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秋山 浩一アキヤマ コウイチ

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職名准教授
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Last Updated :2017/11/08

研究者基本情報

所属学協会

  • 分子生物学会
  • 日本農芸化学会
  • 日本癌学会

研究活動情報

研究キーワード

    分子生物学, 応用微生物学

論文

  • The amino-terminal hydrophilic region of the vacuolar transporter Avt3p is dispensable for the vacuolar amino acid compartmentalization of Schizosaccharomyces pombe.
    Kawano-Kawada M, Chardwiriyapreecha S, Manabe K, Sekito T, Akiyama K, Takegawa K, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 80, (12) 2291 - 2297,   2016年12月
  • Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids.
    Yamauchi S, Tanimura R, Nishiwaki H, Nishi K, Sugahara T, Maruyama M, Ano Y, Akiyama K, Kishida T, Bioorganic & medicinal chemistry letters, 26, (13) 3019 - 3023,   2016年07月
  • Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae.
    Kawano-Kawada M, Pongcharoen P, Kawahara R, Yasuda M, Yamasaki T, Akiyama K, Sekito T, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 80, (2) 279 - 287,   2016年
  • Effect of the structure of dietary epoxylignan on its cytotoxic activity: relationship between the structure and the activity of 7,7'-epoxylignan and the introduction of apoptosis by caspase 3/7.
    Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S, Bioscience, biotechnology, and biochemistry, 80, (4) 669 - 675,   2016年
  • Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae.
    Chardwiriyapreecha S, Manabe K, Iwaki T, Kawano-Kawada M, Sekito T, Lunprom S, Akiyama K, Takegawa K, Kakinuma Y, PloS one, 10, (6) ,   2015年06月
  • Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae.
    Lunprom S, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Akiyama K, Bioscience, biotechnology, and biochemistry, 79, (12) 1972 - 1979,   2015年
  • Cytotoxic activity of butane type of 1,7-seco-2,7'-cyclolignanes and apoptosis induction by Caspase 9 and 3.
    Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S, Bioorganic & medicinal chemistry letters, 24, (17) 4231 - 4235,   2014年09月
  • Cytotoxic activity of dietary lignan and its derivatives: structure-cytotoxic activity relationship of dihydroguaiaretic acid.
    Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S, Journal of agricultural and food chemistry, 62, (23) 5305 - 5315,   2014年06月
  • Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae.
    Sekito T, Sugimoto N, Ishimoto M, Kawano-Kawada M, Akiyama K, Nishimoto S, Sugahara T, Kakinuma Y, The Journal of toxicological sciences, 39, (2) 311 - 317,   2014年04月
  • Structure-cytotoxic activity relationship of sesquilignan, morinol A.
    Yamauchi S, Kawahara S, Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Bioorganic & medicinal chemistry letters, 23, (17) 4923 - 4930,   2013年09月
  • Quantitative structure-activity relationship analysis of antifungal (+)-dihydroguaiaretic acid using 7-phenyl derivatives.
    Hasebe A, Nishiwaki H, Akiyama K, Sugahara T, Kishida T, Yamauchi S, Journal of agricultural and food chemistry, 61, (36) 8548 - 8555,   2013年09月
  • Functional expression of Schizosaccharomyces pombe Vba2p in the vacuolar membrane of Saccharomyces cerevisiae.
    Pongcharoen P, Kawano-Kawada M, Iwaki T, Sugimoto N, Sekito T, Akiyama K, Takegawa K, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 77, (9) 1988 - 1990,   2013年
  • Effect of substituents at phenyl group of 7,7'-dioxo-9,9'-epoxylignane on antifungal activity.
    Nishiwaki H, Ouchi M, Matsugi J, Akiyama K, Sugahara T, Kishida T, Yamauchi S, Bioorganic & medicinal chemistry letters, 22, (21) 6740 - 6744,   2012年11月
  • (-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice.
    Tominaga S, Nishi K, Nishimoto S, Akiyama K, Yamauchi S, Sugahara T, Food & function, 3, (1) 76 - 82,   2012年01月
  • Inhibition of myotube formation by paraquat in the myoblast cell line C2C12.
    Akiyama K, Tone J, Okabe M, Nishimoto S, Sugahara T, Kakinuma Y, The Journal of toxicological sciences, 36, (2) 243 - 246,   2011年04月
  • Disruption of ion homeostasis by verrucosin and a related compound.
    Akiyama K, Tone J, Yamauchi S, Sugahara T, Maruyama M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 75, (5) 1000 - 1002,   2011年
  • Immunomodulatory effect of (--)-matairesinol in vivo and ex vivo.
    Yamawaki M, Nishi K, Nishimoto S, Yamauchi S, Akiyama K, Kishida T, Maruyama M, Nishiwaki H, Sugahara T, Bioscience, biotechnology, and biochemistry, 75, (5) 859 - 863,   2011年
  • Oral administration of paraquat perturbs immunoglobulin productivity in mouse.
    Okabe M, Nishimoto S, Sugahara T, Akiyama K, Kakinuma Y, The Journal of toxicological sciences, 35, (2) 257 - 263,   2010年04月
  • Severe abnormalities in the reproductive organs of mice caused by chemical substances contained in heavy oil.
    Nishimoto S, Yamawaki M, Akiyama K, Kakinuma Y, Kitamura S, Sugahara T, The Journal of toxicological sciences, 34, (2) 239 - 244,   2009年04月
  • Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid.
    Yamauchi S, Masuda T, Sugahara T, Kawaguchi Y, Ohuchi M, Someya T, Akiyama J, Tominaga S, Yamawaki M, Kishida T, Akiyama K, Maruyama M, Bioscience, biotechnology, and biochemistry, 72, (11) 2981 - 2986,   2008年11月
  • Mode of action of the immunostimulatory effect of collagen from jellyfish.
    Nishimoto S, Goto Y, Morishige H, Shiraishi R, Doi M, Akiyama K, Yamauchi S, Sugahara T, Bioscience, biotechnology, and biochemistry, 72, (11) 2806 - 2814,   2008年11月
  • Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity.
    Yoshida T, Yamauchi S, Tago R, Maruyama M, Akiyama K, Sugahara T, Kishida T, Koba Y, Bioscience, biotechnology, and biochemistry, 72, (9) 2342 - 2352,   2008年09月
  • Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
    Tago R, Yamauchi S, Maruyama M, Akiyama K, Sugahara T, Kishida T, Koba Y, Bioscience, biotechnology, and biochemistry, 72, (4) 1032 - 1037,   2008年04月
  • Stereoselective construction of tetra-substituted tetrahydrofuran compounds from benzylic hemiacetal in the presence of H2 and a Pd catalyst: stereoselective synthesis of a stereoisomer of (-)-virgatusin and its antimicrobiological activity.
    Nakato T, Tago R, Akiyama K, Maruyama M, Sugahara T, Kishida T, Yamauchi S, Bioscience, biotechnology, and biochemistry, 72, (1) 197 - 203,   2008年01月
  • Effect of the benzylic structure of lignan on antioxidant activity.
    Yamauchi S, Sugahara T, Matsugi J, Someya T, Masuda T, Kishida T, Akiyama K, Maruyama M, Bioscience, biotechnology, and biochemistry, 71, (9) 2283 - 2290,   2007年09月
  • Use of the benzyl mesylate for the synthesis of tetrahydrofuran lignan: syntheses of 7,8-trans, 7',8'-trans, 7,7'-cis, and 8,8'-cis-virgatusin stereoisomers.
    Yamauchi S, Nakato T, Tsuchiya M, Akiyama K, Maruyama M, Sugahara T, Kishida T, Bioscience, biotechnology, and biochemistry, 71, (9) 2248 - 2255,   2007年09月
  • Antimicrobiological activity of lignan: effect of benzylic oxygen and stereochemistry of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on activity.
    Akiyama K, Maruyama M, Yamauchi S, Nakashima Y, Nakato T, Tago R, Sugahara T, Kishida T, Koba Y, Bioscience, biotechnology, and biochemistry, 71, (7) 1745 - 1751,   2007年07月
  • Antibacterial activity of a virgatusin-related compound.
    Maruyama M, Yamauchi S, Akiyama K, Sugahara T, Kishida T, Koba Y, Bioscience, biotechnology, and biochemistry, 71, (3) 677 - 680,   2007年03月
  • A novel way to express proline-selectively labeled proteins with a wheat germ cell-free protein synthesis system.
    Shimizu M, Ikegami T, Akiyama K, Morita EH, Journal of biochemistry, 140, (3) 453 - 456,   2006年09月
  • The anti-tumor effect of Euchema serra agglutinin on colon cancer cells in vitro and in vivo.
    Fukuda Y, Sugahara T, Ueno M, Fukuta Y, Ochi Y, Akiyama K, Miyazaki T, Masuda S, Kawakubo A, Kato K, Anti-cancer drugs, 17, (8) 943 - 947,   2006年09月
  • Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol.
    Yamauchi S, Sugahara T, Nakashima Y, Okada A, Akiyama K, Kishida T, Maruyama M, Masuda T, Bioscience, biotechnology, and biochemistry, 70, (8) 1934 - 1940,   2006年08月

MISC

  • Targeted disruption of a G-protein β subunit gene results in reduced pathogenicity in Fusarium oxysporum.
    Curr. Genet.,   2003年
  • Targeted disruption of a G protein α subunit gene results in reduced pathogenicity in Fusarium oxysporum
    Curr. Genet., (41) 407 - 413,   2002年
  • Targeted disruption of sti35, a stress-responsive gene in phytopathogenic furgus Fusarium oxysporum
    THANONKEO P, AKIYAMA K, JAIN S, TAKATA R, Curr. Microbiol., 41, (4) 284 - 289,   2000年
  • Detection and cloning of the gene encoding a protein produced by nonpathogenic mutants of Fusarium oxysporum.
    J. Biosci. Bioeng., 90, (3) 302 - 307,   2000年
  • A Family of Basic Amino Acid Transporters of the Vacuolar Membrane from Saccharomyces cerevisiae
    SHIMAZU M, SEKITO T, AKIYAMA K, OHSUMI Y, KAKINUMA Y, J Biol Chem, 280, (6) 4851 - 4857,   2005年
  • Signaling via the G protein α subunit FGA2 is necessary for pathogenesis in Fusarium oxysporum
    JAIN S, AKIYAMA K, TAKATA R, OHGUCHI T, FEBS Microbiol. Lett., 243, (1) 165 - 172,   2005年
  • First enantioselective synthesis of (-)- and (+)-virgatusin,tetra-substituted tetrahydrofuran lignan.
    YAMAUCHI Satoshi, OKAZAKI Momotoshi, AKIYAMA Koichi, SUGAHARA Takuya, KISHIDA Taro, KASHIWAGI Takehiro, Org. Biomol. Chem., 3, (9) 1670 - 1675,   2005年
  • Immunostimulation effects of proteose-peptone component 3 fragment on human hybridomas and peripheral blood lymphocytes.
    Biochim. Biophys. Acta, 1725,   2005年
  • Molecular composition of non-ionic vesicles prepared from Span 80 or Span 85 by a two-step emulsification method.
    J. Disper. Sci. Technol., 27,   2006年
  • Immunostimulation effect of the jellyfish collagen.
    Biosci. Biotechnol. Biochem., 70, (9) 2131 - 2137,   2006年
  • The anti-tumor effect of Euchema serra agglutinin (ESA) on colon cancer cells in vitro and in vivo.
    Anti-Cancer Drug., 17,   2006年
  • Radical and superoxide scavenging activity of matairesinol and oxidized matairesinol.
    Biosci. Biotechnol. Biochem., 70, (8) 1934 - 1940,   2006年
  • Effect of benzylic oxygen on the cytotoxic activity for Colon 26 cell line of phenolic lignans.
    YAMAUCHI Satoshi, SUGAHARA Takuya, NAKASHIMA Yuki, ABE Koki, HAYASHI Yoshimasa, AKIYAMA Koichi, KISHIDA Taro, MARUYAMA Masafumi, Biosci. Biotechnol. Biochem., 70, (12) 2942 - 2947,   2006年
  • Antibacterial Activity of Virgatusin-Related Compound
    MARUYAMA Masafumi, YAMAUCHI Satoshi, AKIYAMA Koichi, SUGAHARA Takuya, KISHIDA Taro, KOBA Yojiro, Biosciences Biotechnology and Biochemistry, 71, (3) 677 - 680,   2007年
  • Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (-)-Virgatusin, and Its Structure-Activity Relationship
    Biosciences Biotechnology and Biochemistry, 71, (4) 1028 - 1035,   2007年
  • Determination of the Stereochemistry of the Tetrahydropyran Sesquineolignans Morinols A and B
    J. Nat. Prod., 70,   2007年
  • Mobilization of a retrotransposon in 5-azacytidine-treated fungus Fusarium oxysporum
    Plant Biotechnology, 24, (3) 345 - 348,   2007年
  • Immunostimulation effect of the jellyfish collagen.
    Animal Cell Technology: Basic & Applied Aspects, 15,   2008年
  • First stereoselective synthesis of meso-secoisolariciresinol and comparison of biological activity with (+) and (-)-secoisolariciresinol.
    SUGAHARA Takuya, YAMAUCHI Satoshi, KONDO Ai, OHNO Fumi, TOMINAGA Siori, NAKASHIMA Yuki, KISHIDA Taro, AKIYAMA Koichi, MARUYAMA Masafumi, Biosci. Biotechnol. Biochem., 71, (12) 2962 - 2968,   2007年
  • Identification of the fnx1(+) and fnx2(+) genes for vacuolar amino acid transporters in Schizosaccharomyces pombe.
    CHARDWIRIYAPREECHA Soracom, SHIMAZU Masamitsu, MORITA Tomotake, SEKITO Takayuki, SEKITO Takayuki, AKIYAMA Koichi, AKIYAMA Koichi, TAKEGAWA Kaoru, KAKINUMA Yoshimi, KAKINUMA Yoshimi, FEBS Lett., 582, (15) 2225 - 2230,   2008年
  • The Effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity.
    TOMINAGA Shiori, SUGAHARA Takuya, SUGAHARA Takuya, NISHIMOTO Sogo, NISHIMOTO Sogo, YAMAWAKI Manami, NAKASHIMA Yuki, KISHIDA Taro, KISHIDA Taro, AKIYAMA Koichi, MARUYAMA Masafumi, YAMAUCHI Satoshi, YAMAUCHI Satoshi, Biosci. Biotechnol. Biochem., 73, (1) 35 - 39,   2009年
  • The structure-activity relationship of flaxseed lignan, secoisolariciresinol.
    Interdisciplinary Studies on Environmental Chemistry: Biological Responses to Chemical Pollutants, 1,   2008年
  • Severe abnormalities in the reproductive organs of mice caused by the chemical substances contained in heavy oil.
    J. Toxicol. Sci., 34, (2) 239 - 244,   2009年
  • Antimicrobial activity of stereoisomers of butane-type lignans.
    Biosci. Biotechnol. Biochem., 73, (8) 1806 - 1810,   2009年
  • Tributyltin induces Yca1p-dependent cell death of yeast Saccharomyces cerevisiae.
    CHAHOMCHUEN Thippayarat, AKIYAMA Koichi, SEKITO Takayuki, SUGIMOTO Naoko, OKABE Masaaki, NISHIMOTO Sogo, SUGAHARA Takuya, KAKINUMA Yoshimi, KAKINUMA Yoshimi, J Toxicol Sci., 34, (5) 541 - 545,   2009年
  • Heavy oil fractions induce negative influences on mouse immune system.
    J Toxicol Sci, 34, (5) 459 - 468,   2009年
  • Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers.
    NAKATO Tomofumi, YAMAUCHI Satoshi, YAMAUCHI Satoshi, TAGO Ryosuke, AKIYAMA Koichi, MARUYAMA Masafumi, SUGAHARA Takuya, SUGAHARA Takuya, KISHIDA Taro, KISHIDA Taro, KOBA Yojiro, Biosci Biotechnol Biochem, 73, (7) 1608 - 1617,   2009年
  • Antimicrobial activity of stereoisomers of morinols a and B, tetrahydropyran sesquineolignans.
    AKIYAMA Koichi, YAMAUCHI Satoshi, YAMAUCHI Satoshi, MARUYAMA Masafumi, SUGAHARA Takuya, SUGAHARA Takuya, KISHIDA Taro, KISHIDA Taro, KOBA Yojiro, Biosci Biotechnol Biochem, 73, (1) 129 - 133,   2009年
  • In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin.
    OMOKAWA Y., KATO K., MIYAZAKI T., WALDE P., AKIYAMA K., SUGAHARA T., MASUDA S., INADA A., OHNISHI Y., SAEKI T., Int J Pharm, 389, (1-2) 157 - 167,   2010年
  • Improved syntheses of morinol C and d by employing mizoroki-heck reaction and their cytotoxic and antimicrobial activities.
    Biosci Biotechnol Biochem., 74, (8) 1641 - 1644,   2010年
  • IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.
    KAWAHARA Saya, IWATA Ipei, FUJITA Eriko, YAMAWAKI Manami, NISHIWAKI Hisashi, SUGAHARA Takuya, SUGAHARA Takuya, YAMAUCHI Satoshi, YAMAUCHI Satoshi, AKIYAMA Koichi, KISHIDA Taro, KISHIDA Taro, Biosci. Biotechnol. Biochem., 74, (9) 1878 - 1883,   2010年
  • Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
    J. Toxicol. Sci., 36, (1) 117 - 120,   2011年
  • Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan
    Biosci. Biotechnol. Biochem., 74, (10) 2071 - 2076,   2010年
  • Heavy oil fraction induces the dysplastic sperm in male mouse.
    J. Toxicol. Sci., 36,   2011年

作品

  • 未利用資源の資化を目的としたリグナン類の新規生理活性評価に関する研究
      2005年 - 2007年

特許

  • 免疫調節蛋白質の製造方法, 特許第4656300


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