀学生賞(博士前期課程の部)
     
    受賞者: 田上 瑠美

Research Grants & Projects

  • Development of risk assessment method and present of brain transfer by ionic environmental contaminants using fish as an indicator
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Date (from‐to) : 2020/04 -2024/03 
    Author : 野見山 桂, 岩田 久人, 池中 良徳, 久保田 彰, 田上 瑠美, 江口 哲史
  • Comprehensive analysis of organic contaminants in the aquatic environment of Asian developing countries by using liquid chromatography-high resolution mass spectrometry
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2020/04 -2022/03 
    Author : 田上 瑠美
  • Levels, fate, bioaccumulation, and risk assessment of harmful environmental chemicals derived from wastes and industrial and domestic drainage in Vietnam
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    Date (from‐to) : 2018/10 -2021/03 
    Author : 国末 達也, 田上 瑠美, 高橋 真, 鈴木 剛, 松神 秀徳
     
    本研究の目的は、近年経済発展が著しいベトナムの首都ハノイおよびその近郊を対象に、現地研究者との共同研究を通じて電気・電子機器廃棄物(e-waste)や使用済み自動車(End-of-Life Vehicles: ELV)に含まれる難燃剤等の有害化学物質、そして生活・工業排水に混入している医薬品・日用品関連化学物質(PPCPs)の汚染実態に加え、生物蓄積とリスクを評価することにある。本年度はベトナムの現地調査を実施し、ハノイ市の一般家庭とハノイ近郊に存在するe-wasteおよびELV処理場から室内ダストを、そして生活・工業排水が流入しているハノイ市の河川から水試料と魚類をサンプリングした。 昨年度確立したスクリーニング法を用いて、e-waste処理場から採取した室内ダストを分析した結果、残留性有機汚染物質(POPs)のPBDEsやHBCDsだけでなく、代替物質として使用されているビストリブロモフェノキシエタン(BTBPE)、デカブロモジフェニルエタン(DBDPE)、デクロランプラス (DP)、オクタブロモトリメチルフェニルインダン(OBIND)、ヘキサブロモベンゼン(HBBz)、ペンタブロモベンゼン(PBBz)、ペンタブロモトルエン(PBT)、ヘキサブロモビフェニル(BB-153)、デクロラン602 (Dec-602)、デクロラン604 (Dec-604)の検出も認められ、多様な有機ハロゲン系難燃剤がe-wasteの不適切処理に伴い作業環境へ放出されていることが判明した。 また、ハノイ市を流れるNhue riverの河川水を化学分析に供試した結果、感染症治療剤、高血圧治療剤、抗不安剤、防腐剤、抗菌剤、紫外線吸収剤、可塑剤など多種のPPCPsが検出され、そのレベルは日本の一般河川と比べ高値を示したことから、これらPPCPsによる河川への直接流入が示唆された。
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2018/04 -2020/03 
    Author : TANOUE RUMI
     
    We determined the uptake and depuration kinetics of 78 PPCPs in three fish species, to examine the factors causing the discrepancy between the bioconcentration factors predicted on the basis of chemical lipophilicity (BCFpredicted) and the bioconcentration factors calculated from the measured PPCP concentrations in the water and fish (BCFmeasured). When comparing BCFmeasured with the BCFpredicted, similar values were observed for >58% of detected compounds. On the other hand, BCFmeasured were 2-4 orders of magnitude lower than the BCFpredicted for some compounds. This was likely due to rapid metabolism and excretion of these compounds, as the calculated half-lives were short. In contrast, 1-2 orders of magnitude higher BCFmeasured than the BCFpredicted were observed for haloperidol and chlorpheniramine, which can be explained by a fast uptake rate and slow depuration rate. The k1 values of the two compounds were relatively high, implying a specific partition to non-lipid components.
  • 下水処理水に含まれる生理活性化学物質の水生生物への移行/残留性の評価
    公益財団法人日本生命財団:平成29年度若手研究・奨励研究助成
    Date (from‐to) : 2017/10 -2018/09 
    Author : 田上 瑠美
  • 魚類における解熱鎮痛消炎剤(NSAIDs)の体内挙動および影響発現との関連解析
    国立大学法人愛媛大学:共同利用・共同研究拠点「化学汚染・沿岸環境研究拠点」(LaMer) 若手国際共同研究
    Date (from‐to) : 2017/04 -2018/03 
    Author : 田上 瑠美
  • 水環境中に残留する生活関連化学物質の魚類への影響評価 〜動態学的および動力学的機構の定量的解析〜
    公益財団法人日本科学協会:平成29年度笹川科学研究助成
    Date (from‐to) : 2017/04 -2018/02 
    Author : 田上 瑠美
  • 水環境に残留する向精神剤の魚類への影響評価 ~動態学的および動力学的機構の定量的解析~
    国立大学法人愛媛大学:共同利用・共同研究拠点「化学汚染・沿岸環境研究拠点」(LaMer) 若手国際共同研究
    Date (from‐to) : 2016/04 -2017/03 
    Author : 田上 瑠美
  • 野生生物における極性PPCPsの汚染実態および生体残留性の解明とリスク評価
    日本学術振興会:科学研究費助成事業 特別研究員奨励費
    Date (from‐to) : 2014/04 -2016/03 
    Author : 田上 瑠美
     
    今年度は、これまでの研究においてPharmaceuticals and Personal Care Products (PPCPs)の特異な生体残留性と曝露リスクが懸念された魚類を対象生物とし研究を進めた。平成27年6月~平成28年3月までの9ヶ月間、英国 Brunel University, Environment, Health & Societies 研究所に留学し「PPCPsの水生生物移行~影響発現に至るまでの一連の流れ」について体系的な整理と数値化に取り組んだ。また、モルヒネ、ヘロイン、コデインに代表されるオピオイド系鎮痛薬はがん性痛の治療に用いられる一方で、それらの非合法的な不正使用が深刻な社会問題となっている。そこで、オピオイド系鎮痛薬のTramadolを対象物質とし、Fathead minnows (n = 96)に21日間流水式で曝露し、行動異常をエンドポイントとした新しい評価手法を用いてTramadolの生態影響を見積もった。また、試験魚の血漿と脳試料を化学分析に供試し、水-魚血漿間および血液-作用組織間におけるTramadolの分配について解析した。 その結果、[1] 水-魚血漿間のTramadol分配に従来の予測モデルが適用可能であること、[2] ヒトとは異なる代謝能を示すこと、[3] SSRIsと同様にTramadolは魚に対して抗不安作用を与えること等、当初の予想を上回る発見があった。魚の行動への影響を生態毒性値として数値化する試験法は標準化されておらず、試験条件、エンドポイントの決定とその定量法、ベースラインの低減・安定化など検討すべき課題が山積している中、本研究では、[1] 曝露前後での比較および[2] Positive controlとの比較を初めて試み、それらのアプローチ法が有益であることを示す先導的成果が得られた。

Teaching Experience

  • Fundamental Chemical ExperimentFundamental Chemical Experiment Ehime University

Others

  • 留学経験
    2013年2月~2013年3月 米国Baylor Universityに留学(約1ヶ月) 2015年6月~2015年3月 英国Brunel Universityに留学(約9ヶ月)
  • 資格
    2009年 5月 環境計量士(濃度関係)国家試験合格 2009年 11月 環境計量講習(濃度関係)修了 2009年 12月 公害防止管理者(水質関係)資格 2019年 2月 環境計量士(濃度関係)登録(登録番号:第11073号)


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