研究者総覧

高田 裕美 (タカタ ヒロミ)

  • 大学院理工学研究科 環境機能科学専攻 准教授
Last Updated :2020/11/10

研究者情報

学位

  • 博士(理学)(愛媛大学)

J-Global ID

研究キーワード

  • 原腸形成   形態形成   細胞分化   胚形成   棘皮動物   Gastrulation   Morphogenesis   Cell differentiation   Embryogenesis   Echinoderm   

経歴

  • 2013年04月 - 現在  愛媛大学大学院理工学研究科准教授
  • 2007年04月 - 2013年03月  愛媛大学大学院理工学研究科助教
  • 1989年09月 - 2007年03月  愛媛大学理学部教務職員

学歴

  • 1989年04月 - 1989年08月   広島大学大学院   生物圏科学研究科博士課程後期   生命機能科学専攻
  • 1987年04月 - 1989年03月   広島大学大学院   生物圏科学研究科博士課程前期   生命機能科学専攻
  • 1983年04月 - 1987年03月   愛媛大学   理学部   生物学科

所属学協会

  • 日本発生生物学会   日本動物学会   

研究活動情報

論文

  • Ichthyological Research 60 1 85 - 88 2013年 [査読有り]
  • Masahumi Kawaguchi, Yuki Sugahara, Tomoe Watanabe, Kouta Irie, Minoru Ishida, Daisuke Kurokawa, Shin-Ichi Kitamura, Hiromi Takata, Itsuki C. Handoh, Kei Nakayama, Yasunori Murakami
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 19 7 2488 - 2497 2012年08月 [査読有り]
     研究論文(学術雑誌) 
    Spills of heavy oil (HO) over the oceans have been proven to have an adverse effect on marine life. It has been hypothesized that exposure of early larvae of sinking eggs to HO leads largely to normal morphology, whereas abnormal organization of the developing neural scaffold is likely to be found. HO-induced disruption of the nervous system, which controls animal behavior, may in turn cause abnormalities in the swimming behavior of hatched larvae. To clarify the toxicological effects of HO, we performed exposure experiments and morphological and behavioral analyses in pufferfish (Takifugu rubripes) larvae. Fertilized eggs of pufferfish were exposed to 50 mg/L of HO for 8 days and transferred to fresh seawater before hatching. The hatched larvae were observed for their swimming behavior, morphological appearance, and construction of muscles and nervous system. In HO-exposed larvae, we did not detect any anomaly of body morphology. However, they showed an abnormal swimming pattern and disorganized midbrain, a higher center controlling movement. Our results suggest that HO-exposed fishes suffer developmental disorder of the brain that triggers an abnormal swimming behavior and that HO may be selectively toxic to the brain and cause physical disability throughout the life span of these fishes.
  • Atsushi Sogabe, Ryota Kawanishi, Hiromi Takata, Yasuhisa Kobayashi
    ICHTHYOLOGICAL RESEARCH 59 1 77 - 82 2012年01月 [査読有り]
     研究論文(学術雑誌) 
    The mating behaviour, fecundity characteristics and egg production process were investigated in the barbed pipefish Urocampus nanus under aquarium conditions. The mating behaviour consisted of five motor patterns, some of which have been generally reported in other syngnathids. Neither the number nor size of newborns related to the size of parents, although there was a negative correlation between the number and size of newborns. The ovary consisted of two germinal ridges, and mature eggs were produced synchronously with multiple ovulations. This type of egg production has thus far been reported only in a polyandrous and sex-role-reversed pipefish.
  • Hiromi Takata, Tetsuya Kominami
    DEVELOPMENT GROWTH & DIFFERENTIATION 53 5 625 - 638 2011年06月 [査読有り]
     研究論文(学術雑誌) 
    We have found a novel embryonic cell population in the keyhole sand dollar Astriclypeus manni, which we refer to as lucent fluorescent cells (LFCs). Live LFCs are transparent, but emit autofluorescence after formaldehyde fixation. LFCs become noticeable in the vegetal plate of early gastrulae immediately after the appearance of pigment cells. As development progresses, LFCs increase in number and migrate from the vegetal plate toward the animal pole in a manner similar to pigment cells. Notably, LFCs also migrate into the oral ectoderm, while pigment cells do not. In addition, we determined that there were nearly 300 LFCs per embryo, which greatly exceeds the number of pigment cells. Treatment with the Notch signaling inhibitor N-[(3,5-Difluorophenyl) acetyl]L- alanyl-2-phenyl] glycine-1,1-dimethylethyl ester (DAPT) resulted in a marked decrease in pigment cell number, but only a modest decrease in LFCs. In DAPT-treated embryos, LFCs had a distribution pattern similar to pigment cells and were excluded from the oral ectoderm. Unlike other sea urchins, Nodal signaling was not involved in the specification of pigment cells and LFCs in these embryos. Pulse treatment and measurement of cell diameters revealed that LFCs underwent 13-15 cycles of cell division and were specified during the 11th cleavage, one cell cycle later than observed for pigment cells. At the pluteus stage, a cluster of LFCs was observed in the animal plate in addition to two rows of LFCs running along the ciliary band. In addition, dozens of LFCs aligned at the uppermost level of the stomodaeum. Therefore, though the two cell populations share some features, LFCs are considerably different from pigment cells.
  • Yukari Ohguro, Hiromi Takata, Tetsuya Kominami
    DEVELOPMENT GROWTH & DIFFERENTIATION 53 1 110 - 123 2011年01月 [査読有り]
     研究論文(学術雑誌) 
    Secondary mesenchyme cells (SMCs) of the sea urchin embryo are composed of pigment cells, blastocoelar cells, spicule tip cells, coelomic pouch cells and muscle cells. To learn how and when these five types of SMCs are specified in the veg(2) descendants, Notch or Nodal signaling was blocked with gamma-secretase inhibitor or Nodal receptor inhibitor, respectively. All types of SMCs were decreased with DAPT, while sensitivity to this inhibitor varied among them. Pulse-treatment revealed that five types of SMCs are divided into "early" (pigment cells and blastocoelar cells) and "late" (spicule tip cells, coelomic pouch cells and muscle cells) groups; the "early" group was sensitive to DAPT up to the hatching, and the "late" group was sensitive until the mesenchyme blastula stage. Judging from timing of the shift of Delta-expressing regions, it was suggested that the "early" group and "late" groups are derived from the lower and the middle tier of veg(2) descendants, respectively. Interestingly, numbers of SMCs were also altered with SB431542; blastocoelar cells, coelomic pouch cells and circum-esophageal muscles decreased, whereas pigment cells and spicule tip cells increased in number. Pulse-treatment showed that the "early" group was sensitive up to the mesenchyme blastula stage, while the "late" group up to the onset of gastrulation. Thus, it became clear that precursor cells of the "early" and "late" groups, which are located in different regions in the vegetal plate, receive Delta and Nodal signals at different timings, resulting in the diversification of SMCs. Based on the obtained results, the specification processes of five types of SMCs are diagrammatically presented.
  • Atsushi Sogabe, Koji Matsumoto, Mizuki Ohashi, Aki Watanabe, Hiromi Takata, Yasunori Murakami, Koji Omori, Yasunobu Yanagisawa
    BIOLOGY LETTERS 4 4 362 - 365 2008年08月 [査読有り]
     研究論文(学術雑誌) 
    Syngnathid fish (pipefish and seahorses) are unique among teleost fish in that their ovary consists of a rolled sheet with germinal ridge(s) on the dorsal side running along the entire length of the sheet. A distinct difference is seen in the ovarian structure between polygamous Syngnathus pipefish and monogamous seahorses (Hippocampus spp.), the former having one germinal ridge and the latter with two ridges. This study examined the ovarian structure and the mode of egg production in a monogamous pipefish Corythoichthys haematopterus. The ovary of C. haematopterus had two germinal ridges like that observed in monogamous seahorses. There were two distinct groups of follicles in the ovary, one being a cohort of extremely small follicles and the other a cohort of follicles developing and increasing in size with the passage of time. We suggest that the ovarian structure and the mode of egg production in this pipefish are adaptations to monogamy.
  • Construction of the water pollution monitor system using the molecular mechanisms of starfish embryogenesis.
    愛媛医学 26 217 - 222 2007年 [査読有り]
  • Number of esophageal muscle fiber changes during normal embryogenesis in sea bats.
    愛媛医学 26 159 - 164 2007年 [査読有り]
  • T Kominami, M Akagawa, H Takata
    DEVELOPMENT GROWTH & DIFFERENTIATION 48 2 101 - 115 2006年02月 [査読有り]
     研究論文(学術雑誌) 
    To gain information on the process of ectoderm patterning, the animal halves of sea urchin embryos were isolated at various stages, and their morphology was examined when control embryos developed into pluteus larvae. The animal halves separated at the 8-cell stage developed into 'dauerblastula', without showing any conspicuous ectoderm differentiation. In contrast, some of the animal halves isolated at the 60-cell stage (after the sixth cleavage) formed a ciliated band and oral opening, suggesting that some patterning signal was transmitted from the vegetal to animal hemisphere during early cleavage. Further patterning of the animal hemisphere did not seem to occur until hatching, since both the animal halves isolated at the 60-cell stage and hatching stage showed the same degree of ectoderm patterning. After hatching, the later animal halves were isolated, the more patterned ectoderm they formed. The animal halves isolated just prior to gastrulation differentiated well-patterned ectoderm. It is of note, however, that the level of separation was a more crucial factor than the timing of separation; even the animal fragments of newly hatched embryos differentiated well-patterned ectoderm if they had been separated at a subequatorial level. This suggests that the signal for ectoderm patterning is transmitted over the equator after hatching, and once the cells in the supra-equatorial region receive the signal, they, in turn, can transmit the signal upwardly. Interestingly, if the third cleavage plane was shifted toward the vegetal pole, the isolated animal pole-side fragments developed into 'embryoids' with fully patterned ectoderm. These results indicate that not the micromere descendants but the subequatorial cytoplasm plays an important role in ectoderm patterning.
  • H Takata, T Kominami
    ZOOLOGICAL SCIENCE 21 10 1025 - 1035 2004年10月 [査読有り]
     研究論文(学術雑誌) 
    To know whether behavior of pigment cells correlates the process of gastrulation or not, gastrulating embryos of several species of regular echinoids (Anthocidaris crassispina, Mespilia globulus and Toxopneustes pileolus) and irregular echinoids (Clypeaster japonicus and Astriclypeus manni) were examined. In M. globulus and A. crassispina, the archenteron elongated stepwise like in well-known sea urchins. In the embryos of both species, fluorescent pigment cells left the archenteron tip and migrated into the blastocoel during gastrulation. In T pileolus, C. japonicus and A. manni, on the other hand, the archenteron elongated at a constant rate throughout gastrulation. In these species, no pigment cell was observed at the archenteron tip during invagination processes; pigment cells began to migrate in the ectoderm from the vegetal pole side toward the apical plate without entering the blastocoel. These results clearly indicate that the behavior of pigment cells closely correlated the manner of gastrulation. Further, it was examined whether the archenteron cells are rearranged during invagination, by comparing the number of cells observed on cross sections of the archenteron at the early and late gastrula stages. The rearrangement was not conspicuous in A. crassispina and M. globulus, in which archenteron elongated stepwise. In contrast, the archenteron cells were remarkably rearranged in C. japonicus, alothough the archenteron elongated continuously. Thus, neither the behavior of pigment cells nor the manner of gastrulation matches the current taxonomic classification of echinoids.
  • T Kominami, H Takata
    DEVELOPMENT GROWTH & DIFFERENTIATION 46 4 309 - 326 2004年08月 [査読有り]
     
    Processes of gastrulation in the sea urchin embryo have been intensively studied to reveal the mechanisms involved in the invagination of a monolayered epithelium. It is widely accepted that the invagination proceeds in two steps (primary and secondary invagination) until the archenteron reaches the apical plate, and that the constituent cells of the resulting archenteron are exclusively derived from the veg2 tier of blastomeres formed at the 60-cell stage. However, recent studies have shown that the recruitment of the archenteron cells lasts as late as the late prism stage, and some descendants of veg1 blastomeres are also recruited into the archenteron. In this review, we first illustrate the current outline of sea urchin gastrulation. Second, several factors, such as cytoskeletons, cell contact and extracellular matrix, will be discussed in relation to the cellular and mechanical basis of gastrulation. Third, differences in the manner of gastrulation among sea urchin species will be described; in some species, the archenteron does not elongate stepwise but continuously. In those embryos, bottle cells are scarcely observed, and the archenteron cells are not rearranged during invagination unlike in typical sea urchins. Attention will be also paid to some other factors, such as the turgor pressure of blastocoele and the force generated by blastocoele wall. These factors, in spite of their significance, have been neglected in the analysis of sea urchin gastrulation. Lastly, we will discuss how behavior of pigment cells defines the manner of gastrulation, because pigment cells recently turned out to be the bottle cells that trigger the initial inward bending of the vegetal plate.
  • H Takata, T Kominami
    DEVELOPMENT GROWTH & DIFFERENTIATION 46 1 23 - 35 2004年02月 [査読有り]
     研究論文(学術雑誌) 
    In the tropical sea urchin Echinometra mathaei, pigment cells are just detectable before the onset of gastrulation, owing to an early accumulation of red pigment granules. Taking advantage of this feature, behavior of pigment cells was studied in relation to the processes of gastrulation. Before the initiation of primary invagination, pigment cells were arranged in a hemi-circle in the dorsal half of the vegetal plate. Inward bending of the vegetal plate first occurred at the position occupied by pigment cells, while the bending was not conspicuous in the ventral half of the blastopore. Rhodamine-phalloidin staining showed that actin filaments were abundant at the apical corticies of pigment cells. It was also found that the onset of gastrulation was considerably delayed in the NiCl2-treated embryos, in which pigment cells were drastically reduced in number. It is notable that the NiCl2-treated embryos began to gastrulate on schedule if they contained a number of pigment cells in spite of treatment. This shows that pigment cells are the bottle cells that trigger the onset of gastrulation. In the embryos devoid of pigment cells, a short stub-like gut rudiment formed in a delayed fashion, and several secondary mesenchyme cells (SMC) appeared at the tip of the rudiment and elongated gradually until its tip reached the apical plate. This observation suggests that the SMC that pull the gut rudiment upward are not pigment cells but blastocoelar cells, because pigment cells change their fate to blastocoelar cells upon NiCl2-treatment.
  • T Kominami, H Takata
    ZOOLOGICAL SCIENCE 20 5 617 - 626 2003年05月 [査読有り]
     研究論文(学術雑誌) 
    Egg volume of a tropical sea urchin Echinometra mathaei is about one half that of other well-known species. We asked whether such a small size of eggs affected the timings of early developmental events or not. Cleavages became asynchronous from the 7th cleavage onward, and embryos hatched out before completion of the 9th cleavage. These timings were one cell cycle earlier than those in well-known sea urchins, raising the possibility that much earlier events, such as the increase in adhesiveness of blastomeres or the specification of dorso-ventral axis (DV-axis), would also occur earlier by one cell cycle. By examining the pseudopodia. formation in dissociated blastomeres, it was elucidated that blastomeres in meso- and macromere lineages became adhesive after the 4th and 5th cleavages, respectively. From cell trace experiments, it was found that the first or second cleavage plane was preferentially employed as the median plane of embryo; the DV-axis was specified mainly at the 16-cell stage. Timings of these events were also one cell cycle earlier than those in Hemicentrotus pulcherrimus. The obtained results suggest that most of the early developmental events in sea urchin embryos do not depend on cleavage cycles, but on other factors, such as the nucleo-cytoplasmic ratio.
  • T Kominami, H Takata
    DEVELOPMENT GROWTH & DIFFERENTIATION 45 2 129 - 142 2003年04月 [査読有り]
     研究論文(学術雑誌) 
    To learn how the dorso-ventral (DV) axis of sea urchin embryos affects the specification processes of secondary mesenchyme cells (SMC), a fluorescent dye was injected into one of the macromeres of 16-cell stage embryos, and the number of each type of labeled SMC was examined at the prism stage. A large number of labeled pigment cells was observed in embryos in which the progeny of the labeled macromere were distributed in the dorsal part of the embryo. In contrast, labeled pigment cells were scarcely noticed when the descendants of the labeled macromere occupied the ventral part. In such embryos, free mesenchyme cells (probably blastocoelar cells) were predominantly labeled. CH3COONa treatment, which is known to increase the number of pigment cells, canceled such patterned specification of pigment cells and blastocoelar cells along the DV axis. Pigment cells were also derived from the ventral blastomere in the treated embryo. In contrast, a similar number of coelomic pouch cells was derived from the labeled macromere, irrespective of the position of its descendants along the DV axis. After examination of the arrangement of blastomeres in late cleavage stage embryos, it was determined that 17-20 veg(2)-derived cells encircled the cluster of micromere descendants after the 9th cleavage. From this number and the numbers of SMC-derived cells in later stage embryos, it was suggested that the most vegetally positioned veg (2) descendants at approximately the 9th cleavage were preferentially specified to pigment and blastocoelar cell lineages. The obtained results also suggested the existence of undescribed types of SMC scattered in the blastocoele.
  • M Masui, H Takata, T Kominami
    ELECTROPHORESIS 23 13 2087 - 2095 2002年07月 [査読有り]
     研究論文(学術雑誌) 
    Spherical blastomeres of starfish embryos begin to adhere to neighboring blastomeres and to become columnar in shape from the 7(th) or 8(th) cleavage onward. Studying development of embryos in the presence of LiCl, we found that developmental changes in cell-cell contacts were accelerated by LiCl. In order to learn why LiCl increased the adhesiveness between blastomeres, the negative surface charge density was estimated by the method of cell electrophoresis. It turned out that the electrophoretic mobility (EPM) of all blastomeres isolated from LiCl-treated embryos before the 512-cell stage was remarkably decreased. At the mid-gastrula stage, however, when constituent cells were connected with each other more tightly, the EPM was significantly retarded irrespectively whether the cells had been isolated from control or from LiCl-treated embryos. From these results of cell electrophoresis we conclude that reduction of the negative surface charge density may be one of the important factors that enhance the adhesion of starfish embryonic cells.
  • T Kominami, H Takata
    DEVELOPMENT GROWTH & DIFFERENTIATION 44 2 113 - 125 2002年04月 [査読有り]
     研究論文(学術雑誌) 
    The process of pigment cell specification in the sand dollar Scaphechinus mirabills was examined by manipulative methods, In half embryos, which were formed by dissociating embryos at the 2-cell stage, the number of pigment cells was significantly greater than half the number of pigment cells observed in control embryos. This relative increase might have been brought about by the change in the arrangement of blastomeres surrounding the micromere progeny. To examine whether such an increase could be induced at a later stage, embryos were bisected with a glass needle. When embryos were bisected before 7 In postfertilization, the sum of pigment calls observed in a pair of embryo fragments was greater than that in control embryos, This relative increase was not seen when embryos were bisected after 7 h postfertilization. From the size of blastomeres, it became clear that the 9th cleavage was completed by 7 In postfertilization. Aphiclicolin treatment revealed that 10-15 pigment founder cells were formed. The results obtained suggest that the pigment founder cells were specified through direct cell contact with micromere progeny after the 9th cleavage, and that most of the founder cells had divided three times before they differentiated into pigment cells.
  • T Kominami, H Takata, M Takaichi
    DEVELOPMENT GROWTH & DIFFERENTIATION 43 6 699 - 707 2001年12月 [査読有り]
     研究論文(学術雑誌) 
    The behavior of pigment cells in sea urchin embryos, especially at the gastrula stage, is not well understood, due to the lack of an appropriate method to detect pigment cells, We found that pigment cells emanated autofluorescence when they were fixed with formalin and irradiated with ultraviolet or green light. In Hemicentrotus pulcherrimus, fluorescent pigment cells became visible at the archenteron tip at the mid-gastrula stage. The cells detached from the archenteron slightly before the initiation of secondary invagination and migrated toward the apical plate. Most pigment cells entered the apical plate. This entry site seemed to be restricted, because pigment cells could not enter the ectoderm and remained in the blastocoele at the vegetal pole side when elongation of archenteron was blocked. Pigment cells that had entered the apical plate soon began to migrate in the aboral ectoderm toward the vegetal pole. In contrast, pigment cells of Scaphechinus mirabilis embryos were first detected in the vegetal plate before the onset of gastrulation. Without entering the blastocoele, these cells began to migrate preferentially in the aboral ectoderm toward the animal pole. When the archenteron tip reached the apical plate, pigment cells had already distributed throughout the aboral ectoderm. Thus, the behavior of pigment cells was quite different between H. pulcherrimus and S. mirabilis.
  • H Takata, T Kominami
    ZOOLOGICAL SCIENCE 18 8 1097 - 1105 2001年11月 [査読有り]
     研究論文(学術雑誌) 
    By immersing sea urchin embryos in seawater containing various concentrations of sucrose, we found that the level of osmotic pressure of blastocoel changed during gastrulation; the level was low around the onset of gastrulation and higher during secondary invagination. To learn how such changes in osmotic pressure related to invagination processes, embryos were shrunken or expanded by means of sucrose treatments, and the degree of invagination was monitored using Nile blue staining. The method elucidated that the cells invaginated during primary invagination occupied only top one third of archenteron at the end of secondary invagination, and that the cells constituting intestine and the posterior half of stomach were recruited into the archenteron after secondary invagination. When embryos were expanded, the degree of invagination was remarkably decreased, indicating that a higher level of expanding force hindered the fulfillment of invagination. On the other hand, shrinkage of blastocoel during secondary invagination increased the degree of invagination. Cell tracing experiments showed that the change in the degree of invagination estimated with Nile blue staining was accompanied with the change in the number of cells incorporated into the archenteron. When embryos were expanded, only the descendants of veg2 constituted the gut rudiment, while a considerable amount of the veg1 descendants were recruited into archenteron when embryos were shrunken. Obtained results suggest that change in the level of osmotic pressure of blastocoel would be necessary for the progress of gastrulation.
  • Gonad structures in tow species of Pisidium (Bivalvia:
    Venus 60 183 - 188 2001年 [査読有り]
  • T Kominami, H Takata
    BIOLOGICAL BULLETIN 199 3 287 - 297 2000年12月 [査読有り]
     研究論文(学術雑誌) 
    The processes of gastrulation in the sand dollar Scaphechinus mirabilis are quite different from those in regular echinoids. In this study, we explored the cellular basis of gastrulation in this species with several methods. Cell-tracing experiments revealed that the prospective endodermal cells were convoluted throughout the invagination processes. Histological observation showed that the ectodermal layer remained thickened, and the vegetal cells retained an elongated shape until the last step of invagination. Further, most of the vegetal ectodermal cells were skewed or distorted. Wedge-shaped cells were common in the vegetal ectoderm, especially at the subequatorial region. In these embryos, unlike the embryos of regular echinoids, secondary mesenchyme cells did not seem to exert the force to pull up the archenteron toward the inner surface of the apical plate. In fact, the archenteron cells were not stretched along the axis of elongation and were in close contact with each other. Here we found that gastrulation was completely blocked when the embryos were attached to a glass dish coated with poly-L-lysine, in which the movement of the ectodermal layer was inhibited. These results suggest that a force generated by the thickened ectoderm, rather than rearrangement of the archenteron cells, may play a key role in the archenteron elongation in S. mirabilis embryos.

講演・口頭発表等

  • 変態期アフリカツメガエルの腎臓構造と窒素排泄について  [通常講演]
    高田 裕美
    日本動物学会中国四国支部愛媛県例会 2018年12月 口頭発表(一般)
  • 変態期アフリカツメガエル消化管の組織構造変化および細胞増殖に対する甲状腺ホルモンの影響  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2017年12月 口頭発表(一般)
  • ハタゴイソギンチャクの刺胞放出のしくみ  [通常講演]
    日本動物学会中国四国支部大会 2015年
  • クロウミウマの卵巣構造と卵生産様式  [通常講演]
    四国魚類研究会 2013年
  • ウニ胚のセロトニン陽性細胞分化はWntとNotchシグナルによって制御される  [通常講演]
    日本動物学会学会 2012年
  • 脊椎動物における小脳神経回路の起源  [通常講演]
    日本動物学会第82回大会 2011年
  • 重油とその構成物質暴露による硬骨魚類の初期発生と行動に及ぼす影響  [通常講演]
    中国四国支部愛媛県例会 2011年
  • 棘皮動物初期胚の細胞分化と形態形成におけるNotchとNodalの役割  [通常講演]
    中国四国支部愛媛県例会 2011年
  • 正形類と歪形類のウニ胚における二次間充織細胞specification過程の相違  [通常講演]
    日本動物学会第81回大会 2010年
  • ウニ胚原腸陥入時に発現が変化する2種の遺伝子について  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2010年
  • スカシカシパンにおける二次間充織細胞の新しいサブポピュレーション  [通常講演]
    日本動物学会第80回大会 2009年
  • カクレクマノミとハタゴイソギンチャクの分布状況と宿主認識のしくみ  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2009年
  • パプアキンイロクワガタはどのようにして宝石の輝きを生み出すのか  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2009年
  • ヨウジウオ科魚類イシヨウジの卵巣構造と卵生産様式について  [通常講演]
    第35回四国魚類研究会 2008年
  • ウニ胚における二次間充織由来細胞specificationの過程  [通常講演]
    日本動物学会第79回大会 2008年
  • ウニ胚の原腸陥入にはたらく力  [通常講演]
    日本動物学会第79回大会 2008年
  • スカシカシパンにおける色素細胞の新しいサブポピュレーション  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2008年
  • ハスノハカシパン胚における背腹軸の確立  [通常講演]
    日本動物学会 2007年
  • ウニ初期胚における頂板specificationの過程  [通常講演]
    日本動物学会 2007年
  • ヨウジウオ科魚類イシヨウジにおける卵巣構造と卵生産様式  [通常講演]
    日本動物学会中国四国支部愛媛県例会 2007年
  • ウニ胚初期卵割期の分裂装置の大きさを決定する要因  [通常講演]
    日本動物学会 2006年
  • 鉱物性汚染物質によるヒトデ幼生食道輪状筋への影響  [通常講演]
    日本動物学会 2005年
  • ウニ初期胚の割球間接着  [通常講演]
    日本動物学会中国四国支部松山例会 2005年
  • ウニ胚における色素細胞の前駆細胞決定のタイミング  [通常講演]
    日本動物学会中国四国支部体会 2004年
  • ウニ胚原腸陥入時の細胞動態  [通常講演]
    日本動物学会 2004年
  • 胚発生を指標とした海洋汚染モニタリングシステムの開発II:イトマキヒトデ幼生食道輪走筋繊維数の変化  [通常講演]
    日本動物学会中国四国支部松山例会 2004年
  • ウニ胚の原腸陥入開始に関わる瓶型細胞は色素細胞である  [通常講演]
    日本動物学会 2003年
  • ウニ胚外胚葉のパターニング  [通常講演]
    日本動物学会第74会大会 2003年
  • ウニ胚原腸陥入時の細胞形態及び細胞数  [通常講演]
    日本動物学会中国四国支部松山例会 2003年
  • ウニ胚後期卵割パターンと二次間充織細胞の決定  [通常講演]
    日本発生生物学会第35回大会 2002年
  • ウニ類における原腸陥入様式と色素細胞の挙動  [通常講演]
    日本動物学会第73回大会 2002年
  • ムラサキウニにおける色素細胞系譜確立のタイミング  [通常講演]
    日本動物学会中国四国支部松山例会 2002年
  • ウニ胚の動植軸に沿ったパターニングは二重勾配による?  [通常講演]
    日本動物学会中国四国支部松山例会 2002年
  • バフンウニの色素細胞は背側割球から多く作られる  [通常講演]
    日本動物学会第72回大会 2001年
  • イトマキヒトデ胚細胞の接着性と表面荷電  [通常講演]
    日本動物学会中国四国支部松山例会 2001年
  • ハスノハカシパンの原腸陥入時に見られるアクチン繊維の分布  [通常講演]
    日本発生生物学会第33回大会 2000年
  • ウニ胚の原腸形成には胞胚腔内の膨圧変化が関与する  [通常講演]
    日本動物学会第71回大会 2000年
  • ハスノハカシパンにおける色素細胞分化  [通常講演]
    日本動物学会中国四国支部松山例会 2000年
  • ハスノハカシパンはにおける原腸陥入のしくみ  [通常講演]
    日本発生生物学会第32回大会 1999年
  • ウニ胚色素細胞の初期分化過程  [通常講演]
    日本発生生物学会第32回大会 1999年
  • シジミ属3種の生殖腺の構造  [通常講演]
    日本動物学会中国四国支部松山例会 1999年
  • ハスノハカシパンにおける原腸陥入機構  [通常講演]
    日本発生生物学会第29回大会 1996年
  • バフンウニの骨片形成細胞分化決定因子の解析  [通常講演]
    日本動物学会中国四国支部松山例会 1996年
  • バフンウニの初期卵割における割球間接着開始機構の解析  [通常講演]
    日本動物学会中国四国支部松山例会 1996年
  • ウニ胚の背腹軸は32〜64細胞期に確立する  [通常講演]
    日本動物学会第66回大会 1995年

委員歴

  • 2016年 - 現在   日本動物学会   愛媛県委員

愛媛大学教員活動実績

教育活動(B)

担当授業科目(B01)

  • 2019, 前期, 学部, 生物学Ⅰ
  • 2019, 前期, 学部, 発生学
  • 2019, 前期, 学部, 生物学ゼミナールⅠ
  • 2019, 前期, 学部, 生物学特別演習Ⅰ
  • 2019, 前期, 学部, 卒業研究Ⅰ
  • 2019, 前期, 学部, 基礎生物学実験
  • 2019, 前期, 学部, 基礎生物学実験
  • 2019, 前期, 修士, 発生機構学
  • 2019, 前期, 修士, 生物環境科学高等実習Ⅱ
  • 2019, 前期, 修士, 生物学ゼミナールI
  • 2019, 前期, 修士, 生物学ゼミナールⅢ
  • 2019, 前期, 修士, 生物学課題実験I
  • 2019, 前期, 修士, 生物学課題実験Ⅲ
  • 2019, 前期, 博士, 生物機能科学特論Ⅹ
  • 2019, 前期, 学部, 基礎生物学実験
  • 2019, 前期, 学部, 生物学
  • 2019, 前期, 学部, 発生学


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