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坪井 敬文ツボイ タカフミ

所属部署
プロテオサイエンスセンター
職名教授
メールアドレスtsuboi.takafumi.mb[at]ehime-u.ac.jp ※[at]を@に書き換えて送信して下さい
ホームページURLhttp://www.ehime-u.ac.jp/~cellfree/proteomedical/malaria.html
生年月日
Last Updated :2017/08/18

研究者基本情報

学歴

  •  - 1986年, 愛媛大学, 医学研究科, 寄生虫学
  •  - 1980年, 愛媛大学, 医学部, 医学科

経歴

  •   2006年, - ベンチャー・ビジネス・ラボラトリー
  •   2003年, - 愛媛大学無細胞生命科学工学研究センター、プロテオーム・医薬部門
  •   1997年,  - 2003年,  愛媛大学医学部(分子寄生虫学講座)
  •   1986年,  - 1997年,  愛媛大学医学部(寄生虫学講座)
  •   1981年,  - 1982年,  愛媛県温泉郡川内町国民健康保険診療所
  •   1980年,  - 1981年,  愛媛大学医学部附属病院

所属学協会

  • 日本寄生虫学会
  • 日本熱帯医学会
  • 日本感染症学会
  • アメリカ熱帯医学会(THE AMERICAN SOCIETY OF TROPICL MEDICINE AND HYGIENE)
  • 日本分子生物学会
  • 日本生化学会

委員歴

  •   1998年, 日本寄生虫学会, 評議員
  •   2007年, 日本寄生虫学会, 教育委員
  •   2009年, 日本寄生虫学会, プログラム委員
  •   2007年, 日本熱帯医学会, 編集委員

研究活動情報

研究キーワード

    マラリア, ワクチン, 無細胞タンパク質合成, 分子生物学

MISC

  • マラリアワクチン開発の現状
    臨床と微生物, (Vol. 29 (2)) 119 - 125,   2002年
  • マラリア伝搬阻止ワクチンの開発
    愛媛医学, (Vol. 18 (3)) 353 - 357,   1999年
  • マラリア感染の生物学
    Progress in Medicine, (Vol. 21) 325 - 329,   2001年
  • マラリア原虫の宿主細胞侵入における先端部小器官の役割
    愛媛医学, 12, (2) 145 - 151,   1993年
  • マンソン裂頭条虫擬充尾虫感染ハムスターの高中性脂肪血症の成因に関する研究
    愛媛医学, 5,   1986年
  • マンソン裂頭条虫擬充尾虫が産生する成長ホルモン様物質の特性
    寄生虫学雑誌, 42, (3) 185 - 192,   1993年
  • マンソン裂頭条虫断頭擬充尾虫の雄マウスに対する成長促進作用について
    寄生虫学雑誌, 33,   1984年
  • 高知県産サワガニにおける宮崎肺吸虫の寄生状況
    寄生虫学雑誌, 41, (5) 408 - 413,   1992年
  • ヒト寄生太平洋裂頭条虫の光顕及び走査電顕的研究
    寄生虫学雑誌, 42, (5) 422 - 428,   1993年
  • 愛媛県における恙虫の疫学的研究
    愛媛医学, 13, (1) 45 - 49,   1994年
  • Lipid metabolism in golden hamsters infected with plerocercoids of Spirometra erinacei
    Parasitology, 93,   1986年
  • Decrease of liver glycogen content in golden hamsters infected with plerocercoids of Spirometra erinacei
    Parasitology Research,   1991年
  • Mechanism of the hypertrglyceridemia induced by the infection with Spirometra erinacei plerocercoids in golden hamsters.
    Ehime Medical Journal, 5,   1986年
  • Growth-stimulating effect in male mice inoculatecl with headless fragments of Spirometra erinacei (Rudolphi, 1819)plerocercoids
    Japanese Journal of Parasitology, 33,   1984年
  • Effect of infection with Spirometra erinacei plerodcercoid on thyroid hormone in mice
    Parasitology Research, 74, (3) 262 - 266,   1988年
  • Carbohydrate metabolism in intact golden hamsters infected with plerocercoids of Spirometra erinacei (Cestoda : Diphyllobothriidae)
    Parasitology Research, 74, (2) 183 - 187,   1987年
  • Comparison of isozyme patterns between Spirometra erinncei and Spirometra mansonoids by isoelectric focusing
    journal of Parasitology, 78, (4) 735 - 738,   1992年
  • Incidence of the encysted larvae of Paragonimus miyazaki in the freshwater crab, Geothelphusa dehaani, collected in kochi Refecture, in Shikoku Region, Japan
    Japanese Journal of Parasitology, 41, (5) 408 - 413,   1992年
  • Light and scanning electron microscopy of Diphyllobothrium pacificum expelled from a man
    Japanese Journal of Parasitology, 42, (5) 422 - 428,   1993年
  • Geographical distribution of the lung fluke, Paragonimus miyazakii. in the eastern part of Yamaguchi Prefecture, Japan
    Bulletin of the Biogeographical Society of Japan, 48, (2) 35 - 39,   1993年
  • Characteristics of the growth hormone-like factor produced by plerocercoids of Spirometra erinacei
    Japanese Journal of Parasitology, 42, (3) 185 - 192,   1993年
  • Studies on the lung fluke, Paragonimus miyazaki, in Ehime Prefecture, Japan VIII. Survey of the second intermediate host, Geothelphusa dehaani, on the northern piedmont of Ishizuchi mountains
    Ehime Medical Journal, 12, (3) 406 - 410,   1993年
  • The first distributional record for (Paragonimus miyazakii)■.-. metacercarise in Fukushima Prefecture, Japan
    Japanese Journal of Parasitology, 43, (1) 35 - 37,   1994年
  • Hepatotrophic activity in mowe serum infected with plerocercoids of (Spirometra erinacei)■.-.
    Parasitology Research, 80,   1994年
  • Natural variation within the principal adhesion domain of the (Plasmodium vivax)■.-. Duffy binding protein
    Infection and Immunity, 62, (12) 5581 - 5586,   1994年
  • Epidemiological study of chigger mites in Ehime Prefecture, Japan
    13, (1) 45 - 49,   1994年
  • Incidence of paragonimus miyazakii Metacercariae in the Crab, Geothelphusa dehaani, Collected in Karoashi-gun, Shimane Prefecture, Japan
    Bulletin of the Biogeographical Society of Japan, 49, (1) 17 - 21,   1994年
  • Murine Complement reduces infectivity of Plasmodium yoelii to mosquitoes
    Infection and Immunity, 63, (9) 3702 - 3704,   1995年
  • Geographical distuibution of the lung fluke, Paragonimus miyazakii in the western part of Yamaguchi Prefecture, Japan
    Bulletin of the Biogeographical Society of Japan, 50,   1995年
  • (Plasmodium)■.-. (vivax)■.-. : Favored gene frequencies of the merozoite surface protein-1 and the multiplicity of infection in a malaria endemic region.
    Experimental Parasitology, 83,   1996年
  • Primary structure of a novel ookinete surface protein from (Plasmodium)■.-. (berghei)■.-..
    TSUBOI T, CAO Y‐M, KASLOW D C, SHIWAKU K, TORII M, Molecular and Biochemical Parasitology, 85, (1) 131 - 134,   1997年
  • Two antigens on zygotes and ookinetes of (Plasmodium)■.-. (yoelii)■.-. and (Plasmodium)■.-. (berghei)■.-. that are distinct targets of Transmission-blocking immunity
    Infection and Immunity, 65, (6) 2260 - 2264,   1997年
  • Comparison of (Plasmodium)■.-. (yoelii)■.-. ookinete surface antigens with human and avian malaria parasite homolognes reveals two highly conserved regions
    TSUBOI T, KASLOW D C, CAO Y‐M, SHIWAKU K, TORII M, Molecular and Biochemical Parasitology, 87, (1) 107 - 111,   1997年
  • Nitric oxide inhibits the development of (Plasmodium)■.-. (yoelii)■.-. gametocytes into gametes.
    CAO Y‐M, TSUBOI T, TORII M, Parasitology International, 47, (2) 157 - 166,   1998年
  • Geographical distribution of the lung fluke, (Paragonimus)■.-. (miyazakii)■.-., in the central part of Yamaguchi Prefecture, Japan.
    Bulletin of the Biogeographical Society of Japan, 53, (2) 49 - 54,   1998年
  • Infected host serum blocks transmission of (Plasmodium)■.-. (yoelii)■.-. via a nitric oxide-dependent mechanism.
    CAO Y‐M, TSUBOI T, LIU Y‐J, TORII M, Parasitology International, 47, (3) 225 - 232,   1998年
  • Sequence polymorphism in two novel (Plasmodium)■.-. (vivax)■.-. ookinete surface proteins, Pvs25 and Pvs28, that are malaria transmission-blocking vaccine candidates.
    Molecular Medicine, 4,   1998年
  • Stage-specific expression of heat shock protein 90 in murine malavia parasite (Plasmodium yoelii.)■.-.
    Experimental Parasitology, 93,   1999年
  • Gametocyte-dominant expression of a novel P-type ATPase in (Plasmodium yoelii.)■.-.
    Molecular Biochemical Parasitology, 104,   1999年
  • Micronemal transport of (Plasmodium)■.-. ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion.
    Infection and Immunity, 68, (11) 6461 - 6465,   2000年
  • Antibodies to malaria vaccine candidates Pvs25 and Pvs28 completely block the ability of (Plasmodium vivax)■.-. to infect mosquitoes
    Infection and Immunity, 68, (12) 6618 - 6623,   2000年
  • Conserved regions of the (Plasmodium yoelii)■.-. rhoptry protein RhopH3 revealed by comparison with the (P. falciparum)■.-. homologue
    Molecular and Biochemical Parasitology, 112,   2001年
  • Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2, in Plasmodium ovale.
    Mol. Biochem. Parasitol., (113) 341 - 344,   2001年
  • von Willebrand factor A domain-related protein, a novel microneme protein of the malaria ookinete highly conserved throughout Plasmodium parasites.
    Mol. Biochem. Parasitol., (116) 65 - 72,   2001年
  • Development of a method for the in vitro production of Plasmodium vivax ookinetes.
    J. Parasitol., (87) 928 - 930,   2001年
  • The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and P. yoelii.
    Mol. Biochem. Parasitol., (118) 223 - 231,   2001年
  • Gene structure and expression of a Plasmodium falciparum 220-kilodalton protein homologous to the Plasmodium vivax reticulocyte binding proteins.
    Mol. Biochem. Parasitol., (121(2)) 275 - 278,   2002年
  • Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins.
    Mol. Biochem. Parasitol., (122(2)) 223 - 226,   2002年
  • The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion.
    LING I T, FLORENS L, DLUZEWSKI A R, KANEKO O, GRAINGER M, TSUBOI T, HOPKINS J M, JOHNSON J R, MATTEI D, Molecular Microbiology, 52, (1) 107 - 118,   2004年
  • A rapid genotyping method for the Vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.
    TSUBOI T, KANEKO O, CAO Y‐M, TACHIBANA M, YAKUSHIJIN Y, NAGAO T, KANBARA H, TORII M, ElsevierParasitology International, 53, (3) 211 - 216,   2004年
  • Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite.
    ElsevierMolecular and Biochemical Parasitology, 140,   2005年
  • A rapid genotyping method for the Vivax malaria transmission-blocking vaccine candidates, Pvs25 and Pvs28.
    TSUBOI T, KANEKO O, CAO Y‐M, TACHIBANA M, YAKUSHIJIN Y, NAGAO T, KANBARA H, TORII M, ElsevierParasitology International, 53, (3) 211 - 216,   2004年
  • The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion.
    LING I T, FLORENS L, DLUZEWSKI A R, KANEKO O, GRAINGER M, TSUBOI T, HOPKINS J M, JOHNSON J R, MATTEI D, Molecular Microbiology, 52, (1) 107 - 118,   2004年
  • Transmission-blocking vaccine of vivax malaria.
    TSUBOI T, TACHIBANA M, KANEKO O, TORII M, ElsevierParasitology International, 52, (1) 1 - 11,   2003年
  • Characterisation of the rhoph 2 gene of Plasmodium falciparum and Plasmodium yoelii
    ElsevierMolecular and Biochemical Parasitology, 127, (1) 47 - 57,   2003年
  • Gene structure and ookinete expression of the chitirase genes of plasmodium vivax and Plasmodium yoelii.
    ElsevierMolecular and Biochemical Parasitology, 130, (1) 51 - 54,   2003年
  • Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins.
    ElsevierMolecular and Biochemical Parasitology, 122, (2) 223 - 226,   2002年
  • Gene structure and expression of a Plasmodium falciparum 220-kilodalton protein homologous to the Plasmodium vivax reticulocyte binding proteins
    ElsevierMolecular and Biochemical Parasitology, 121, (2) 275 - 278,   2002年
  • The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii.
    ElsevierMolecular and Biochemical Parasitology, 118, (2) 223 - 231,   2001年
  • Conserved Regions of the Plasmodium yoelii Rhoptry Protein RhopH3 Revealed by Comparison with the P. falciparum Homologue.
    ElsevierMolecular and Biochemical Parasitology, 112, (2) 297 - 299,   2001年
  • Presence of three distinct ookinete surface protein genes, Pos25, Pos28-1, and Pos28-2 in Plasmodium ovale.
    ElsevierMolecular and Biochemical Parasitology, 113, (2) 341 - 344,   2001年
  • 愛媛県で発症した最近のマラリア症例について
    愛媛医学会愛媛医学, 23, (4) 338 - 341,   2004年
  • Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex
    Molecular and Biochemical Parasitology, 143, (1) 20 - 28,   2005年
  • The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP.
    KANEKO Osamu, TEMPLETON Thomas J., IRIKO Hideyuki, IRIKO Hideyuki, TACHIBANA Mayumi, OTSUKI Hitoshi, TAKEO Satoru, SATTABONGKOT Jetsumon, TORII Motomi, TSUBOI Takafumi, TSUBOI Takafumi, ELSEVIERParasitology International, 55, (3) 227 - 231,   2006年
  • 2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei.
    ElsevierMol. Biochem. Parasitol., 148,   2006年
  • Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections
    Mol. Biochem. Parasitol., 150,   2006年
  • Detection of Four Plasmodium Species by Genus- and Species-Specific Loop-Mediated Isothermal Amplification for Clinical Diagnosis
    Journal of Clinical Microbiology, 45, (8) 2521 - 2528,   2007年
  • Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates.
    TSUBOI Takafumi, TAKEO Satoru, IRIKO Hideyuki, JIN Ling, TSUCHIMOCHI Masateru, MATSUDA Shusaku, HAN Eun‐Taek, OTSUKI Hitoshi, KANEKO Osamu, SATTABONGKOT Jetsumon, UDOMSANGPETCH Rachanee, SAWASAKI Tatsuya, TORII Motomi, ENDO Yaeta, American Society For MicrobiologyInfection and immunity, 76, (4) 1702 - 1708,   2008年
  • Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
    Molecular and Biochemical Parasitology, 151, (2) 216 - 219,   2007年
  • Reemerging vivax malaria: changing patterns of annual incidence and control programs in the Republic of Korea.
    Korean Journal of Parasitology, 44, (4) 285 - 294,   2006年
  • The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries.
    GHONEIM Ahmed, KANEKO Osamu, TSUBOI Takafumi, TSUBOI Takafumi, TORII Motomi, Parasitology International, 56, (1) 31 - 43,   2007年
  • Plasmodium berghei XAT: protective 155/160 kDa antigens are located in parasitophorous vacuoles of schizont-stage parasite.
    Experimental Parasitology, 116, (4) 450 - 457,   2007年
  • Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum.
    Molecular and Biochemical Parasitology, 158, (1) 11 - 21,   2008年
  • Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito.
    Molecular and Biochemical Parasitology, 159, (2) 142 - 145,   2008年
  • Control of cell wall assembly by a histone-like protein in Mycobacteria.
    KATSUBE Tomoya, MATSUMOTO Sohkichi, TAKATSUKA Masaki, OKUYAMA Megumi, OZEKI Yuriko, NAITO Mariko, NISHIUCHI Yukiko, FUJIWARA Nagatoshi, YOSHIMURA Mamiko, TSUBOI Takafumi, TORII Motomi, OSHITANI Nobuhide, ARAKAWA Tetsuo, KOBAYASHI Kazuo, Journal of Bacteriology, 189, (22) 8241 - 8249,   2007年
  • Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast
    MAEDA Takuya, SAITO Tomoya, HARB Omar S., ROOS David S., TAKEO Satoru, SUZUKI Hiroko, TSUBOI Takafumi, TAKEUCHI Tsutomu, ASAI Takashi, ElsevierParasitology International, 58, (1) 101 - 105,   2009年
  • Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.
    CAO Jun, CAO Jun, KANEKO Osamu, KANEKO Osamu, THONGKUKIATKUL Amporn, TACHIBANA Mayumi, OTSUKI Hitoshi, GAO Qi, TSUBOI Takafumi, TSUBOI Takafumi, TORII Motomi, ElseviorParasitology International, 58, (1) 29 - 35,   2009年
  • A small-scale systematic analysis of alternative splicing in Plasmodium falciparum.
    IRIKO Hideyuki, IRIKO Hideyuki, IRIKO Hideyuki, JIN Ling, JIN Ling, KANEKO Osamu, KANEKO Osamu, TAKEO Satoru, HAN Eun−taek, HAN Eun−taek, TACHIBANA Mayumi, OTSUKI Hitoshi, TORII Motomi, TSUBOI Takafumi, TSUBOI Takafumi, ElseviorParasitology International, 58, (2) 196 - 199,   2009年
  • Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus.
    Jpn J Infect Dis., 62,   2009年
  • Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.
    OTSUKI Hitoshi, KANEKO Osamu, KANEKO Osamu, THONGKUKIATKUL Amporn, THONGKUKIATKUL Amporn, TACHIBANA Mayumi, IRIKO Hideyuki, IRIKO Hideyuki, TAKEO Satoru, TSUBOI Takafumi, TORII Motomi, The Proceedings of the National Academy of Sciences USA (PNAS), 106, (17) 7167 - 7172,   2009年
  • Serodiagnostic applicability of recombinant antigens of Clonorchis sinensis expressed by wheat germ cell-free protein synthesis system
    ElsevierDiagnostic Microbiology and Infectious Disease, 64, (3) 334 - 339,   2009年
  • Enzymatic characterization of the Plasmodium vivax chitinase, a potential malaria transmission-blocking target
    TAKEO Satoru, HISAMORI Daisuke, MATSUDA Shusaku, VINETZ Joseph, SATTABONGKOT Jetsumon, TSUBOI Takafumi, TSUBOI Takafumi, ElsevierParasitology International, 58, (3) 243 - 248,   2009年
  • Sterile protection against Plasmodium knowlesi in Rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies
    Public Library of Science (PLoS), a nonprofit organizationPLoS ONE, 4,   2009年
  • Wheat germ cell-free technology for accelerating the malaria vaccine research
    Informa HealthcareExpert Opinion on Drug Discovery, 4, (11) 1191 - 1199,   2009年
  • Evidence for the transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa.
    University of Chicago PressJournal of Infectious Diseases, 200, (9) 1465 - 1469,   2009年
  • マラリアワクチンの開発—ポストゲノムマラリアワクチン研究
    医学のあゆみ, 229, (4) 252 - 256,   2009年
  • ポストゲノムマラリアワクチン抗原探索の切り札—コムギ胚芽無細胞蛋白質合成法
    共立出版蛋白質 核酸 酵素, 54, (8) 1041 - 1046,   2009年
  • The wheat germ cell-free protein synthesis system: A key tool for novel malaria vaccine candidate discovery
    TSUBOI T., TAKEO S., ARUMUGAM T.U., OTSUKI H., TORII M., ElsevierActa Tropica, 114, (3) 171 - 176,   2010年

書籍等出版物

作品

  • 無細胞タンパク質合成系の保健衛生および畜産分野への応用
      2005年 - 2007年

受賞

  •   1985年, 第32回日本栄養改善学会賞
  •   1993年, 第1回愛媛医学会賞
  •   2006年, 第53回小泉賞

競争的資金



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