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倉本 誠クラモト マコト

所属部署
学術支援センター
職名准教授
メールアドレスkuramoto.makoto.mx[at]ehime-u.ac.jp ※[at]を@に書き換えて送信して下さい
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生年月日
Last Updated :2017/08/18

研究者基本情報

学歴

  •  - 1994年, 静岡大学, 理学研究科, 化学
  •  - 1996年, 静岡大学, 電子科学研究科, 電子材料科学専攻
  •  - 1992年, 静岡大学, 理学部, 化学

所属学協会

  • 日本化学会

研究活動情報

研究キーワード

    天然物化学

論文

  • Damage to cultivated Japanese pearl oysters by oxidative stress that was related to "mass mortality".
    Uchimura Y, Yamashita H, Kuramoto M, Ishihara K, Sugimoto M, Nakajima N, Bioscience, biotechnology, and biochemistry, 67, (11) 2470 - 2473,   2003年11月

MISC

  • 愛媛県産海綿動物由来の生物活性物質
    坂本求, 倉本誠, 黒川嘉彦, 横尾義貴, 森重樹, 宇野英満, 日本化学会春季年会講演予稿集(CD-ROM), 96th,   2016年03月10日
  • 愛媛県産海綿動物由来の生物活性物質探索
    坂本求, 倉本誠, 黒川嘉彦, 森重樹, 宇野英満, 日本化学会講演予稿集, 95th,   2015年03月11日
  • Identification of UV-fluorescence components associated with and detection of surface damage in Green Pepper (Capsicum annum L)
    Danial Fatchurrahman, Makoto Kuramoto, Naoshi Kondo, Yuichi Ogawa, Tetsuhito Suzuki, 23rd International Conference in Central Europe on Computer Graphics, Visualization and Computer Vision, WSCG 2015 - Full Papers Proceedings,   2015年01月01日, Fluorescence imaging has been used to detect fruit surface damage, but has not yet been applied to vegetables, such as green pepper. In this report, we extract and identify fluorescent components from the exocarp (skin) of green pepper. The fluorescence excitation and emission wavelengths of these extracted compounds were determined using a fluorescence spectrophotometer and identified using nuclear magnetic resonance spectroscopy and mass spectrometry. Red and blue fluorescent components with excitation and emission wavelengths 667-685 nm and 400-438 nm respectively, were found. In subsequent research, the red fluorescent compounds were targeted, as these compounds have a higher fluorescence intensity, around 97 a.u. Pheophytin a is one of these red fluorescent compounds, appearing in the mass spectrum at 871 m/z. Furthermore, when a fluorescence imaging system was set up, with halogen illumination, it was shown that this system could successfully detect surface damage in green pepper.
  • 愛媛県産海洋生物由来の生物活性物質の構造解析
    坂本求, 黒川嘉彦, 倉本誠, 森重樹, 宇野英満, 日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集, 82nd-98th,   2015年
  • 愛媛県産海綿動物由来の含窒素化合物の探索
    黒川嘉彦, 倉本誠, 森重樹, 宇野英満, 日本化学会講演予稿集, 94th,   2014年03月12日
  • 大学院進学を希望する新入生へのサポート活動
    倉本 誠, 大学教育実践ジャーナル = Journal of faculty and staff development in higher education, (12) 55 - 59,   2014年
  • Identification of UV-fluorescence components for detecting peel defects of lemon and yuzu using machine vision
    Md Abdul Momin, Makoto Kuramoto, Naoshi Kondo, Kyohei Ido, Yuichi Ogawa, Tomoo Shiigi, Usman Ahmad, Engineering in Agriculture, Environment and Food, 6,   2013年12月12日, Fluorescence imaging has been used to detect peel defects in many citrus varieties, but not in lemon and yuzu. In this study, we extract and identify fluorescent components from the peel of lemon and yuzu. The characteristics of excitation and fluorescence of these extracted components were determined, and their identity clarified using NMR spectroscopy. Extracted fluorescent components for both lemon and yuzu have a coumarin structure. Two coumarins (5-7-dimethoxycoumarin,5-geranyloxy-7-methoxycoumarin)were identified in lemon and one(5-geranyloxycoumarin)in yuzu. Their excitation and fluorescence wavelength were observed at 320-330nm and 380-400nm,respectively. Moreover, when a fluorescence imaging system was set-up with UV-A illumination, it was shown that this system can detect peel defects in lemon, and to a lesser extent in yuzu.
  • アコヤガイ赤変病のアコヤガイで多く蓄積される細胞毒とステロール類
    内村祐之, 倉本誠, 水産増殖, 61, (2) 183 - 187,   2013年06月20日
  • 愛媛県産海綿動物由来の含窒素化合物の探索
    黒川嘉彦, 倉本誠, 横尾義貴, 森重樹, 宇野英満, 日本化学会講演予稿集, 93rd,   2013年03月08日
  • 構造解析技術の向上による新機能性物質の探索と創出の加速
    宇野英満, 谷弘幸, 倉本誠, 森重樹, 伊藤智志, 上村明男, 古田弘幸, 伊藤敏幸, 加藤知香, 北条正司, 馮旗, 高木由美子, 愛媛大学社会連携推進機構研究成果報告書, (6) 4 - 6,   2013年03月
  • アコヤガイ赤変病のアコヤガイで多く蓄積される細胞毒とステロール類
    内村 祐之, 倉本 誠, 水産増殖, 61, (2) 183 - 187,   2013年, 健常貝,病貝をエタノール中でミキサーを使い磨粉し冷暗所に 1ヶ月放置して,天然生理活性物質の分離法で濾液の生理活性物質の探索を行った。それぞれの分画をアコヤガイ初代培養血球に加え,細胞毒性を指標に細胞毒を精製した。その結果,病貝には細胞毒成分が多く含まれ,酸化された脂質あるいは糖の含有量が多いことがわかった。また,分画の過程で病貝から多く回収された白色結晶は2種類の植物ステロール,Cholesterol およびその代謝中間体であった。病貝で Cholesterol 前駆体の蓄積が顕著であったことから,細胞毒の悪影響で Cholesterol が代謝されず,性ホルモンが生成されなかったと推察された。
  • Investigation of excitation wavelength for fluorescence emission of citrus peels based on UV-VIS spectra
    Md Abdul Momin, Naoshi Kondo, Makoto Kuramoto, Yuichi Ogawa, Kazuya Yamamoto, Tomoo Shiigi, Engineering in Agriculture, Environment and Food, 5,   2012年11月22日, A study was conducted to investigate the best wavelengths for fluorescence excitation and the resulting fluorescence wavelengths in the range of 300-700 nm with citrus peels taken from 15 varieties, which are concerned with detection of surface defects of citrus fruits. Characteristics of UV absorbance, excitation and fluorescence spectra were observed by variety, and principle components analysis (PCA) and discriminate analysis (DA) were used to categorize the citrus varieties by fluorescence intensity levels in order to give some tips for optimizing the fluorescence imaging based machine vision system. The observed proper excitation wavelength for best fluorescence emmision and resulting peak fluorescence wavelength varied variety to variety and ranged from 350 to 380 nm and 490 to 540 nm respectively. The selected varieties of citrus were categorized successfully into four groups of known fluorescence level, namely strong, medium, weak and no fluorescence groups.
  • 皮膚科受診患者の「健康食品・サプリメント」摂取調査
    町野博, 倉本誠, 宇野満英, 西日本皮膚科, 74,   2012年04月01日
  • カンキツ果皮に含まれる蛍光物質に関する研究
    倉本誠, 中平祐也, 近藤直, 小川雄一, 山本一哉, MOMIN MD. Abdul, 井戸恭平, 日本化学会講演予稿集, 92nd,   2012年03月09日
  • アコヤガイ赤変病に罹病した貝で多発するレンガ色真珠の分析
    内村 祐之, 倉本 誠, 曽根 謙一, 水産増殖 = The aquiculture, 59, (4) 573 - 577,   2011年12月20日, アコヤガイ赤変病が発生以来、収穫された真珠にレンガ色の真珠(濁り玉)の割合が増加した。この真珠は収穫された真珠の有機物を除去する脱色作業でも除去されないことが多いため、真珠生産者では商品価値のある真珠の収量は激減した。そこで、レンガ色の正体を明らかにするため、濁り珠を破砕し抽出した真珠の色素のNMR分析と、電子顕微鏡による正常な真珠との結晶構造を比較した。色素のNMR分析では、これまで報告されたメラニンのほかに、アコヤガイ体内のラジカル損傷産物である過酸化脂質が検出された。一方、電子顕微鏡観察では、濁り珠は正常な真珠に比べ稜柱層が有意に厚いことがわかった。抽出された色素は、真珠加工会社の脱色過程で除去されることから、レンガ色の正体は厚く形成された稜柱層にあると考えられた。
  • Evaluation of the reasons why freshly appearing citrus peel fluorescence during automatic inspection by fluorescent imaging technique
    Md Abdul Momin, Naoshi Kondo, Makoto Kuramoto, Yuichi Ogawa, Kazuya Yamamoto, Tomoo Shiigi, Kazunori Ninomiya, Proceedings of SPIE - The International Society for Optical Engineering, 8000,   2011年09月05日, Defective unshu oranges (Citrus reticulate Blanco var. unshu) were sorted based on fluorescent imaging technique in a commercial packinghouse but fresh appearing unshu were rejected due to fluorescence appearing on their peel. We studied the various visible patterns based on colour, fluorescence and microscopic images, where even areas of the peel that are not obviously damaged can have fluorescence, to provide a categorization of fluorescence reasons. The categorization corresponded to: 1) hole and flow; 2) influenced by damaged or rotten fruits that have released peel oil onto it; 3) immature or poor peel quality; 4) whitish fluorescence due to agro-chemicals and 5) variation of the growing season. The identification of such patterns of fluorescence might be useful for citrus grading industry to take some initiatives to make the entire automated system more efficient. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
  • Study on excitation and fluorescence spectrums of Japanese citruses to construct machine vision systems for acquiring fluorescent images
    Md Abdul Momin, Naoshi Kondo, Makoto Kuramoto, Yuichi Ogawa, Tomoo Shigi, Proceedings of SPIE - The International Society for Optical Engineering, 8027,   2011年09月05日, Research was conducted to acquire knowledge of the ultraviolet and visible spectrums from 300 -800 nm of some common varieties of Japanese citrus, to investigate the best wave-lengths for fluorescence excitation and the resulting fluorescence wave-lengths and to provide a scientific background for the best quality fluorescent imaging technique for detecting surface defects of citrus. A Hitachi U-4000 PC-based microprocessor controlled spectrophotometer was used to measure the absorption spectrum and a Hitachi F-4500 spectrophotometer was used for the fluorescence and excitation spectrums. We analyzed the spectrums and the selected varieties of citrus were categorized into four groups of known fluorescence level, namely strong, medium, weak and no fluorescence.The level of fluorescence of each variety was also examined by using machine vision system. We found that around 340-380 nm LEDs or UV lamps are appropriate as lighting devices for acquiring the best quality fluorescent image of the citrus varieties to examine their fluorescence intensity. Therefore an image acquisition device was constructed with three different lighting panels with UV LED at peak 365 nm, Blacklight blue lamps (BLB) peak at 350 nm and UV-B lamps at peak 306 nm. The results from fluorescent images also revealed that the findings of the measured spectrums worked properly and can be used for practical applications such as for detecting rotten, injured or damaged parts of a wide variety of citrus. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
  • Porphyrin molecular tweezers for fullerenes
    Hidemitsu Uno, Mina Furukawa, Akiko Fujimoto, Hiroki Uoyama, Hajime Watanabe, Tetsuo Okujima, Hiroko Yamada, Shigeki Mori, Makoto Kuramoto, Tatsunori Iwamura, Noriyuki Hatae, Fumito Tani, Naoki Komatsu, Journal of Porphyrins and Phthalocyanines, 15,   2011年09月01日, Facing zinc bisporphyrins connected with diethanoanthracene and diethanonaphthacene (syn-1 and syn-2) are prepared by double [3+1] porphyrin synthesis of tripyrranedicarbaldehyde with syn-5,11-dimethoxy-4,6,10,12- tetrahydro-4,12;6,10-diethanoanthracene[2,3-c;7,8-c′]dipyrrole and syn-4,7,11,14- tetrahydro-4,14;7,11-diethanonaphthacene[2,3-c;8,9-c′] dipyrrole. These bisporphyrins contain large clefts with different sizes capable for complexation with fullerenes such as C60 and C70. These designed syn-oriented bisporphyrins serve as effective and selective molecular tweezers for C70. Binding affinity of the zinc bisporphyrins, namely, syn-1 and syn-2, towards C60 and C 70 in solution is determined by employing UV-vis spectrophotometric technique. Values of binding constants (K) in toluene for the non-covalent complexes of syn-1 with C60 and C70 are estimated to be 3.1(4) × 104 and 5.0(2) × 105 M-1, respectively, and those of syn-2 with C60 and C70 are enumerated to be 2.1(4) × 104 and 1.70(13) × 10 5 M-1, respectively. Binding of C60 and C 70 in the clefts of syn-1 and syn-2 is clearly demonstrated by the crystal structures of C60/syn-1, C70/syn-1, C 60/syn-2, and C70/syn-2 complexes. In the crystal structures with C70, the directions of the long axis of C 70 are found to be quite different: in the case of C 70/syn-1 complex the axis lies perpendicularly to the line connecting two zinc atoms; however, for the C70/syn-2 complex, the axis occupies in-plane to the same line. Both the clefts of syn-1 and syn-2 are induced to fit the included fullerenes by domed out-of-plane distortion of porphyrin rings. Moreover, the bicyclo[2.2.2]octadiene moieties of syn-1 are widened by complexation with the fullerenes, while the same moieties of syn-2 are narrowed by the complexation. Therefore, syn-1 catches the fullerenes at the shallow part of the cleft. On the other hand, syn-2 catches the fullerenes at the bottom part of the cleft. NMR experiments of the complexes in THF-d 8 also support these orientations even in solution. © 2011 World Scientific Publishing Company.
  • Influence of conductivity on the generation of a radio frequency plasma surrounded by bubbles in water
    T. Maehara, S. Honda, C. Inokuchi, M. Kuramoto, S. Mukasa, H. Toyota, S. Nomura, A. Kawashima, Plasma Sources Science and Technology, 20,   2011年06月01日, A radio frequency plasma was generated and maintained in water over a wide range of water conductivities (0.2-7000 mS m-1). The conductivity of water was changed by adding NaCl to it. The size of the plasma increased with conductivity. Although the intensity of the OH(A-X) line monotonically decreased with increasing conductivity, the generation of hydrogen peroxide and the degradation of methylene blue suggested that the number of generated OH radicals decreased with increasing conductivity in the range 0.2-80 mS m-1 and increased in the range 80-7000 mS m-1. Ultraviolet irradiation was found to enhance the degradation of methylene blue not only in pure water but also in high-conductivity water (≃5000 mS m-1). © 2011 IOP Publishing Ltd.
  • 石けんグリースの劣化生成物の分析
    宇佐美洋介, 児玉竜二, 中村誠一, 戸田哲也, 倉本誠, 横尾義貴, 日本トライボロジー学会トライボロジー会議予稿集, 2011-5,   2011年04月22日
  • 蛍光画像を用いた柑橘系果実の腐敗果検出
    小川雄一, ABDUL Momin Md., 倉本誠, 河野靖, 椎木友朗, 山本一哉, 近藤直, レーザー研究, 39, (4) 255 - 261,   2011年04月15日
  • 生物活性海洋アルカロイドの構造と機能(共著)
    倉本誠, CHOU T, 上村大輔, 有機合成化学協会誌, 57, (2) 105 - 115,   1999年02月01日, In our continuing search for bioactive substances from marine organisms, four novel alkaloids, pinnatoxins, halichlorine, pinnaic acids and norzoanthamine were isolated. The structures and functions of these marine alkaloids are described here.
    Pinnatoxins, potent shellfish poison, were purified form the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channel. Especially, toxicity of pinnatoxins B, C is as significant as that of tetrodotoxin. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1 at IC50 7 μg/ml. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina and noncardiovascular inflammatory diseases. Pinnaic acids, cPLA2 inhibitor, were also obtained from the Pinna muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp. which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug.
  • 愛媛県産海綿動物由来の含窒素化合物の探索
    横尾義貴, 倉本誠, 宇野英満, 日本化学会講演予稿集, 91st,   2011年03月11日
  • 皮膚科受診患者の健康食品・サプリメント摂取調査
    町野博, 倉本誠, 宇野英満, 皮膚病診療, 32, (8) 914 - 922,   2010年08月01日
  • 植物体中のFe2+は植物脂質からのエチレン生成に重要な役割を果たす
    石井孝昭, 伊藤正宗, 倉本誠, CRUZ A. F., 園芸学研究 別冊, 9,   2010年03月21日
  • 愛媛県産海洋生物由来の生物活性物質
    横尾義貴, 三宅教道, 二宮高裕, 倉本誠, 宇野英満, 日本化学会講演予稿集, 90th,   2010年03月12日
  • 共生微生物由来の生物活性物質の探索
    横尾義貴, 中島隼紀, 佐藤誠造, 倉本誠, 宇野英満, 日本化学会西日本大会講演要旨集, 2009,   2009年11月07日
  • 海洋生物に含まれる生体機能分子の探索
    二宮高裕, 横尾義貴, 三宅教道, 倉本誠, 宇野英満, 日本化学会西日本大会講演要旨集, 2009,   2009年11月07日
  • 海綿動物由来のアルカロイドCylindradine類の構造解析
    三宅教道, 倉本誠, 石丸恵久, 小野昇, 宇野英満, 日本化学会講演予稿集, 89th,   2009年03月13日
  • A double image acquisition system with visible and UV LEDs for citrus fruit
    Naoshi Kondo, Peter P. Ling, Mitsutaka Kurita, Paolo D. Falzea, Takahisa Nishizu, Makoto Kuramoto, Yuichi Ogawa, Yoshihide Minami, American Society of Agricultural and Biological Engineers - Food Processing Automation Conference 2008,   2008年12月01日, There are many types of citrus fruit grading machine with machine vision capability. While most of them sort fruit by size, shape, and color, detection of rotten fruit remains challenging because their appearances are similar to normal parts. Objectives of this research were to investigate if fluorescence would be a good indicator of the fruit rot, and to develop an economical solution to add the rot inspection capability to an existing machine vision fruit inspection station. A machine vision system consisting of a pair of white and ultra violet (UV) LED lighting devices and a color CCD camera was proposed for the citrus fruit grading task. Since the time lag between the color and fluorescence image captures was short (14ms), it was possible to inspect color, shape, size, and rot of a fruit on the move before it leaves an existing industrial inspection chamber.
  • Isolation and structural elucidation of a growth stimulant for arbuscular mycorrhizal fungus from Laminaria japonica Areschoug
    Kousaku Kuwada, Makoto Kuramoto, Masaru Utamura, Itaru Matsushita, Takaaki Ishii, Journal of Applied Phycology, 18,   2006年12月01日, Arbuscular Mycorrhizal (AM) fungi enhance terrestrial plant growth by forming a symbiotic relationship with the roots of its host plant. A growth stimulant for AM fungi was isolated from a brown alga Laminaria japonica Areschoug. The active substance for in vitro AM hyphal growth was isolated from 75% methanol extracts of L. japonica using a succession of chromatographic procedures, including flash chromatography equipped with an octa decyl silane (ODS) column, gel filtration chromatography and HPLC using an ODS column. Spores of Gigaspora margarita Becker & Hall, an AM fungus, were exposed to the compound in vitro, and hyphal growth of G. margarita was measured after two weeks of incubation. At 40 mg L-1, the compound significantly stimulated the in vitro hyphal growth of G. margarita, compared to the control. This compound was elucidated as 5′-deoxy-5′-methylamino-adenosine by EIMS and NMR spectrum. © 2006 Springer Science+Business Media B.V.
  • Ircinamine B, bioactive alkaloid from marine sponge Dactylia sp.
    Seizo Sato, Seizo Sato, Makoto Kuramoto, Noboru Ono, Tetrahedron Letters, 47,   2006年11月06日, Ircinamine B was isolated from the marine sponge Dactylia sp., which was collected at Cape Sada in Japan. Based on extensive spectral analysis, the structures of the isolated metabolites were established. This novel compound showed moderate activity against the murine leukemia cell line P388 (IC50 0.28 μg/mL). © 2006 Elsevier Ltd. All rights reserved.
  • Effect of mannitol from Laminaria japonica, other sugar alcohols, and marine alga polysaccharides on in vitro hyphal growth of Gigaspora margarita and root colonization of trifoliate orange
    K. Kuwada, M. Kuramoto, M. Utamura, I. Matsushita, Y. Shibata, T. Ishii, Plant and Soil, 276,   2005年10月01日, A compound that stimulated the growth of an arbuscular mycorrhizal (AM) fungus was isolated from 75% methyl alcohol (MeOH) extracts of a brown alga, Laminaria japonica Areschoug, using high-pressure liquid chromatography (HPLC). This compound (Compound 1) was identified as mannitol by HPLC and nuclear magnetic resonance (NMR) spectroscopy. Compound 1 and purchased polysaccharides (alginic acid, fucoidan, carrageenan and mannan from marine algae) were tested for in vitro hyphal growth of an AM fungus, Gigaspora margarita Becker and Hall. Compound 1 (50-500 mg L-1) and carrageenan (1000 mg L-1) significantly stimulated the hyphal growth of germinating spores of Gi. margarita. The application of 100 mg L-1 of Compound 1 to trifoliate orange (Poncirus trifoliata Raf.) inoculated with Gi. margarita promoted root colonization and increased plant growth. These results suggest low concentrations of mannitol are among the reasons for enhanced hyphal growth and root colonization by the application of algal extracts. Other sugar alcohols (100-300 mg L-1 of xylitol, sorbitol and meso-erythritol) also increased the hyphal growth of Gi. margarita. © Springer 2005.
  • Ircinamine, a novel cytotoxic alkaloid from Ircinia sp.
    Makoto Kuramoto, Tohru Fujita, Noboru Ono, Chemistry Letters,   2002年04月05日, Ircinamine was isolated from the marine sponge Ircinia sp., and its structure was elucidated by detailed spectroscopic analysis. This novel compound showed moderate activity against the murine leukemia cell line P388.
  • Growth stimulants for vesicular-arbuscular mycorrhizal fungi in satsuma mandarin pomace
    Jiro Aikawa, Takaaki Ishii, Makoto Kuramoto, Kazuomi Kadoya, Journal of the Japanese Society for Horticultural Science, 69,   2000年07月01日, The isolation and identification of growth stimulants for vesicular-arbuscular mycorrhizal (VAM) fungi in the 25% methanol (MeOH) extracts of satsuma mandarin (Citrus unshiu Marc.) pomace extracts were carried out. Three compounds were isolated from the eluates by using a high pressure liquid chromatograph (HPLC). When the effect of the three compounds was tested on the in vitro hyphal growth of a VAM fungus, Gigaspora margarita, two compounds had a stimulatory effect. The two stimulants were identified as hesperidin (hesperetin-7-β-rutinoside) and narirutin (naringenin-7-β-rutinoside). Narirutin at 1 to 30 ppm and hesperidin at 1 to 10 ppm significantly stimulated the hyphal growth of G. margarita.
  • Neoilludins A and B, new bioactive components from Lampteromyces japonicus
    Makoto Kuramoto, Takuya Tsukihara, Noboru Ono, Chemistry Letters,   1999年12月01日, Neoilludins A and B were isolated from Lampteromyces japonicus, and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analysis of proton-proton coupling constants and NOE experiments. These compounds are cytotoxic and exhibit antibacterial activity.
  • 共生微生物由来の生物活性物質の探索
    横尾義貴, 佐藤誠造, 倉本誠, 宇野英満, 日本化学会講演予稿集, 89th,   2009年03月13日
  • 栄養管理室におけるリスクマネジメント
    村上智子, 大山明子, 近藤高弘, 倉本誠雄, 釋迦堂益子, 東輝一朗, 日本病院学会プログラム・抄録, 59th,   2009年
  • カンキツ果実の選別および腐敗検出のための画像入力システム
    栗田充隆, 近藤直, 西津貴久, 倉本誠, 小川雄一, 山本一哉, 南佳秀, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2008,   2008年06月05日
  • 愛媛県産海綿動物由来のフラノテルペン類の合成研究
    高木貴浩, 稲葉正樹, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 88th,   2008年03月12日
  • 水中高周波プラズマによる過酸化水素の発生と有機物の分解
    大西真悟, 前原常弘, 宮本一平, 倉本誠, 山下浩, 向笠忍, 豊田洋通, 野村信福, 川嶋文人, 応用物理学会中国四国支部・日本物理学会中国支部・四国支部・日本物理教育学会中国四国支部支部学術講演会講演予稿集, 2008,   2008年
  • 愛媛県産海洋生物由来の生物活性物質の探索
    三宅教道, 倉本誠, 宇野英満, 日本化学会西日本大会講演要旨集, 2007,   2007年11月10日
  • 温州ミカン果皮に含まれる蛍光物質の特定と蛍光画像を利用した腐敗果実検出システム
    山本一哉, 近藤直, 谷脇滋宗, 倉本誠, 栗田充隆, 二宮和則, 日本機械学会年次大会講演論文集, 2007, (Vol.5) 471 - 472,   2007年09月07日
  • エチレンの前駆物質としてのブドウ葉内脂質の単離と解析
    落合彩織, 土橋由起子, 川下智美, 倉本誠, 石井孝昭, 園芸学研究 別冊, 6,   2007年03月24日
  • エチレンの前駆物質としてのブドウ葉内脂質の単離と解析
    落合 彩織, 土橋 由起子, 川下 智美, 倉本 誠, 石井 孝昭, 園芸学研究. 別冊, 園芸学会大会研究発表要旨, 6,   2007年03月24日
  • 蛍光画像を用いた柑橘系果実の腐敗果検出
    小川 雄一, Momin Md. ABDUL, 倉本 誠, 河野 靖, 椎木 友朗, 山本 一哉, 近藤 直, レーザー研究, 39, (4) 255 - 261,   2011年04月15日, The fluorescent substances in citrus fruit peels were investigated by NMR analysis and excitation, and
  • 愛媛県産海洋生物由来の生物活性物質の探索
    三宅教道, 石丸恵久, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 87th,   2007年03月12日
  • 愛媛ブランド真珠生産技術開発事業(養殖水産物ブランド・ニッポン推進対策事業)I 真珠品質向上試験
    内村祐之, 曽根謙一, 倉本誠, 石丸恵久, 愛媛県水産試験場事業報告, 2005,   2006年09月
  • 海綿由来フラノテルペン類縁体の構造解析
    稲葉正樹, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 86th,   2006年03月13日
  • 海綿動物由来の新規Phakellin誘導体の構造
    石丸恵久, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 86th,   2006年03月13日
  • 愛媛県産海綿動物由来の細胞毒性物質
    中鋪愛, 佐藤誠造, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 86th,   2006年03月13日
  • 水中プラズマによるメチレンブルー溶液の分解
    橋本幸生, 黒河賢哉, 前原常弘, 豊田洋通, 野村信福, 倉本誠, 応用物理学会中国四国支部・日本物理学会中国支部・四国支部・日本物理教育学会中国四国支部支部学術講演会講演予稿集, 2006,   2006年
  • アーバスキュラー菌根共生に関与するジペプチド
    堀井幸江, 倉本誠, 石井孝昭, 園芸学会雑誌 別冊, 74,   2005年10月01日
  • アーバスキュラー菌根共生に関与するジペプチド
    堀井 幸江, 倉本 誠, 石井 孝昭, 園芸学会雑誌. 別冊, 園芸学会大会研究発表, 74,   2005年10月01日
  • 2A1-B07 カンキツ果実の選別および腐敗検出のための画像入力システム(農業用ロボット・メカトロニクス)
    栗田 充隆, 近藤 直, 西津 貴久, 倉本 誠, 小川 雄一, 山本 一哉, 南 佳秀, ロボティクス・メカトロニクス講演会講演概要集, 2008,   2008年06月06日, There are many types of orange fruit grading machines with machine vision systems, but it is still difficult to detect rotten parts, because their colors are similar with normal parts. Objectives of this research are to investigate the excitation wavelengths of the substances for determination of lighting device specification, and to construct an inspection system for fruit grading by color image and for the rotten part detection by UV lighting device. From an analysis of orange fruit skins, it was found one of major fluorescent substances was flavonoid methyl whose exciting wavelength was 365nm and fluorescence wavelength was about 530nm. A machine vision system consisting of a pair of white and UV LED lighting devices and a color CCD camera was proposed for orange fruit grading. Since the time between color and fluorescence image inputs was short enough (14ms), it was considered that UV LEDs addition to white LEDs-color TV camera system installed in fruit grading lines made rotten fruit detection possible.
  • 4230 温州ミカン果皮に含まれる蛍光物質の特定と蛍光画像を利用した腐敗果実検出システム(S68 農業ロボット,S68 農業ロボット)
    山本 一哉, 近藤 直, 谷脇 滋宗, 倉本 誠, 栗田 充隆, 二宮 和則, 年次大会講演論文集 : JSME annual meeting, 2007, (5) 471 - 472,   2007年09月07日, It is known that rotten parts of orange fruit fluoresce when they are excited by UV light. From an analysis of orange fruit skin, it was found that one of the major fluorescent substances was flavonoid methyl ether group whose exciting wavelength was 365nm and fluorescence wavelength was about 530nm. Based on the result, a lighting device with 120365nm-wavelength LEDs was manufactured and fluorescence images of rotten citrus fruit were acquired by a machine vision system with the three lighting devices. In this paper, a machine vision system with a pair of white and UV LED lighting devices and a color TV camera was proposed for the orange fruit grading system which could automatically detect rotten fruits.
  • バヒアグラス由来のVA菌根菌成長促進活性物質
    稲葉正樹, 石丸恵久, 倉本誠, 小野昇, 石井孝昭, 日本化学会講演予稿集, 85th,   2005年03月11日
  • ペプチドはVA菌根共生に作用する
    堀井幸江, 倉本誠, 佐藤健司, 石井孝昭, 園芸学会雑誌 別冊, 73,   2004年04月03日
  • ペプチドはVA菌根共生に作用する
    堀井 幸江, 倉本 誠, 佐藤 健司, 石井 孝昭, 園芸学会雑誌. 別冊, 園芸学会大会研究発表, 73,   2004年04月03日
  • 28pUC-8 水中における高周波プラズマ(プラズマ科学,28pUC プラズマ基礎(非線形現象),領域2(プラズマ基礎・プラズマ科学・核融合プラズマ・プラズマ宇宙物理))
    前原 常弘, 田所 篤, 向笠 忍, 倉本 誠, 岩前 敦, 豊田 洋通, 野村 信福, 日本物理学会講演概要集, 61,   2006年03月04日
  • 愛媛県産海綿動物由来の生物活性物質
    川上恵, 石丸恵久, 三好彰, 倉本誠, 小野昇, 日本化学会講演予稿集, 84th,   2004年03月11日
  • 海産アルカロイドIrcinamine Bの構造
    佐藤誠造, 倉本誠, 小野昇, 日本化学会講演予稿集, 84th,   2004年03月11日
  • 未解明生物現象を司る鍵化学物質 アコヤガイ赤化大量死原因物質の探索
    倉本誠, 内村祐之, 未解明生物現象を司る鍵化学物質 平成11-14年度 No.11175101,   2004年
  • VA菌根菌生長促進物質としてのペプチドおよびトリプトファン誘導体
    堀井幸江, 倉本誠, 佐藤健司, 石井孝昭, 園芸学会雑誌 別冊, 72,   2003年09月20日
  • VA菌根菌生長促進物質としてのペプチドおよびトリプトファン誘導体
    堀井 幸江, 倉本 誠, 佐藤 健司, 石井 孝昭, 園芸学会雑誌. 別冊, 園芸学会大会研究発表, 72,   2003年09月20日
  • 食品に含まれる抗抑うつ活性物質の探索
    石丸恵久, 倉本誠, 小野昇, 吉村裕之, 日本化学会講演予稿集, 83rd,   2003年03月03日
  • アコヤガイ大量死原因物質の探索
    川上恵, 倉本誠, 内村祐之, 小野昇, 日本化学会講演予稿集, 83rd,   2003年03月03日
  • Ircinia sp.由来の生物活性物質の探索
    大野修, 佐藤誠造, 倉本誠, 小野昇, 日本化学会講演予稿集, 83rd,   2003年03月03日
  • 雌性動物の抑うつ状態に対するローヤルゼリーの効果
    吉村 裕之, 別宮 直子, 倉本 誠, 沖原 清司, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 22,   2002年12月25日
  • Effect of mannitol from Laminaria japonica, other suger alcohols and marine alga polysaccharides on invitro hyphal growth of Gigaspora margarita and root colonization of trifoliate orange
    Springerplant and soil, 276,   2005年
  • Ircinia sp.由来の細胞毒性物質
    大野修, 倉本誠, 小野昇, 日本化学会講演予稿集, 81st,   2002年03月11日
  • アコヤガイ大量死原因物質の探索
    川上恵, 倉本誠, 内村祐之, 小野昇, 日本化学会講演予稿集, 81st,   2002年03月11日
  • 高生存アコヤ貝選抜試験 水産生物育種の効率化基礎技術の開発 (愛媛県水産試験場S)
    内村祐之, 倉本誠, 兵頭勝也, 浜田耕治, 広瀬琢磨, 愛媛県水産試験場事業報告, 2000,   2002年03月
  • 海洋生物由来の生物活性物質
    倉本誠, 日本化学会中国四国・同九州支部合同大会講演要旨集, 2001,   2001年10月27日
  • 愛媛県産海洋生物由来の細胞毒性物質
    倉本誠, 藤田徹, 大野修, 川上恵, 小野昇, 天然有機化合物討論会講演要旨集, 43rd,   2001年09月01日
  • アコヤガイの病状探索と耐病性貝の作出 I 病貝から抽出した成分からの知見
    倉本誠, 内村祐之, 中島伸佳, 日本魚病学会大会プログラムおよび講演要旨, 2001,   2001年03月29日
  • 愛媛県産海綿由来の細胞毒性物質
    倉本誠, 藤田徹, 小野昇, 日本化学会講演予稿集, 79th,   2001年03月15日
  • ウンシュウミカンジュースかす中の VA 菌根菌生長促進物質
    相川 次郎, 石井 孝昭, 倉本 誠, 門屋 一臣, 園芸学会雑誌, 69, (4) 385 - 389,   2000年07月15日, カンキツジュースかす中に存在するVA菌根菌生長促進物質の単離および同定を試みた.材料には, フラッシュクロマトグラフィーによって分画し, あらかじめVA菌根菌生長促進物質が存在することを確認していたウンシュウミカンジュースかす抽出物の25%メタノール溶出物を用いた.その結果, この溶出物中から3種類の物質が単離され, この内2種類の物質においてVA菌根菌の菌糸生長を促す効果が認められた.この活性物質はヘスペリジンおよびナリルチンと同定された.これらのフラボノイドが菌糸生長に及ぼす影響を調査したところ, へスペリジンでは1から10ppm, ナリルチンでは1から30ppmの範囲内で菌糸生長が著しく促進された.
  • 愛媛県産海綿由来の細胞毒性物質
    藤田徹, 倉本誠, 小野昇, 日本化学会講演予稿集, 78th,   2000年03月15日
  • 赤化アコヤガイ蓄積物質の構造解析
    月原拓也, 倉本誠, 内村祐之, 小野昇, 日本化学会講演予稿集, 78th,   2000年03月15日
  • アコヤガイ感染症の病状 II 栄養障害と今後の対策
    倉本誠, 内村祐之, 藤田慶之, 森実庸男, 日本魚病学会大会プログラムおよび講演要旨, 1999,   1999年03月29日
  • 赤変化アコヤガイ由来の血球変性物質の探索
    倉本誠, 内村祐之, 小野昇, 日本化学会講演予稿集, 76th,   1999年03月15日
  • Growth Stimulatory Substances for Mycorrhizal Fungi in Composted Organic Matter
    T. Ishii, H. Kitabayashi, M. Nakano, H. Motosugi, M. Kuramoto, Acta Horticulture, 638,   2004年12月01日, Non-gaseous growth stimulatory substances for vesicular-arbuscular mycorrhizal (VAM) fungi in 45 day-fermented bahiagrass (Paspalum notatum Flügge.) shoots and leaves were isolated and identified. The VA M growth stimulants were eupalitin and 2, 3-dihydroeupalitin. Eupalitin at concentrations high enough to stimulate the hyphal growth of VAM fungi was detected in this composted bahiagrass shoots and leaves. The results suggest that some flavonoids such as eupalitin and 2, 3-dihydroeupalitin remain even in the composted organic matter or its water extract. We indicate that the effectiveness of composted organic matter application that stimulates the growth of mycorrhizal fungi will result from not only the evolution of gaseous mycorrhizal growth stimulants from the composted organic matter but also the presence of non-gaseous ones such as flavonoids.
  • 海産未利用資源由来の有用分子の探索
    藤田徹, 倉本誠, 小野昇, 日本化学会講演予稿集, 76th,   1999年03月15日
  • 十字路
    倉本 誠, 片桐 信弥, 国嶋 崇隆, 有機合成化学協会誌, 57, (2) 141 - 141,   1999年
  • Synthesis and absolute stereochemistry of tanzawaic acid (GS-1302)
    Hirokazu Arimoto, Kazuya Nishimura, Makoto Kuramoto, Daisuke Uemura, Tetrahedron Letters, 39,   1998年12月17日, The first total synthesis of tanzawaic acid A(GS-1302-3) is described. The stereocontrolled synthetic route allowes the absolute stereochemistry to be determined. One key transformation in the sequence involves a Stille coupling with a highly hindered aryl triflate. Examples and results of several coupling reactions are also included.
  • ツキヨタケ由来の生物活性物質
    月原拓也, 倉本誠, 小野昇, 日本化学会講演予稿集, 75th,   1998年09月
  • ノルゾアンタミンの構造活性相関
    倉本誠, 佐藤浩子, 有本博一, 上村大輔, 日本化学会講演予稿集, 75th,   1998年09月
  • 抗炎症性リード化合物Tanzawaic acidの合成研究
    西村和也, 有本博一, 倉本誠, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 75th,   1998年09月
  • Norzoanthamine類の生物活性と化学変換
    林孝二, 倉本誠, 山口宏二, 辻智子, 上村大輔, 日本化学会講演予稿集, 74th,   1998年03月
  • 抗炎症性リード化合物Tanzawaic acidの合成研究
    西村和也, 有本博一, 倉本誠, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 74th,   1998年03月
  • ツキヨタケ由来の新規イルジン同族体の構造
    月原拓也, 倉本誠, 宇野英満, 小野昇, 日本化学会講演予稿集, 74th,   1998年03月
  • Absolute stereocmemistry of halichlorine; a potent inhibitor of VCAM-1 induction
    Hirokazu Arimoto, Ichiro Hayakawa, Makoto Kuramoto, Daisuke Uemura, Tetrahedron Letters, 39,   1998年02月19日, The absolute stereochemistry of a marine alkaloid halichlorine, which significantly inhibits VCAM-1 induction in HUVE cells, was established by synthesis of a degradation product of natural product.
  • Tanzawaic acids A, B, C, and D: Inhibitors of superoxide anion production from Penicillium citrinum
    Makoto Kuramoto, Kaoru Yamada, Mayumi Shikano, Kazunaga Yazawa, Hirokazu Arimoto, Tomoyuki Okamura, Daisuke Uemura, Chemistry Letters,   1997年12月01日, Tanzawaic acids have been isolated from Penicillium citrinum and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analyses of 1H-1H coupling constants and NOE data. Tanzawaic acid B (GS-1302-1) significantly inhibits superoxide anion production in human neutrophils.
  • Development of Chemical Substances Regulating Biofilm Formation
    Akihiro Yamada, Hitomi Kitamura, Kaori Yamaguchi, Seketsu Fukuzawa, Chiyuki Kamijima, Kazunaga Yazawa, Makoto Kuramoto, Gui Yang Sheng Wang, Yasuyuki Fujitani, Daisuke Uemura, Bulletin of the Chemical Society of Japan, 70,   1997年12月01日, The chemical substances which regulate biofilm formation were examined, and a bioassay system which uses marine bacteria with adhering properties was developed. This bioassay system is suitable for screening crude extracts from marine organisms. Using this system, those substances which regulate biofilm formation were isolated from marine organisms. For example, bis(deacetyl)solenolide D was obtained from the marine sponge Psammaplysilla purpurea. Novel nitroalkanes were also isolated from the Okinawan sponge Callyspongia sp. Ethyl N-(2-phenylethyl)carbamate isolated from the marine bacteria SCRC3P79 (Cytophaga sp.) inhibited biofilm formation. Furthermore, the N,N-dichloro, isocyanide, isothiocyanate, and dithiocarbamate derivatives of 2-(4-nitrophenyl)ethylamine, significantly inhibited the growth of marine attaching bacteria. Interestingly, most of the marine sponges examined contained anti-biofilm compounds, such as benzoic acid, aeroplysinin-I, and bromoageliferin.
  • ノルゾアンタミン類の化学変換
    林孝二, 上村大輔, 倉本誠, 山口宏二, 辻智子, 日本化学会講演予稿集, 73rd,   1997年09月
  • 生物活性海洋アルカロイドHalichlorineの合成研究
    早川一郎, 有本博一, 上村大輔, 倉本誠, 日本化学会講演予稿集, 73rd,   1997年09月
  • 104(P51) 骨粗鬆症抑制作用物質Norzoanthamineの構造活性相関(ポスター発表の部)
    山口 宏二, 矢田 美日, 辻 智子, 倉本 誠, 林 孝二, 上村 大輔, 天然有機化合物討論会講演要旨集, (39) 619 - 624,   1997年07月20日, Norzoanthamine (1), is a zoanthamine-type alkaloid isolated from the colonial zoanthid Zoanthus sp. Norzoanthamines inhibit IL-6 production. Furthermore, norzoanthamine hydrochloride, which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug. Although the relative configuration of norzoanthamine was established based on an X-ray crystallographic analysis, the absolute conformation of norzoanthamines, including zoanthamines which have been reported previously, remains unclear. To investigate their biogenesis and mechanism of biologocal action, we conducted chemical and spectroscopic studies to determine the absolute configuration of norzoanthamines. We report here the absolute stereochemistry, a proposed biogenesis and bioactivities of norzoanthamines.
  • 骨粗しょう症抑制作用物質ノルゾアンタミンの構造活性相関
    山口宏二, 矢田美日, 辻智子, 倉本誠, 林孝二, 上村大輔, 天然有機化合物討論会講演要旨集, 39th,   1997年07月
  • 生体機能解明試薬の開発
    倉本誠, CHOU T, 上村大輔, 静岡大学大学院電子科学研究科研究報告, (18) 83 - 89,   1997年03月
  • バイオフィルム形成制御物質の研究
    山田昭浩, 山口果生里, 北村仁美, 矢沢一良, 福沢世傑, WANG G-Y-S, 倉本誠, 上村大輔, 静岡大学大学院電子科学研究科研究報告, (18) 101 - 107,   1997年03月
  • O2-産生阻害物質タンザワ酸類の立体構造と生物活性
    倉本誠, 岡村智之, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 72nd,   1997年03月
  • 抗炎症性リード化合物Tanzawaic acidの合成研究
    西村和也, 有本博一, 倉本誠, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 72nd,   1997年03月
  • 生物活性海洋アルカロイドHalichlorineの合成研究
    早川一郎, 有本博一, 上村大輔, 倉本誠, 日本化学会講演予稿集, 72nd,   1997年03月
  • 生体機能解明試薬の開発
    倉本 誠, 周 [トウ], 上村 大輔, 静岡大学大学院電子科学研究科研究報告, 18,   1997年03月
  • バイオフィルム形成制御物質の研究
    山田 昭浩, 山口 果生里, 北村 仁美, 矢沢 一良, 福沢 世傑, 王 貴陽生, 倉本 誠, 上村 大輔, 静岡大学大学院電子科学研究科研究報告, 18,   1997年03月
  • 抗炎症抗生物質タンザワチンSC‐1
    有本博一, 倉本誠, 西村和也, 矢沢一良, 上村大輔, 中部化学関係学協会支部連合秋季大会講演予稿集, 27th,   1996年10月
  • 生物活性海洋アルカロイドHalichlorineの合成研究
    有本博一, 早川一郎, 倉本誠, 上村大輔, 中部化学関係学協会支部連合秋季大会講演予稿集, 27th,   1996年10月
  • 伊豆産海綿由来の細胞毒性物質
    藤谷泰之, 倉本誠, 山田薫, 有本博一, 上村大輔, 中部化学関係学協会支部連合秋季大会講演予稿集, 27th,   1996年10月
  • ゾアンタミン類の化学変換
    林孝二, 倉本誠, 有本博一, 上村大輔, 山田薫, 中部化学関係学協会支部連合秋季大会講演予稿集, 27th,   1996年10月
  • 14 生物活性海洋アルカロイド,ハリクロリン,ピンナ酸,およびノルゾアンタミン類の構造(口頭発表の部)
    倉本 誠, 有本 博一, 林 孝二, 早川 一郎, 上村 大輔, 周 丹, 山田 薫, 辻 智子, 山口 宏二, 矢沢 一良, 天然有機化合物討論会講演要旨集, (38) 79 - 84,   1996年09月02日, In our continuing search for biologically active substances from marine organisms, three novel alkaloids halichlorine (1), pinnaic acid (2) and norzoanthamine (4) were isolated. The structures of these alkaloids were elucidated mainly by detailed analysis of NMR data and MS spectral data. Halichlorine (1) was isolated from the marine sponge Halichondria okadai Kadota. This compound inhibits the induction of VCAM-1 (vascular cell adhesion molecule-1) at IC_<50> 7μg/ml. Drugs that block the induced expression of VCAM-1 may be useful for treating atherosclerosis, coronary artery diseases, angina and noncardiovascular inflammatory diseases. We report here the isolation and structural elucidation of 1. A cytosolic 85-kDa phospholipase (cPLA_2) exhibits specificity for the release of arachidonic acid from membrane phospholipids. Therefore, compounds that inhibit cPLA_2 activity have been targeted as anti-inflammatory agents. Pinnaic acid (2) isolated from the Okinawan bivalve Pinna muricata, inhibits the cPLA_2 activity at 0.2mM. Interestingly, the structure of 1 is closely related to that of 2. Therefore, each carbon atom has been tentatively numbered under biogenetic consideration of formation of the N-C23 bond. Further studies on chemistry of halichlorine, including its absolute configuration, biogenetic pathway and structure-activity relationships, are currently in progress in our laboratory. Biogenetic pathway of zoanthamine and norzoanthamines (4) exhibiting inhibitory effect of IL-6 production will be described here.
  • 80(P-37) 愛媛県産海洋生物由来の細胞毒性物質(ポスター発表の部)
    倉本 誠, 藤田 徹, 大野 修, 川上 恵, 小野 昇, 天然有機化合物討論会講演要旨集, (43) 473 - 478,   2001年09月01日, Ehime Prefecture was surrounded in the sea, and the fishery was popular from a past. Especially, many marine organisms are got around Sada Cape by the effect of the tide. Though in the Misaki town, the fishing using the network is carried out, seaweed and sponge are large obtained with the fish. However, sponge and seaweed without the value as goods are being discarded without utilizing. In our continuing search for biologically active substances from such marine organisms, three furanoterpenes (1, 2, 3) and novel alkaloid (4) were isolated from the marine sponge Ircinia sp. collected at Sada Cape. The methanolic extract of Ircinia sp. was extracted with ethyl acetate. The ethyl acetate extraction showed cytotoxic activity (IC_<50> 0.02 μg/ml) against the murine leukemia cell line P388. The residue was purified by hexane extraction, SiO_2 column chromatography, and HPLC to give cytotoxic compounds (1-4). The structures of these compounds were elucidated mainly by detailed analysis of NMR data and MS spectral data. Some kind of brown alga has also given the damage to other organism in order to put the acid out, when it is injured, while self it discolors to the green. This property seems to be the prey aversion for the predator. Polyhalogenated monoterpenes (5, 6) were isolated from such brown alga Desmarestia ligurata. The structure of 5 was deduced by the detailed comparison with known compounds. Interestingly, the result of the optical rotation estimated that 5 was an enantiomer of known compound. These compound showed weak activity against the murine leukemia cell line P388. We reported here the isolation and structural elucidation of these compounds.
  • 生物活性海洋アルカロイド,ハリクロリン,ピンナ酸,およびノルゾアンタミン類の構造
    倉本誠, 有本博一, 林孝二, 早川一郎, 上村大輔, CHOU T, 山田薫, 辻智子, 矢沢一良, 天然有機化合物討論会講演要旨集, 38th,   1996年09月
  • 放線菌由来の新規マクロライドの構造
    倉本誠, 山田薫, 矢沢一良, 伊集院保治, 上村大輔, 日本化学会講演予稿集, 70th,   1996年03月
  • バイオフィルム形成阻害活性物質
    山田昭浩, 矢沢一良, 倉本誠, 藤谷泰之, WANG G‐Y‐S, 上村大輔, 日本化学会講演予稿集, 70th,   1996年03月
  • バイオフィルム形成阻害活性を有するフェネチルアミン誘導体
    藤谷泰之, 倉本誠, WANG G‐Y‐S, 山田昭浩, 上村大輔, 日本化学会講演予稿集, 70th,   1996年03月
  • バイオフィルム形成阻害活性を有する新規ニトロアルカンの構造
    WANG G‐Y‐S, 倉本誠, 藤谷泰之, 山田昭浩, 上村大輔, 日本化学会講演予稿集, 70th,   1996年03月
  • 海洋由来放線菌類の代謝産物
    上村大輔, 山田薫, 倉本誠, マリンバイオテクノロジー研究発表会講演要旨集, 5th,   1996年
  • 生物活性海洋アルカロイド類
    倉本誠, 周丹, 有本博一, 上村大輔, マリンバイオテクノロジー研究発表会講演要旨集, 5th,   1996年
  • 39 バイオフィルム形成制御物質(口頭発表の部)
    山田 昭浩, 山口 果生里, 北村 仁美, 矢沢 一良, 福沢 世傑, 王 貴陽生, 倉本 誠, 上村 大輔, 天然有機化合物討論会講演要旨集, (37) 224 - 229,   1995年09月01日, Search for chemical substances regulating the biofilm formation has been carried out. The assay system has been developed by using the marine bacterium possessing the attaching properties (Rhodospirillum salexigens SCRC 113). This bioassay system in laboratory is suitable for screening the crude extracts from marine organisms and the synthetic compounds. First, the adhesion inhibitory of samples was determined by monitoring amounts of polysaccharide produced by the bacteria as evaluation of the biofilm formation. Substances regulating the biofilm formation have been isolated from marine organisms. For example, bisdeacetylsolenolide D, a biofilm formation inhibitor and butenolide derivative (Hateramine), a biofilm formation accelator have been obtained from marine sponges, respectively. Ethyl N-(2-phenethyl) carbamate (1) isolated from the marine bacterium SCRC3P79 (Cytophaga sp.), remarkably inhibited the biofilm formation. The synthetic compound p-nitro derivative (2), exhibited significant inhibition of the biofilm formation. Furthermore, (2) exhibited antibacterial activity. However this assay system was replaced to new method, because procedure described here did not afford enough reproducibility of the data. Secondly, growth inhibition with tested samples against the attaching bacteria was indicated by measurement of absorbance of the culture medium and the biofilm formation was estimated. Aeroplysinin-I isolated from marine sponge Pssamaplysilla purpurea, exhibited inhibition of the biofilm formation. New nitroalkanes, (3) and (4), have been obtained from an unidentified marine sponge. The synthetic compounds (5), (6), (7) and (8) exhibited significant inhibition of the biofilm formation. As expected, the compounds (5), (6), (7) and (8) exhibited remarkable inhibition of the biofilm formation in the field experiment.
  • バイオフィルム形成制御物質
    山田昭浩, 山口果生里, 北村仁美, 矢沢一良, 福沢世傑, WANG G‐Y‐S, 倉本誠, 上村大輔, 天然有機化合物討論会講演要旨集, 37th,   1995年09月
  • バイオフィルム形成制御物質
    山田昭浩, 北村仁美, 山口果生里, 矢沢一良, 倉本誠, 上村大輔, 日本化学会講演予稿集, 69th,   1995年03月
  • 強力な細胞毒性を有する海洋バクテリア由来のリポペプチド (1)
    WANG G‐Y‐S, 倉本誠, 山田薫, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 69th,   1995年03月
  • 強力な細胞毒性を有する海洋バクテリア由来のリポペプチド (2)
    倉本誠, WANG G‐Y‐S, 山田薫, 矢沢一良, 上村大輔, 日本化学会講演予稿集, 69th,   1995年03月
  • 新規貝毒Pinnatoxinsの構造研究
    CHOU T, 灰野岳晴, 永津明人, 倉本誠, 上村大輔, 日本化学会講演予稿集, 69th,   1995年03月
  • 海洋微生物由来の生物活性物質
    倉本誠, 石田貴子, 山田薫, 上村大輔, マリンバイオテクノロジー研究発表会講演要旨集, 4th,   1995年
  • バイオフィルム形成制御物質
    山田昭浩, 北村仁美, 山口果生里, 矢沢一良, 倉本誠, 上村大輔, 日本化学会講演予稿集, 68th,   1994年09月
  • 海洋微生物由来のバイオフィルム形成阻害物質の探索
    倉本誠, 上村大輔, 山田昭浩, 北村仁美, 矢沢一良, 日本化学会講演予稿集, 68th,   1994年09月
  • オカダ酸の構造活性相関 (2)
    石田貴子, 倉本誠, 山田薫, 伊集院保治, 上村大輔, 日本化学会講演予稿集, 67th,   1994年03月
  • Halichlorine, an Inhibitor of VCAM-1 Induction from Marine Sponge Halichondria okadai Kadota. (共著)
    KURAMOTO M, TONG C, YAMADA K, CHIBA T, HAYASHI Y, UEMURA D, Tetrahedron Letters, 37, (22) 3867 - 3870,   1996年05月01日, The novel alkaloid halichlorine was isolated from Halichondria okadai Kadota and its structure was elucidated by spectroscopic analysis. The relative stereochemistry was clarified by a detailed analysis of coupling constants and the NOESY spectrum. Halichlorine significantly inhibits VCAM-1 induction in cultured HUVE (human umbilical vein endothelial) cells.
  • オカダ酸の構造活性相関 (1)
    倉本誠, 石田貴子, 山田展子, 山田薫, 伊集院保治, 上村大輔, 日本化学会講演予稿集, 67th,   1994年03月
  • バイオフィルム形成制御物質 (2)
    山田昭浩, 北村仁美, 山口果生里, 矢沢一良, 倉本誠, 上村大輔, 日本化学会講演予稿集, 67th,   1994年03月
  • Absolute Configuration of Norzoanthamine, a promising Candidate for an Osteoporotic Drug. (共著)
    KURAMOTO M, HAYASHI K, FUJITANI Y, YAMAGUCHI K, TSUJI T, YAMADA K, IJUIN Y, UEMURA D, Tetrahedron Letters, 38, (32) 5683 - 5686,   1997年08月01日, The absolute configuration of norzoanthamine (1) was determined to be 2R, 4S, 6S, 9S, 10R, 12R, 13R, 18S, 21S, and 22S based on 1H NMR spectral data of the MTPA esters of norzoanthamine derivatives. The possible biogenesis of zoanthamines is also proposed.
  • バイオフィルム形成制御物質 (1)
    北村仁美, 山田昭浩, 山口果生里, 福沢世傑, 矢沢一良, 倉本誠, 上村大輔, 日本化学会講演予稿集, 67th,   1994年03月
  • Three Nobel Anti-microfouling Nitroalkyl Pyridine Alkaloids from the Okinawan Marine Sponge Callyspongia sp. (共著)
    WANG G‐Y‐S, KURAMOTO M, UEMURA D, YAMADA A, YAMAGUCHI K, YAZAWA K, Tetrahedron Letters, 37, (11) 1813 - 1816,   1996年03月11日, Three novel nitroalkyl pyridine alkaloids, untenines A, B and C, with anti-microfouling activity, were first isolated from the Okinawan marine sponge Callyspongia sp. Their structures were elucidated on the basis of spectroscopic methods. The synthesis of untenine A was also carried out.
  • カンスイニンAの構造研究
    後藤幹裕, 倉本誠, 伊集院保治, 上村大輔, 日本化学会講演予稿集, 67th,   1994年03月
  • Pinnaic Acid and Tauropinnaic Acid : Two Novel Fatty Acids Composing a 6-Azaspiro [4.5] decane Unit from the Okinawan Bivalve Pinna muricata. (共著)
    CHOU T, KURAMOTO M, OTANI Y, SHIKANO M, YAZAWA K, UEMURA D, Tetrahedron Letters, 37, (22) 3871 - 3874,   1996年05月01日, Two novel fatty acids with cPLA2 inhibitory activity, pinnaic acid and tauro-pinnaic acid, were isolated from the Okinawan bivalve Pinna muricata. Their structures, including the relative stereochemistry at C5, C9, C13 and C14, were elucidated by extensive 2D NMR spectroscopic analysis. Copyright © 1996 Elsevier Science Ltd.
  • 89 オカダ酸の構造活性相関(ポスター発表の部)
    倉本 誠, 石田 貴子, 山田 展子, 山田 昭浩, 上村 大輔, 灰野 岳晴, 山田 薫, 伊集院 保治, 藤田 憲一, 天然有機化合物討論会講演要旨集, (35) 693 - 700,   1993年09月10日, Marine organisms produce novel compounds with remarkable biological activitites. Our studies have been carried out in order to clarify function-fine structure interrelationship of the super-carbon-chain compounds such as okadaic acid (2). This super-carbon-chain compound exhibits marked in vitro cytotoxicity and causes diarrhetic shellfish poisoning. Interestingly, okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Then, the conjugated form of okadaic acid with glycine, glycookadaic acid was proved to be an anticachexia substance. Our study toward elucidation of interrelationship between fine structure and activity was started. By the NMR data analysis, we proposed importance of the formation of a flexible cavity between C1 carboxyl group and C24 hydroxyl group. Based on the flexible cavity hypothesis (Fig. 1), C24 hydroxyl group was epimerized by reaction sequencing. Epimerization at C24 was reduced the cytotoxicity of okadaic acid by two orders of magnitude. Two corresponding epimers at C27 and C7 were obtained by chemical reactions. Experiment for cytotoxicity of these epimers is currently under way. Our flexible caivity hypothesis will be supported by the fact that two epimers does not work against L1210 tumor cells.
  • Isolation and Structure of Pinnatoxin D, a New Shellfish Poison from Okinawan Bivalve Pinna muricata. (共著)
    CHOU T, HAINO T, KURAMOTO M, UEMURA D, Tetrahedron Letters, 37, (23) 4027 - 4030,   1996年06月03日, A new shellfish poison, pinnatoxin D, has been isolated from the Okinawan bivalve Pinna muricata. The planar structure was elucidated by extensive 2D NMR experiments, and the relative stereochemistry was deduced by NOESY data and 3J(H-H) coupling constants. Pinnatoxin D is a novel amphoteric carbocyclic compound which is composed of a 6,7-spiro-ring, a 5,6-bicyclo ring and a 6,5,6-trispiro ketal involving 15 chiral centers.
  • 生体機能解明試薬の開発
    静岡大学大学院電子科学研究科研究報告, (17) 83 - 89,   1996年
  • バイオフィルム形成制御物質の研究
    静岡大学大学院電子科学研究科研究報告, (17) 101 - 107,   1996年
  • オカダ酸の構造活性相関
    倉本誠, 石田貴子, 山田昭浩, 山田展子, 上村大輔, 灰野岳晴, 山田薫, 伊集院保治, 藤田憲一, 天然有機化合物討論会講演要旨集, 35th,   1993年09月
  • オカダ酸の構造活性相関
    石田貴子, 倉本誠, 上村大輔, 日本化学会講演予稿集, 66th,   1993年09月
  • オカダ酸の構造活性相関
    山田展子, 倉本誠, 上村大輔, 日本化学会講演予稿集, 65th,   1993年03月
  • 各種オカダ酸誘導体の構造活性相関
    倉本誠, 石田貴子, 灰野岳晴, 上村大輔, 日本化学会講演予稿集, 65th,   1993年03月
  • オカダ酸の構造活性相関
    第35回天然有機化合物討論会, (35) 693 - 700,   1993年
  • Structure-Activity Relationship of Norzoanthamine, Exhibiting Significant Inhibition of Osteoporosis.
    Makoto Kuramoto, Koji Hayashi, Kohji Yamaguchi, Mika Yada, Tomoko Tsuji, Daisuke Uemura, Bulletin of the Chemical Society of Japan, 71, (4) 771 - 779,   1998年04月01日, Norzoanthamine is a zoanthamine-type alkaloid from the colonial zoanthid Zoanthus sp. Norzoanthamine hydrochloride, which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug. Although the relative configuration of norzoanthamine was established based on an X-ray crystallographic analysis, the absolute stereochemistry of norzoanthamine remains unclear. To investigate their biogenesis and mechanisms of biological action, we conducted chemical and spectroscopic studies to determine the absolute configuration of norzoanthamines.
  • 生物活性海洋アルカロイド,ハリクロリン,ピンナ酸,およびノルゾアンタミン類の構造
    第38回天然有機化合物討論会, 38,   1996年
  • Suppressive Effect of Norzoanthamine Hydrochloride on Experimental Osteoporosis in Overiectomized Mice(共著)
    Kohji Yamaguchi, Mika Yada, Tomoko Tsuji, Makoto Kuramoto, Daisuke Uemura, Biological & Pharmarceutical Bulletin, 22, (9) 920 - 924,   1999年09月01日, Norzoanthamine is an alkaloid isolated from a colonial zoanthid. We examined the effects of norzoanthamine hydrochloride on bone weight, strength and morphology in ovariectomized mice, a postmenopausal osteoporosis model. Norzoanthamine hydrochloride significantly suppressed the decrease in femoral weight and bone biomechanical parameters caused by ovariectomy without an increase in uterine weight. This means that norzoanthamine hydrochloride does not have an estrogen-like effect on reproductive organs. Morphological observations of longitudinally ground sections of the humeri showed that norzoanthamine hydrochloride administration (2 mg/kg/d, p.o.) completely suppressed the loss of trabecular bone. Furthermore, norzoanthamine hydrochloride thickened the cortical bone. Based on these results, norzoanthamine hydrochloride may act as both a suppressor of bone resorption and an enhancer of bone formation in vivo.
  • Homocereulide, an Extremely Potent Cytotoxic Depsipeptide from the Marine Bacterium Bacillus cereus. (共著)
    WANG G‐Y‐S, KURAMOTO M, YAMADA K, YAZAWA K, UEMURA D, Chemistry Letters, (9) 791 - 792,   1995年
  • Development of Novel Reagents for Understanding the Biological Functionalities. (共著)
    Reports of The Graduate School of Electronic Science and Technology Shizuoka University, (17) 83 - 89,   1996年
  • Studies in Bioactive Marine Alkaloids
    Makoto Kuramoto, Hirokazu Arimoto, Daisuke Uemura, Journal of Synthetic Organic Chemistry, Japan, 61, (11) 1099 - 1105,   2003年11月01日, In our continuing search for bioactive substances from marine organisms, novel alkaloids were isolated. The structures and functions of these marine alkaloids are described here. Pinnatoxins and pteriatoxins, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina, and noncardiovascular inflammatory diseases. Pinnaic acids, which are cPLA2 inhibitors, were also obtained from P. muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice, and could be a good candidate for an osteoporotic drug. Aburatubolactams, inhibitors of Superoxide anion generation, were isolated from Streptomyces sp.
  • Research of Chemical Substances Regulating Biofilm Formation. (共著)
    Reports of The Graduate School of Electronic Science and Technology Shizuoka University, (17) 101 - 107,   1996年
  • Structures of Bioactive Marine Alkaloids, Halichlorine, Pinnaic Acids and Norzoanthamine. (共著)
    38th Symposium on the Chemistry of Natural Products, 38,   1996年
  • Microwave plasma in hydrocarbon liquids
    Shinfuku Nomura, Hiromichi Toyota, Shinobu Mukasa, Hiroshi Yamashita, Tsunehiro Maehara, Makoto Kuramoto, APPLIED PHYSICS LETTERS, 88,   2006年05月21日, The generation of microwave plasma in liquid with vapor bubbles has been achieved and will soon be applied to high-speed chemical vapor deposition. Vapor bubbles are induced from an electrode by heating. The deposition rate of diamondlike carbon films depends on the pressure and the power of the microwave supply. Polycrystalline silicon carbide is synthesized on a silicon substrate in a mixture of n -dodecane and silicone oil. The dispersion of water droplets in liquid creates many pores on the silicon carbide films. The synthesis of carbon nanotubes can be achieved in liquid benzene. © 2006 American Institute of Physics.
  • Tanzawaic Acids A, B, C, and D : Inhibitors of Superoxide Anion Production from Penicillium citrinum. (共著)
    Chemistry Letters, (9) 885 - 886,   1997年
  • Development of a method for determining illudin S in food by gas chromatography-mass spectrometry.
    Mieko Kanamori-Kataoka, Yasuo Seto, Makoto Kuramoto, Journal of Health Science, 52, (3) 237 - 242,   2006年05月01日, A method was developed for determining illudin S, a naturally occurring toxin in the mushroom Lampteromyces japonicus in food samples with the use of gas chromatography-mass spectrometry (GC-MS). Samples of a model food, 'Ton-jiru' (miso soup), were spiked with authentic illudin S, which was then extracted from the samples by a two-step solvent extraction with ethyl acetate and acetonitrile-n-hexane, followed by solid phase extraction using a normal phase Bond Elut SI cartridge. The recovery of illudin S from the samples was in the range of 61-74%. Illudin S was identified by its GC retention time and both electron and chemical ionization mass spectra. In the splitless injection mode, the calibration curves for peak area ratio of illudin S to anthracene (internal standard) were linear, in the range from 150 pg to 150 ng with correlation coefficients exceeding 0.997, and the detection limit was 36 pg per injection volume (1 μl).
  • Development of Chemical Substances Regulating Biofilm Formation. (共著)
    Bulletin of the Chemical Society of Japan, 70, (12) 3061 - 3069,   1997年
  • Abusolute Stereochemistry of Halichlorine ; A Potent Inhibitor of VCAM-1 Induction.
    Tetrahedron Letters, 39,   1998年
  • Radio Frequency Plasma in Water
    MAEHARA Tsunehiro, TOYOTA Hiromichi, KURAMOTO Makoto, IWAMAE Atsushi, TADOKORO Atsushi, MUKASA Shinobu, YAMASHITA Hiroshi, KAWASHIMA Ayato, NOMURA Shinfuku, Japanese Journal of Applied Physics, 45, (11) 8864 - 8868,   2006年11月15日, We generate a radio frequency (RF) plasma in water at an atmospheric pressure by applying an RF power of 13.56 MHz from an electrode. The plasma is in a bubble formed in water. On the basis of hydrogen spectral lines under the assumption of thermal equilibrium, the temperature of the plasma is estimated to be 4000-4500 K. Spectroscopic measurements show that hydrogen and oxygen are excited in the plasma. The plasma is also obtained in tap water or NaCl solution with a high conductivity. In the solution, sodium spectral lines are observed. Colored water containing methylene blue is exposed to the plasma. The absorbence spectra of the colored water before and after exposure to the plasma suggest the decomposition of organic matter due to chemical reactions involving active species, such as OH-radicals. © 2006 The Japan Society of Applied Physics.
  • Intravenous Infusion of Dihydroginsenoside Rb1 Prevents Compressive Spinal Cord Injury and Ischemic Brain Damage through Upregulation of VEGF and Bcl-XL
    Masahiro Sakanaka, Pengxiang Zhu, Bo Zhang, Tong Chun Wen, Fang Cao, Yong Jie Ma, Keiichi Samukawa, Noriaki Mitsuda, Junya Tanaka, Makoto Kuramoto, Hidemitsu Uno, Ryuji Hata, Ryuji Hata, J. Neurotrauma, 24,   2007年06月01日, Red ginseng root (Panax Ginseng CA Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. One of the major components of Red ginseng root is ginsenoside Rb1 (gRb1). Previously, we showed that intravenous infusion of gRb1 ameliorated ischemic brain damage through upregulation of an anti-apoptotic factor, Bcl-xL and that topical application of gRb1 to burn wound lesion facilitated wound healing through upregulation of vascular endothelial growth factor (VEGF). In the present study, we produced dihydroginsenoside Rb1 (dgRb1), a stable chemical derivative of gRb1, and showed that intravenous infusion of dgRb1 improved spinal cord injury (SCI) as well as ischemic brain damage. As we expected, the effective dose of dgRb1 was ten times lower than that of gRb1. Intravenous infusion of dgRb1 at this effective dose did not affect brain temperature, blood pressure or cerebral blood flow, suggesting that dgRb1 rescued damaged neurons without affecting systemic parameters. In subsequent in vitro studies that focused on dgRb1-induced expression of gene products responsible for neuronal death or survival, we showed that dgRb1 could upregulate the expression of not only Bcl-xL, but also a potent angiogenic and neurotrophic factor, VEGF. We also showed that dgRb1-induced expression of bcl-xL and VEGF mRNA was HRE (hypoxia response element) and STRE (signal transducers and activators of transcription 5 (Stat5) response element) dependent, respectively. © Mary Ann Liebert, Inc.
  • Neoilludins A and B, New Bioactive Components from Liampteromyces japonicus
    Chemistry Letters, (10) 1113 - 1114,   1999年
  • Growth stimulatory substances for vesicular-arbuscular mycorrhizal fungin Satsuma mandarin juice pamace
    相川 次郎, 石井 孝昭, 倉本 誠, 門屋 一臣, J.Japan Soc.Hort.Sci., 69, (4) 385 - 389,   2000年
  • Structure-Activity Relationship of Okadaic Acid, a Potent Proteinphosphatases PP1 and PP2A Inhibitor: 24-epi-Okadaic Acid and a 18-Membered Lactone Analog
    Masaki Kita, Makoto Kuramoto, Tatsuhiko Chiba, Akihiro Yamada, Akihiro Yamada, Nobuko Yamada, Takako Ishida, Takako Ishida, Takeharu Haino, Kaoru Yamada, Kaoru Yamada, Yasuharu Ijuin, Osamu Ohno, Daisuke Uemura, Daisuke Uemura, Heterocycles, 28,   2008年11月01日, X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity. © 2008 The Japan Institute of Heterocyclic Chemistry All rights reserved.
  • Ircinamine, a Novel Cytotoxic Alkaloid from Irciria sp.
    KURAMOTO M, FUJITA T, ONO N, Chemistry Letters, (4) 464 - 465,   2002年
  • Degradation of Methylene Blue by RF Plasma in Water
    MAEHARA T., MIYAMOTO I., KUROKAWA K., HASHIMOTO Y., IWAMAE A., KURAMOTO M., YAMASHITA H., MUKASA S., TOYOTA H., NOMURA S., KAWASHIMA A., SpringerPlasma Chemistry and Plasma Processing, 28, (4) 467 - 482,   2008年08月01日, Radio frequency (RF) plasma in water was used for the degradation of methylene blue. The fraction of decomposition of methylene blue and the intensity of the spectral line from OH radical increased with RF power. RF plasma in water also produced hydrogen peroxide. The density of hydrogen peroxide increased with RF power and exposure time. When pure water (300 mL) is exposed to plasma at 310 W for 15 min, density of hydrogen peroxide reaches to 120 mg/L. Methylene blue after exposed to plasma degraded gradually for three weeks. This degradation may be due to chemical processes via hydrogen peroxide and tungsten. The comparison between the experimental and calculated spectral lines of OH radical (A-X) shows that the temperature of the radical is around 3,500 K. Electron density is evaluated to be 3.5 × 10 20 m -3 from the stark broadening of the H β line. © 2008 Springer Science+Business Media, LLC.
  • Cylindradines A and B: Novel Bromopyrrole Alkaloids from Marine Sponge Axinella cylindratus
    KURAMOTO Makoto, MIYAKE Norimichi, ISHIMARU Yoshihisa, ONO Noboru, UNO Hidemitsu, Org. Lett., 10, (23) 5465 - 5468,   2008年12月01日, (Chemical Equation Presented) The novel alkaloids cylindradines A and B were isolated from Axinella cylindratus, and their structures were elucidated by spectroscopic analyses. Stereochemistries of these compounds were determined by X-ray analysis. Cylindradines showed moderate inhibitory activity against the murine leukemia cell line P388. © 2008 American Chemical Society.
  • Degradation of methylene blue by radio frequency plasmas in water under ultraviolet irradiation
    Tsunehiro Maehara, Kyohei Nishiyama, Shingo Onishi, Shinobu Mukasa, Hiromichi Toyota, Makoto Kuramoto, Shinfuku Nomura, Ayato Kawashima, Elsevier B.V.Journal of Hazardous Materials, 174,   2010年02月15日, The degradation of methylene blue by radio frequency (RF) plasmas in water under ultraviolet (UV) irradiation was studied experimentally. When the methylene blue solution was exposed to RF plasma, UV irradiation from a mercury vapor lamp enhanced degradation significantly. A lamp without power supply also enhanced degradation since weak UV light was emitted weakly from the lamp due to the excitation of mercury vapor by stray RF power. Such an enhancement is explained by the fact that after hydrogen peroxide is produced via the recombination process of OH radicals around the plasma, OH radicals reproduced from hydrogen peroxide via the photolysis process degrade methylene blue. © 2009 Elsevier B.V. All rights reserved.
  • Tryptophan dimer produced by water-stressed bahia grass is an attractant for Gipaspora margarita and Glomus caledonium
    HORII Sachie, MATSUMURA Atsushi, KURAMOTO Makoto, ISHII Takaaki, SpringerWorld Journal of Microbiology and Biotechnology, 25, (7) 1207 - 1215,   2009年07月01日, We isolated and elucidated the structure of several stimulants for arbuscular mycorrhizal fungi (AMF) in water-stressed bahia grass roots. We could isolate some compounds that promoted the growth of Gigaspora margarita Becker and Hall and Glomus caledonium (Nicol. and Gerd.) Trappe and Gerd. In these compounds, tryptophan dimer (Trp-Trp) was elucidated the structure. Trp-Trp was abundantly produced in water-stressed bahia grass roots and exuded to the soil, although it was scarcely detected in non-stressed root exudates. Interestingly, this peptide strongly attracted the hyphae of Gi. margarita and G. caledonium and promoted their hyphal growth in vitro (1.8 × longer than the control). Tryptophan, however, had no effect on hyphal growth and attraction. Thus, Trp-Trp exuded from water-stressed roots would play an important role as a major signal for AMF. © 2009 Springer Science+Business Media B.V.
  • Formation of OH radical and hydrogen peroxide via RF plasma in water
    Sndai Plasma forumProceedings of International Interdisciplinary-Symposium on Gaseous and Liquid Plasmas, Sndai Plasma forum,   2008年
  • Identification of Fluorescent Substance in Mandarin Orange Skin for Machine Vision System to Detect Rotten Citrus Fruits
    Naoshi Kondo, Makoto Kuramoto, Hiroshi Shimizu, Yuichi Ogawa, Mitsutaka Kurita, Takahisa Nishizu, Vui Kiong Chong, Kazuya Yamamoto, Asian Agricultural and Biological Engineering AssociationEngineering in Agriculture, Environment and Food, 2, (2) 54 - 59,   2009年12月01日, As basic research to develop a machine vision system to detect rotten mandarin orange, the extraction and identification of fluorescent substances contained in rotten parts of mandarin orange were conducted, and the excitation and fluorescence wavelengths of the substance were determined. Although it has been reported that damaged orange fruit skins are often fluoresced by UV light, it was suggested that fluorescent substances exist not only in the rotten parts of skins but also the normal parts of skins from this research. The fluorescent substances were extracted from 1kg of mandarin peel, and NMR analysis and mass spectrometry were conducted. From this experiment, it was found that the fluorescent substance was quite possibly heptamethylflavone and that the excitation and fluorescent wavelengths of one of the substances were 360 to 375nm and 530 to 550nm, respectively.
  • Stellettazole D, a Cytotoxic Imidazole Alkaloid from the Marine Sponge Jaspis duoaster
    Seizo Sato, Fumie Iwata, Jiro Takeo, Hiroyuki Kawahara, Makoto Kuramoto, Hidemitsu Uno, 日本化学会, 40, (2) 186 - 187,   2011年02月04日, A new cytotoxic imidazole alkaloid, stellettazole D, containing norsesquiterpene and aminopropylimidazolium units, has been isolated from the marine sponge Jaspis duoaster. The structure of stellettazole D was assigned on the basis of NMR, mass spectrometry, and IR spectral data. Stellettazole D has moderate cytotoxicity against a limited number of tumor cells. © 2011 The Chemical Society of Japan.
  • Effect of the Temperature of Water on the Degradation of Methylene Blue by the Generation of Radio Frequency Plasma in Water
    プラズマ・核融合学会, 8,   2009年
  • Influence of Conductivity on Generation of Radio Frequency Plasma Surrounded with Bubbles in Water
    IOP Publishing LimitedPlasma Sources Science and Technology, 20,   2011年
  • オカダ酸の構造活性相関
    倉本誠, 山田昭浩, 上村大輔, 日本化学会講演予稿集, 63rd,   1992年03月

書籍等出版物

作品

  • 天然物由来の機能分子探索
      2006年 - 2006年

特許

  • 非晶質炭素膜の製造方法, 村瀬 仁俊, 下 俊久, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, JP2006306997, WO2006-107002
  • カーボンナノチューブの製法方法および製造装置, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, JP2004014094, WO2005-033007
  • カーボンナノチューブの製法方法および製造装置, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, 特願2005-514423, 特許第4674304号, 特許第4674304号
  • 非晶質炭素膜の製造方法, 村瀬 仁俊, 下 俊久, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, 特願2007-511222, 特許第4871860号, 中国 ZL200680009747.7
  • 新規イソプレニルアルカロイド、その製造法および用途, 佐藤 誠造, 岩田 史恵, 竹尾 仁良, 川原 裕之, 倉本 誠, 特願2009-122833, 特開2010-270058
  • 金属ベリリウム、金属ベリリウム製造方法、金属ベリリウム製造装置およびX線計測用窓, 野村 信福, 豊田 洋通, 倉本 誠, 山下 浩, 手塚 裕, 特願2004-045547, 特開2005-232556
  • 金属ベリリウム製造方法, 野村 信福, 豊田 洋通, 倉本 誠, 山下 浩, 手塚 裕, 特願2004-045547, 特開2005-232556, 特許第4406692号, 特許第4406692号
  • シリコン酸化膜の製造方法, 村瀬 仁俊, 下 俊久, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, 特願2005-099536, 特開2006-274426
  • シリコン酸化膜の製造方法, 村瀬 仁俊, 下 俊久, 野村 信福, 豊田 洋通, 山下 浩, 倉本 誠, 特願2005-099536, 特開2006-274426, 特許第4665111号, 特許第4665111号
  • 化学反応装置および有害物質分解方法, 豊田 洋通, 野村 信福, 山下 浩, 倉本 誠, 山本 義志, 特願2004-090106, 特開2004-306029
  • 機能化繊維および機能化繊維の製造方法, 山本 泰正, 豊田 洋通, 野村 信福, 倉本 誠, 山下 浩, 特願2003-340892, 特開2005-105465
  • 機能化繊維の製造方法, 山本 泰正, 豊田 洋通, 野村 信福, 倉本 誠, 山下 浩, 特願2003-340892, 特開2005-105465, 特許第4452775号
  • ローヤルゼリー又はその水溶性画分を有効成分とする抗うつ性組成物, 吉村 裕之, 別宮 直子, 倉本 誠, 特願2002-296555, 特開2004-131407
  • ケールを有効成分とする組成物, 吉村 裕之, 別宮 直子, 倉本 誠, 石丸 惠久, 高岡 照海, 特願2002-293730, 特開2004-123667
  • ジンセノサイドRb1様物質のスクリーニング方法, 阪中 雅広, 橋本 公二, 田中 潤也, 宇野 英満, 倉本 誠, 寒川 慶一, 木村 善行, 特願2002-288637, 特開2004-077456
  • 凍結細胞保存剤, 阪中 雅広, 橋本 公二, 八幡 陽子, 田中 潤也, 宇野 英満, 倉本 誠, 秦 龍二, 特願2001-374509, 特開2003-225084
  • 血管再生促進剤, 阪中 雅広, 田中 潤也, 秦 龍二, 宇野 英満, 倉本 誠, 橋本 公二, 満田 憲昭, 特願2001-365282, 特開2002-322068
  • ジンセノサイド類誘導体からなる抗アポトーシス剤又は再生促進剤, 阪中 雅広, 田中 潤也, 仲田 公彦, 宇野 英満, 倉本 誠, 特願2001-044818, 特開2002-249498
  • アゾジリキソフラノシドアデニン誘導体, 桑田 光作, 松下 至, 倉本 誠, 石井 孝昭, 特願平10-061386, 特開平11-255795
  • アゾジリキソフラノシドアデニン誘導体, 桑田 光作, 松下 至, 倉本 誠, 石井 孝昭, 特願平10-061386, 特開平11-255795, 特許第4236016号
  • ヒドロナフタレン誘導体を有効成分とする抗炎症剤、抗癌剤及び新規ヒドロナフタレン誘導体, 上村 大輔, 矢澤 一良, 鹿野 真弓, 倉本 誠, 篠原 結子, 篠原 力, 山田 薫, 有本 博一, 特願平9-125198, 特開平10-147551
  • スピロ[1−アザビシクロ[4.4.0]デカ−3−エン−9,1’−シクロペンタン]誘導体, 上村 大輔, 倉本 誠, 周 ▲丹▼, 山田 薫, 特願平8-022200, 特開平9-208588
  • オリゴマイシンSC類及び制癌剤, 上村 大輔, 倉本 誠, 山田 薫, 矢澤 一良, 鹿野 真弓, 特願平8-022199, 特開平9-208587
  • スピロ[1−アザビシクロ[4.4.0]デカ−3−エン−9,1’−シクロペンタン]誘導体, 上村 大輔, 倉本 誠, 周 ▲丹▼, 山田 薫, 特願平8-022200, 特開平9-208588, 特許第3879088号

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