Researcher Database

SHIGEMATSU, Yuji

FacultyGraduate School of Medicine Program for Nursing and Health Sciences
PositionProfessor
Last Updated :2019/08/19

Researcher Profile and Settings

Profile and Settings

Name

  • Name

    SHIGEMATSU, Yuji

Affiliations

Affiliation & Job

  • Section

    Graduate School of MedicineNurse Course
  • Job title

    Professor

Education, Etc.

Degree

  • Medicine

その他基本情報

Academic & Professional Experience

  • 20050000, 20060000
  • 20050000, 20060000,  Ehime University School of Medicine, Faculty of Nursing and Health Sciences

Research Activities

Research Areas, Etc.

Research Interests

  • Hypertension
  • Left ventricular hypertrophy
  • target organ damage
  • insulin resistance

Book, papers, etc

Books etc

Conference Activities & Talks

  • PE-439 Comparison of the Prognosis in Patients with Hypertrophic Obstructive Cardiomyopathy Between Before and After the Treatment with Antiarrhythmic Drug, Cibenzoline(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd An, Hamada Mareomi, Izumi Naoki, Yamane Kenichi, Ohshima Kousei, Ishibashi Ken, Ohshima Kiyotaka, Ikeda Shuntaro, Shigematsu Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20090301
  • FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Aono Jun, Fujita Teppei, Sasaki Kaori, Seike Fumiyasu, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20090301
  • 20081020
  • PJ-913 Radial strain as a possible parameter of the extent of the delayed-enhacement in patients with hypertrophic cardiomyopathy(MRI / MRA(04)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Saitoh Makoto, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Yoshii Toyofumi, Inoue Katsuji, Hiasa Go, Sumimoto Takumi, Inoue Yuuma, Higashino Hiroshi, Mochizuki Teruhito, Honnda Toshio, Sadamoto Kazuhiko, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Saitoh Makoto, Uetani Teruyoshi, Izoe Yosuke, Fujita Teppei, Shimizu Hideaki, Shigematsu Yuji, Hamada Mareomi, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OJ-117 The effect of cibenzoline in patients with hypertrophic obstructive cardiomyopathy-Insights from changes In left ventricular regional-temporal heterogeneity(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd Annual Scient, Saitoh Makoto, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Yoshii Toyofumi, Inoue Katsuji, Hiasa Go, Sumimoto Takumi, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • A985G Polymorphism of the Endothelin-2 Gene and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy, NAGAI Takayuki, OGIMOTO Akiyoshi, OKAYAMA Hideki, OHTSUKA Tomoaki, SHIGEMATSU Yuji, HAMADA Mareomi, MIKI Tetsuro, HIGAKI Jitsuo, Circulation Journal, 20071120, Background It was recently suggested that the angiotensin-converting enzyme insertion/insertion genotype, which is considered to be protective against cardiovascular disease, was a significant risk factor for atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to investigate the association between the endothelin-2 (EDN2) A985G polymorphism and AF in patients with HCM. Methods and Results The EDN2 A985G polymorphism (rs 5800) was genotyped in 110 patients with HCM who had no clinically documented AF before medical treatment. The distribution of the EDN2 genotypes (G/G, G/A, and A/A) was 77.3%, 19.1%, and 3.6%, respectively. The EDN2 A allele frequency was 0.21 in 26 patients who subsequently developed AF during long-term follow-up and 0.11 in 84 patients who remained in sinus rhythm. The distribution of genotypes of the dominant EDN2 A allele between the two groups was significantly different by chi-square analysis (42.3% vs 16.7%, p=0.014). In a multivariate model, the A985 allele of the EDN2 gene was associated with increased adjusted risk for the occurrence of AF (p=0.018). Conclusion The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for AF in patients with HCM. (Circ J 2007; 71: 1932 - 1936)
  • 20071020
  • 20071020
  • 20070701
  • PE-212 T-182C Polymorphism of the Norepinephrine Transporter (SLC6A2) Gene and Cardiovascular Events in Patients with Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Saito Makoto, Uetani Teruyoshi, Izoe Yosuke, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • OJ-053 Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Affects Left Ventricular Pressure Gradient Response to Cibenzoline in Patients with Hypertrophic Obstructive Cardiomyopathy(Cardiomyopathy, basic/clinical-2, The 71st Annual Scientific M, Nagai Takayuki, Ogimoto Akiyoshi, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • OJ-052 Association between Endothelin-2 A985G Polymorphism and Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Nagai Takayuki, Ogimoto Akiyoshi, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • FRS-085 Association between G674A Polymorphism of the Connexin 40.1 Gene and Atrial Fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia (clinical) ; Pathophysiology of Atrial Fibrillation, The 71st Annual Scientific Meeting of the Japanese Cir, Ogimoto Akiyoshi, Okayama Hideki, Nagai Takayuki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Inaba Shinji, Saito Makoto, Uetani Teruyoshi, Izoe Yosuke, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • 20060420
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  • PJ-227 Small Left Ventricular Cavity as a Risk Factor for Drug Tolerance of Renin-Angiotensin System Inhibitors in Patients with Hypertension(Hypertension, clinical-9 (H) PJ38,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Kurata Akira, Yoshii Toyofumi, Oshita Akira, Saito Makoto, Uetani Teruyoshi, Hirose Noriko, Hasebe Yasuko, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20060301
  • 20051020
  • 20051020
  • 20051020
  • Sex-Related Differences in Relation of Insulin Resistance to Left Ventricular Geometry in Patients With Essential Hypertension(Hypertension, Clinical 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Ohshita Akira, Yoshii Toyofumi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Short-Term Effect of Amiodarone on Inflammatory Markers and Left Ventricular Function in Patients with Advanced Heart Failure Receiving Carvedilol(Heart Failure, Clinical 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Ohtsuka Tomoaki, Hirose Noriko, Mori Hideki, Ohshita Akira, Yoshii Toyofumi, Kurata Akira, Morioka Norikatsu, Inoue KATSUJI, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Evaluation of Pulmonary Venous Stenoses by Multi-slice Computed Tomography in Children with Congenital Heart Disease(X-ray/CT/MRI/DSA 1 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Kurata Akira, Higaki Takashi, Murakami Yoshitaka, Mochizuki Teruhito, Miyagawa Masao, Higashino Hiroshi, Haraikawa Toyoaki, Kido Teruhito, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Koyama Yasushi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Thallium-201 Myocardial Scintigraphy for Prediction of Prognosis in Patients with Dilated Cardiomyopathy Treated with Beta-blocker(Nuclear Cardiology 2 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Ohshita Akira, Yoshii Toyofumi, Mori Hideki, Hirose Noriko, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Relations of Uric Acid to Demographic, Left Ventricular Geometric and Renal Variables in Patients with Essential Hypertension(Hypertension, Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Yoshii Toyofumi, Ohshita Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Prognostic Impact of Myocardial Microvascular Integrity in Patients With Hypertrophic Cardiomyopathy(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Inoue Katsuji, Hirose Noriko, Mori Hideki, Ohshita Akira, Yoshii Toyofumi, Kurata Akira, Morioka Norikatsu, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Hamada Mareomi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Endothelial Nitric Oxide Synthase Polymorphism (Glu298Asp) on Cardiovascular Events for Patients with Hypertrophic Cardiomyopathy(Myocardial Disease, Cardiomyopathy and Myocarditis (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ, Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Yoshii Toyofumi, Ohshita Akira, Mori Hideki, Nakura Jun, Hamada Mareomi, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Assessment of Myocardial Ischemia by Adenosine 5-triphosphate Stress Multi-slice Computed Tomography : Alternative to Stress Myocardial Perfusion Scintigraphy(Recent Advance in Cardiovascular Imaging Technique (X-ray/CT/MRI/DSA) (I), The 69th Annual Scien, Kurata Akira, Hirose Noriko, Mori Hideki, Oshita Akira, Yoshii Toyofumi, Morioka Norikatsu, Inoue Katsuji, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Kido Teruhito, Haraikawa Toyoaki, Higashino Hroshi, Koyama Yasushi, Mochizuki Teruhito, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Image Fusion of Coronary Tree and Left Ventricular Function Using 16-MSCT(Recent Advance in Cardiovascular Imaging Technique (X-ray/CT/MRI/DSA) (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Higashino Hiroshi, Haraikawa Toyoaki, Kurat Akira, Kido Teruhito, Koyama Yasushi, Miyagawa Masao, Shigematsu Yuji, Higaki Jitsuo, Mochizuki Teruhito, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • 20041020
  • 20041020
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  • 20040420
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  • PE-274 Serum Marker of Angiogenesis and Myocardial Ultrasonic Tissue Characterization in Patients with Idiopathic Dilated Cardiomyopathy(Cardiomyopathy, Clinical 2 (M) : PE47)(Poster Session (English)), Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-595 Myocardial damage on Thallium-201 scintigraphy and prognosis in patients with dilated cardiomyopathy treated with beta-blocker(Cardiomyopathy, Clinical 7 (M) : PJ100)(Poster Session (Japanese)), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Ohshita Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-427 Cibenzoline can Attenuate LV Diastolic Functions According to the Reduction of LV Diastolic Pressures in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, Clinical 5 (M) : PJ71)(Poster Session (Japanese)), Hamada Mareomi, Ikeda Shuntaro, Watanabe Koki, Suzuki Jun, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-423 Increased Circulating Levels of Heart-Type Fatty Acid-Binding Protein in Patients with Hypertrophic Cardiomyopathy : its Relation to the Thallium-201 Perfusion Defects(Cardiomyopathy, Clinical 5 (M) : PJ71)(Poster Session (Japanese)), Morioka Norikatsu, Shigematsu Yuji, Ohshita Akira, Kurata Akira, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-415 Brain natriuretic peptide is a potent prognostic variable in hemodialysis patients without cardiac dysfunction(Kidney/Renal Circulation 2 (H) : PJ69)(Poster Session (Japanese)), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Murakami Bonpei, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-121 Genetic Predisposition to Hypertension Versus Insulin Resistance as Risk Factors for Hypertensive Left Ventricular Hypertrophy(Hypertension, Clinical 2 (H) : PJ20)(Poster Session (Japanese)), Shigematsu Yuji, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-391 Prognostic Impact of Myocardial Microvascular Integrity in Patients With Idiopathic Dilated Cardiomyopathy(Echo/Doppler 13 (I) : OJ47)(Oral Presentation (Japanese)), Inoue Katsuji, Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-275 Effect of Carvedilol on Myocardial Microvascular Integrity and Cardiac Function in Patients With Idiopathic Dilated Cardiomyopathy(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese)), Inoue Katsuji, Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-247 Determination of Left Ventricular Mass and Coronary Blood Flow in Hypertensive Patients with Negative T Wave on Electrocardiogram(Hypertension, Clinical 5 (H) : OJ29)(Oral Presentation (Japanese)), Hamada Mareomi, Inaba Shinji, Komatsu Jiro, Ikeda Shuntaro, Watanabe Koki, Shigematsu Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-224 Effect of the GNB3 Gene Variant on Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy(Cardiomyopathy, Clinical 1 (M) : OJ26)(Oral Presentation (Japanese)), Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Ohshita Akira, Nakura Jun, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-160 Relationship between Myocardial Fibrosis and the Circulating Levels of Myocardial Collagen Markers(X-ray/CT/MRI/DSA2 (I) : OJ19)(Oral Presentation (Japanese)), Matsunaka Tsuyoshi, Hamada Mareomi, Matsumoto Yuji, Takada Yasuharu, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Higaki Jitsuo, Koyama Yasushi, Kawakami Hideo, Matsuoka Hiroshi, Itoh Taketoshi, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OE-298 Atrial Fibrillation in Patients with Hypertrophic Non-obstructive Cardiomyopathyls Associated with Low Left Ventricular Peak Wall Stress(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English)), Ohshima Kiyotaka, Shigematsu Yuji, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Higaki Jitsuo, Hamada Mareomi, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OE-117 Eplerenone, a Selective Aldosterone Receptor Antagonist, Inhibits Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English)), Suzuki Jun, Iwai Masaru, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Horiuchi Masatsugu, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • FRS-082 Endothelial Nitric Oxide Synthase Gene Polymorphism (Glu298Asp) in Patients with Coexistent Hypertrophic Cardiomyopathy and Coronary Vasospasm(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English)), Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Ohshita Akira, Hamada Mareomi, Nakura Jun, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • 20031020
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  • Subendocardial Microvasucular Abnormalities in Patients with Hypertrophic Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Contribution of Genetic Predispositions to Hypertension to Left Ventricular Hypertrophy Is Mediated by Insulin Resistance, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Aortic Compliance in Essential Hypertension Is Associated with Insulin Resistance Metabolic Syndrome, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Renin Profile and Coronary Endothelium-Dependent Vasodilation in Essential Hypertension, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Effect of Beta-Blocker Therapy on Thallium-201 Perfusion Defects in Patients with Dilated Cardiomyopathy, Hara Yuji, Hamada Mareomi, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Brain Natriuretic Peptide Level Can Differentiate Patients with Essential Hypertension from Patients with Hypertensive Hypertrophic Cardiomyopathy, Suzuki Jun, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Myocardial Structural Abnormalities Contribute to Left Ventricular Enlargement and Dysfunction in Patients with Dilated Cardiomyopathy ; Usefulness of Ultrasonic Tissue Characterization, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Myocardial Fibrosis Using Gadolinium-DTPA Enhanced Magnetic Resonance Imaging and Left Ventricular Function in Hypertrophic Cardiomyopathy, Matsunaka Tsuyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Matsumoto Yuuji, Takada Yasuharu, Matsuoka Hiroshi, Kawakami Hideo, Koyama Yasushi, Itoh Taketoshi, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Long-Term Effects of Carvedilol Versus Metoprolol on Left Ventricular Function, Remodeling and Neurohumoral Factors in Patients with Idiopathic Dilated Cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Microvascular Damage Contributes to the Left Ventricular Dysfunction in Patients with Idiopathic Dilated Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Inoue Katsuji, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Circulating Interleukin-13 and Left Ventricular Remodeling in Patients with Idiopathic Dilated Cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relation between Angiotensin-Converting Enzyme II Genotype and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy, Ogimoto Akiyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Heart Failure Is the Highest Incidence of Cardiovascular Events and Deaths in Patients with Hypertrophic Cardiomyopathy : A 14-Year Follow-Up Study, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
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  • Assessment of Microvascular Integrity by Intravenous Myocardial Contrast Echocardiography in Patients With Hypertrophic Cardiomyopathy, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Association of Monocyte Chemoattractant Protein 1 (MCP-1) Gene Polymorphism With Susceptibility to Dilated Cardiomyopathy, Ogimoto Akivoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Nakura Jun, Kohara Katsuhiko, Tabara Yasuharu, Miki Tetsuro, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Circulating levels of insulin-like growth factor-I and its binding proteins in patients with hypertrophic cardiomyopathy, Saeki Hideyuki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Insulin resistance and tumor necrosis factor- α in patients with dilated cardiomyopathy : effect of beta-blocker, Hara Yuji, Hamada Mareomi, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunjo, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Relation Between Angiotensin-Converting Enzyme II Genotype and Atrial Fibrillation in Japanese Patients With Hypertrophic Cardiomyopathy, Ogimoto Akiyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunjo, Nakura Jun, Miki Tetsuro, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Relationship between insulin resistance and coronary endothelium-dependent vasodilation in essential hypertension, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Tumor necrosis factor-alpha and matrix metalloproteinase activity in patients with idiopathic dilated cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Increased Circulating Levels of Procollagen Peptides in Patients with Hypertrophic Cardiomyopathy, Saeki Hideyuki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Effect of carvedilol on cardiac matrix remodeling in patients with idiopathic dilated cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Ten-year follow-up study of thallium-201 myocardial scintigraphy in 104 patients with hypertrophic cardiomyopathy, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
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  • EXERCISE-INDUCED MYOCARDIAL ISCHEMIA IN HYPERTENSIVE PATIENTS WITH ANGIOGRAPHICALLY NORMAL CORONARY ARTERIES-ASSOCIATION WITH CORONARY VASOSPASM-, SHIGEMATSU Yuji, KUWAHARA Taishi, KAWAKAMI Hideo, OKAYAMA Hideki, HARA Yuji, HAYASHI Yutaka, KODAMA Koji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19960620
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  • USEFULNESS AND LIMITATION OF BLOOD PRESSURE MONITORING BY ARTERIAL TONOMETRY, KUWAHARA Taishi, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, HAYASHI Yutaka, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • INTRACAVITARY FILLING PATTERN IN THE FAILING LEFT VENTRICLE ASSESSED BY INTRAVENOUS INJECTION OF SONICATED ALBUMIN, HAYASHI Yutaka, HAMADA Mareomi, KUWAHARA Taishi, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ALTERNATION OF THE GENES ENCODING SARCOPLASMIC RETICULUM PROTEINS IN DIABETIC-RAT HEART, OKAYAMA Hideki, KAWAKAMI Hideo, MAGUCHI Motofumi, NISHIDA Wataru, KOHARA Katsuhiko, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • EFFECT OF ANTIHYPERTENSIVE THERAPY ON AORTIC DISTENSIBILITY IN PATIENTS WITH HYPERTENSION:COMPARISON WITH ALACEPRIL AND TRICHLORMETHIAZIDE, HONDA Toshio, MATSUMOTO Yuji, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • TARGET ORGAN DAMAGE IN PRIMARY ALDOSTERONISM:COMPARISON WITH ESSENTIAL HYPERTENSION, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ESTIMATION OF SYSTOLIC PULMONARY ARTERY PRESSURE BY A THALLIUM-201 MYOCARDIAL IMAGING IN PATIENTS WITH RIGHT VENTRICULAR OVERLOAD, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • Increased Secretion of Atrial and Brain Natriuretic Peptides during Acute Myocardial Ischemia in Patients with Angina Pectoris., MARUMOTO Kazumasa, ABURAYA Masahito, KUWAHARA Taishi, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • EVALUATION OF AORTIC DISTENSIBILITY IN HEMODIALYSIS PATIENTS USING CINE MAGNETIC RESONANCE, MATSUMOTO Yuji, HONDA Toshio, SHIGEMATSU Yuji, SUMIMOTO Takumi, MUKAI Mikio, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • HETEROGENEITY OF VASODILATOR RESPONSE TO ACETYLCHOLINE AND ATP IN CORONARY AND RENAL ARTERIES, MUKAI Mikio, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, HAYASHI Yutaka, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ALTERNATION OF A-AND B-TYPE NATRIURETIC PEPTIDE GENES ASSOCIATED WITH PROGRESSION AND REGRESSION OF CARDIAC HYPERTROPHY IN RENOVASCULAR HYPERTENSIVE RAT, KAWAKAMI Hideo, OKAYAMA Hideki, MARUMOTO Kazumasa, ABURAYA Masahiti, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
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  • DISPARATE RESPONSE BETWEEN IMPULSE AND ELASTANCE TO β-ADRENERGIC STIMULATION IN HUMAN HYPERTENSIVE HEARTS, Suzuki Makoto, Kuwahara Taishi, Okayama Hideki, Mukai Mikio, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • HEMODYNAMIC CHARACTERISTICS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY WHO HAVE A HISTORY OF SYNCOPE, Shigematsu Yuji, Hamada Mareomi, Mukai Mikio, Sumimoto Takumi, Hiwada Kunio, Japanese circulation journal, 19940620
  • LEFT VENTRICULAR CARDIAC STRUCTURE AND SYSTOLIC FUNCTION IN ELDERLY PATIENTS WITH "BURNED-OUT" ESSENTIAL HYPERTENSION, Sumimoto Takumi, Mukai Mikio, Shigematsu Yuji, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • LEFT VENTRICULAR ADAPTATION TO HYPERTENSION AND EXTRACARDIAC TARGET ORGAN DAMAGE, Shigematsu Yuji, Hamada Mareomi, Mukai Mikio, Sumimoto Takurni, Hiwada Kunio, Japanese circulation journal, 19940620
  • ACTIVE RECOIL IN ISOLATED MYOCYTES : ROLE OF INTRACELLULAR RESTORING FORCE, Okayama Hideki, Kawakami Hideo, Kobayashi Takamasa, Suzuki Makoto, Mukai Mikio, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • THE DIFFERENCE IN CHANGING PATTERN BETWEEN TL-201 AND I-123 MIBG MYOCARDIAL DISTRIBUTION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Kuwahara Taishi, Mukai Mikio, Kawakami Hideo, Okayama Hideki, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • THALLIUM-201 MYOCARDIAL SCINTIGRAPHIC CHANGES DURING 50-MONTH FOLLOW-UP PERIOD IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Hamada Maremi, Sumimoto Takumi, Shigematsu Yuji, Mukai Mikio, Okayama Hideki, Suzuki Makoto, Kobayash Takamasa, Marumoto Kazumasa, Mineoi Kazuaki, Hiwada Kunio, Japanese circulation journal, 19940620
  • TWO TYPES OF HEART FAILURE IN PATIENTS WITH AORTITIS SYNDROME, Mukai Mikio, Kuwahara Taishi, Okayama Hideki, Suzuki Makoto, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
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  • ACCURATE DIAGNOSIS OF METASTATIC CARDIAC LEIOMYOSARCOMA WITH INFUNDIBULAR STENOSIS AND CARDIAC TAMPONADE BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY AND Gd-DTPA MAGNETIC RESONANCE IMAGING : Report of a Case, SUZUKI MAKOTO, HAMADA MAREOMI, ABE MITSUNORI, MATSUOKA HIROSHI, SHIGEMATSU YUJI, SUMIMOTO TAKUMI, HIWADA KUNIO, OSUKA YO, Japanese circulation journal, 19940220, We present a patient with metastatic cardiac leiomyosarcoma that was diagnosed antemortem by transesophageal echocardiography (TEE) and ECG-gated magnetic resonance imaging with gadolinium diethylene triaminepentaacetic acid (Gd-DTPA MRI). TEE and Gd-DTPA MRI clearly revealed the morphological characteristics of infundibular stenosis and cardiac tamponade. Our patient has survived about 30 months after cardiac surgery. Since sarcoma is usually associated with a very poor prognosis, surgical treatment should be performed as soon as possible. TEE with color Doppler imaging and Gd-DTPA MRI are very useful diagnostic methods for determining the precise anatomical characterization of cardiac tumor, and these procedures are prerequisite to precise therapy.
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  • -0536-CLINICAL SIGNIFICANCE OF NEGATIVE T WAVE IN PRECORDEAL LEADS ON ELCTROCARDIOGRAM IN ESSENTIAL HYPERTENSIVES : WITH SPECIAL REFERENCE TO THE LEFT VENTRICULAR MASS, Ohtani Takashi, Hamada Mareomi, Suzuki Makoto, Shigematsu Yuji, Sumimoto Takumi, Fujiwara Yasushi, Hiwada Kunio, Japanese circulation journal, 19900720
  • -0299-PERSISTENT ELEVATIONS OF SERUM CARDIAC ENZYMES IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Hamada Mareomi, Ohtani Takashi, Shigematsu Yuji, Fujiwara Yasushi, Sumimoto Takumi, Hiwada Kunio, Japanese circulation journal, 19900720
  • STUDY OF AORTIC ANEURYSM BY CINE MAGNETIC RESONANCE IMAGING : CT, MRI : 53 Annual Scientific Meeting, Japanese Circulation Society, Matsuoka Hiroshi, Niida Akira, Miki Hitoshi, Shigematsu Yuji, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19890820
  • DISPARATE DIFFERENCE OF LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH ESSNTIAL HYPERTENSION AND HYPERTROPHIC CARDIOMYOPATHY : DOES DISPROPORTIONATE SEPTAL HYPERTROPHY EXIST IN ESSENTIAL HYPERTENSIVES? : Hypertension : 53 Annual Scientific Meeting, Japanes, Fujiwara Yasushi, Hamada Mareomi, Sekiya Michihito, Sumimoto Takumi, Tsuruoka Takashi, Shigematsu Yuji, Mukai Mikio, Kodama Koji, Hiwada Kunio, Kokubu Tatsuo, Japanese circulation journal, 19890820
  • SPECIFIC DIASTOLIC FILLING PATTERN IN CORONARY ARTERY DISEASE WITH SEVERELY DEPRESSED LEFT VENTRICULAR FUNCTION : Ischemic Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society, Sekiya Michihito, Kodama Koji, Mukai Mikio, Tsuruoka Takashi, Shigematsu Yuji, Sumimoto Takumi, Fujiwara Yashushi, Hamada Mareomi, Hiwada Kunio, Kokubo Tatsuo, Japanese circulation journal, 19890820
  • Abnormal blood pressure response to atrial pacing in patients with hypertrophic cardiomyopathy., HAMADA M., Mukai Mikio, Kodama Koji, Tsuruoka Takashi, Shigematsu Yuji, Fujiwara Yasushi, Sumimoto Takumi, Sekiya Michihito, Hiwada Kunio, Kokubu Tatsuo, Jpn.Circ.J., 19890000
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  • MORPHOLOGICAL AND FUNCTIONAL IDENTIFICATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY ESTIMATED BY LEFT VENTRICULOGRAM AT THE RIGHT ANTERIOR OBLIQUE PROJECTION : Cardiomyopathy (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CI, Doiuchi Junji, Hamada Mareomi, Sigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Mukai Mikio, Nishitani Koji, Kokubu Tatsuo, Japanese circulation journal, 19860820
  • CLINICAL SIGNIFICANCE OF SYSTOLIC TIME INTERVALS IN DETECTING THE STENOSIS OF PROXIMAL LEFT CORONARY ARTERY : Ischemic Heart Disease (V) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Kazatani Yukio, Hamada Mareomi, Sekiya Michihito, Shigematsu Yuji, Nishiyama Seichi, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19850820
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  • NONINVASIVE EVALUATION OF LEFT VENTRICULAR FUNCTION AND THE EFFECTS OF Ca^<2+> ANTAGONIST IN HYPERTENSION WITH ANGINA PECTORIS : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society, Ochi Takaaki, Hamada Mareomi, Shigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19840820
  • CALCIUM-CHANNEL BLOCKERS AND BETA-ADRENERGIC BLOCKER : THE DIFFERENCE EFFECTS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society, Doiuchi Junji, Hamada Mareomi, Shigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Ochi Takaaki, Ito Taketoshi, Tatsuo Kokubu, Japanese circulation journal, 19840820
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  • TIME ANALYSIS: MORE SENSITIVE TECHNIQUE IN THE EVALUATION OF THE LEFT VENTRICULAR FUNCTION IN ESSENTIAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension, Ochi Takaaki, Shigematsu Yuji, Kazatani Yukio, Matsuzaki Keisuke, Nishitani Koji, Toki Hideo, Hamada Mareomi, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820
  • ABNORMAL BLOOD PRESSURE RESPONSE OF VALSALVA MANEUVER IN ESSENTIAL HYPERTENSIVES WITH PAROXYSMAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension, Kazatani Yukio, Hamada Mareomi, Shigematsu Yuji, Matsuzaki Keisuke, Ariki Kiwa, Kan Takuya, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820
  • DIFFERENCE IN MYOCARDIAL CHARACTERISTICS BETWEEN HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL HYPERTROPHY DUE TO ESSENTIAL HYPERTENSION USING THE EARLY DIASTOLIC TIME INTERVALS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION , Hamada Mareomi, Matsuzaki Keisuke, Shigematsu Yuji, Kazatani Yukio, Kato Masakazu, Doiuchi Junji, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820

Misc

  • Multi-coronary Arterial Spasm 4 Years after Percutaneous Transluminal Coronary Angioplasty : A Case Report, HARA Yuji, OHSHIMA Kiyotaka, OHTSUKA Tomoaki, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, KODAMA Koji, SHIGEMATSU Yuji, HAMADA Mareomi, OHTANI Takashi, Japanese journal of interventional cardiology, Japanese journal of interventional cardiology, 13, 5, 467, 472, 19981010, 09148922, http://ci.nii.ac.jp/naid/10008359902
  • 189, 9, 638, 641, 19990529, 00392359, http://ci.nii.ac.jp/naid/40000119578
  • Hypertrophic Cardiomyopathy With Mid-Ventricular Obstruction and Splenic Infarction Associated With Paroxysmal Atrial Fibrillation : A Case Report, TOKUYASU Kazuki, HARA Yuji, MATSUMOTO Yuji, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, HIASA Go, KITAMI Yutaka, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Journal of cardiology, Journal of cardiology, 34, 5, 273, 277, 19991115, 09145087, http://ci.nii.ac.jp/naid/10005540365
  • Relative Wall Thickness Is an Independent Predictor of Left Ventricular Systolic and Diastolic Dysfunctions in Essential Hypertension., LI Liqi, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Hypertension Research, 日本高血圧学会, Hypertension Research, 24, 5, 493, 499, 20010000, 0916-9636, http://ci.nii.ac.jp/naid/130004436923, The objective of this study was to elucidate the relationship between left ventricular geometry and left ventricular (LV) function in patients with untreated essential hypertension. We evaluated LV systolic and diastolic functions by M-mode echocardiography in 24 normotensive control subjects (NC) and 129 patients with essential hypertension. Patients were divided into four groups according to the relative wall thickness and LV mass index: a normal left ventricle (n=57), a concentric remodeling (n=7), a concentric hypertrophy (n=31), and an eccentric hypertrophy (n=34) group. LV systolic function as measured by midwall fractional shortening (FS) was significantly decreased in both the concentric remodeling and concentric hypertrophy groups; no differences were observed for endocardial FS. LV diastolic function as measured by isovolumic relaxation time (IRT) was also decreased in both the concentric remodeling and concentric hypertrophy groups. In multivariate analysis, relative wall thickness (p<0.0001), end-systolic wall stress (p<0.0001), and systolic blood pressure (p=0.002) were independently associated (r2=0.72) with midwall FS in a model including age, LV mass index, body mass index, diastolic blood pressure and IRT. In addition, relative wall thickness (p=0.0008) and age (p<0.0001) were independently associated (r2=0.31) with IRT in a model including LV mass index, end-systolic wall stress, body mass index, systolic and diastolic blood pressures and midwall FS. We conclude that LV geometry as evaluated by relative wall thickness may provide a further independent stratification of LV systolic and diastolic functions in essential hypertension.
    (Hypertens Res 2001; 24:493-499)
  • Antiarrhythmic Drug, Cibenzoline, can Directly Improve the Left Ventricular Diastolic Function in Patients With Hypertrophic Cardiomyopathy, HAMADA Mareomi, SHIGEMATSU Yuji, HARA Yuji, SUZUKI Makoto, OHTSUKA Tomoaki, HIASA Go, OGIMOTO Akiyoshi, SAEKI Hideyuki, SUZUKI Jun, HIWADA Kunio, Jpn Circ J, 社団法人日本循環器学会, Japanese circulation journal, 65, 6, 531, 538, 20010520, 0047-1828|1347-4839, 10.1253/jcj.65.531, http://ci.nii.ac.jp/naid/110002625713, The effect of cibenzoline on left ventricular diastolic function was investigated in patients with hypertrophic cardiomyopathy (HCM). Before and 2 h after an oral administration of 200 mg of cibenzoline, echocardiographic, apexcardiographic and gated radionuclide angiographic studies were performed in 12 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 7 with hypertrophic nonobstructive cardiomyopathy (HNCM). After administration of cibenzoline, the left ventricular pressure gradient decreased from 96±33 mmHg to 29±22 mmHg (<0.0001). Fractional shortening decreased from 53.3±7.5 to 45.4±6.2% (p=0.0008) in patients with HOCM and from 49.9±8.7 to 40.9±7.5% (p=0.0039) in patients with HNCM. On the other hand, E-wave velocity increased and A-wave velocity decreased in both groups. The time between the second heart sound and O point was shortened from 253±53 to 176±21 ms (p<0.0001) in patients with HOCM and from 245±54 to 185±44 ms (p=0.0050) in patients with HNCM. The time to peak filling rate was shortened from 248±79 to 190±40ms (p=0.0072) in patients with HOCM and from 218±33 to 163±26ms (p=0.0052) in patients with HNCM. These results indicate that in patients with HCM, cibenzoline suppresses left ventricular systolic function, but can markedly improve left ventricular diastolic dysfunction through its direct action. (Jpn Circ J 2001; 65:531-538)
  • 17, 2, 53, 56, 20020000, 0910-8327, 10.1007/s003800200043
  • Use of Thallium-201 Myocardial Scintigraphy for the Prediction of the Response to β-Blocker Therapy in Patients With Dilated Cardiomyopathy, HARA Yuji, HAMADA Mareomi, OHTUKA Tomoaki, OGIMOTO Akiyoshi, SAEKI Hideyuki, SUZUKI Jun, MATSUNAKA Tsuyoshi, NAKATA Shigeru, SHIGEMATSU Yuji, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 66, 12, 1139, 1143, 20021120, 1346-9843|1347-4820, 10.1253/circj.66.1139, http://ci.nii.ac.jp/naid/110002666177, This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predict the usefulness of β-blocker therapy in patients with dilated cardiomyopathy (DCM). Tl-201 and MIBG were performed in 47 patients before β-blocker therapy. Patients were classified into group A, if their cardiac function improved, and group B, whose function remained unchanged. Two types of extent score (ES) by Tl-201 were proposed to quantitate myocardial damage, mean - 2SD (ES-2) and mean - 3SD (ES-3). The ES difference between ES-2 and ES-3 was calculated, and according to ES and ES difference, DCM cases were classified into 3 groups: mild-defect type (mild-type), moderate-defect type (moderate-type) and severe-defect type (severe-type). The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated, and the percent washout ratio of myocardial MIBG was obtained from these data. Group A comprised 18 mild-type, 14 moderate-type and 1 severe-type cases, and group B comprised 5 mild-type, 4 moderate-type and 5 severe-type cases. A significant relation was observed between the defect type on Tl-201 and the response to β-blocker therapy (p=0.0090). Both H/M MIBG uptake ratios and washout ratio were not significantly different in the 2 groups. Tl-201 may be useful for predicting the response to β-blocker therapy in patients with DCM. (Circ J 2002; 66: 1139 - 1143)
  • Attenuation of Biventricular Pressure Gradients by Cibenzoline in an 18-Year-Old Patient With Hypertrophic Obstructive Cardiomyopathy, HIASA Go, HAMADA Mareomi, SHIGEMATSU Yuji, HARA Yuji, OHTSUKA Tomoaki, OGIMOTO Akiyoshi, SAEKI Hideyuki, SUZUKI Jun, MATSUNAKA Tsuyoshi, HAMADA Hironobu, OKURA Takafumi, HIWADA Kunio, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 66, 12, 1173, 1175, 20021120, 13469843, http://ci.nii.ac.jp/naid/110002666183, An 18-year-old male patient with biventricular hypertrophic obstructive cardiomyopathy (HOCM) had successful reduction of the pressure gradients by cibenzoline. At 11 months after birth, he was first diagnosed with cardiac murmurs and by the age of 5 years, he was diagnosed with subpulmonic infundibular stenosis with a pressure gradient of 10 mmHg by cardiac catheterization. At the age of 14, re-catherterization revealed hypertrophic cardiomyopathy with isolated obstruction of the right ventricular outflow tract, with a pressure gradient of 70 mmHg, but no obstruction in the left ventricle. He began daily treatment with 30 mg propranolol. At the age of 18, he was admitted for cardiac evaluation. An echocardiogram revealed left mid-ventricular and subpulmonic obstructions associated with pressure gradients of 88 mmHg and 65 mmHg, respectively. A single oral dose of 200 mg of cibenzoline decreased the pressure gradients in the left and right ventricles (38 mmHg and 36 mmHg, respectively). He was then given 300 mg daily of cibenzoline, and both pressure gradients remained low without any complications 8 months later at the time of discharge. (Circ J 2002; 66: 1173 -1175)
  • 124, 4, 1275, 1283, 20030000, 10.1378/chest.124.4.1275
  • 41, Suppl 1, S5-S10, 20030000
  • Benefical effect of cibenzoline in a patient with hypertrophic obstructive cardiomyopathy complicated with idiopathic interstitial pneumonia, SAITO Makoto, HARA Yuji, SHIGEMATSU Yuji, OHTSUKA Tomoaki, SAEKI Hideyuki, OGIMOTO Akiyoshi, YOKOYAMA Akihito, HAMADA Mareomi, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 40, 1, 62, 64, 20030125, 03009173, http://ci.nii.ac.jp/naid/10010526910, A 72-year-old woman who had idiopathic interstitial pneumonia was admitted due to general fatigue. Echocardiography revealed asymmetric septal hypertrophy and systolic anterior movement of the mitral valve. In addition, Doppler echocardiography revealed a pressure gradient of 52mmHg in the left ventricular outflow tract. Hypertrophic obstructive cardiomyopathy was diagnosed. Because she had a respiratory disease, she was treated with cibenzoline instead of beta-blockers. After treatment her pressure gradient decreased to 10mmHg, but respiratory symptom remained unchanged. This finding suggests that cibenzoline is useful for patients with hypertrophic obstructive cardiomyopathy complicated with respiratory disease.
  • Effect of Beta-Blockers on Insulin Resistance in Patients With Dilated Cardiomyopathy, HARA Yuji, HAMADA Mareomi, SHIGEMATSU Yuji, OHTSUKA Tomoaki, OGIMOTO Akiyoshi, HIGAKI Jitsuo, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 8, 701, 704, 20030720, 1346-9843|1347-4820, 10.1253/circj.67.701, http://ci.nii.ac.jp/naid/110002666385, The aim of this study was to evaluate the effect of β-blockers on insulin resistance in patients with dilated cardiomyopathy (DCM). A secondary aim was to determine the effect of this treatment on plasma concentrations of tumor necrosis factor-α (TNF-α) and to investigate the relationships between this adipocytokine and insulin resistance. Insulin resistance determined using the Homeostatic Model Assessment (HOMA), echocardiographic measurements and analysis of plasma TNF-α concentration were carried out in 47 patients with DCM without diabetes mellitus before and after 6 months of β-blocker therapy. A reduction in left ventricular dimensions and an associated increase in ejection fraction occurred with β-blocker. The treatment resulted in a significant decrease in insulin resistance (HOMA index: Baseline, 2.73±3.36 vs, Month 6, 1.58±1.33, p=0.0347). Beta-blockade was also associated with a decrease in plasma TNF-α concentration although no significant relationship between this change and the improvement in insulin resistance was observed. Beta-blocker therapy in patients with DCM improved not only cardiac function, but also insulin resistance. The mechanism of the change in insulin function remains unclear, but may be related to improvements in left ventricular function or an attenuation of the inhibitory effect of reduction in TNF-α on insulin signaling. (Circ J 2003; 67: 701 - 704)
  • Rapid Progression of Primary Cardiac Leiomyosarcoma with Obstruction of the Left Ventricular Outflow Tract and Mitral Stenosis, OGIMOTO Akiyoshi, HAMADA Mareomi, OHTSUKA Tomoaki, HARA Yuji, SHIGEMATSU Yuji, YOKOYAMA Akihito, IMAGAWA Hiroshi, KAWACHI Kanji, KITO Katsumi, HIGAKI Jitsuo, Internal Medicine, Japanese Society of Internal Medicine, Internal medicine, 42, 9, 827, 830, 20030901, 09182918, http://ci.nii.ac.jp/naid/50000297093
  • Effect of Beta-Blocker Therapy in Elderly Patients With Dilated Cardiomyopathy, HARA Yuji, HAMADA Mareomi, SHIGEMATSU Yuji, OHTSUKA Tomoaki, OGIMOTO Akiyoshi, SUZUKI Jun, HIGAKI Jitsuo, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 10, 826, 829, 20030920, 1346-9843|1347-4820, 10.1253/circj.67.826, http://ci.nii.ac.jp/naid/110002666223, The aim of this study was to evaluate whether β-blocker therapy can be safely administered to and improve cardiac function of elderly patients with dilated cardiomyopathy (DCM). Echocardiography and measurement of the concentrations of natriuretic peptides were carried out in 67 patients with DCM before and after 6 months of β-blocker therapy: 20 patients ≥65 years of age (older group); 47 <65 years of age (younger group). In all patients, β-blocker was safely administered and well tolerated. There was no significant difference in the dose of β-blocker between 2 groups. A reduction in the left ventricular dimensions and an associated increase in ejection fraction occurred in both treatment groups. The β-blocker treatment resulted in a significant decrease in the concentrations of natriuretic peptides in both groups. In conclusion, β-blocker therapy is well-tolerated and has similar effects on cardiac function in older and younger patients with DCM. (Circ J 2003; 67: 826 - 829)
  • Ischemia in the Territory of the First Major Septal Perfurator Branch Anomalously Originating From the First Diagonal Branch Leads to a Transient Leftward Shift of the QRS Axis in the Frontal Plane : A Case Report, KODAMA-TAKAHASHI Koji, SUZUKI Jun, WATANABE Akira, OHTSUKA Tomoaki, HASHIDA Hidetoshi, IKEDA Shutaro, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 10, 885, 888, 20030920, 13469843, http://ci.nii.ac.jp/naid/110002666235, A patient with non-Q wave myocardial infarction had severe luminal narrowing in the first major septal perforator branch, which arose anomalously from the first diagonal branch. In this case, an exercise ECG showed a transient leftward QRS axis shift. (Circ J 2003; 67: 885 - 888)
  • 126, 3, 679, 686, 20040000, 10.1378/chest.126.3.679
  • Cardiac tamponade with paroxysmal atrial flutter controlled by antituberculous therapy, Ogimoto Akiyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Saeki Hideyuki, Katayama Hitoshi, Hamada Hironobu, Higaki Jitsuo, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 41, 1, 112, 116, 20040000, 0300-9173, http://ci.nii.ac.jp/naid/130003652929, We report a rare and unique case of possible extrapulmonary tuberculosis in an 83-year-old man who had cardiac tamponade and paroxysmal atrial flutter. The patient was admitted to our hospital because of syncope. The cardiac tamponade and paroxysmal atrial flutter were treated by pericardiocentesis and drainage of bloody pericardial fluid. Mycobacterium tuberculosis was not detected in diagnostic specimens, nor was any evidence of malignancy found. The remarkable elevation of adenosine deaminase and the predominance of lymphocytes in the pericardial fluid, considering the past history of tuberculosis, led to a diagnosis of extrapulmonary tuberculosis. After receiving standard antituberculous therapy by ethambutol, isoniazid, and rifampicin, the patient recovered and has remained well up to the present day. Thirty-six months have passed since his recovery without the recurrence of cardiac tamponade or any other cardiac events.
  • 17-Year Follow-up Study of a Patient With Obstructive Hypertrophic Cardiomyopathy With a Deletion Mutation in the Cardiac Myosin Binding Protein C Gene, OGIMOTO Akiyoshi, HAMADA Mareomi, NAKURA Jun, SHIGEMATSU Yuji, HARA Yuji, OHTSUKA Tomoaki, MORISHIMA Atsuyuki, KIMURA Akinori, MIKI Tetsuro, HIWADA Kunio, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 68, 2, 174, 177, 20040120, 13469843, http://ci.nii.ac.jp/naid/110002667503, A 60-year-old Japanese man with obstructive hypertrophic cardiomyopathy was found to have a mutation in the cardiac myosin binding protein C gene: a single base deletion of a thymidine residue at nucleotide 11645 (codon 593) in exon 18. He was diagnosed at the age of 43 and has been followed for 17 years. During this follow-up period, echocardiograms and mechanocardiograms revealed progressive hypertrophy until the age of 54, then gradual dilation of the left ventricle associated with a decrease in the obstruction. Paroxysmal atrial fibrillation occurred at the age of 52 and progressed to chronic atrial fibrillation at the age of 53. He had congestive heart failure at the age of 58. (Circ J 2004; 68: 174 - 177)
  • Cardiac tamponade with paroxysmal atrial flutter controlled by antituberculous therapy, OGIMOTO Akiyoshi, HAMADA Mareomi, SHIGEMATSU Yuji, HARA Yuji, SAEKI Hideyuki, KATAYAMA Hitoshi, HAMADA Hironobu, HIGAKI Jitsuo, Japanese journal of geriatrics, 日本老年医学会, 日本老年医学会雑誌, 41, 1, 112, 116, 20040125, 03009173, http://ci.nii.ac.jp/naid/10012898734
  • Insulin Resistance in Patients With Hypertrophic Cardiomyopthy, MURAKAMI Kazuo, SHIGEMATSU Yuji, HAMADA Mareomi, HIGAKI Jitsuo, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 68, 7, 650, 655, 20040620, 13469843, http://ci.nii.ac.jp/naid/110002692173, Background The aim of the present study was to investigate whether or not insulin resistance is present in hypertrophic cardiomyopathy (HCM), and also whether it is related to the clinical manifestations of HCM. Methods and Results The study group comprised 55 patients with HCM, 35 with essential hypertension (EHT) and 15 normotensive control subjects (NC). An insulin resistance index was estimated using the homeostasis model assessment (HOMA-IR) of fasting insulin - glucose interactions. In patients with HCM, prognosis and cardiovascular events were also checked. The HOMA-IR values in the HCM group (2.90±1.22) were significantly higher than those in the EHT (1.69±0.77) and NC groups (0.91±0.24). The HOMA-IR values in the EHT group were significantly higher than those in the NC group. Multiple regression analyses determined that left ventricular pressure gradient without provocation (p<0.0001), interventricular septal thickness (p=0.0143) and body mass index (p=0.0412) were independent determinants of insulin resistance in patients with HCM. During a mean follow-up of 105±50 months, 4 patients with HCM died suddenly and all of them had high HOMA-IR values. Conclusions The results suggest that patients with HCM without apparent diabetes mellitus or hypertension have insulin resistance and that insulin resistance may be related to the manifestations of HCM. (Circ J 2004; 68: 650 - 655)
  • 25, 2, 124, 129, 20040630, 03891844, http://ci.nii.ac.jp/naid/10013304098
  • 149, 3, e19, 20050000, 10.1016/j.ahj.2004.09.020
  • 83, 8, 619, 625, 20050000, 10.1007/s00109-005-0641-9
  • 46, 8, 1585, 20050000, 10.1016/j.jacc.2005.07.035
  • Antiarrhythmic Drug Cibenzoline Attenuates Left Ventricular Pressure Gradient and Improves Transmitral Doppler Flow Pattern in Patients With Hypertrophic Obstructive Cardiomyopathy Caused by Midventricular Obstruction, Hamada Mareomi, Higaki Jitsuo, Shigematsu Yuji, Inaba Shinji, Aono Jun, Ikeda Shuntaro, Watanabe Kouki, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Circulation Journal, 社団法人日本循環器学会, 日本循環器學誌, 69, 8, 940, 945, 20050000, 1346-9843|1347-4820, 10.1253/circj.69.940, http://ci.nii.ac.jp/naid/110002696205, Background Recent interventional and surgical therapies to attenuate left ventricular pressure gradient (LVPG) can be difficult to perform in patients with hypertrophic obstructive cardiomyopathy (HOCM) cuased by midventricular obstruction (MVO), owing to the risk of inducing or deteriorating mitral regurgitation. Methods and Results The effects of the antiarrhythmic drug, cibenzoline, on LVPG and left ventricular (LV) diastolic function estimated by the change in the transmitral Doppler flow pattern were examined in 23 patients with HOCM and MVO. Hemodynamic changes 2 h after a single dose of 200 mg of cibenzoline and 3 months after oral administration of 300-450 mg of cibenzoline per day were examined. At 2 h after the treatment, LVPG decreased from 79±37 mmHg to 24±21 mmHg (p<0.0001). E-wave velocity significantly increased and A-wave velocity significantly decreased, and thus the E/A ratio increased from 0.83±0.39 to 1.36±0.50 (p<0.0001). After 3 months of treatment, LVPG remained decreased, and the E-wave and A-wave velocities and the E/A ratio remained improved. Conclusions Cibenzoline can attenuate LVPG and ameliorate LV diastolic dysfunction in patients with HOCM caused by MVO, which suggests a new strategy for the management of this condition. (Circ J 2005; 69: 940 - 945)
  • 104, 1, 16, 21, 20050000, 10.1159/000086048
  • A 73-year-old man with primary pulmonary hypertension, Kono Tamami, Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Okura Takafumi, Inoue Katsuji, Higaki Jitsuo, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 42, 1, 116, 120, 20050000, 0300-9173, http://ci.nii.ac.jp/naid/130003444606, A rare case of primary pulmonary hypertension was observed in a 73-year-old man. Angina pectoris was diagnosed at the age of 67 and he received several percutaneous coronary interventions because of refractory restenosis. He also had coronary artery bypass surgery at the age of 69. After 4 years, he again suffered from dyspnea and chest pain upon physical exertion. On admission to our hospital, a chest radiograph showed dilatation of bilateral pulmonary arteries. Moreover, echocardiography showed right ventricular dilatation and tricuspid regurgitation. Continuous wave Doppler imaging revealed a pressure gradient of 82.1mmHg. Pulmonary capillary wedge pressure was normal, but pulmonary artery pressure was elevated upon cardiac catheterization. Because there was no apparent etiology of pulmonary hypertension, primary pulmonary hypertension was diagnosed and appropriate conventional therapy was started.
  • Repeated changes of electrocardiogram caused by Takotsubo-type cardiomyopathy: A case with hypertrophic nonobstructive cardiomyopathy:A case with hypertrophic nonobstructive cardiomyopathy, Miyoshi Seigo, Hara Yuji, Ogimoto Akiyoshi, Shigematsu Yuji, Okura Takafumi, Higaki Jitsuo, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 42, 1, 112, 115, 20050000, 0300-9173, http://ci.nii.ac.jp/naid/130003444605, A 67-year-old woman had been examined due to abnormalities on electrocardiography (ECG) at a medical checkup three years previously. When a negative T-wave was seen in leads I, aVL, and V1 to V4, but the abnormal findings were improved at consultation. Echocardiography revealed apical hypertrophy and hypertrophic nonobstructive cardiomyopathy was diagnosed. She felt chest discomfort in September, 2003 and an ECG showed a negative T-wave in leads I, II, III, aVL, aVF and V2 to V6 and an elongation of QT interval. Left ventriculography revealed myocardial hypertrophy at the left ventricular apex and left ventriclar wall motion was normal. Coronary angiography did not show any significant luminal narrowing. I-123 metaiodobenzyl-guanitidine scintigraphy showed marked perfusion defects at the left ventricular apex. After five months, ECG showed an improvement of the QT interval and a decrease in the negative T-wave. We considered that the repeated changes of ECG were caused by Takotsubo-type cardiomyopathy.
  • A 73-year-old man with primary pulmonary hypertension, KONO Tamami, OGIMOTO Akiyoshi, SHIGEMATSU Yuji, HARA Yuji, OKURA Takafumi, INOUE Katsuji, HIGAKI Jitsuo, Japanese journal of geriatrics, 日本老年医学会, 日本老年医学会雑誌, 42, 1, 116, 120, 20050125, 03009173, http://ci.nii.ac.jp/naid/10015425536
  • Repeated changes of electrocardiogram caused by Takotsubo-type cardiomyopathy : A case with hypertrophic nonobstructive cardiomyopathy, MIYOSHI Seigo, HARA Yuji, OGIMOTO Akiyoshi, SHIGEMATSU Yuji, OKURA Takafumi, HIGAKI Jitsuo, Japanese journal of geriatrics, 日本老年医学会, 日本老年医学会雑誌, 42, 1, 112, 115, 20050125, 03009173, http://ci.nii.ac.jp/naid/10015425526
  • Sex-Related Differences in Relations of Uric Acid to Left Ventricular Hypertrophy and Remodeling in Japanese Hypertensive Patients, KURATA Akira, SHIGEMATSU Yuji, HIGAKI Jitsuo, Hypertens Res, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 28, 2, 133, 139, 20050201, 09169636, http://ci.nii.ac.jp/naid/10016430657
  • Myocardial Perfusion Imaging Using Adenosine Triphosphate Stress Multi-Slice Spiral Computed Tomography : Alternative to Stress Myocardial Perfusion Scintigraphy, KURATA Akira, MOCHIZUKI Teruhito, KOYAMA Yasushi, HARAIKAWA Toyoaki, SUZUKI Jun, SHIGEMATSU Yuji, HIGAKI Jitsuo, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 69, 5, 550, 557, 20050420, 13469843, http://ci.nii.ac.jp/naid/110002696139, Background The present study was designed to: (i) detect myocardial ischemia in contrast enhanced multi-slice spiral computed tomography (CE-MSCT) using adenosine triphosphate (ATP) pharmacological stress test; and (ii) evaluate the potential of ATP stress CE-MSCT in a clinical setting. Methods and Results Twelve patients underwent ATP stress CE-MSCT and stress thallium-201 myocardial perfusion scintigraphy (MPS) and 9 of the patients received conventional coronary angiography (CAG). Dual CE-MSCT scans were performed for stress and rest images, with and without intravenous infusion of ATP (0.16 mg · kg-1 · min-1) at intervals of 20 min. Myocardial perfusion and coronary artery were visually evaluated using MSCT and compared the results obtained from MPS and CAG. Of 36 territories, stress images of CE-MSCT described 26 hypo-perfusion areas and MPS described 22 redistributions. The agreement between MSCT and MPS was 83% (30/36, p<0.05). In 141 coronary artery segments of 9 patients undergoing CAG, rest images of CE-MSCT, which had significantly higher assessability than stress images (89% vs 48%, p<0.05), described 76% (13/17) of culprit coronary stenoses. Conclusions Although CT-angiography should be currently assessed using rest images, ATP stress CE-MSCT can describe both ATP-induced myocardial ischemia and coronary artery stenoses in patients with coronary artery disease. (Circ J 2005; 69: 550 - 557)
  • 214, 5, 400, 404, 20050730, 00392359, http://ci.nii.ac.jp/naid/40006774340
  • Sex-Related Differences in the Relations of Insulin Resistance and Obesity to Left Ventricular Hypertrophy in Japanese Hypertensive Patients, SHIGEMATSU Yuji, NORIMATSU Sadako, OHTSUKA Tomoaki, OKAYAMA Hideki, HIGAKI Jitsuo, Hypertens Res, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 29, 7, 499, 504, 20060701, 09169636, http://ci.nii.ac.jp/naid/10018346770
  • Effect of Intravenous Administration of Cibenzoline on Left Ventricular Diastolic Pressures in Patients With Hypertrophic Cardiomyopathy : Its Relationship to Transmitral Doppler Flow Profiles, HAMADA Mareomi, AONO Jun, IKEDA Shuntaro, WATANABE Kouki, INABA Shinji, SUZUKI Jun, OHTSUKA Tomoaki, SHIGEMATSU Yuji, Circulation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 71, 10, 1540, 1544, 20070920, 13469843, http://ci.nii.ac.jp/naid/110006391128, Background Cibenzoline is able to improve left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), but the exact mechanism remains to be determined. Methods and Results The present study was designed to elucidate the effect of intravenous administration of 1.4 mg/kg of cibenzoline on aortic and LV pressures, and transmitral Doppler flow pattern in 7 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with hypertrophic nonobstructive cardiomyopathy (HNCM). Before and at the end of the administration, aortic and LV pressures, LV pressure gradient (LVPG) and transmitral Doppler velocity profiles were examined. After the administration of cibenzoline, LV minimal and end-diastolic pressures decreased from 9±4 mmHg to 1±5 mmHg (p=0.0049) and from 22±7 mmHg to 14±5 mmHg (p=0.0106) in patients with HOCM, and from 9±5 mmHg to 5±3 mmHg (p=0.0036) and from 20±6 mmHg to 14±3 mmHg (p=0.0033) in patients with HNCM. LVPG decreased in all patients with HOCM. E-wave velocity increased, A-wave velocity decreased, and thus the E/A ratio increased from 0.77±0.29 to 1.20±0.48 (p=0.0004). Conclusions Reduction of LV diastolic pressures by intravenous administration of cibenzoline may be related to an improvement in the E/A ratio in patients with HCM. (Circ J 2007; 71: 1540 - 1544)
  • Relation of insulin resistance and hyperuricemia as important factors of metabolic syndrome to obesity, 蘇 静, 重松 裕二, The Japanese journal of constitutional medicine, 日本体質医学会, The Japanese journal of constitutional medicine, 70, 1, 16, 22, 20080200, 13477137, http://ci.nii.ac.jp/naid/40015920350
  • Diagnosis and Management of Hypertrophic Cardiomyopathy, HAMADA Mareomi, IZUMI Naoki, YAMANE Kenichi, OHSHIMA Kousei, ISHIBASHI Ken, OHSHIMA Kiyotaka, IKEDA Shuntaro, SHIGEMATSU Yuji, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 日本心臓病学会, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 4, 1, 1, 19, 20090715, 18824501, http://ci.nii.ac.jp/naid/10025349988
  • 3, 3, 50, 56, 20100300, http://ci.nii.ac.jp/naid/40017285686
  • Evidences of ARB interventional studies that prevent the progression of hypertension and hypertensive target organ damage, 重松 裕二, 檜垣 實男, Japanese journal of clinical medicine, 日本臨床社, Japanese journal of clinical medicine, 69, 0, 597, 600, 20110100, 00471852, http://ci.nii.ac.jp/naid/40018269708
  • Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy : Association with insulin resistance, SHIGEMATSU Yuji, HAMADA Mareomi, NAGAI Takayuki, NISHIMURA Kazuhisa, INOUE Katsuji, SUZUKI Jun, OGIMOTO Akiyoshi, HIGAKI Jitsuo, Journal of cardiology, Journal of cardiology, 58, 1, 18, 25, 20110715, 09145087, http://ci.nii.ac.jp/naid/10031159569
  • Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients With Dilated Cardiomyopathy, OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SHIGEMATSU Yuji, TABARA Yasuharu, MIKI Tetsuro, HIGAKI Jitsuo, Circulation Journal, 一般社団法人 日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 76, 8, 2003, 2008, 20120725, 13469843, http://ci.nii.ac.jp/naid/10030505036, Background: Sustained cardiac adrenergic stimulation has been implicated in the progression of cardiovascular events in patients with dilated cardiomyopathy (DCM). Our group hypothesized that a combination of polymorphisms that result in increased synaptic norepinephrine release and enhanced receptor function would predispose patients with DCM to cardiovascular events. The effect of polymorphisms in adrenergic receptor-related genes on cardiovascular event-free survival in patients with idiopathic DCM was evaluated. Methods and Results: Genotyping at 3 loci (ADRB1 Ser49Gly and Arg389Gly, and NET T-182C) was performed in 83 patients with DCM. Patients were followed prospectively to the endpoint of cardiovascular events (mean follow-up, 45 months). Cardiovascular events were defined as cardiac death and emergent hospitalization as a result of congestive heart failure, arrhythmia, and cerebrovascular events. Analyses were conducted based on the number of predicted risk genotypes a patient carried. The ADRB1 Ser49 allele carrier, ADRB1 Arg389 allele carrier, and NET-182CC genotype were defined as the predicted risk genotypes. Cardiovascular event-free survival was compared based on the number of predicted risk genotypes. Cardiovascular event-free survival was significantly better in patients with fewer than 3 predicted risk genotypes than in those with 3 predicted risk genotypes. Conclusions: Genotyping at these 3 loci might be a useful approach for identification of patients with DCM at risk for cardiovascular events.  (Circ J 2012; 76: 2003–2008)
  • Mechanisms of blood pressure elevation in salt intake, 重松 裕二, 循環器内科, 科学評論社, 循環器内科, 72, 2, 161, 165, 20120800, 1884-2909, http://ci.nii.ac.jp/naid/40019426470
  • Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy, INOUE Katsuji, OKAYAMA Hideki, NISHIMURA Kazuhisa, NAGAI Takayuki, SUZUKI Jun, OGIMOTO Akiyoshi, SAITO Makoto, YOSHII Toyofumi, HIASA Go, SUMIMOTO Takumi, FUNADA Jun-ichi, SHIGEMATSU Yuji, HAMADA Mareomi, HIGAKI Jitsuo, Circulation Journal, 一般社団法人 日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 77, 4, 1040, 1045, 20130325, 13469843, http://ci.nii.ac.jp/naid/10031139009, Background: The interventricular septum in hypertrophic cardiomyopathy (HC) has a unique shape, which is characterized by the convex curvature toward the left ventricle (LV). The aim of this study was to examine the relationship between curvature of the LV wall and regional myocardial strain. Methods and Results: Fifty-six patients with HC (mean age, 55±12 years) and 20 age- and sex-matched control subjects (mean age, 56±8 years) were enrolled. The curvature index (1/radius) was measured by drawing along the endocardial surface from the apical 4-chamber and short axis views. Peak systolic strain was calculated in the septal and lateral walls using 2-D speckle tracking echocardiography. The septal curvature index and septal longitudinal strain were significantly lower in the HC group than in the control group. A multivariate model using the HC patient data showed that the septal curvature index and septal thickness were the independent determinants of septal longitudinal strain (septal curvature index: β=–0.421, P<0.001; septal thickness: β=0.401, P=0.002). In addition, global longitudinal strain and E/e’ were worse in the lower septal curvature index group compared with the higher group. Conclusions: Septal longitudinal strain is associated with the degree of septal curvature. This indicates a possible link between LV wall configuration and regional myocardial function.  (Circ J 2013; 77: 1040–1045)
  • Anticoagulant therapy with dabigatran in elderly patients ≥80 years of age with atrial fibrillation, Kono Tamami, Ogimoto Akiyoshi, Aono Jun, Okura Takafumi, Shigematsu Yuji, Higaki Jitsuo, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 51, 4, 350, 355, 20140000, 0300-9173, http://ci.nii.ac.jp/naid/130004699378, Aim: Atrial fibrillation is a potent risk factor for stroke, and the administration of anticoagulant therapy is important for preventing thromboembolism. Dabigatran is the first new oral anticoagulant developed as an alternative to warfarin. However, serious major gastrointestinal bleeding events have been observed in elderly patients in post-market case reports. We therefore retrospectively investigated elderly cases of the use of anticoagulant therapy with dabigatran.
    Methods: Twenty-eight patients over 80 years of age were treated with anticoagulant therapy at our satellite hospital. Nine of the patients received dabigatran, and all others received warfarin. We evaluated the CHADS2 score, HAS-BLED score, renal function and incidence of adverse effects in nine patients treated with dabigatran.
    Results: All of the nine patients received 220 mg/day of dabigatran, with no antiplatelet agents. Seven patients continued to receive dabigatran. One patient had an impaired renal function (Cr 1.55 mg/dl, Ccr 30 ml/min). However, the activated partial thromboplastin time (APTT) was not prolonged and neither major bleeding nor stroke were noted in seven patients. Although two patients were unable to continue dabigatran treatment due to APTT prolongation, no serious complications were observed during the administration of dabigatran.
    Conclusions: No serious adverse effects of dabigatran anticoagulant therapy were detected in our elderly patients. Although it is necessary to monitor the risk of bleeding, renal dysfunction, effects of drug combination and so on, some elderly patients with atrial fibrillation are good candidates for dabigatran treatment.
  • Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy, Iio Chiharuko, Shigematsu Yuji, Tabara Yasuharu, Kohara Katsuhiko, Miki Tetsuro, Hamada Mareomi, Higaki Jitsuo, Ogimoto Akiyoshi, Nagai Takayuki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Uetani Teruyoshi, Okayama Hideki, Okura Takafumi, International Heart Journal, 一般社団法人 インターナショナル・ハート・ジャーナル刊行会, International Heart Journal, 56, 4, 421, 427, 20150000, 1349-2365, http://ci.nii.ac.jp/naid/130005087577, Arrhythmias are associated with reduced quality of life and poor prognosis in patients with hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the SCN10A gene was associated with the PR interval. We examined whether the PR prolonging allele (A allele) in the SCN10A gene may be associated with cardiac conduction abnormalities in HCM patients.
    We genotyped the polymorphism in 149 HCM patients. Conduction abnormalities were defined as first-degree heart block, bundle-branch block, and bifascicular heart block. Patients were divided into two groups: group A consisted of 122 patients (82%) without a conduction abnormality; and group B consisted of 27 patients (18%) with one or more cardiac conduction abnormalities. The frequency distribution of the SCN10A genotypes (G/G, G/A, and A/A) among the patients with HCM was 71%, 26%, and 3%, respectively. A cardiac conduction abnormality was documented in 9% with G/G and 40% with G/A or A/A. There was a significant difference in the genotype distribution between the two groups (P = 0.0002). In the dominant A allele model, there was a significant difference in genotypes between the two groups (P < 0.0001). In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).
    The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.
  • Elevated Cardiac Enzymes in Hypertrophic Cardiomyopathy Patients With Heart Failure – A 20-Year Prospective Follow-up Study –, Hamada Mareomi, Shigematsu Yuji, Ohtani Takashi, Ikeda Shuntaro, Circulation Journal, 一般社団法人 日本循環器学会, 日本循環器學誌, 80, 1, 218, 226, 20160000, 1346-9843, http://ci.nii.ac.jp/naid/130005116989, Background:To better understand the evolution of typical hypertrophic cardiomyopathy (HCM) to heart failure (HF), we investigated the relationship between serum biochemical abnormalities and changes in left ventricular (LV) remodeling.Methods and Results:Seventy-seven HCM patients were followed for 20 years. Creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), LDH-1, troponin T and myosin light chain-1 (MLC-1) were measured. Abnormal CK-MB elevation was observed in 64% of HCM patients. LDH-1 was not significantly different compared with the control subjects. Troponin T elevation was observed in 3 HCM patients and MLC-1 elevation was not observed. According to median CK-MB, HCM patients were divided into 2 groups: group H (CK-MB ≥2.5%, n=33) and group L (CK-MB <2.5%, n=44). During the follow-up period in group H, LV end-diastolic dimension increased (P<0.0001), fractional shortening decreased (P<0.0004), and left atrial dimension increased (P<0.0001). The markers reflecting LV hypertrophy were significantly decreased. In group L, LV end-diastolic dimension increased (P<0.02) and left atrial dimension increased (P<0.0001). HF was observed in 18 patients in group H and in 4 in group L. There were 14 HF deaths in group H and 2 in group L, and 3 sudden cardiac deaths in group H.Conclusions:Persistent elevation of cardiac enzymes in HCM patients indicates ongoing myocardial injury, ultimately resulting in death by HF. (Circ J 2016; 80: 218–226)
  • Transmitral Doppler Flow Pattern in Left Atrial Myxoma, Hamada Mareomi, Ogimoto Akiyoshi, Shigematsu Yuji, Internal Medicine, The Japanese Society of Internal Medicine, Internal Medicine, 57, 14, 2093, 2094, 20180000, 0918-2918, http://ci.nii.ac.jp/naid/130007404896
  • Mitral Prosthetic Valve Replaced Twice Due to Repeated Prosthetic Valve Endocarditis: A Case Report, HASHIDA Hidetoshi, HAMADA Mareomi, IKEDA Shuntaro, KUWAHARA Taishi, OKAYAMA Hideki, HARA Yuji, KODAMA Koji, SHIGEMATSU Yuji, KAZETANI Yukio, TOMINO Tetsuo, SATOH Harumitsu, HIWADA Kunio, Journal of cardiology, Journal of cardiology, 29, 137, 141, 19970610, 09145087, http://ci.nii.ac.jp/naid/10006347940
  • 88, 6, 683, 685, 20010000, 10.1016/S0002-9149(01)01817-3
  • Myocardial Ischemia Induced by Anomalous Aortic Origin of the Right Coronary Artery in a Patient with Atrial Septal Defect., Maki Fumie, Ohtsuka Tomoaki, Suzuki Makoto, Hara Yuji, Shigematsu Yuji, Hamada Mareomi, Kawachi Kanji, Hiwada Kunio, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 3, 371, 376, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070726, A 27-year-old woman with atrial septal defect (ASD) and a sensation of squeezing in the anterior chest by effort was admitted to our hospital. In addition to the ASD, the coronary angiogram showed an abnormal anomalous position of the right coronary artery. Exercise thallium (Tl)-201 cardiac scintigram with an electrocardiogram clearly detected myocardial ischemia in the inferior area. In the operative findings, the orifice of the right coronary artery was positioned high above the commissure between the right and left sinuses of Valsalva, and it ran between the aorta and pulmonary trunk. Considering myocardial ischemia possibly caused by the anomalous origin of the right coronary artery, a coronary artery bypass graft (CABG) was simultaneously performed to the right coronary artery with direct closure of ASD. The myocardial ischemic finding in the inferior area disappeared after the operation, and she was also relieved from the chest pain. In view of these findings, we suggest that an active combination treatment such as CABG and ASD closure is highly successful in a patient with a threatening coronary anomaly and congenital heart disease.
  • Congenitally Corrected Transposition of the Great Arteries in a 65-Year-Old Woman., Sasaki Osamu, Hiwada Kunio, Hamada Mareomi, Hiasa Go, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Suzuki Makoto, Hara Yuji, Shigematsu Yuji, Araki Shuhei, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 5, 645, 649, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070778, A 65-year-old Japanese woman was admitted to hospital because of exertional dyspnea. Transthoracic echocardiography showed diffuse hypokinesis of the left-sided ventricular wall, but was not clear enough to provide useful information because of the rotation of the cardiac apex and the presence of lung tissue. Systemic ventriculography showed that the left-sided ventricle with heavy trabeculations was morphologically similar to a normal right ventricle. Magnetic resonance imaging (MRI) clearly revealed corrected transposition of the great arteries. Because this patient had no severe associated cardiac anomalies, systemic ventricular dysfunction is thought to be the major cause of exertional dyspnea. MRI is a useful non-invasive method for the rapid evaluation of cardiac morphology.
  • Hypoglycemic Syncope Induced by a Combination of Cibenzoline and Angiotensin Converting Enzyme Inhibitor., Ogimoto Akiyoshi, Hiwada Kunio, Hamada Mareomi, Saeki Hideyuki, Hiasa Go, Ohtsuka Tomoaki, Hashida Hidetoshi, Hara Yuji, Okura Takafumi, Shigematsu Yuji, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 2, 255, 259, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070739, A 65-year-old Japanese woman with dilated cardiomyopathy, hypothyroidism and refractory sustained ventricular tachycardia experienced a near-death hypoglycemic syncope. The attack seemed to be induced by a high level of serum insulin, probably due to cibenzoline and by concomitant use of an angiotensin converting enzyme inhibitor (ACEI). Additionally, decreased food intake because of a severe toothache may have contributed to the deterioration of her condition. This case warns cardiologists that a combined cibenzoline and ACEI therapy can provoke serious adverse effects such as hypoglycemic syncope in the elderly. Therefore, the possibility of a hypoglycemic attack associated with these drugs should be explained to patients who are in poor condition.
  • 89, 8, 996, 999, 20020000, 10.1016/S0002-9149(02)02258-0
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  • Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy, OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, OHTSUKA Tomoaki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SHIGEMATSU Yuji, TABARA Yasuharu, KOHARA Katsuhiko, MIKI Tetsuro, HIGAKI Jitsuo, J Cardiol, Journal of cardiology, 54, 1, 66, 70, 20090815, 0914-5087, 10.1016/j.jjcc.2009.04.001, http://ci.nii.ac.jp/naid/10025184385
  • A 66-year-old Woman with a Patent Ductus Arteriosus and no Significant Progression of Pulmonary Arterial Pressure Over 17 Years, MATSUNAKA Tsuyoshi, HARA Yuji, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, KAWAKAMI Hideo, OKAYAMA Hideki, HAYASHI Yutaka, KODAMA Koji, SHIGEMATSU Yuji, KOHARA Katsuhiko, HAMADA Mareomi, HIWADA Kunio, 日本老年医学会雑誌, 日本老年医学会雑誌, 33, 9, 697, 701, 19960925, 03009173, http://ci.nii.ac.jp/naid/10013851975
  • 27, 7, 417, 420, 20040000
  • The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients, SHIGEMATSU Yuji, NORIMATSU Sadako, OGIMOTO Akiyoshi, OHTSUKA Tomoaki, OKAYAMA Hideki, HIGAKI Jitsuo, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 32, 6, 500, 504, 20090601, 0916-9636|1348-4214, 10.1038/hr.2009.41, http://ci.nii.ac.jp/naid/10024831267
  • A 66-year-old Woman with a Patent Ductus Arteriosus and no Significant Progression of Pulmonary Arterial Pressure Over 17 Years., Matsunaka Tsuyoshi, Shigematsu Yuji, Kohara Katsuhiko, Hamada Mareomi, Hiwada Kunio, Hara Yuji, Ikeda Shuntaro, Hashida Hidetoshi, Kuwahara Taishi, Kawakami Hideo, Okayama Hideki, Hayashi Yutaka, Kodama Koji, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 33, 9, 697, 701, 19960000, 0300-9173, http://ci.nii.ac.jp/naid/130003444332, We report the case of a 66-year-old woman with a patent ductus arteriosus and no significant progression of pulmonary arterial pressure over 17 years. She was admitted to our hospital in 1978 because of palpitations on exertion and chest discomfort. Cardiac catheterization was done, and she was given a diagnosis of patent ductus arteriosus. Because the left-to-right shunt was small (15%) and because there was no evidence of pulmonary hypertension (38/18mmHg), she was treated medically. In 1995 she was admitted again, to determine the cause of a cerebral infarction. The cerebral infarction was believed to habe been caused by an embolism due to atrial fibrillation. She underwent cardiac catheterization again. The left-to-right shunt had increased to 41%, but the pulmonary artery pressure had not changed (27/14mmHg). Intravascular ultrasound imaging was used to evaluate the ductus arteriosus. The diameter of the ductus was 4.4mm and calcification was not observed. During the 17 years of follow-up, heart size increased slightly, but pulmonary artery pressure did not change. In addition, intravascular ultrasound was very useful for evaluating the condition of the ductus arteriosus.
  • Familial Hypertrophic Cardiomyopathy Generating a Marked Left Ventricular Pressure Gradient in an 82-Year-Old Woman, HAMADA Mareomi, SHIGEMATSU Yuji, KOBAYASHI Takamasa, KODAMA Koji, HAYASHI Yutaka, HARA Yuji, OKAYAMA Hideki, KAWAKAMI Hideo, KUWAHARA Taishi, IKEDA Shuntaro, HASHIDA Hidetoshi, HIWADA Kunio, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 33, 4, 284, 292, 19960425, 03009173, http://ci.nii.ac.jp/naid/10013851445, Familial nonobstructive hypertrophic cardiomyopathy in 78-year-old woman was diagnosed in 1988. Since then she has been treated with a beta-blocking drug and a calcium antagonist. Her clinical condition was NYHA I or II for several years. Echocardiography revealed asymmetric septal hypertrophy in 1988 (interventricular septal thickness=21mm, posterior wall thickness=10mm). Systolic anterior motion of the mitral valve was first observed at the end of 1992. The left ventricular pressure gradient also gradually increased; it was about 138mmHg in 1993 (age 82 yrs). The left ventricular ejection time index increased from 376msec in May, 1992 to 459msec in May, 1994. In September, 1994, the patient's condition gradually deteriorated (NYHA IV), and she was admitted to our hospital. To attenuate the left ventricular pressure gradient, 150mg of disopyramide was administered. Her condition markedly improved: the left ventricular pressure gradient decreased from 180mmHg to 76mmHg, and the left ventricular ejection time index decreased from 485msec to 419msec. These results indicate that a left ventricular pressure gradient can be generated rapidly even in a very old patient, and that disopyramide may be useful to attenuate the left ventricuolar pressure gradient.
  • Serum Creatinine Level Underestimates Hypertensive Renal Involvement in Elderly Patients with Essential Hypertension, SHIGEMATSU Yuji, HAMADA Mareomi, HIASA Go, SASAKI Osamu, OHTSUKA Tomoaki, HASHIDA Hidetoshi, IKEDA Shuntaro, SUZUKI Makoto, HARA Yuji, HIWADA Kunio, Hypertens Res, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 22, 4, 297, 301, 19991101, 09169636, http://ci.nii.ac.jp/naid/10008737177
  • Apical Hypertrophic Cardiomyopathy Associated With Life-Threatening Paroxysmal Atrial Flutter With a Slow Ventricular Response:- A Case Report -, Hiasa Go, Shigematsu Yuji, Hiwada Kunio, Hamada Mareomi, Kodama Koji, Watanabe Sanae, Ohtsuka Tomoaki, Ikeda Shuntaro, Hashida Hidetoshi, Kuwahara Taishi, Hara Yuji, Japanese Circulation Journal, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 64, 3, 225, 228, 20000000, 0047-1828, http://ci.nii.ac.jp/naid/130004427688, A 58-year-old male patient had apical hypertrophic cardiomyopathy (HCM) associated with a life-threatening tachycardia due to atrial flutter. Following palpitation and dyspnea for 2-3h, he became unconscious because of circulatory catastrophe, but was fully resuscitated. An electrocardiogram recorded just before the loss of consciousness revealed atrial flutter at a rate of 260 beats/min with a 2:1 ventricular response. He was diagnosed as having apical HCM based on the echocardiographic and left ventriculographic findings. Atrial stimulation at a rate of 150 pacings/min for 1 min caused a marked drop in systemic systolic blood pressure from 170 to 120 mmHg. The patient was treated with 150 mg of cibenzoline per day to prevent supraventricular tachyarrhythmias and to improve left ventricular diastolic function. At the time of the recent follow-up at 2 and a half years, he felt quite well.
  • Apical Hypertrophic Cardiomyopathy Associated With Life - Threatening Paroxysmal Atrial Flutter With a Slow Ventricular Response - A Case Report -, HIASA Go, HAMADA Mareomi, KODAMA Koji, WATANABE Sanae, OHTSUKA Tomoaki, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 64, 3, 225, 228, 20000220, 00471828, http://ci.nii.ac.jp/naid/110002571798, A 58-year-old male patient had apical hypertrophic cardiomyopathy(HCM) associated with a life-threatening tachycardia due to atrial flutter. Following palpitation and dyspnea for 2-3 h, he became unconscious because of circulatory catastrophe, but was fully resuscitated. An electrocardiogram recorded just before the loss of consciousness revealed atrial flutter at a rate of 260 beats/min with a 2:1 ventricular response. He was diagnosed as having apical HCM based on the echocardiographic and left ventriculographic findings. Atrial stimulation at a rate of 150 pacings/min for 1 min caused a marked drop in systemic systolic blood pressure from 170 to 120 mmHg. The patient was treated with 150 mg of cibenzoline per day to prevent supraventricular tachyarrhythmias and to improve left ventricular diastolic function. At the time of the recent follow-up at 2 and a half years, he felt quite well.
  • Effect of Beta - Blocker on Left Ventricular Function and Natriuretic Peptides in Patients, With Chronic Heart Failure Treated With Angiotensin - Converting Enzyme Inhibitow, HARA Yuji, HAMADA Mareomi, SHIGEMATSU Yuji, SUZUKI Makoto, KODAMA Koji, KUWAHARA Taishi, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, HIASA Go, HIWADA Kunio, Japanese Circulation Journal, 社団法人日本循環器学会, Japanese circulation journal, 64, 5, 365, 369, 20000420, 00471828, http://ci.nii.ac.jp/naid/110002571823, To evaluate whether or not β-blockers can improve the condition of patients with heart failure treated with a combination of diuretics, digitalis and angiotensin-converting enzyme inhibitor (ACEI), 52 patients with chronic heart failure who have been treated with ACEI for more than 6 months were enrolled. They were divided into 2 groups: 26 patients continued the same therapy another 6 months or more (group A), and 26 patients were given oral metoprolol for 6 months or more, in addition to the ACEI (group B). Echocardiographic parameters and atrial and brain natriuretic peptides (ANP, BNP) were measured. The left ventricular dimensions at end-diastole and end-systole were significantly decreased and fractional shortening was significantly increased in group B after 6 months’ treatment with the β-blocker, but these parameters remained unchanged in group A. Plasma levels of both ANP and BNP were significantly decreased in group B, but remained unchanged in group A. These results indicate that concomitant β-blocker therapy can improve left ventricular function and attenuate plasma ANP and BNP levels in patients with chronic heart failure treated with ACEI.
  • Time-Course Changes in Left Ventricular Geometry and Function during the Development of Hypertension in Dahl Salt-Sensitive Rats, QU Peng, HAMADA Mareomi, IKEDA Shuntaro, HIASA Go, SHIGEMATSU Yuji, HIWADA Kunio, Hypertens Res, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 23, 6, 613, 623, 20001101, 09169636, http://ci.nii.ac.jp/naid/10008740952
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  • Influence of Aging Upon Changes in Symptoms and Cardiac Size Associated with Surgical Repair of Atrial Septal Defect in Adults., Shigematsu Yuji, Hamada Mareomi, Okayama Hideki, Hara Yuji, Hayashi Yutaka, Kodama Koji, Hiwada Kunio, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 32, 11, 736, 740, 19950000, 0300-9173, http://ci.nii.ac.jp/naid/130003652088, To elucidate the influence of aging upon the improvement of symptoms and cardiac size associated with surgical repair of atrial septal defect, clinical symptoms, cardiothoracic ratio and hemodynamic variables in older patients (group A; age at operation ≥50 years old, n=11) were compared with those in younger patients (group B; age at operation <50 years old, n=8). There were no differences in hemodynamic variables, i.e., peak systolic pulmonary pressure, pulmonary to systolic flow ratio (Qp/Qs), pulmonary to systolic vascular resistance ratio (Rp/Rs) and left to right shunt ratio between the two groups. Symptomatic benefits occurred in all patients, although 3 patients in group A who had atrial fibrillation preoperatively still displayed symptoms such as exertional dyspnea. The postoperative (after 3 months) cardiothracic ratio improved in all patients except for 3 patients in group A who were operated at over 60 years of age. Although there was no significant difference in preoperative cardiothoracic ratio between the two groups, the postoperative cardiothoracic ratio in group B was significantly smaller than that in group A. These results indicate that operative closure of atrial septal defect is recommended for all patients aged 50 years old or older, but early improvement of symptoms and cardiomegaly in older patients is lower than that in younger patients.
  • Intra-ventricular Pressure Gradient and Systolic Anterior Movement of the Mitral Valve Associated with Administration of Dopamine in a 91-year-old Patient., Okayama Hideki, Hamada Mareomi, Shigematsu Yuji, Abe Mitsunori, Mukai Mikio, Matsuoka Hiroshi, Sumimoto Takumi, Hiwada Kunio, Murakami Bonpei, Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 31, 3, 244, 248, 19940000, 0300-9173, http://ci.nii.ac.jp/naid/130003652035, A 91-year-old woman had decreased systemic blood pressure accompanied by dyspnea and general fatigue after resection of a face tumor (Merkel cell carcinoma). Dopamine was administered to elevate systemic blood pressure, but it did not sufficiently restore the hemodynamic status. Left ventricular apical aneurysm was observed on echocardiogram. Furthermore, SAM (systolic anterior movement of the mitral valve) was observed on M-mode echocardiogram and a pressure gradient of 34.6mmHg in the midventricular position was confirmed by continuous wave Doppler using the Bernoulli equation. After volume overload and discontinuation of dopamine, SAM completely disappeared and midventricular pressure gradient markedly decreased. Her general condition improved. Because of the narrowed outflow tract, hypercontractile state induced by β adrenergic stimulation seemed to be one of the important factors for the genesis of SAM and pressure gradient.
  • Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy, Kawakami Hideo, Shigematsu Yuji, Ohtsuka Tomoaki, Okayama Hideki, Hayashi Yutaka, Hara Yuji, Kodama Koji, Hamada Mareomi, Hiwada Kunio, Japanese Circulation Journal, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 62, 12, 873, 876, 19980000, 0047-1828, http://ci.nii.ac.jp/naid/130004427432, To examine the prognostic role of the circulating soluble form of Fas (sFas), circulating sFas levels were measured in 33 patients with dilated cardiomyopathy (DCM) and 12 age-matched normal control subjects (NC) using an enzyme-linked immunosorbent assay (ELISA). Circulating sFas levels in DCM were significantly higher than those in NC (2.42±1.02 vs 1.66±0.20 ng/ml, p=0.015). Patients with DCM were stratified into 2 groups [group I (n=15): sFas ≥2.06 ng/ml; group II (n=18): sFas <2.06 ng/ml] on the basis of the mean value plus 2SD of circulating sFas level in NC. The circulating sFas level was significantly increased in relation to the severity of heart failure and correlated positively to left ventricular end-diastolic pressure in DCM. However, there were no significant differences in left ventricular dimension between the 2 groups. There were 5 deaths from worsening heart failure in group II, but there were no deaths in group I during the follow-up period. In conclusion, circulating sFas levels were increased in patients with DCM. Circulating sFas levels are increased in proportion to the severity of heart failure and may provide prognostic information independent of left ventricular geometry. (Jpn Circ J 1998; 62: 873 - 876)
  • An Early Systolic Sound Associated With Midventricular Obstruction in a Patient With Hypertrophic Cardiomyopathy, OHTSUKA Tomoaki, HAMADA Mareomi, HARA Yuji, KUWAHARA Taishi, KODAMA Koji, SHIGEMATSU Yuji, IWATA Takeru, HIWADA Kunio, Japanese Circulation Journal, 社団法人日本循環器学会, Japanese circulation journal, 62, 5, 385, 388, 19980420, 00471828, http://ci.nii.ac.jp/naid/110002561018, A 57-year-old woman was admitted for examination because of chest discomfort. Transthoracic echocardiography was performed and she was diagnosed as having hypertrophic cardiomyopathy. An echocardiogram also revealed that she had midventricular obstruction with a pressure gradient of 125 mmHg determined by Doppler echocardiography. A phonocardiogram showed an early systolic sound and the beginning of the sound coincided with the time of septal-posterior wall contact. In addition, the timing also corresponded to the sudden obstruction of blood flow in the region of the midventricular narrowing. Furthermore, this sound markedly decreased with the reduction in pressure gradient caused by cibenzoline treatment. Thus, it was concluded that the early systolic sound was associated with midventricular obstruction and produced by a rapid deceleration of the interventricular flow caused by midventricular obstruction. (Jpn Circ J 1998; 62: 385-388)
  • Marked Attenuation of Mitral Regurgitation by Stent Implantation : A Patient With Unstable Angina, OHTSUKA Tomoaki, HAMADA Mareomi, KODAMA Koji, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HIWADA Kunio, Journal of cardiology, Journal of cardiology, 31, 91, 95, 19980610, 09145087, http://ci.nii.ac.jp/naid/10006348116
  • Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy, KAWAKAMI Hideo, SHIGEMATSU Yuji, OHTSUKA Tomoaki, OKAYAMA Hideki, HAYASHI Yutaka, HARA Yuji, KODAMA Koji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 62, 12, 873, 876, 19981120, 00471828, http://ci.nii.ac.jp/naid/110002561127, To examine the prognostic role of the circulating soluble form of Fas(sFas), circulating sFas levels were measured in 33 patients with dilated cardiomyopathy(DCM)and 12 age-matched normal control subjects(NC)using an enzyme-linked immunosorbent assay(ELISA). Circulating sFas levels in DCM were significantly higher than those in NC(2.42±1.02 vs 1.66±0.20ng/ml, p=0.015). Patients with DCM were stratified into 2 groups[group I(n=15) : sFas32.06ng/ml ; group II(n=18) : sFas<2.06ng/ml]on the basis of the mean value plus 2SD of circulating sFas level in NC. The circulating sFas level was significantly increased in relation to the severity of heart failure and correlated positively to left ventricular end-diastolic pressure in DCM. However, there were no significant differences in left ventricular dimension between the 2 groups. There were 5 deaths from worsening heart failure in group II, but there were no deaths in group I during the follow-up period. In conclusion, circulating sFas levels were increased in patients with DCM. Circulating sFas levels are increased in proportion to the severity of heart failure and may provide prognostic information independent of left ventricular geometry.
  • Relation between Coronary Blood Flow and Left Ventriculaar Mass in Hypertension : Noninvasive Quantification of Coronary Blood Flow by Thallium-201 Myocardial Scintigraphy, HAMADA Mareomi, KUWAHARA Taishi, SHIGEMATSU Yuji, KODAMA Koji, HARA Yuji, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, NAKATA Shigeru, HIWADA Kunio, Hypertension Research, 日本高血圧学会, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 21, 4, 227, 234, 19981201, 09169636, http://ci.nii.ac.jp/naid/10009563564, This study was conducted to quantify coronary blood flow (CBF) noninvasively according to the fractionation principle and to elucidate the relation between CBF and left ventricular hypertrophy. CBF/cardiac output (CO), estimated on the basis of the ratio of myocardial uptake/total injected dose of thallium-201(% cardiac uptake), was determined in 14 control subjects and 40 patients with essential hypertension. CBF and CBF per 100g of myocardium (unit CBF) were calculated according to the following formulas: CBF=% cardiac uptake×CO, and unit CBF=(CBF/LVM)×100, where CO and left ventricular mass (LVM) are echocardiographically determined. There was good reproducibility of % cardiac uptake (r=0.983, p<0.0001). Percent cardiac uptake was greater in hypertensive patients (4.65±1.44%) than in control subjects (3.64±0.64%), and there was a positive correlation between % cardiac uptake and LVM. CBF (ml/min) was greater in hypertensive patients (240.7±80.5) than in control subjects (194.9±36.9), but unit CBF (ml/min/100g) was less in hypertensive patients (102.2± 26.7) than in control subjects (150.3±30.5). Multiple regression analyses showed that LVM was the most potent independent predictor of resting CBF in hypertension. Our results indicate that CBF, determined by thallium-201 myocardial scintigraphy, increases parallel to the increase in LVM, but unit CBF decreases even in the resting condition in patients with essential hypertension. (Hypertens Res 1998; 21: 227-234)
  • Serum Creatinine Level Underestimates Hypertensive Renal Involvement in Elderly Patients with Essential Hypertension., Shigematsu Yuji, Hiwada Kunio, Hamada Mareomi, Hiasa Go, Sasaki Osamu, Ohtsuka Tomoaki, Hashida Hidetoshi, Ikeda Shuntaro, Suzuki Makoto, Hara Yuji, Hypertension Research, 日本高血圧学会, Hypertension Research, 22, 4, 297, 301, 19990000, 0916-9636, http://ci.nii.ac.jp/naid/130003456407, It is well recognized that serum creatinine level provides a quick general assessment of renal function. However, we frequently encounter elderly hypertensive patients with renal involvement whose serum creatinine levels are within normal limits. The aim of this study was thus to determine whether serum creatinine level is a sensitive indicator of renal function in elderly hypertensive patients. Study groups were classified according to age: 82 elderly patients (aged 65 yr or older) and 98 middle-aged patients (aged 40-65 yr) with essential hypertension. To assess hypertensive renal involvement, serum creatinine and serum uric acid levels were measured. We also measured the left ventricular mass (LVM) index by using echocardiography as a marker of hypertensive target organ damage. There was no age-related difference in the LVM index, but the serum creatinine level in elderly hypertensive patients was significantly lower than that in middle-aged hypertensive patients. There was no significant difference in serum uric acid level between the two groups. In addition, the LVM index was correlated with the serum uric acid level (r=0.46, p=0.0001) but not with the serum creatinine level in elderly hypertensive patients. In middle-aged hypertensive patients, the LVM index was related to both serum uric acid level (r=0.41, p=0.007) and serum creatinine level (r=0.43, p=0.003). In conclusion, serum creatinine level may underestimate hypertensive renal involvement in elderly hypertensive patients. In contrast, serum uric acid level may be a sensitive indicator of hypertensive target organ damage irrespective of age. (Hypertens Res 1999; 22: 297-301)
  • 54, 0, 201, 202, 19901220, 00471828, http://ci.nii.ac.jp/naid/110002616459
  • Systolic Time Intervals Can Detect Patients with Angina Pectoris at High-Risk, HAMADA Mareomi, SHIGEMATSU Yuji, KODAMA Kouji, HARA Yuji, KUWAHARA Taishi, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, SASAKI Osamu, HIWADA Kunio, 日本臨床生理学会雑誌 = Japanese journal of applied physiology, 日本臨床生理学会雑誌 = Japanese journal of applied physiology, 27, 1, 51, 60, 19970201, 02867052, http://ci.nii.ac.jp/naid/10008697739
  • Two cases of apical hypertrophy associated with rapid electrocardiographic change from normal to giant negative T, Matsuoka Hiroshi, Shigematsu Yuji, Nishitani Koji, Sekiya Michihito, Kazatani Yukio, Ochi Takaaki, Hamada Mareomi, Ito Taketoshi, Kokubu Tatsuo, Shinzo, 心臓, 心臓, 17, 8, 886, 892, 19850000, 0586-4488, http://ci.nii.ac.jp/naid/130004411506, 肥大型心筋症の心電図変化は多彩である.胸部誘導の深い陰性T波もその1つであり,高頻度に認められる変化であるが,正常T波から陰性T波への自然経過を観察し得た症例はまれである.今回,われわれは数年間の経過で正常T波から漸次陰性T波へと移行した心尖部肥大型心筋症を2症例経験した.症例1は54歳,男性.胸痛精査の目的で入院した.心電図は左軸偏位と陰性T波を認めた.この陰性T波は最近の約4年間で正常T波から移行したものであった.症例2は49歳,男性.胸痛および失神の精査目的で入院した.心電図では左室側高電位と巨大陰性T波を認めた.この症例においても最近の約2年半で正常T波から巨大陰性T波へ移行していた.症例1,2ともに右前斜位の左室造影において,スペード型を呈した.冠動脈造影では有意狭窄を認めず,心尖部肥大型心筋症と診断した.心電図検査は肥大型心筋症の診断上,重要な役割を演じている.しかし,今回報告したごとく,短期間で著明な経時的心電図変化を呈する症例も認められ,本症の診断には慎重を要するものと考えられた.
  • Two cases of familial hypertrophic cardiomyopathy showing persistent ST segment elevation, Shigematsu Yuji, Hamada Mareomi, Doiuchi Junji, Inoue Yoshikazu, Fujiwara Yasushi, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Shinzo, 心臓, 心臓, 18, 5, 561, 566, 19860000, 0586-4488, http://ci.nii.ac.jp/naid/130004135496, 肥大型心筋症の心電図変化は多彩であるが,ST上昇を示す症例の報告はまれである.われわれは持続性ST上昇を示した家族性肥大型心筋症2症例を経験した.
    症例1は41歳,男性.主訴;前胸部痛およびフラツキ感.血圧108/74mmHg.心電図所見;V1-4誘導でST上昇およびI,II,III,aVF,V5,6誘導で陰性T波を認めた.症例2は36歳,男性.主訴;労作時の動悸およびフラツキ感.症例1の従兄弟である.心電図所見;I, V5誘導でST およびII, III, aVF ,V3,4,6誘導で陰性T波を認めた.2症例とも,心エコー図でASH , 左室流出路狭窄所見を示した. また,症例1では主要冠動脈に有意狭窄を認めず,左室造影で著明な心室中隔肥厚を示した.家族歴も濃厚であり,肥大型心筋症と診断した.
    主要冠動脈が正常な肥大型心筋症に心筋梗塞の合併することはすでに報告されている.われわれの2症例においても心電図上持続性ST上昇が認められ,心筋障害の関与が示唆された.肥大型心筋症の心電図を評価する際,心筋肥厚に加え心筋障害による変化を考慮する必要があると思われた.
  • The study of three cases of mitral stenosis with movable left atrial thrombus, Ishimaru Mayumi, Matsuzaki Keisuke, Shigematsu Yuji, Sueda Shozo, Kazatani Yukio, Sekiya Michihito, Ochi Takaaki, Hamada Mareomi, Ito Taketoshi, Kokubu Tatsuo, Shinzo, 心臓, 心臓, 17, 6, 615, 622, 19850000, 0586-4488, http://ci.nii.ac.jp/naid/130004411484, 左房内可動血栓は,全身への塞栓あるいは僧帽弁口への嵌頓のため,突然死の原因ともなりうる.われわれは,心エコー図により発見された,左房内可動血栓を有する僧帽弁狭窄症患者3例を経験したので,その発生因子および発生機序について検討した.3例中,2例は球状浮遊血栓であり,1例は有茎性可動血栓であったが,3例とも塞栓症を合併しており,左房内可動血栓においては塞栓症が頻発する可能性の高いことを示唆していた.さらにワーファリンコントロール中に左房内浮遊血栓が僧帽弁口を通過し,塞栓症を起こした症例もあるため,僧帽弁狭窄症における抗凝固療法は,症状,心エコー図所見などに注意を払い,慎重に開始すべきであると思われた.また,上記3例と,壁在血栓を有する患者5例および血栓を有さない僧帽弁狭窄症患者7例の心エコー図上の特徴を比較検討したが,左房径,僧帽弁口面積および左心機能に差は認められず,可動血栓の成因としては心房細動以外に所見は得られなかった.しかし,われわれの症例および文献的考察より,この可動血栓は短期間で発生,発育する可能性が示唆されるため,頻回に心エコー図をとり,その有無を確認すべきであると思われた.
  • COMPARISON OF THE MYOCARDIAL CHARACTERISTICS BETWEEN HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL HYPERTROPHY DUE TO ESSENTIAL HYPERTENSION USING THE EARLY DIASTOLIC TIME INTERVALS, HAMADA Mareomi, MATSUZAKI Keisuke, KAZATANI Yukio, SHIGEMATSU Yuji, KATO Masakazu, DOIUCHI Junji, OCHI Takaaki, ITO Taketoshi, KOKUBU Tatsuo, Nihon Naika Gakkai Zasshi, 一般社団法人 日本内科学会, 日本内科学会雑誌, 72, 8, 1013, 1019, 19830000, 0021-5384, http://ci.nii.ac.jp/naid/130000891698, 肥大型心筋症(HCM)と高血圧心(HT)を鑑別する目的でHCM群35名(閉塞型10名,非閉塞型25名), HT群22名,健常対照群(N群)22名に拡張早期時相分析を行ない検討した.拡張早期時相は心エコー図,心尖拍動図,心音図を同時記録し, (1) IIA-O時間(IIA音から心尖拍動図のO点まで), (2) IIA-MVO時間(IIAから僧帽弁開放点まで), (3) MVO-O時間および, (4) MVO-O/IIA-MVO比を測定した.結果: (1)IIA-O時間はN群119±9msec, HT群170±20 (p<0.001, VS N),閉塞型171±34 (NS, VS HT),非閉塞型276±73 (p<0.001, VS HT)であつた. (2) IIA-MVO時間はN群66±11msec, HT群103±13 (p<0.001, VS N),閉塞型83±13 (p<0.001, VS HT),非閉塞型100±18 (NS, VS HT)であつた. (3) MVO-O時間はN群53±9msec, HT群67±14 (p<0.001, VS N),閉塞型89±24 (p<0.01, VS HT),非閉塞型175±68 (p<0.001, VS HT)であつた. (4) MVO-O/IIA-MVO比はN群0.89±0.32, HT群0.66±0.16 (p<0.01, VSN),閉塞型1.08±0.24 (p<0.001, VS HT),非閉塞型1.79±0.71 (p<0.001, VS HT)であつた.以上の結果より, HCM, HT両群とも等容拡張期であるIIA-MVO時間の延長を認めるが, HCMではさらに血液流入時相であるMVO-0時相により著明な延長を認め,このことが両者の重要な鑑別点であることが判明した. MVO-O/IIA-MVO比がN群に比しHT群は低値を, HCM群は逆に高値を示し,特にこれまで鑑別が極めて困難とされてきたHT群と非閉塞型を明瞭に区別し得たことは,本指標が今後両者の鑑別に極めて有用であるものと考えられた.
  • Mechanism of Atrial Fibrillation and Increased Incidence of Thromboembolism in Patients With Hypertrophic Cardiomyopathy, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, MATSUOKA Hiroshi, SUMIMOTO Takumi, HIWADA Kunio, Jpn Circ J, 社団法人日本循環器学会, Japanese circulation journal, 59, 6, 329, 336, 19950520, 00471828, http://ci.nii.ac.jp/naid/110002564915, To elucidate the morphologic characteristics of the left ventricle in patients with hypertrophic cardiomyopathy who developed atrial fibrillation, we studied left ventricular geometry by two-dimensional echocardiography in 92 patients with hypertrophic cardiomyopathy. These patients were divided into two groups; 24 patients with transient or persistent atrial fibrillation (group I) and 68 patients with sinus rhythm (group II). Left ventricular chamber size in group I was significantly smaller than that in group II. Left ventricular chamber size was correlated positively with stroke volume, and was correlated negatively with left ventricular end-diastolic pressure. The incidence of systemic thromboembolism in group I was 7.1% per patient year. In hypertrophic cardiomyopathy, the size of the left ventricle appears to have major pathophysiologic significance in the development of atrial fibrillation. In addition, since patients with hypertrophic cardiomyopathy who develop atrial fibrillation have a potential risk of systemic thromboembolism, prophylactic anticoagulant therapy should be performed in these patients.
  • Clinical Significance of Negative T Wave on Electrocardiogram in Patients with Essential Hypertension: Its Relation with Left Ventricular Mass., Ohtani Takashi, Hamada Mareomi, Matsuoka Hiroshi, Shigematsu Yuji, Sumimoto Takumi, Hiwada Kunio, Hypertension Research, 日本高血圧学会, Hypertension Research, 16, 3, 191, 195, 19930000, 0916-9636, http://ci.nii.ac.jp/naid/130003456152, To elucidate the clinical significance of negative T wave on electrocardiogram in patients with essential hypertension, the relation between negative T wave and left ventricular mass (LVM) was studied in 89 patients with essential hypertension. Left ventricular hypertrophy was defined as an LVM index of equal to or greater than 125g/m2. Essential hypertensive patients were classified into the following three groups: Group I (n=46) with neither left ventricular hypertrophy nor a history of hypertensive heart failure, Group II (n=33) with left ventricular hypertrophy and without a history of hypertensive heart failure, and Group III (n=10) with both left ventricular hypertrophy and a history of hypertensive heart failure. Negative T waves in essential hypertensive patients were observed in 4.3% of Group I, 51.5% of Group II and 100% of Group III. LVM indices in Groups I, II and III were 97±18(g/m2), 151±20 (p<0.01vs. I) and 238±23 (p<0.01vs. II), respectively. There was a significant relationship between the depth of negative T wave and LVM index (r=0.61, p<0.001). However, there was no significant difference in LVM index between Group II with negative T wave and without negative T wave. Essential hypertensive patients with more than 190g/m2 of LVM index developed hypertensive heart failure. These findings indicate that the negative T wave and its depth in patients with essential hypertension correlate well with LVM, but myocardial injury and ischemia associated with ventricular hypertrophy also have some influences on the appearance of negative T wave. (Hypertens Res 1993;16: 191-195)
  • Fatal Pulmonary Hypertension in a Patient with Mixed Connective Tissue Disease: Report of an Autopsy Case., SUZUKI Makoto, HAMADA Mareomi, SEKIYA Michihito, SHIGEMATSU Yuji, GO Soei, HIWADA Kunio, Internal Medicine, 一般社団法人 日本内科学会, Internal Medicine, 31, 1, 74, 77, 19920000, 0918-2918, http://ci.nii.ac.jp/naid/130000770364, A 34-yr-old woman with mixed connective tissue disease (MCTD) who died of heart failure due to pulmonary hypertension (PH) is reported. She showed various symptoms and signs over the previous 8 yr, including lymphadenopathy, Raynaud's phenomenon, polyarthralgia, sclerodactylia, esophageal disturbance, PH, Sjören's syndrome and renal tubular acidosis. Autopsy findings revealed severe intimal proliferation with marked luminal narrowing of the small arteries in the lung. Echocardiographic and mechanocardiographic methods were very useful for assessment of the degree of right ventricular dysfunction associated with PH on the early stage of MCTD.
    (Internal Medicine 31 : 74-77, 1992)
  • Familial Primary Pulmonary Hypertension. Report of Two Siblings., KODAMA Koji, HAMADA Mareomi, SHIGEMATSU Yuji, SUZUKI Makoto, HIWADA Kunio, HAYASHI Yutaka, HASHIMOTO Hiroyuki, HASHIMOTO Haruhisa, SUGITA Atsuro, Japanese Journal of Medicine, 社団法人 日本内科学会, Japanese Journal of Medicine, 30, 3, 273, 277, 19910000, 0021-5120, http://ci.nii.ac.jp/naid/130003514427, Familial primary pulmonary hypertension was found in two siblings (sister and brother). The woman noted exertional dyspnea at the age of 28 yr. The younger brother noticed exertional dyspnea, cough with bloody sputum and pretibial edema at the age of 38 yr. We diagnosed them as primary pulmonary hypertension as based on hemodynamicand histopathological findings. Regardless of the treatment, both patients died of right-sided heart failure with a short time course. We examined their family members, but there were no other members with primary pulmonary hypertension.
  • Persistent elevation of cardiac enzymes in a patient with hypertrophic cardiomyopathy. With special reference to electrocardiographic, echocardiographic and 201-thallium myocardial scintigraphic findings., HAMADA MAREOMI, SHIGEMATSU YUJI, FUJIWARA YASUSHI, SUMIMOTO TAKUMI, HIWADA KUNIO, KOKUBU TATSUO, Japanese Circulation Journal, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 54, 4, 354, 360, 19900000, 0047-1828, http://ci.nii.ac.jp/naid/130003547963, A 17-year-old female patient with hypertrophic cardiomyopathy whose serum cardiac enzymes (creatine phosphokinase = CPK, lactic dehydrogenase = LDH) showed persistent elevation was presented. Percent of CPK-MB and LDHl in 6-year-follow-up period ranged from 3.2% to 8.5%, and 58.0% to 63.2%, respectively. This finding strongly suggests the existence of a small amount of continuous myocardial necrosis for a long time. The influence of cardiac enzyme release on the heart was assessed by serial checks of electrocardiogram, echocardiogram and 201-thallium myocardial scintigram. In serial checks of electrocardiograms, markedly decreased R wave amplitude ranging between 31% and 47% was observed in II, III, aVF and V3-6. On echocardiograms, asymmetric septal hypertrophy and a narrow left ventricular cavity were observed in all echocardiograms through the follow-up period. But, in most recent apical two-dimensional echocardiograms, hourglass appearance of the left ventricle due to a distinct cavity-formation at the apex was observed. In 201-thallium single photon emission computed tomogram, hypoperfusion area markedly extended in anterior and lateral parts. These changes in electrocardiograms, echocardiograms and 201-thallium myocardial scintigrams seemed to reflect myocardial necrosis. Our case points to a mechanism for hypertrophic cardiomyopathy to change, over time, to dilated cardiomyopathy-like features.
  • Difference in myocardial characteristics between hypertrophic cardiomyopathy and myocardial hypertrophy due to essential hypertension., HAMADA MAREOMI, MATSUZAKI KEISUKE, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKIYA MICHIHITO, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, Japanese Circulation Journal, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 49, 3, 267, 275, 19850000, 0047-1828, http://ci.nii.ac.jp/naid/130003547367, To investigate the qualitative difference in myocardial hypertrophy that exists between hypertrophic cardiomyopathy (HCM) and essential hypertension (HT), we measured the mean wall thickness (MWT), the early diastolic time intervals (IIA-MVO time: from the second heart sound to the point of mitral valve opening, MVO-O time: from MVO to the O point of apexcardiogram) and the MVO-O/IIA-MVO ratio. The MWT in HCM and HT was measured by biventriculogram and echocardiogram, respectively. The MWT showed no significant difference between HT (1.31±3.0 mm) and non-obstructive type of HCM (14.8±3.7), but the MWT in obstructive type (1.08±0.24) was significantly thinner than that in HT. As the MWT increased, both IIA-MVO and MVO-O time were prolonged in both groups. But the mode of prolongation was quite different. In HT, the prolongation of the IIA-MVO time was almost always greater than that of MVO-O time. In HCM, the prolongation of the latter was greater than that of the former. The MVO-O/IIA-MVO ratio in HT was significantly greater. These findings suggest that the differences in the early diastolic time intervals between HCM and HT are not due to the magnitude of the left ventricular hypertrophy, but due to myocardial characteristics.
  • Difference in myocardial characteristics between hypertrophic cardiomyopathy and myocardial hypertrophy due to essential hypertension., HAMADA M., MATSUZAKI KEISUKE, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKIYA MICHIHITO, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, Jpn.Circ.J., 社団法人日本循環器学会, Jpn.Circ.J., 49, 267, 275, 19850000, 00471828, http://ci.nii.ac.jp/naid/110002579972, To investigate the qualitative difference in myocardial hypertrophy that exists between hypertrophic cardiomyopathy (HCM) and essential hypertension (HT), we measured the mean wall thickness (MWT), the early diastolic time intervals (II_A-MVO time: from the second heart sound to the point of mitral valve opening, MVO-O time: from MVO to the O point of apexcardiogram) and the MVO-O/II_A-MVO ratio. The MWT in HCM and HT was measured by biventriculogram and echocardiogram, respectively. The MWT showed no significant difference between HT (1.31±3.0 mm) and non-obstructive type of HCM (14.8±3.7), but the MWT in obstructive type (1.08±0.24) was significantly thinner than that in HT. As the MWT increased, both II_A-MVO and MVO-O time were prolonged in both groups. But the mode of prolongation was quite different. In HT, the prolongation of the II_A-MVO time was almost always greater than that of MVO-O time. In HCM, the prolongation of the latter was greater than that of the former. The MVO-O/II_A-MVO ratio in HT was significantly greater. These findings suggest that the differences in the early diastolic time intervals between HCM and HT are not due to the magnitude of the left ventricular hypertrophy, but due to myocardial characteristics.
  • NONINVASIVE EVALUATION OF LEFT VENTRICULAR FUNCTION BY SYSTOLIC TIME INTERVALS IN ESSENTIAL HYPERTENSION WITH ANGINA PECTORIS, OCHI TAKAAKI, HAMADA MAREOMI, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKITA MICHIHITO, ITO TAKETOSHI, KOKUBU TATSUO, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 48, 12, 1299, 1305, 19841220, 00471828, http://ci.nii.ac.jp/naid/110002578185, In order to clarify the hemodynamic characteristics in essential hypertension (HT) with angina pectoris (AP), systolic time intervals (STIs) were measured in 13 normal subjects (N), 23 patients with AP, 43 HT (WHO stage I: 13, WHO stage II: 23, WHO stage III: 7) and 19 HT with AP (WHO I: 9, WHO II: 10). The ET/PEP ratio was 2.41±0.24 in N, 2.70±0.34 in AP (p<0.02, vs N), 2.25±0.29 in WHO I, 2.13±0.25 in WHO II (p<0.01, vs N), 1.54±0.37 in WHO III (p<0.001, vs N), 2.68±0.32 in WHO I with AP (p<0.05 vs N: p<0.005, vs HT) and 2.71±0.30 in WHO II with AP (p<0.02, vs N: p<0.001, vs HT). Ejection time index (ETI) was 385±15 msec in N, 399±16 in AP (p<0.05, vs N), 387±13 in WHO I, 385±15 in WHO II, 363±25 in WHO III (p<0.05, vs N), 393±16 in WHO I with AP and 402±15 in WHO II with AP (p<0.05, vs N: p<0.01, vs HT). Pre-ejection period index (PEPI) was 142±10 msec in N, 135±11 in AP, 148±12 in WHO I, 156±13 in WHO II (p<0.005, vs N), 192±24 in WHO III (p<0.001, vs N), 134±13 in WHO I with AP (p<0.05, vs HT) and 136±9 in WHO II with AP (p<0.001, vs HT). These results showed that the ET/PEP ratio in HT with AP was significantly higher than that in HT alone, and this increase in ET/PEP ratio was mainly due to the shortening of PEP interval in WHO stage I and the lengthening of ET in addition to it in WHO stage II. Thus, the changes of STIs in essential hypertension, but identical with those in patients with angina pectoris.
  • Clinical significance of systolic time intervals for the evaluation of left ventricular function in patients with coronary artery disease., HAMADA MAREOMI, KAZATANI YUKIO, SHIGEMATSU YUJI, MATSUZAKI KEISUKE, IMAMURA YOICHI, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, Japanese Circulation Journal, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 47, 7, 810, 816, 19830000, 0047-1828, http://ci.nii.ac.jp/naid/130003547134, Systolic time intervals and cardiac output were measured in 10 normal subjects (group I), 25 patients with angina pectoris (group II) and 32 patients with old myocardial infarction who were subdivided into 3 groups (group III : ejection fraction (EF) ⩾50% without congestive heart failure (CHF), group IV : EF < 50% without CHF and group V with CHF irrespective of the level of EF). Because the number of the patients of group V was too small and only this group was undergoing treatment during the study, the results obtained from this group were used for comparison only. The ET/PEP ratio was 2.41 ± 0.28 in group I, 2.70 ± 0.34 in group II (p < 0.02 as compared with group I), 2.35 ± 0.30 in group III and 2.11 ± 0.18 in group IV (p < 0.01 as compared with group I). The ejection time (ET) showed no significant difference between group I and group III or IV. The pre-ejection period (PEP) showed no significant difference between groups I and II. In groups III and IV, the PEP was prolonged as the EF decreased. These results indicate that the increase of the ET/PEP ratio in group II was mainly due to the prolongation of the ET, and the decrease of the ET/PEP ratio in group IV was not directly related to the ET but to the PEP prolongation. Both the stroke index (SI) and the mean systolic ejection rate (MSER) in groups III and IV were significantly low as compared with those in group I, but those in group II showed no significant difference as compared with those in group I. These findings suggest that the prolongation of ET in groups II, III and IV indicates a compensatory mechanism to maintain the SI.
  • Angiotensin-converting enzyme inhibitors as a new therapy for atrial fibrillation? Controversy. (Letter), American Heart Journal, 149, 3, e19, 20050000, 10.1016/j.ahj.2004.09.020
  • Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina., Springer-Verlag GmbHJournal of Molecular Medicine, 83, 8, 619, 625, 20050000, 10.1007/s00109-005-0641-9
  • Black pearl in the LIFE study: angiotensin II receptor blockade on atrial fibrillation for future personalized medicine. (Letter), American College of CardiologyJournal of the American College of Cardiology, 46, 8, 1585, 20050000, 10.1016/j.jacc.2005.07.035
  • Effect of beta-blocker therapy on myocardial perfusion defects in thallium-201 scintigraphy in patients with dilated cardiomyopathy., Karger, International Journal of Cardiovascular Medicine, Surgery and PathologyCardiology, 104, 1, 16, 21, 20050000, 10.1159/000086048
  • Cardiac sympathetic nerve activity can detect congestive heart failure sensitively in patients with hypertrophic cardiomyopathy., The American College of Chest PhysiciansChest, 126, 3, 679, 686, 20040000, 10.1378/chest.126.3.679
  • Diagnostic usefulness of carotid pulse tracing in patients with hypertrophic obstructive cardiomyopathy due to midventricular obstruction: a comparison with idiopathic hypertrophic subaortic stenosis., The American College of Chest PhysiciansChest, 124, 4, 1275, 1283, 20030000, 10.1378/chest.124.4.1275
  • Effect of the addition of a beta-blocker on left ventricular remodeling and prognosis in patients with dilated cardiomyopathy treated with angiotensin-converting enzyme inhibitor., Lippincott Williams & WilkinsJournal of Cardiovascular Pharmacology, 41, Suppl 1, S5-S10, 20030000
  • Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy., Springer TokyoHeart and Vessels, 17, 2, 53, 56, 20020000, 0910-8327, 10.1007/s003800200043
  • Effect of patency from coronary angioplasty during acute myocardial infarction on left ventricular remodeling and levels of natriuretic peptides later., ELSEVIERThe American Journal of Cardiology, 88, 6, 683, 685, 20010000, 10.1016/S0002-9149(01)01817-3
  • Comparison of effects of carvedilol versus metoprolol on cytokine levels in patients with idiopathic dilated cardiomyopathy., ELSEVIERThe American Journal of Cardiology, 89, 8, 996, 999, 20020000, 10.1016/S0002-9149(02)02258-0
  • Serum levels of matrix metalloproteinases and tumor necrosis factor-alpha in patients with idiopathic dilated cardiomyopathy and effect of carvedilol on these levels., ELSEVIERThe American Journal of Cardiology, 91, 8, 1024, 1027, 20030000, 10.1016/S0002-9149(03)00133-4
  • Relation of circulating interleukin-6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction., Clinical Cardiology, 27, 7, 417, 420, 20040000
  • Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy., European Society of CardiologyThe European Journal of Heart Failure, 7, 4, 689, 695, 20050000, 10.1016/j.ejheart.2004.09.011
  • Relation of genetic predisposition and insulin resistance to left ventricular hypertrophy in hypertension., ELSEVIERThe American Journal of Hypertension, 18, 4 Pt 1, 457, 463, 20050000, 10.1016/j.amjhyper.2004.10.027
  • Dopamine agonists and valvular heart disease in Japanese patients with Parkinson’s disease., J Neurol, 254, S4, 54, 57, 20070000, 10.1007/s00415-007-4009-7
  • Pharmacogenetic interactions between angiotensin-converting enzyme insertion/deletion polymorphism and response to cibenzoline in patients with hypertrophic obstructive cardiomyopathy., Journal of Cardiovascular Pharmacology, 55, 5, 506, 510, 20100000, 0160-2446, 10.1097/FJC.0b013e3181d8bc4b
  • The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease., ElsevierInternational Journal of Cardiology, Epub ahead of print, 20100000, 10.1016/j.ijcard.2010.04.040
  • Usefulness of the MOSAIC (measurement of stenosis by aliasing coronary flow) method using transthoracic color Doppler echocardiography in unstable angina patients., ElsevierInternational Journal of Cardiology, Epub ahead of print, 20100000, 10.1016/j.ijcard.2010.05.007


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