研究者データベース

重松 裕二シゲマツ ユウジ

所属部署名大学院医学系研究科 看護学専攻
職名教授
Last Updated :2019/08/19

研究者基本情報

基本情報

氏名

  • 氏名

    重松 裕二
  • 氏名(カナ)

    シゲマツ ユウジ

所属

所属・職名

  • 部署

    大学院医学系研究科 看護学専攻
  • 職名

    教授

学歴等

学位

  • 医学

その他基本情報

経歴

  • 20050000, 20060000,  愛媛大学医学部看護学
  • 20050000, 20060000

研究活動情報

研究分野等

研究キーワード

  • 高血圧症
  • 左室肥大
  • 標的臓器障害
  • インスリン抵抗性

著書・発表論文等

書籍等出版物

講演・口頭発表等

  • PE-439 Comparison of the Prognosis in Patients with Hypertrophic Obstructive Cardiomyopathy Between Before and After the Treatment with Antiarrhythmic Drug, Cibenzoline(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd An, Hamada Mareomi, Izumi Naoki, Yamane Kenichi, Ohshima Kousei, Ishibashi Ken, Ohshima Kiyotaka, Ikeda Shuntaro, Shigematsu Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20090301
  • FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Aono Jun, Fujita Teppei, Sasaki Kaori, Seike Fumiyasu, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20090301
  • 38) 肥大型心筋症における心臓MRIの遅延造影像とRadial strainの関連(第92回日本循環器学会中国・四国合同地方会), 齋藤 実, 岡山 英樹, 西村 和久, 井上 勝次, 鈴木 純, 大木元 明義, 大塚 知明, 井上 祐馬, 倉田 聖, 東野 博, 望月 輝一, 本田 俊雄, 貞本 和彦, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20081020
  • PJ-913 Radial strain as a possible parameter of the extent of the delayed-enhacement in patients with hypertrophic cardiomyopathy(MRI / MRA(04)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Saitoh Makoto, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Yoshii Toyofumi, Inoue Katsuji, Hiasa Go, Sumimoto Takumi, Inoue Yuuma, Higashino Hiroshi, Mochizuki Teruhito, Honnda Toshio, Sadamoto Kazuhiko, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Saitoh Makoto, Uetani Teruyoshi, Izoe Yosuke, Fujita Teppei, Shimizu Hideaki, Shigematsu Yuji, Hamada Mareomi, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OJ-117 The effect of cibenzoline in patients with hypertrophic obstructive cardiomyopathy-Insights from changes In left ventricular regional-temporal heterogeneity(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd Annual Scient, Saitoh Makoto, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Yoshii Toyofumi, Inoue Katsuji, Hiasa Go, Sumimoto Takumi, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Suzuki Jun, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20080301
  • A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy., NAGAI Takayuki, OGIMOTO Akiyoshi, OKAYAMA Hideki, OHTSUKA Tomoaki, SHIGEMATSU Yuji, HAMADA Mareomi, MIKI Tetsuro, HIGAKI Jitsuo, Circulation Journal, 20071120, Background It was recently suggested that the angiotensin-converting enzyme insertion/insertion genotype, which is considered to be protective against cardiovascular disease, was a significant risk factor for atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to investigate the association between the endothelin-2 (EDN2) A985G polymorphism and AF in patients with HCM. Methods and Results The EDN2 A985G polymorphism (rs 5800) was genotyped in 110 patients with HCM who had no clinically documented AF before medical treatment. The distribution of the EDN2 genotypes (G/G, G/A, and A/A) was 77.3%, 19.1%, and 3.6%, respectively. The EDN2 A allele frequency was 0.21 in 26 patients who subsequently developed AF during long-term follow-up and 0.11 in 84 patients who remained in sinus rhythm. The distribution of genotypes of the dominant EDN2 A allele between the two groups was significantly different by chi-square analysis (42.3% vs 16.7%, p=0.014). In a multivariate model, the A985 allele of the EDN2 gene was associated with increased adjusted risk for the occurrence of AF (p=0.018). Conclusion The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for AF in patients with HCM. (Circ J 2007; 71: 1932 - 1936)
  • 144)経胸壁ドプラ心エコー図で左冠動脈近位部のmosaic血流が診断に有用であった不安定狭心症の1例(第90回日本循環器学会中国・四国合同地方会), 大木元 明義, 岡山 英樹, 大塚 知明, 倉田 聖, 西村 和久, 永井 啓行, 稲葉 慎二, 齋藤 実, 上谷 晃由, 井添 洋輔, 藤田 鉄平, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20071020
  • 191)Bentall術後23年目の偽性大動脈瘤に再手術を施行した大動脈炎症候群の1例(第90回日本循環器学会中国・四国合同地方会), 井添 洋輔, 大木元 明義, 岡山 英樹, 大塚 知明, 倉田 聖, 西村 和久, 永井 啓行, 稲葉 慎二, 齋藤 実, 上谷 晃由, 藤田 鉄平, 重松 裕二, 檜垣 實男, 青見 茂之, Circulation journal : official journal of the Japanese Circulation Society, 20071020
  • 尿酸ナトリウム結晶を吸着物質とするIgM精製法, 岩田 英信, 重松 裕二, 金子 希代子, 痛風と核酸代謝 = Gout and nucleic acid metabolism, 20070701
  • PE-212 T-182C Polymorphism of the Norepinephrine Transporter (SLC6A2) Gene and Cardiovascular Events in Patients with Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Kurata Akira, Nishimura Kazuhisa, Nagai Takayuki, Inaba Shinji, Saito Makoto, Uetani Teruyoshi, Izoe Yosuke, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • OJ-053 Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Affects Left Ventricular Pressure Gradient Response to Cibenzoline in Patients with Hypertrophic Obstructive Cardiomyopathy(Cardiomyopathy, basic/clinical-2, The 71st Annual Scientific M, Nagai Takayuki, Ogimoto Akiyoshi, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • OJ-052 Association between Endothelin-2 A985G Polymorphism and Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Nagai Takayuki, Ogimoto Akiyoshi, Okayama Hideki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • FRS-085 Association between G674A Polymorphism of the Connexin 40.1 Gene and Atrial Fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia (clinical) ; Pathophysiology of Atrial Fibrillation, The 71st Annual Scientific Meeting of the Japanese Cir, Ogimoto Akiyoshi, Okayama Hideki, Nagai Takayuki, Nishimura Kazuhisa, Kurata Akira, Ohtsuka Tomoaki, Inaba Shinji, Saito Makoto, Uetani Teruyoshi, Izoe Yosuke, Shigematsu Yuji, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20070301
  • 16)経胸壁心エコーににて左主幹部のacceleration flowが検出された1例(第87回日本循環器学会中国・四国合同地方会), 泉 直樹, 廣瀬 典子, 齋藤 実, 吉井 豊史, 長谷部 靖子, 大下 晃, 倉田 聖, 大木元 明義, 大塚 知明, 岡山 英樹, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20060420
  • 248)収縮性心外膜炎の1例 : 各種診断法における拘束性心筋症との鑑別診断について(第87回日本循環器学会中国・四国合同地方会), 酒井 恵理子, 大木元 明義, 岡山 英樹, 大塚 知明, 倉田 聖, 吉井 豊史, 大下 晃, 斎藤 実, 上谷 晃由, 長谷部 靖子, 廣瀬 典子, 重松 裕二, 檜垣 實男, 西山 誠一, Circulation journal : official journal of the Japanese Circulation Society, 20060420
  • 128)生体肝移植後の肝動脈狭窄にPTAを施行した1例(第87回日本循環器学会中国・四国合同地方会), 齋藤 実, 廣瀬 典子, 上谷 晃由, 長谷部 靖子, 吉井 豊史, 大下 晃, 倉田 聖, 大木元 明義, 大塚 知明, 岡山 英樹, 重松 裕二, 檜垣 實男, 藤山 泰二, 福原 稔之, Circulation journal : official journal of the Japanese Circulation Society, 20060420
  • PJ-227 Small Left Ventricular Cavity as a Risk Factor for Drug Tolerance of Renin-Angiotensin System Inhibitors in Patients with Hypertension(Hypertension, clinical-9 (H) PJ38,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the, Ogimoto Akiyoshi, Okayama Hideki, Ohtsuka Tomoaki, Kurata Akira, Yoshii Toyofumi, Oshita Akira, Saito Makoto, Uetani Teruyoshi, Hirose Noriko, Hasebe Yasuko, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20060301
  • ミルリノンが著効した超高齢者難治性心不全の1例(第86回日本循環器学会四国地方会), 吉井 豊史, 大塚 知明, 廣瀬 典子, 大下 晃, 倉田 聖, 森岡 紀勝, 井上 勝次, 大木元 明義, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20051020
  • 高齢者PDA症例に対するカテーテルコイル塞栓術の治療経験(第86回日本循環器学会四国地方会), 廣瀬 典子, 大塚 知明, 大下 晃, 吉井 豊史, 倉田 聖, 森岡 紀勝, 井上 勝次, 大木元 明義, 原 裕二, 重松 裕二, 檜垣 實男, 高田 秀実, 村上 至孝, 檜垣 高史, Circulation journal : official journal of the Japanese Circulation Society, 20051020
  • 重篤な不整脈を呈し, 心サルコイドーシスによる重症拡張型心筋症と思われた1例(第86回日本循環器学会四国地方会), 大木元 明義, 重松 裕二, 原 裕二, 大塚 知明, 井上 勝次, 森岡 紀勝, 倉田 聖, 吉井 豊史, 大下 晃, 森 英城, 広瀬 典子, 檜垣 實男, 平松 伸一, 石戸谷 浩, 堀 隆樹, 武内 克介, Circulation journal : official journal of the Japanese Circulation Society, 20051020
  • Sex-Related Differences in Relation of Insulin Resistance to Left Ventricular Geometry in Patients With Essential Hypertension(Hypertension, Clinical 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Ohshita Akira, Yoshii Toyofumi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Short-Term Effect of Amiodarone on Inflammatory Markers and Left Ventricular Function in Patients with Advanced Heart Failure Receiving Carvedilol(Heart Failure, Clinical 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Ohtsuka Tomoaki, Hirose Noriko, Mori Hideki, Ohshita Akira, Yoshii Toyofumi, Kurata Akira, Morioka Norikatsu, Inoue KATSUJI, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Evaluation of Pulmonary Venous Stenoses by Multi-slice Computed Tomography in Children with Congenital Heart Disease(X-ray/CT/MRI/DSA 1 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Kurata Akira, Higaki Takashi, Murakami Yoshitaka, Mochizuki Teruhito, Miyagawa Masao, Higashino Hiroshi, Haraikawa Toyoaki, Kido Teruhito, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Koyama Yasushi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Thallium-201 Myocardial Scintigraphy for Prediction of Prognosis in Patients with Dilated Cardiomyopathy Treated with Beta-blocker(Nuclear Cardiology 2 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Ohshita Akira, Yoshii Toyofumi, Mori Hideki, Hirose Noriko, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Relations of Uric Acid to Demographic, Left Ventricular Geometric and Renal Variables in Patients with Essential Hypertension(Hypertension, Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Yoshii Toyofumi, Ohshita Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Prognostic Impact of Myocardial Microvascular Integrity in Patients With Hypertrophic Cardiomyopathy(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Inoue Katsuji, Hirose Noriko, Mori Hideki, Ohshita Akira, Yoshii Toyofumi, Kurata Akira, Morioka Norikatsu, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Hamada Mareomi, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Endothelial Nitric Oxide Synthase Polymorphism (Glu298Asp) on Cardiovascular Events for Patients with Hypertrophic Cardiomyopathy(Myocardial Disease, Cardiomyopathy and Myocarditis (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ, Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Inoue Katsuji, Morioka Norikatsu, Kurata Akira, Yoshii Toyofumi, Ohshita Akira, Mori Hideki, Nakura Jun, Hamada Mareomi, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Assessment of Myocardial Ischemia by Adenosine 5-triphosphate Stress Multi-slice Computed Tomography : Alternative to Stress Myocardial Perfusion Scintigraphy(Recent Advance in Cardiovascular Imaging Technique (X-ray/CT/MRI/DSA) (I), The 69th Annual Scien, Kurata Akira, Hirose Noriko, Mori Hideki, Oshita Akira, Yoshii Toyofumi, Morioka Norikatsu, Inoue Katsuji, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Kido Teruhito, Haraikawa Toyoaki, Higashino Hroshi, Koyama Yasushi, Mochizuki Teruhito, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • Image Fusion of Coronary Tree and Left Ventricular Function Using 16-MSCT(Recent Advance in Cardiovascular Imaging Technique (X-ray/CT/MRI/DSA) (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Higashino Hiroshi, Haraikawa Toyoaki, Kurat Akira, Kido Teruhito, Koyama Yasushi, Miyagawa Masao, Shigematsu Yuji, Higaki Jitsuo, Mochizuki Teruhito, Circulation journal : official journal of the Japanese Circulation Society, 20050301
  • 47) 拡張型心筋症における心筋組織性状および左室内dyssynchronyに対するカルベジロールの効果(第84回日本循環器学会四国地方会), 井上 勝次, 大塚 知明, 大下 晃, 吉井 豊史, 倉田 聖, 森岡 紀勝, 大島 清孝, 鈴木 純, 大木元 明義, 舩田 淳一, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20041020
  • 46) Amiodarone低用量療法により心機能の改善を認めた難治性心不全合併拡張型心筋症の1例(第84回日本循環器学会四国地方会), 長尾 知明, 大塚 知明, 大下 晃, 吉井 豊史, 倉田 聖, 森岡 紀勝, 井上 勝次, 鈴木 純, 大木元 明義, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20041020
  • 27) 大動脈弁輪拡張症に合併した左心耳瘤の1例(第84回日本循環器学会四国地方会), 倉田 聖, 大蔵 隆文, 大下 晃, 吉井 豊史, 大島 清孝, 森岡 紀勝, 井上 勝次, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20041020
  • 16) 冠動脈起始異常による狭心症の1例(第84回日本循環器学会四国地方会), 三好 誠吾, 原 裕二, 重松 裕二, 大塚 知明, 大木元 明義, 鈴木 純, 井上 勝次, 大島 清孝, 森岡 紀勝, 倉田 聖, 大下 晃, 吉井 豊史, 大蔵 隆文, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20041020
  • 175) 経静脈性心筋コントラストエコー法を用いた肥大型心筋症における心内膜下心筋血液量の検討(第83回日本循環器学会中国・四国合同地方会), 井上 勝次, 大下 晃, 倉田 聖, 森岡 紀勝, 大島 清孝, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, 濱田 希臣, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • 174) 心エコー図を用いた非閉塞性肥大型心筋症の心房細動の予測(第83回日本循環器学会中国・四国合同地方会), 大島 清孝, 大下 晃, 倉田 聖, 森岡 紀勝, 井上 勝次, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • 128) Multidetector-row CT(MDCT)が治療戦略を決める上で有用であった胃潰瘍合併の二例(第83回日本循環器学会中国・四国合同地方会), 倉田 聖, 原 裕二, 大下 晃, 井上 勝次, 大島 清孝, 森岡 紀勝, 鈴木 純, 大木元 明義, 大塚 知明, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • 58) 拡張型心筋症におけるβ遮断薬療法の効果 : 脳性ナトリウム利尿ペプチド低値群と高値群との比較(第83回日本循環器学会中国・四国合同地方会), 原 裕二, 重松 裕二, 大塚 知明, 大木元 明義, 鈴木 純, 井上 勝次, 大島 清孝, 森岡 紀勝, 倉田 聖, 大下 晃, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • 52) 広範な心筋維化に伴い難治性心不全を呈した心サルコイドーシスの一剖検例(第83回日本循環器学会中国・四国合同地方会), 城徳 昌典, 大塚 知明, 大下 晃, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 鈴木 純, 大木元 明義, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • 16) 拡張型心筋症様の左室拡大とび慢性壁運動低下を認めた多枝冠攣縮性狭心症の一例(第83回日本循環器学会中国・四国合同地方会), 鈴木 純, 大下 晃, 倉田 聖, 大島 清孝, 森岡 紀勝, 井上 勝次, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20040420
  • PE-274 Serum Marker of Angiogenesis and Myocardial Ultrasonic Tissue Characterization in Patients with Idiopathic Dilated Cardiomyopathy(Cardiomyopathy, Clinical 2 (M) : PE47)(Poster Session (English)), Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-595 Myocardial damage on Thallium-201 scintigraphy and prognosis in patients with dilated cardiomyopathy treated with beta-blocker(Cardiomyopathy, Clinical 7 (M) : PJ100)(Poster Session (Japanese)), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Ohshita Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-427 Cibenzoline can Attenuate LV Diastolic Functions According to the Reduction of LV Diastolic Pressures in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, Clinical 5 (M) : PJ71)(Poster Session (Japanese)), Hamada Mareomi, Ikeda Shuntaro, Watanabe Koki, Suzuki Jun, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-423 Increased Circulating Levels of Heart-Type Fatty Acid-Binding Protein in Patients with Hypertrophic Cardiomyopathy : its Relation to the Thallium-201 Perfusion Defects(Cardiomyopathy, Clinical 5 (M) : PJ71)(Poster Session (Japanese)), Morioka Norikatsu, Shigematsu Yuji, Ohshita Akira, Kurata Akira, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-415 Brain natriuretic peptide is a potent prognostic variable in hemodialysis patients without cardiac dysfunction(Kidney/Renal Circulation 2 (H) : PJ69)(Poster Session (Japanese)), Hara Yuji, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Murakami Bonpei, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • PJ-121 Genetic Predisposition to Hypertension Versus Insulin Resistance as Risk Factors for Hypertensive Left Ventricular Hypertrophy(Hypertension, Clinical 2 (H) : PJ20)(Poster Session (Japanese)), Shigematsu Yuji, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-391 Prognostic Impact of Myocardial Microvascular Integrity in Patients With Idiopathic Dilated Cardiomyopathy(Echo/Doppler 13 (I) : OJ47)(Oral Presentation (Japanese)), Inoue Katsuji, Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-275 Effect of Carvedilol on Myocardial Microvascular Integrity and Cardiac Function in Patients With Idiopathic Dilated Cardiomyopathy(Echo/Doppler 10 (I) : OJ32)(Oral Presentation (Japanese)), Inoue Katsuji, Ohtsuka Tomoaki, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Ohshima Kiyotaka, Suzuki Jun, Ogimoto Akiyoshi, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-247 Determination of Left Ventricular Mass and Coronary Blood Flow in Hypertensive Patients with Negative T Wave on Electrocardiogram(Hypertension, Clinical 5 (H) : OJ29)(Oral Presentation (Japanese)), Hamada Mareomi, Inaba Shinji, Komatsu Jiro, Ikeda Shuntaro, Watanabe Koki, Shigematsu Yuji, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-224 Effect of the GNB3 Gene Variant on Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy(Cardiomyopathy, Clinical 1 (M) : OJ26)(Oral Presentation (Japanese)), Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Ohshita Akira, Nakura Jun, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OJ-160 Relationship between Myocardial Fibrosis and the Circulating Levels of Myocardial Collagen Markers(X-ray/CT/MRI/DSA2 (I) : OJ19)(Oral Presentation (Japanese)), Matsunaka Tsuyoshi, Hamada Mareomi, Matsumoto Yuji, Takada Yasuharu, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Higaki Jitsuo, Koyama Yasushi, Kawakami Hideo, Matsuoka Hiroshi, Itoh Taketoshi, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OE-298 Atrial Fibrillation in Patients with Hypertrophic Non-obstructive Cardiomyopathyls Associated with Low Left Ventricular Peak Wall Stress(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English)), Ohshima Kiyotaka, Shigematsu Yuji, Ohshita Akira, Kurata Akira, Morioka Norikatsu, Inoue Katsuji, Suzuki Jun, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Hara Yuji, Higaki Jitsuo, Hamada Mareomi, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • OE-117 Eplerenone, a Selective Aldosterone Receptor Antagonist, Inhibits Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English)), Suzuki Jun, Iwai Masaru, Ohtsuka Tomoaki, Hara Yuji, Shigematsu Yuji, Higaki Jitsuo, Horiuchi Masatsugu, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • FRS-082 Endothelial Nitric Oxide Synthase Gene Polymorphism (Glu298Asp) in Patients with Coexistent Hypertrophic Cardiomyopathy and Coronary Vasospasm(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English)), Ogimoto Akiyoshi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Ohshita Akira, Hamada Mareomi, Nakura Jun, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20040301
  • 難聴が確定診断のきっかけとなった大動脈炎症候群の1例(第82回日本循環器学会四国地方会), 井上 勝次, 濱田 希臣, 倉田 聖, 森岡 紀勝, 大島 清孝, 松中 豪, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • エストロゲン受容体拮抗薬Tamoxifenに伴う二次性拡張型心筋症の1例(第82回日本循環器学会四国地方会), 井添 洋輔, 大塚 知明, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 松中 豪, 鈴木 純, 大木元 明義, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • 心房細動を合併した肥大型心筋症における微小心筋傷害の検出 : 心臓由来脂肪酸結合蛋白を用いて(第82回日本循環器学会四国地方会), 森岡 紀勝, 倉田 聖, 大島 清孝, 井上 勝次, 松中 豪, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • 頚動脈波一次微分を用いた肥大型閉塞性心筋症の検討(第82回日本循環器学会四国地方会), 大島 清孝, 濱田 希臣, 倉田 聖, 森岡 紀勝, 井上 勝次, 鈴木 純, 松中 豪, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • 肥大型心筋症における脳性利尿ペプチト値の規定因子についての検討(第82回日本循環器学会四国地方会), 松中 豪, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, 松本 有司, 高田 泰治, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • 興味ある心電図変化を認めた肥大型心筋症に心筋梗塞を合併した一例(第82回日本循環器学会四国地方会), 山下 嘉郎, 原 裕二, 濱田 希臣, 重松 裕二, 大塚 知明, 大木元 明義, 松中 豪, 鈴木 純, 井上 勝次, 大島 清孝, 森岡 紀勝, 倉田 聖, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • シベンゾリン治療中に著明な圧較差の上昇を認め,心房細動を併発した肥大型閉塞性心筋症の1例(第82回日本循環器学会四国地方会), 坂上 智城, 大塚 知明, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 松中 豪, 鈴木 純, 大木元 明義, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20031020
  • 189)僧帽弁狭窄と左室内圧較差を呈した心臓平滑筋肉腫の1例, 大木元 明義, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, 濱田 良宏, 今川 弘, 河内 寛治, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 161)肥大型非閉塞型心筋症における頚動脈波の特徴, 大島 清孝, 倉田 聖, 森岡 紀勝, 井上 勝次, 鈴木 純, 松中 豪, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 160)肥大型心筋症における死亡原因頻度の検討 : 突然死と心不全, 倉田 聖, 濱田 希臣, 重松 裕二, 原 裕二, 大塚 知明, 大木元 明義, 松中 豪, 鈴木 純, 井上 勝次, 大島 清孝, 森岡 紀勝, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 158)拡張型心筋症における心筋組織性状と心機能の関連について : Integrated Backscatterを用いた検討, 井上 勝次, 濱田 希臣, 倉田 聖, 森岡 紀勝, 大島 清孝, 鈴木 純, 松中 豪, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 115)非対称性中隔肥大を認め,弁置換術後に著明な心肥大の退縮を認めた大動脈弁狭窄症の1例, 榎本 大次郎, 大塚 知明, 倉田 聖, 森岡 紀勝, 井上 勝次, 大島 清孝, 鈴木 純, 松中 豪, 大木元 明義, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, 三根生 和明, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 57)本態性高血圧患者における大動脈コンプライアンスとインスリン抵抗性の関係, 森岡 紀勝, 重松 裕二, 倉田 聖, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 大木元 明義, 大塚 知明, 原 裕二, 濱田 希臣, 檜垣 實男, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 53)ウロキナーゼ持続静注療法が著効した慢性肺血栓塞栓症の1例, 森岡 紀勝, 上谷 晃由, 大塚 知明, 重松 裕二, 原 裕二, 佐伯 秀幸, 鈴木 純, 大木元 明義, 井上 勝次, 大島 清孝, 森 英城, 濱田 希臣, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 85)MCE及び心筋IBSが心筋組織性状診断に有用であった心サルコイドーシスの1例, 井上 勝次, 濱田 希臣, 森 英城, 森岡 紀勝, 大島 清孝, 松中 豪, 鈴木 純, 大木元 明義, 佐伯 秀幸, 大塚 知明, 原 裕二, 重松 裕二, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 31)心サルコイドーシスの治療効果判定にCardiac perfusion MRIが有用であった1例, 松中 豪, 倉田 聖, 森岡 紀勝, 大島 清孝, 井上 勝次, 鈴木 純, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 檜垣 實男, 松本 有司, 高田 泰治, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 38)トロポニンT遺伝子(TNNT2,G/u 116Val)に変異を認めた肥大型心筋症の1例, 大木元 明義, 濱田 希臣, 森 英城, 森岡 紀勝, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 佐伯 秀幸, 大塚 知明, 原 裕二, 重松 裕二, 三木 哲郎, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 4)冠動脈内ステント留置後,ステント内再狭窄を繰り返し,治療に難渋した金属(マンガン)アレルギーの1例, 上谷 晃由, 大塚 知明, 重松 裕二, 原 裕二, 佐伯 秀幸, 鈴木 純, 大木元 明義, 井上 勝次, 大島 清孝, 森岡 紀勝, 森 秀城, 濱田 希臣, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 31)MCEでβ遮断薬療法による冠微小循環障害の改善効果を確認し得た拡張型心筋症の2例, 井上 勝次, 濱田 希臣, 森 英城, 森岡 紀勝, 大島 清孝, 松中 豪, 鈴木 純, 大木元 明義, 佐伯 秀幸, 大塚 知明, 原 裕二, 重松 裕二, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • 32)β遮断薬療法としてメトプロロールで失敗したが,カルベジロールが導入できた拡張型心筋症の1例, 斎藤 実, 原 裕二, 重松 裕二, 大塚 知明, 佐伯 秀幸, 鈴木 純, 大木元 明義, 井上 勝次, 大島 清孝, 森 英城, 濱田 希臣, Circulation journal : official journal of the Japanese Circulation Society, 20030420
  • Subendocardial Microvasucular Abnormalities in Patients with Hypertrophic Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Contribution of Genetic Predispositions to Hypertension to Left Ventricular Hypertrophy Is Mediated by Insulin Resistance, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Aortic Compliance in Essential Hypertension Is Associated with Insulin Resistance Metabolic Syndrome, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Renin Profile and Coronary Endothelium-Dependent Vasodilation in Essential Hypertension, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Effect of Beta-Blocker Therapy on Thallium-201 Perfusion Defects in Patients with Dilated Cardiomyopathy, Hara Yuji, Hamada Mareomi, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Brain Natriuretic Peptide Level Can Differentiate Patients with Essential Hypertension from Patients with Hypertensive Hypertrophic Cardiomyopathy, Suzuki Jun, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Inoue Katsuji, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Myocardial Structural Abnormalities Contribute to Left Ventricular Enlargement and Dysfunction in Patients with Dilated Cardiomyopathy ; Usefulness of Ultrasonic Tissue Characterization, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Myocardial Fibrosis Using Gadolinium-DTPA Enhanced Magnetic Resonance Imaging and Left Ventricular Function in Hypertrophic Cardiomyopathy, Matsunaka Tsuyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Matsumoto Yuuji, Takada Yasuharu, Matsuoka Hiroshi, Kawakami Hideo, Koyama Yasushi, Itoh Taketoshi, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Long-Term Effects of Carvedilol Versus Metoprolol on Left Ventricular Function, Remodeling and Neurohumoral Factors in Patients with Idiopathic Dilated Cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Microvascular Damage Contributes to the Left Ventricular Dysfunction in Patients with Idiopathic Dilated Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Inoue Katsuji, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relationship between Circulating Interleukin-13 and Left Ventricular Remodeling in Patients with Idiopathic Dilated Cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Relation between Angiotensin-Converting Enzyme II Genotype and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy, Ogimoto Akiyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Morioka Norikatsu, Ohshima Kiyotaka, Kurata Akira, Miki Tetsuro, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • Heart Failure Is the Highest Incidence of Cardiovascular Events and Deaths in Patients with Hypertrophic Cardiomyopathy : A 14-Year Follow-Up Study, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Inoue Katsuji, Matsunaka Tsuyoshi, Ohshima Kiyotaka, Morioka Norikatsu, Kurata Akira, Higaki Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 20030301
  • 157)コハク酸シベンゾリンの内服により低血糖症状の増悪を認めた肥大型非閉塞性心筋症の1症例(日本循環器学会 第79回中国四国地方会), 森 英城, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 佐伯 秀幸, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 94)重症大動脈弁閉鎖不全症を認めた若年者大動脈弁二尖弁の1例(日本循環器学会 第79回中国四国地方会), 松中 豪, 森 英城, 大島 清孝, 井上 勝次, 鈴木 純, 佐伯 秀幸, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 河内 寛治, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 52)トロポニンI遺伝子(TNNI3,IVS6 : -24〜-22del)に遺伝子変異を認めた心尖部肥大型心筋症の1例(日本循環器学会 第79回中国四国地方会), 大木元 明義, 森 英城, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 佐伯 秀幸, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 名倉 潤, 三木 哲郎, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 42)心室中部閉塞性心筋症における頸動脈波形の特徴(日本循環器学会 第79回中国四国地方会), 大島 清孝, 濱田 希臣, 重松 裕二, 原 裕二, 大塚 知明, 井上 勝次, 鈴木 純, 松中 豪, 佐伯 秀幸, 大木元 明義, 森 英城, 日和田 邦男, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 40)高周波カテーテルアブレーションとシベンゾリンの併用療法が左室内圧較差の軽減に有効であったWPW症候群合併肥大型閉塞性心筋症の1例(日本循環器学会 第79回中国四国地方会), 上谷 晃由, 大塚 知明, 佐藤 真, 森 英城, 大島 清孝, 井上 勝次, 鈴木 純, 松中 豪, 佐伯 秀幸, 大木元 明義, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 立野 博也, 風谷 幸男, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 27)経静脈性心筋コントラストエコーが左室リモデリングの予測に有用であった急性心筋梗塞の2例(日本循環器学会 第79回中国四国地方会), 井上 勝次, 森 英城, 大島 清孝, 鈴木 純, 松中 豪, 佐伯 秀幸, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • 9)アンジオテンシンII受容体拮抗薬カンデサルタンはラット急性虚血再灌流心においてアポトーシスを増加させる(日本循環器学会 第79回中国四国地方会), 重松 裕二, 大塚 知明, 原 裕二, 濱田 希臣, 日和田 邦男, Circulation journal : official journal of the Japanese Circulation Society, 20020420
  • Assessment of Microvascular Integrity by Intravenous Myocardial Contrast Echocardiography in Patients With Hypertrophic Cardiomyopathy, Inoue Katsuji, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Association of Monocyte Chemoattractant Protein 1 (MCP-1) Gene Polymorphism With Susceptibility to Dilated Cardiomyopathy, Ogimoto Akivoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Nakura Jun, Kohara Katsuhiko, Tabara Yasuharu, Miki Tetsuro, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Circulating levels of insulin-like growth factor-I and its binding proteins in patients with hypertrophic cardiomyopathy, Saeki Hideyuki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Insulin resistance and tumor necrosis factor- α in patients with dilated cardiomyopathy : effect of beta-blocker, Hara Yuji, Hamada Mareomi, Shigematsu Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunjo, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Relation Between Angiotensin-Converting Enzyme II Genotype and Atrial Fibrillation in Japanese Patients With Hypertrophic Cardiomyopathy, Ogimoto Akiyoshi, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunjo, Nakura Jun, Miki Tetsuro, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Relationship between insulin resistance and coronary endothelium-dependent vasodilation in essential hypertension, Shigematsu Yuji, Hamada Mareomi, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Tumor necrosis factor-alpha and matrix metalloproteinase activity in patients with idiopathic dilated cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Increased Circulating Levels of Procollagen Peptides in Patients with Hypertrophic Cardiomyopathy, Saeki Hideyuki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Suzuki Jun, Matsunaka Tsuyoshi, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Effect of carvedilol on cardiac matrix remodeling in patients with idiopathic dilated cardiomyopathy, Ohtsuka Tomoaki, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • Ten-year follow-up study of thallium-201 myocardial scintigraphy in 104 patients with hypertrophic cardiomyopathy, Hamada Mareomi, Shigematsu Yuji, Hara Yuji, Ohtsuka Tomoaki, Ogimoto Akiyoshi, Saeki Hideyuki, Matsunaka Tsuyoshi, Suzuki Jun, Inoue Katsuji, Ohshima Kiyotaka, Mori Hideki, Hiwada Kunio, Circulation journal : official journal of the Japanese Circulation Society, 20020331
  • 92) 当院における過去10年間の冠動脈先天異常の経験(日本循環器学会 第78回四国地方会), 佐藤 真, 大塚 知明, 鈴木 純, 松中 豪, 大木元 明義, 佐伯 秀幸, 日浅 豪, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20011020
  • 47) WPW症候群を合併した肥大型心筋症の臨床像(日本循環器学会 第78回四国地方会), 重松 裕二, 鈴木 純, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 原 裕二, 松中 豪, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20011020
  • 46) 肥大型閉塞性心筋症患者のQTc時間に及ぼすシベンゾリンの影響(日本循環器学会 第78回四国地方会), 鈴木 純, 濱田 希臣, 重松 裕二, 原 裕二, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 松中 豪, 日和田 邦男, Japanese circulation journal, 20011020
  • 40) カルシウム拮抗薬の投与により左室内圧較差が増大した肥大型閉塞性心筋症の1例(日本循環器学会 第78回四国地方会), 日浅 豪, 濱田 希臣, 松中 豪, 鈴木 純, 佐伯 秀幸, 大木元 明義, 大塚 知明, 濱田 泰伸, 原 裕二, 重松 裕二, 日和田 邦男, 川上 秀生, 伊藤 武俊, 松岡 宏, 小山 靖史, 井上 勝次, 西村 和久, Japanese circulation journal, 20011020
  • 31) 僧帽弁置換術後ワーファリン内服中に脳出血を繰りかえした1例(日本循環器学会 第78回四国地方会), 大木元 明義, 鈴木 純, 松中 豪, 佐伯 秀幸, 日浅 豪, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 濱田 泰伸, 日和田 邦男, Japanese circulation journal, 20011020
  • 30) 大動脈弁置換術後のワーファリンコントロール中, 脳梗塞を発症した大動脈炎症候群の1例(日本循環器学会 第78回四国地方会), 松中 豪, 鈴木 純, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20011020
  • 25) Cilostazolにより胸痛発作が誘発され不安定化した安定狭心症の1例(日本循環器学会 第78回四国地方会), 菅 千賀, 大塚 知明, 鈴木 純, 松中 豪, 大木元 明義, 佐伯 秀幸, 日浅 豪, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20011020
  • 209) 胸水貯留,肝腫大を繰り返した収縮性心膜炎の1例, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 泰伸, 濱田 希臣, 日和田 邦男, 城 忠文, 河内 寛治, Japanese circulation journal, 20010420
  • 119) シベンゾリン投与にて両心室内圧較差が軽減した若年性肥大型心筋症の1例, 日浅 豪, 濱田 希臣, 松中 豪, 鈴木 純, 佐伯 秀幸, 大木元 明義, 大塚 知明, 濱田 泰伸, 大蔵 隆文, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 20010420
  • 186) 本態性高血圧患者の血管障害に及ぼす年齢の影響, 重松 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 鈴木 純, 松中 豪, 大塚 知明, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20010420
  • 122) 特発性大動脈弁下狭窄症患者における心室中部閉塞共存の頻度, 鈴木 純, 濱田 希臣, 重松 裕二, 原 裕二, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 松中 豪, 日和田 邦男, Japanese circulation journal, 20010420
  • 124) ミオシン結合蛋白C(MYBPC3,Delta 593S)の遺伝子変異を認めた拡張相肥大型心筋症の1例, 大木元 明義, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 名倉 潤, 三木 哲郎, Japanese circulation journal, 20010420
  • 84) 高血圧症の経過中に特発性嚢胞性中膜壊死性大動脈弁輪拡張症を発症した一症例, 佐藤 真, 大塚 知明, 鈴木 純, 松中 豪, 大木元 明義, 佐伯 秀幸, 日浅 豪, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 河内 寛治, Japanese circulation journal, 20010420
  • 30) 僧帽弁置換術後ワーファリン治療中に右心不全増悪に伴い小腸出血による貧血が進行した1症例, 鈴木 純, 松中 豪, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20010420
  • 81) 拡張早期心音を認めた肺動脈弁逆流症の1例, 河野 浩明, 原 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 重松 裕二, 濱田 希臣, 日和田 邦夫, Japanese circulation journal, 20001020
  • 78) 抗結核薬投与が有効であった血性心タンポナーデの1例, 大木元 明義, 佐伯 秀幸, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦夫, Japanese circulation journal, 20001020
  • 59) 着脱式コイルによる塞栓術にて治療した成人期動脈管開存症の1例, 永井 啓行, 鈴木 誠, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 山本 英一, 檜垣 高史, 貴田 嘉一, Japanese circulation journal, 20001020
  • 25) 肥大型心筋症患者に認められるインスリン抵抗性 : インスリン抵抗性指数(HOMA-R)を用いた検討, 重松 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20001020
  • 23) 心尖部肥大型心筋症として経過観察中に左室中部閉塞をきたした1例, 大木元 明義, 佐伯 秀幸, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20001020
  • 22) 心筋中部ならびに流出路狭窄による二元性肥大型閉塞性心筋症に対するcibenzolineの有用性, 槙 史絵, 鈴木 誠, 大木元 明義, 佐伯 秀幸, 日浅 豪, 大塚 知明, 佐々木 修, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20001020
  • 166) 肥大型心筋症による大動脈弁閉鎖不全症にて弁置換術を施行した1症例, 門脇 徹, 原 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000420
  • 163) 心不全を繰り返し,心嚢拡大を認めた拡張型心筋症の1剖検例, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000420
  • 161) AEC阻害薬からA II受容体拮抗薬への変更により心機能の改善を認めた拡張型心筋症の1例, 原 裕二, 濱田 希臣, 重松 裕二, 鈴木 誠, 大塚 知明, 佐々木 修, 日浅 豪, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000420
  • 62) 心房中隔欠損症に冠動脈の高位起始異常を合併した一例, 槙 史絵, 鈴木 誠, 井谷 修, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 河内 寛治, Japanese circulation journal, 20000420
  • 46) ロキソプロフェンNa(ロキソニン)により右心不全の増悪を来した心房中隔欠損症手術後の一例, 永井 啓行, 鈴木 誠, 西村 和久, 佐伯 秀幸, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000420
  • P913 急性心筋梗塞に対する虚血再灌流後のIL-6活性化の規定因子ならびIL-6活性化に基く慢性期心筋障害への影響, 鈴木 誠, 濱田 希臣, 重松 裕二, 原 裕二, 佐々木 修, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000301
  • P515 本態性高血圧における血清尿酸値と左室肥大様式の関連, 重松 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000301
  • P366 高血圧患者の単位心筋当たりの冠血流量に及ぼす心血管危険因子の影響, 佐々木 修, 濱田 希臣, 重松 裕二, 大木元 明義, 佐伯 秀幸, 日浅 豪, 大塚 知明, 鈴木 誠, 原 裕二, 日和田 邦男, Japanese circulation journal, 20000301
  • P363 本態性高血圧患者における左室肥大様式とインスリン抵抗性の関連 : HOMAインスリン抵抗性指数 (HOMA-R) を用いた検討, 佐伯 秀幸, 重松 裕二, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000301
  • P093 2核種同時解析(^<123>I-MIBG, ^<201>Tl心筋SPECT)による肥大型心筋症患者の病期判定, 日浅 豪, 濱田 希臣, 佐伯 秀幸, 大木元 明義, 大塚 知明, 佐々木 修, 鈴木 誠, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 20000301
  • 0905 la群抗不整脈薬シベンゾリンの肥大型心筋症の拡張期心機能に及ぼす影響, 濱田 希臣, 重松 裕二, 原 裕二, 鈴木 誠, 池田 俊太郎, 佐々木 修, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000301
  • 0874 脈圧の高血圧心に対する影響ならびに頚動脈弾性機能との関係, 鈴木 誠, 濱田 希臣, 重松 裕二, 原 裕二, 佐々木 修, 大塚 知明, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000301
  • 0871 本態性高血圧患者の大動脈コンプライアンスと遺伝的素因の関連, 重松 裕二, 佐伯 秀幸, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 20000301
  • 0813 高血圧性心不全への進展における心室ならび心房心筋細胞のリモデリングと収縮能の変化, 鈴木 誠, 濱田 希臣, 重松 裕二, 原 裕二, 佐々木 修, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000301
  • 0714 肥大型心筋症患者における血中心筋逸脱酵素値は10年後の左室形態と予後に密接に関連している, 濱田 希臣, 重松 裕二, 原 裕二, 鈴木 誠, 佐々木 修, 大塚 知明, 日浅 豪, 大木元 明義, 佐伯 秀幸, 日和田 邦男, Japanese circulation journal, 20000301
  • 60)本態性高血圧患者の重症度に及ぼす遺伝的素因の影響, 重松 裕二, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19991020
  • 59)修正大血管転位症の1例 : 65歳女性, 佐々木 修, 日浅 豪, 大木元 明義, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 重松 裕二, 大蔵 隆文, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19991020
  • 39)Ia群抗不整脈シベンゾリンの肥大型心筋症の収縮期および拡張期におよぼす影響, 大木元 明義, 池田 俊太郎, 重松 裕二, 日浅 豪, 佐々木 修, 大塚 知明, 橋田 英俊, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19991020
  • 38)感染性心内膜炎による僧帽弁閉鎖不全にて心不全を合併した閉塞性肥大型心筋症の1例, 倉田 聖, 原 裕二, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 重松 裕二, 大蔵 隆文, 濱田 希臣, 日和田 邦男, 大谷 敬之, 河内 寛治, Japanese circulation journal, 19991020
  • 37)心室中部閉塞型肥大型心筋症に対するシベンゾリン有効性についての検討, 西村 和久, 鈴木 誠, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 原 裕二, 重松 裕二, 大蔵 隆文, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19991020
  • 18)冠動脈閉塞および冠攣縮を合併した若年冠拡張症の1例, 小松 次郎, 原 裕二, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 重松 裕二, 大蔵 隆文, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19991020
  • 223)タリウム心筋シンチグラフィを用いた冠血流量測定の意義, 佐々木 修, 大木元 明義, 日浅 豪, 大塚 知明, 長岡 祥宣, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 201)陳旧性心筋梗塞患者に対する経皮的冠動脈形成術の左室リモデリングの抑制効果, 原 裕二, 大木元 明義, 日浅 豪, 長岡 祥宣, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 146)突然死した肥大型心筋症10例の臨床的特徴, 重松 裕二, 大木元 明義, 日浅 豪, 長岡 祥宣, 橋田 英俊, 池田 俊太郎, 佐々木 修, 大塚 知明, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 145)肥大型閉塞性心筋症の血中脳性利尿ペプチド(BNP)高値の機序, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 長岡 祥宣, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 111)ナトリウム利尿ペプチドの特異的動態を示した原発生肺高血圧症の2症例, 大塚 知明, 濱田 希臣, 大木元 明義, 日浅 豪, 佐々木 修, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19990820
  • 104)収縮期心時相分析が診断の一助となった褐色細胞腫の一例, 日浅 豪, 濱田 希臣, 重松 裕二, 原 裕二, 鈴木 誠, 橋田 英俊, 池田 俊太郎, 大塚 知明, 佐々木 修, 大木元 明義, 日和田 邦男, 大谷 敬之, Japanese circulation journal, 19990820
  • 63)大動脈弁・僧帽弁閉鎖不全症に対する二弁置換術8年後に三尖弁閉鎖不全症による右心不全を発症した1症例, 西村 和久, 鈴木 誠, 大木元 明義, 大塚 知明, 佐々木 修, 長岡 祥宣, 日浅 豪, 池田 俊太郎, 橋田 英俊, 原 裕二, 大蔵 隆文, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 13)失神発作を契機として診断された異型狭心症の1例, 倉田 聖, 原 裕二, 大木元 明義, 長岡 祥宣, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 9)コリンエステラーゼ阻害薬(マイテラーゼ:Ambenonium Chloride)による重症筋無力症の治療中に顕性化した冠攣縮性狭心症の1例, 吉井 豊史, 鈴木 誠, 大木元 明義, 大塚 知明, 佐々木 修, 長岡 祥宣, 日浅 豪, 池田 俊太郎, 橋田 英俊, 原 裕二, 大蔵 隆文, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990820
  • 0267 冠攣縮を有する高血圧患者に認められるび慢性冠動脈血管反応性異常, 重松 裕二, 大木元 明義, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990301
  • 0423 心房細胞が拡張型心筋症患者の血中ナトリウム利尿ペプチドにおよぼす影響, 原 裕二, 濱田 希臣, 重松 裕二, 鈴木 誠, 橋田 英俊, 池田 俊太郎, 佐々木 修, 大塚 知明, 日浅 豪, 大木元 明義, 日和田 邦男, Japanese circulation journal, 19990301
  • P722 急性心筋梗塞に対する再灌流療法(PTCA)後の慢性期左室リモデリングの進展に及ぼす高血圧性心肥大の影響, 鈴木 誠, 大木元 明義, 日浅 豪, 大塚 知明, 佐々木 修, 池田 俊太郎, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19990301
  • P671 高血圧患者の左室収縮機能に及ぼす冠血流量の影響, 佐々木 修, 濱田 希臣, 重松 裕二, 大木元 明義, 日浅 豪, 大塚 知明, 池田 俊太郎, 橋田 英俊, 鈴木 誠, 原 裕二, 日和田 邦男, Japanese circulation journal, 19990301
  • P112 代償性心肥大から非代償性心不全へのリモデリング過程における転写因子NF-kBの関与, 池田 俊太郎, 濱田 希臣, 日浅 豪, 大木元 明義, 佐々木 修, 大塚 知明, 橋田 英俊, 佐藤 豊, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19990301
  • P064 虚血再灌流モデルにおける炎症性サイトカイン発現に対するIschemic preconditioningの効果, 日浅 豪, 濱田 希臣, 池田 俊太郎, 大木元 明義, 佐々木 修, 大塚 知明, 橋田 英俊, 鈴木 誠, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19990301
  • 77)リズミックが著効を呈した洞結節機能不全症候群の1例, 池田 俊太郎, 大塚 知明, 田中 清宣, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, 越智 直登, 茎田 仁志, Japanese circulation journal, 19980320
  • 52)Midwall Fractional Shorteningを用いた高血圧性肥大心の左室収縮機能の検討, 重松 裕二, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980320
  • 38)三尖弁位人工弁機能不全による右心不全をきたした1例, 井上 勝次, 児玉 光司, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, 岩田 猛, Japanese circulation journal, 19980320
  • 24)心筋梗塞患者における201Tl心筋シンチグラムと収縮期心時相分析の関連, 原 裕二, 濱田 希臣, 重松 裕二, 児玉 光司, 桑原 大志, 池田 俊太郎, 橋田 英俊, 佐々木 修, 大塚 知明, 日和田 邦男, Japanese circulation journal, 19980320
  • 17)Nisoldipine投与により発作の増悪を認めた冠攣縮性狭心症の1例, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980320
  • 15)経皮的冠動脈形成術後4年を経過して新たに冠攣縮性狭心症を認めた1例, 大島 清孝, 原 裕二, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980320
  • 13)Myocardial bridgeの部位に一致して冠攣縮を認めた心筋梗塞例および狭心症例, 森岡 紀勝, 児玉 光司, 橋田 英俊, 桑原 大志, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980320
  • 3)冠攣縮性狭心症患者における一過性右側胸部誘導QRS波前方成分増大に関する検討, 児玉 光司, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980320
  • P224 圧負荷肥大心の非代償期へのリモデリング過程におけるアポトーシス及びアポトーシス関連遺伝子発現の変化, 池田 俊太郎, 濱田 希臣, 日浅 豪, 曲 鵬, 佐々木 修, 大塚 知明, 橋田 英俊, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19980228
  • P595 急性圧負荷にともなう筋小胞体カルシウム調節蛋白の遺伝子発現変化 : ラット肺動脈縮搾モデルを用いて, 池田 俊太郎, 濱田 希臣, 日浅 豪, 曲 鵬, 佐々木 修, 大塚 知明, 橋田 英俊, 桑原 大志, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19980228
  • P447 本態性高血圧症における左室肥大様式は左室収縮機能障害の独立した規定因子である, 重松 裕二, 日浅 豪, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980228
  • P377 冠攣縮性狭心症を合併する肥大型心筋症患者の冠攣縮発作時心電図の特徴, 児玉 光司, 日浅 豪, 大塚 知明, 佐々木 修, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19980228
  • P375 典型的な肥大型心筋症から末期心不全への移行 : 210名の12年間の解析, 濱田 希臣, 重松 裕二, 児玉 光司, 原 裕二, 桑原 大志, 橋田 英俊, 池田 俊太郎, 佐々木 修, 大塚 知明, 日浅 豪, 日和田 邦男, Japanese circulation journal, 19980228
  • P105 虚血性心疾患における可溶性Fas測定の臨床的意義 : 虚血性心筋細胞障害とアポトーシスとの関連性, 大塚 知明, 濱田 希臣, 重松 裕二, 児玉 光司, 原 裕二, 桑原 大志, 橋田 英俊, 池田 俊太郎, 佐々木 修, 日浅 豪, 日和田 邦男, 本田 俊雄, 大谷 敬之, Japanese circulation journal, 19980228
  • 0697 急性心筋梗塞急性期におけるアポトーシスの関与と梗塞サイズ・血行動態との関連性 : 可溶性Fas測定による検討, 大塚 知明, 濱田 希臣, 重松 裕二, 児玉 光司, 原 裕二, 桑原 大志, 橋田 英俊, 池田 俊太郎, 佐々木 修, 日浅 豪, 日和田 邦男, 本田 俊雄, 大谷 敬之, Japanese circulation journal, 19980228
  • 69) 冠攣縮性狭心症を合併した本態性高血圧患者の神経体液性因子の特徴, 重松 裕二, 桑原 大志, 大塚 知明, 児玉 光司, 橋田 英俊, 濱田 希臣, 原 裕二, 日和田 邦男, 池田 俊太郎, Japanese circulation journal, 19970820
  • 73) 安静時201TI心筋シンチグラムで全体的な高洗い出し率を示した心アミロイドーシスの3例, 森岡 紀勝, 児玉 光司, 井上 勝次, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970820
  • 41) MRIが治療方針決定に有用であった慢性心外膜炎の1例, 渡邉 彰, 原 裕二, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, 桜木 悟, 河内 寛治, Japanese circulation journal, 19970820
  • 52) 収縮早期に過剰心音を認めた心室中部閉塞性肥大型心筋症の一例, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970820
  • 60) β遮断薬の効果発現に長期を要した慢性心不全の1例, 池田 俊太郎, 大塚 知明, 橋田 英俊, 桑原 大志, 児玉 光司, 原 裕二, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970820
  • 51) 冠攣縮を伴う肥大型心筋症患者の臨床的特徴, 児玉 光司, 濱田 希臣, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19970820
  • 46) 僧帽弁置換術後, 2度の再発性人工弁心膜炎のため, 2度の弁置換術を施行した1例, 橋田 英俊, 大塚 知明, 池田 俊太郎, 桑原 大志, 原 裕二, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970820
  • P737 肥大型心筋症における冠導管血管のアセチルコリンに対する反応性, 児玉 光司, 濱田 希臣, 佐々木 修, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19970305
  • P685 不均等中隔肥大を示す高血圧患者のナトリウム利尿ペプチド(ANP、BNP)動態は肥大型心筋症に一致する, 佐々木 修, 濱田 希臣, 重松 裕二, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 原 裕二, 児玉 光司, 日和田 邦男, Japanese circulation journal, 19970305
  • P536 冠動脈血管反応性異常を示した本態性高血圧患者の左室形態、神経体液性因子の特徴, 重松 裕二, 佐々木 修, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 児玉 光司, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970305
  • P534 高血圧に伴った心電図陰性T波の成因について : 安静時Tl-201心筋シンチグラフィーを用いての解析, 桑原 大志, 濱田 希臣, 佐々木 修, 大塚 知明, 池田 俊太郎, 橋田 英俊, 原 裕二, 児玉 光司, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19970305
  • P298 左室収縮末期壁応力は拡張型心筋症の重要な予後予測因子の一つである, 原 裕二, 濱田 希臣, 重松 裕二, 児玉 光司, 桑原 大志, 橋田 英俊, 池田 俊太郎, 佐々木 修, 大塚 知明, 日和田 邦男, Japanese circulation journal, 19970305
  • P276 左前下行枝近位部病変検出における平均前額面QRS電気軸左方偏位の有用性 : 運動負荷試験と冠動脈形成術との対比, 児玉 光司, 濱田 希臣, 佐々木 修, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19970305
  • 0969 肥大型心筋症における血中アドレノメジュリン測定の意義 : 血中ノルエピネフリン、心房性および脳性利尿ホルモンとの比較, 濱田 希臣, 佐々木 修, 大塚 知明, 橋田 英俊, 池田 俊太郎, 桑原 大志, 原 裕二, 児玉 光司, 重松 裕二, 日和田 邦男, 南野 直人, 寒川 賢治, 松尾 壽之, Japanese circulation journal, 19970305
  • 66) 洞機能不全を合併した肺分画症の一例, 松中 豪, 原 裕二, 佐々木 修, 池田 俊太郎, 橋田 英俊, 桑原 大志, 岡山 英樹, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970120
  • 64) 肥大型閉塞性心筋症の左室内圧較差に対するシベンゾリン(Ia抗不整脈薬)の効果, 重松 裕二, 橋田 英俊, 池田 俊太郎, 桑原 大志, 岡山 英樹, 原 裕二, 児玉 光司, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970120
  • 13) 当院における狭心症患者のQOLの検討, 原 裕二, 林 豊, 佐々木 修, 池田 俊太郎, 橋田 英俊, 桑原 大志, 岡山 英樹, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19970120
  • EXERCISE-INDUCED MYOCARDIAL ISCHEMIA IN HYPERTENSIVE PATIENTS WITH ANGIOGRAPHICALLY NORMAL CORONARY ARTERIES-ASSOCIATION WITH CORONARY VASOSPASM-, SHIGEMATSU Yuji, KUWAHARA Taishi, KAWAKAMI Hideo, OKAYAMA Hideki, HARA Yuji, HAYASHI Yutaka, KODAMA Koji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19960620
  • P062 左室肥大を有する本態性高血圧患者の心交感神経機能障害, 桑原 大志, 濱田 希臣, 原 裕二, 林 豊, 児玉 光司, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19960220
  • 0891 肥大型閉塞性心筋症で認められる収縮早期心音の発生機序と臨床的意義, 池田 俊太郎, 濱田 希臣, 重松 裕二, 児玉 光司, 林 豊, 原 裕二, 岡山 英樹, 川上 秀生, 桑原 大志, 橋田 英俊, 日和田 邦男, Japanese circulation journal, 19960220
  • 0490 運動負荷試験における一過性前額面QRS軸左方偏位の意義 : 左前下行枝近位部病変検出の感度と特異度, 児玉 光司, 濱田 希臣, 池田 俊太郎, 橋田 英俊, 桑原 大志, 川上 秀生, 岡山 英樹, 原 裕二, 林 豊, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19960220
  • 0278 高血圧患者における冠動脈血管反応性異常 : 運動負荷T1心筋シンチグラムにおける再分布との関連, 重松 裕二, 桑原 大志, 川上 秀生, 岡山 英樹, 原 裕二, 林 豊, 児玉 光司, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19960220
  • 69) Budd-Chiari症候群による肺硬変症に合併した肺高血圧症の1剖検例(日本循環器学会 第66回四国地方会), 日浅 豪, 岡山 英樹, 桑原 大志, 川上 秀生, 林 豊, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19960220
  • 38) 心尖拍動図より左房粘液腫の僧帽弁口への嵌頓の存在を疑えるか(日本循環器学会 第66回四国地方会), 佐藤 澄子, 岡山 英樹, 住元 巧, 川上 秀生, 林 豊, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19960220
  • 35) 心不全治療効果判定の指標としての等容拡張時間の有用性(日本循環器学会 第66回四国地方会), 児玉 光司, 岡山 英樹, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19960220
  • 27) 高血圧性肥大心における単離心筋細胞の収縮拡張動態とアンジオテンシンIIの影響(日本循環器学会 第66回四国地方会), 小林 卓正, 濱田 希臣, 岡山 英樹, 重松 裕二, 住元 巧, 日和田 邦男, Japanese circulation journal, 19960220
  • 25) 心肥大および標的臓器障害の進展 : 原発性アルドステロン症と本態性高血圧症の比較(日本循環器学会 第66回四国地方会), 重松 裕二, 濱田 希臣, 林 豊, 児玉 光司, 住元 巧, 日和田 邦男, Japanese circulation journal, 19960220
  • 24) 脳出血を合併した高血圧性肥大型心筋症(日本循環器学会 第66回四国地方会), 三根生 和明, 越智 隆明, 矢野 和夫, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19960220
  • USEFULNESS AND LIMITATION OF BLOOD PRESSURE MONITORING BY ARTERIAL TONOMETRY, KUWAHARA Taishi, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, HAYASHI Yutaka, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • INTRACAVITARY FILLING PATTERN IN THE FAILING LEFT VENTRICLE ASSESSED BY INTRAVENOUS INJECTION OF SONICATED ALBUMIN, HAYASHI Yutaka, HAMADA Mareomi, KUWAHARA Taishi, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ALTERNATION OF THE GENES ENCODING SARCOPLASMIC RETICULUM PROTEINS IN DIABETIC-RAT HEART, OKAYAMA Hideki, KAWAKAMI Hideo, MAGUCHI Motofumi, NISHIDA Wataru, KOHARA Katsuhiko, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • EFFECT OF ANTIHYPERTENSIVE THERAPY ON AORTIC DISTENSIBILITY IN PATIENTS WITH HYPERTENSION:COMPARISON WITH ALACEPRIL AND TRICHLORMETHIAZIDE, HONDA Toshio, MATSUMOTO Yuji, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • TARGET ORGAN DAMAGE IN PRIMARY ALDOSTERONISM:COMPARISON WITH ESSENTIAL HYPERTENSION, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ESTIMATION OF SYSTOLIC PULMONARY ARTERY PRESSURE BY A THALLIUM-201 MYOCARDIAL IMAGING IN PATIENTS WITH RIGHT VENTRICULAR OVERLOAD, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 19950620
  • Increased Secretion of Atrial and Brain Natriuretic Peptides during Acute Myocardial Ischemia in Patients with Angina Pectoris., MARUMOTO Kazumasa, ABURAYA Masahito, KUWAHARA Taishi, MUKAI Mikio, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • EVALUATION OF AORTIC DISTENSIBILITY IN HEMODIALYSIS PATIENTS USING CINE MAGNETIC RESONANCE, MATSUMOTO Yuji, HONDA Toshio, SHIGEMATSU Yuji, SUMIMOTO Takumi, MUKAI Mikio, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • HETEROGENEITY OF VASODILATOR RESPONSE TO ACETYLCHOLINE AND ATP IN CORONARY AND RENAL ARTERIES, MUKAI Mikio, KAWAKAMI Hideo, MARUMOTO Kazumasa, KOBAYASHI Takamasa, OKAYAMA Hideki, HAYASHI Yutaka, SHIGEMATSU Yuji, SUMIMOTO Takumi, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • ALTERNATION OF A-AND B-TYPE NATRIURETIC PEPTIDE GENES ASSOCIATED WITH PROGRESSION AND REGRESSION OF CARDIAC HYPERTROPHY IN RENOVASCULAR HYPERTENSIVE RAT, KAWAKAMI Hideo, OKAYAMA Hideki, MARUMOTO Kazumasa, ABURAYA Masahiti, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 19950620
  • 173)心筋シンチグラフィーにおいて異常心筋像を呈したKugelberg-belander病の1例(日本循環器学会第65回中国四国地方会), 若宮 留美, 向井 幹夫, 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 秀樹, 林 豊, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 165)心機能低下を合併した筋緊張性ジストロフィーの1例(日本循環器学会第65回中国四国地方会), 酒井 希美子, 岡山 英樹, 林 豊, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 161)拡張型心筋症の兄弟例(日本循環器学会第65回中国四国地方会), 林 豊, 重松 裕二, 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 英樹, 向井 幹夫, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 160)心不全を合併する肥大型心筋症と拡張型心筋症の形態および予後の比較(日本循環器学会第65回中国四国地方会), 重松 裕二, 岡山 英樹, 林 豊, 向井 幹夫, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 154)発病約1ケ月後に肺動脈内血栓溶解療法が奏効した肺血栓塞栓症の2症例(日本循環器学会第65回中国四国地方会), 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 英樹, 林 豊, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 49)高血圧症患者のハンドグリップ負荷時の血圧反応の程度と左室心筋重量の関係(日本循環器学会第65回中国四国地方会), 向井 幹夫, 岡山 英樹, 林 豊, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 83)CAPDに続き腎移植を施行し、心機能の改善を認めたuremic cardiomyopathyの1例(日本循環器学会第64回四国地方会), 小林 卓正, 三根生 和明, 川上 秀生, 丸本 和正, 岡山 英樹, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 81)急性右心不全を来した若年者甲状腺機能亢進症の一例(日本循環器学会第64回四国地方会), 三根生 和明, 向井 幹夫, 桑原 大志, 川上 秀生, 小林 卓正, 丸本 和正, 岡山 英樹, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 77)急性血圧変化時の非観血的血圧測定の追随性(日本循環器学会第64回四国地方会), 川上 秀生, 桑原 大志, 三根生 和明, 丸本 和正, 小林 卓正, 岡山 英樹, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 54)肥大型心筋症の長期観察に伴う^<201>TIおよび^<123>I-MIBG心筋像の変化の定量評価(日本循環器学会第64回四国地方会), 桑原 大志, 向井 幹夫, 川上 秀生, 丸本 和正, 岡山 英樹, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 52)長期観察後も^<123>I-MIBGの改善を認めないStunned myocardiumの1症例(日本循環器学会第64回四国地方会), 野本 高彦, 向井 幹夫, 桑原 大志, 川上 秀生, 岡山 秀樹, 小林 卓正, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 42)頚動脈小体腫瘍による頚動脈洞症候群の1例(日本循環器学会第64回四国地方会), 岡山 英樹, 川上 秀生, 桑原 大志, 三根生 和明, 丸本 和正, 小林 卓正, 林 豊, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • 41)高レニン血症を伴った心不全を繰り返した大動脈炎症候群の1例(日本循環器学会第64回四国地方会), 向井 幹夫, 野本 高彦, 桑原 大志, 三根生 和彦, 川上 秀生, 岡山 英樹, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950620
  • P314 非観血的連続血圧測定法であるトノメータ法による中心血圧測定の有用性とその限界, 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 英樹, 林 豊, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • P261 Sonicated albumin経静脈内投与による左心機能障害患者の左室流入動態の解析, 林 豊, 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 英樹, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • P189 実験的糖尿病ラットにおける筋小胞体カルシウム調節蛋白遺伝子発現の検討, 岡山 英樹, 川上 秀生, 間口 元文, 西田 亙, 小原 克彦, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • 1239 高血圧患者における大動脈伸展性に対する降圧薬の効果 : ACE阻害薬と利尿薬の比較, 本田 俊雄, 松本 有司, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • 1055 右室負荷疾患におけるタリウム心筋シンチグラフィーを用いた肺動脈圧の定量的評価, 重松 裕二, 濱田 希臣, 向井 幹夫, 住元 巧, 日和田 邦男, Japanese circulation journal, 19950301
  • 1234 原発性アルドステロン症における標的臓器障害の進展 : 本態牲高血圧症との比較, 重松 裕二, 濱田 希臣, 向井 幹夫, 住元 巧, 日和田 邦男, Japanese circulation journal, 19950301
  • 0579 運動負荷急性心筋虚血のナトリウム利尿ペプチド系分泌動態に及ぼす影響に関する検討, 丸本 和正, 油屋 真仁, 桑原 大志, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • 0465 シネMRIを用いた透析患者の大動脈壁硬化の検討, 松本 有司, 本田 俊雄, 重松 裕二, 住元 巧, 向井 幹夫, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • 0453 臓器血管間に血管内皮機能のheterogeneityが存在するか : 冠動脈と腎動脈の比較, 向井 幹夫, 桑原 大志, 川上 秀生, 丸本 和正, 小林 卓正, 岡山 英樹, 林 豊, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • 0114 圧負荷肥大心の進展と退縮に伴う心筋内ナトリウム利尿ペプチド遺伝子発現の変化, 川上 秀生, 岡山 英樹, 丸本 和正, 油屋 真仁, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19950301
  • DISPARATE RESPONSE BETWEEN IMPULSE AND ELASTANCE TO β-ADRENERGIC STIMULATION IN HUMAN HYPERTENSIVE HEARTS, Suzuki Makoto, Kuwahara Taishi, Okayama Hideki, Mukai Mikio, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • HEMODYNAMIC CHARACTERISTICS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY WHO HAVE A HISTORY OF SYNCOPE, Shigematsu Yuji, Hamada Mareomi, Mukai Mikio, Sumimoto Takumi, Hiwada Kunio, Japanese circulation journal, 19940620
  • LEFT VENTRICULAR CARDIAC STRUCTURE AND SYSTOLIC FUNCTION IN ELDERLY PATIENTS WITH "BURNED-OUT" ESSENTIAL HYPERTENSION, Sumimoto Takumi, Mukai Mikio, Shigematsu Yuji, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • LEFT VENTRICULAR ADAPTATION TO HYPERTENSION AND EXTRACARDIAC TARGET ORGAN DAMAGE, Shigematsu Yuji, Hamada Mareomi, Mukai Mikio, Sumimoto Takurni, Hiwada Kunio, Japanese circulation journal, 19940620
  • ACTIVE RECOIL IN ISOLATED MYOCYTES : ROLE OF INTRACELLULAR RESTORING FORCE, Okayama Hideki, Kawakami Hideo, Kobayashi Takamasa, Suzuki Makoto, Mukai Mikio, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • THE DIFFERENCE IN CHANGING PATTERN BETWEEN TL-201 AND I-123 MIBG MYOCARDIAL DISTRIBUTION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Kuwahara Taishi, Mukai Mikio, Kawakami Hideo, Okayama Hideki, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • THALLIUM-201 MYOCARDIAL SCINTIGRAPHIC CHANGES DURING 50-MONTH FOLLOW-UP PERIOD IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Hamada Maremi, Sumimoto Takumi, Shigematsu Yuji, Mukai Mikio, Okayama Hideki, Suzuki Makoto, Kobayash Takamasa, Marumoto Kazumasa, Mineoi Kazuaki, Hiwada Kunio, Japanese circulation journal, 19940620
  • TWO TYPES OF HEART FAILURE IN PATIENTS WITH AORTITIS SYNDROME, Mukai Mikio, Kuwahara Taishi, Okayama Hideki, Suzuki Makoto, Shigematsu Yuji, Sumimoto Takumi, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19940620
  • 同程度の心肥大を有する褐色細胞腫患者と本熊性高血圧症患者のタリウム-201心筋シンチグラムの比較 : 第58回日本循環器学会学術集会, 阿部 充伯, 濱田 希臣, 岡山 英樹, 向井 幹夫, 重松 裕二, 住元 巧, 小原 克彦, 日和田 邦男, Japanese circulation journal, 19940301
  • 高血圧心におけるβアドレナリン受容体刺激時の収縮力の解析 : 第58回日本循環器学会学術集会, 鈴木 誠, 桑原 大志, 岡山 英樹, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19940301
  • 失神を主症状とする肥大型心筋症の血行動態上の特徴 : 第58回日本循環器学会学術集会, 重松 裕二, 濱田 希臣, 向井 幹夫, 住元 巧, 日和田 邦男, Japanese circulation journal, 19940301
  • 本態性高血圧患者の左室肥大様式と心臓外標的臓器障害の進展 : 第58回日本循環器学会学術集会, 重松 裕二, 濱田 希臣, 向井 幹夫, 住元 巧, 日和田 邦男, Japanese circulation journal, 19940301
  • 心筋細胞におけるactive recoil : 第58回日本循環器学会学術集会, 岡山 英樹, 川上 秀生, 小林 卓正, 鈴木 誠, 向井 幹夫, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19940301
  • 肥大型心筋症の経過観察に伴う^<201>T1および^<123>I : MIBG心筋像の変化の差異 : 第58回日本循環器学会学術集会, 桑原 大志, 向井 幹夫, 重松 裕二, 鈴木 誠, 岡山 英樹, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19940301
  • タリウム心筋シンチグラフィを用いた5年の経過観察による肥大型心筋症の心筋性状の変化 : 第58回日本循環器学会学術集会, 濱田 希臣, 住元 巧, 重松 裕二, 向井 幹夫, 岡山 英樹, 鈴木 誠, 小林 卓正, 丸本 和正, 日和田 邦男, Japanese circulation journal, 19940301
  • 大動脈炎症群における心不全の原因と左室の形態的特徴 : 第58回日本循環器学会学術集会, 向井 幹夫, 桑原 大志, 小林 卓正, 岡山 英樹, 鈴木 誠, 重松 裕二, 住元 巧, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19940301
  • ACCURATE DIAGNOSIS OF METASTATIC CARDIAC LEIOMYOSARCOMA WITH INFUNDIBULAR STENOSIS AND CARDIAC TAMPONADE BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY AND Gd-DTPA MAGNETIC RESONANCE IMAGING : Report of a Case, SUZUKI MAKOTO, HAMADA MAREOMI, ABE MITSUNORI, MATSUOKA HIROSHI, SHIGEMATSU YUJI, SUMIMOTO TAKUMI, HIWADA KUNIO, OSUKA YO, Japanese circulation journal, 19940220, We present a patient with metastatic cardiac leiomyosarcoma that was diagnosed antemortem by transesophageal echocardiography (TEE) and ECG-gated magnetic resonance imaging with gadolinium diethylene triaminepentaacetic acid (Gd-DTPA MRI). TEE and Gd-DTPA MRI clearly revealed the morphological characteristics of infundibular stenosis and cardiac tamponade. Our patient has survived about 30 months after cardiac surgery. Since sarcoma is usually associated with a very poor prognosis, surgical treatment should be performed as soon as possible. TEE with color Doppler imaging and Gd-DTPA MRI are very useful diagnostic methods for determining the precise anatomical characterization of cardiac tumor, and these procedures are prerequisite to precise therapy.
  • 拡張型心筋症の治療効果判定における等容拡張時間測定の有用性 : 日本循環器学会第55回中国・四国地方会, 鈴木 誠, 濱田 希臣, 大谷 敬志, 阿部 充伯, 竹崎 雅之, 藤原 康史, 住元 巧, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19930520
  • 心房細動を伴う肥大型心筋症に高頻度で認められる動脈塞栓症 : 日本循環器学会第55回中国・四国地方会, 重松 裕二, 濱田 希臣, 鈴木 誠, 大谷 敬之, 安部 充伯, 藤原 康史, 住元 巧, 日和田 邦男, Japanese circulation journal, 19930520
  • 肥大型心筋症患者の経年的心電図変化 : 日本循環器学会第55回中国・四国地方会, 大谷 敬之, 濱田 希臣, 鶴岡 高志, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19930520
  • 持続的な心筋壊死の存在が示唆された肥大型心筋症の2症例 : 日本循環器学会第55回中国・四国地方会, 重松 裕二, 濱田 希臣, 藤原 康史, 住元 巧, 日和田 邦男, Japanese circulation journal, 19930520
  • MR angioimaging(磁気共鳴血管画像法)の臨床応用 : 日本循環器学会第55回中国・四国地方会, 松岡 宏, 仁井 田明, 三木 均, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19930520
  • 僧帽弁逸脱症候群におけるシネMRIの有用性 : SE法及びカラードップラー法との比較 : 日本循環器学会第55回中国・四国地方会, 松岡 宏, 仁井 田明, 三木 均, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19930520
  • 肥大型心筋症における^<123>I-Metaiodobenzilguanidine(MIBG)心筋シンチの有用性 : 日本循環器学会第55回中国・四国地方会, 藤原 康史, 重松 裕二, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19930520
  • 肥大型心筋症患者の胸痛と冠動脈-左心腔内シャント : ポスター発表 : 第57回日本循環器学会学術集会, 濱田 希臣, 岡山 英樹, 鈴木 誠, 大谷 敬之, 阿部 充伯, 松岡 宏, 重松 裕二, 住元 巧, 日和田 邦男, Japanese circulation journal, 19930301
  • タリウム心筋SPECTを用いた原発性アルドステロン症の心筋障害の評価 : ポスター発表 : 第57回日本循環器学会学術集会, 阿部 充伯, 濱田 希臣, 松岡 宏, 住元 巧, 重松 裕二, 鈴木 誠, 大谷 敬之, 岡山 英樹, 小林 卓正, 川上 秀生, 日和田 邦男, Japanese circulation journal, 19930301
  • 圧負荷肥大心及び非肥大心の出力特性 : ポスター発表 : 第57回日本循環器学会学術集会, 鈴木 誠, 濱田 希臣, 住元 巧, 重松 裕二, 日和田 邦男, Japanese circulation journal, 19930301
  • 実験的糖尿病ラットの心機能異常 : 単離心筋細胞における検討 : 口述発表 : 第57回日本循環器学会学術集会, 岡山 英樹, 濱田 希臣, 重松 裕二, 川上 秀生, 小林 卓正, 日和田 邦男, Japanese circulation journal, 19930301
  • 胸痛発作時にST上昇を示した肥大型心筋症の1症例, 松岡 宏, 仁志川 高雄, 伊藤 武俊, 藤原 康史, 住元 巧, 向井 幹夫, 鶴岡 高志, 重松 裕二, 関谷 達人, 浜田 希臣, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 等容拡張時間は心機能障害の重症度を反映するか?, 藤原 康史, 浜田 希臣, 向井 幹夫, 鶴岡 高志, 重松 裕二, 住元 巧, 関谷 達人, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 肥大型心筋症患者における右房ペーシング負荷に対する血圧反応性の異常, 向井 幹夫, 浜田 希臣, 鶴岡 高志, 重松 裕二, 藤原 康史, 住元 巧, 関谷 達人, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 肥大型心筋症における非肥厚左室後壁運動の検討, 重松 裕二, 浜田 希臣, 向井 幹夫, 鶴岡 高志, 住元 巧, 藤原 康史, 関谷 達人, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 冠動脈瘻9例の検討, 鶴岡 高志, 関谷 達人, 向井 幹夫, 住元 巧, 藤原 康史, 重松 裕二, 浜田 希臣, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 家族性高コレステロール血症患者の冠動脈造影像の検討, 住元 巧, 浜田 希臣, 向井 幹夫, 鶴岡 高志, 重松 裕二, 藤原 康史, 関谷 達人, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • Radionuclide angiographyによる虚血性心疾患患者の拡張期心機能の評価, 関谷 達人, 向井 幹夫, 住元 巧, 鶴岡 高志, 重松 裕二, 藤原 康史, 浜田 希臣, 日和田 邦男, 国府 達郎, Japanese circulation journal, 19921020
  • 本態性高血圧症の病期進展と左心機能の変化(日本循環器学会 第57回中国・四国地方会), 林 夢, 鈴木 誠, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920720
  • 大動脈瘤のシネMRIによる検討 : 日本循環器学会第54回中国・四国地方会, 松岡 宏, 仁井田 明, 三木 均, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 大動脈弁逸脱による大動脈弁閉鎖不全症を合併した閉塞性肥大型心筋症の1症例 : 日本循環器学会第54回中国・四国地方会, 阿部 充伯, 重松 裕二, 鈴木 誠, 大谷 敬之, 藤原 康史, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 重症心機能障害患者の予後決定因子 : 日本循環器学会第54回中国・四国地方会, 鈴木 誠, 関谷 達人, 鶴岡 高志, 大谷 敬之, 重松 裕二, 住元 巧, 藤原 康史, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • Hyperkinetic heart syndromeの経過中に心機能障害の認められた1症例 : 日本循環器学会第54回中国・四国地方会, 大谷 敬之, 鈴木 誠, 阿部 充伯, 重松 裕二, 藤原 康史, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 老年まで無症状に経過した両側性肺動静脈瘻の1手術例 : 日本循環器学会第54回中国・四国地方会, 松田 昌三, 重松 裕二, 鶴岡 高志, 藤原 康史, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, 松岡 宏, Japanese circulation journal, 19920520
  • 高血圧性心肥大におけるRV_6/RV_5比の検討 : 日本循環器学会第54回中国・四国地方会, 相原 邦行, 住元 巧, 鈴木 誠, 大谷 敬之, 阿部 充伯, 重松 裕二, 藤原 康史, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 本態性高血圧症と肥大型心筋症の左室肥大様の検討 : 日本循環器学会第54回中国・四国地方会, 藤原 康史, 大谷 敬之, 鈴木 誠, 阿部 充伯, 重松 裕二, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 代償不全期高血圧性心機能障害の特徴と降圧効果 : 日本循環器学会第54回中国・四国地方会, 重松 裕二, 鈴木 誠, 大谷 敬之, 阿部 充伯, 藤原 康史, 住元 巧, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 無痛性陳旧性心筋梗塞および自己免疫異常を認めたIIa型高脂血症の1症例 : 日本循環器学会第54回中国・四国地方会, 西田 亙, 住元 巧, 阿部 充伯, 鈴木 誠, 大谷 敬之, 重松 裕二, 藤原 康史, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19920520
  • 二次性高血圧症の治癒と左心機能の変化, 重松 裕二, 濱田 希臣, 岡山 英樹, 大谷 敬之, 鈴木 誠, 竹崎 雅之, 阿部 充伯, 藤原 康史, 住元 巧, 日和田 邦男, Japanese circulation journal, 19911120
  • シネMRIによる心房中隔欠損症における短絡の評価 : 超音波断層カラードップラー法との対比, 松岡 宏, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19911120
  • 右室負荷疾患における^<201>Tl心筋シンチの右室描出の意義, 重松 裕二, 濱田 希臣, 藤原 康史, 鈴木 誠, 大谷 敬之, 岡山 英樹, 阿部 充伯, 竹崎 雅之, 住元 巧, 日和田 邦男, Japanese circulation journal, 19911120
  • シネMRIによる弁逆流の評価 : 超音波断層カラードップラー法との対比, 松岡 宏, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19911120
  • 肥大型心筋症におけるDisopyramideとDiltiazemの収縮期および拡張期心時相に及ぼす効果, 大谷 敬之, 住元 巧, 重松 裕二, 藤原 康史, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19911120
  • 本態性高血圧症と肥大型心筋症におけるiodine123 metaiodo benzylguanidineの左室心筋への分布の差異, 藤原 康史, 濱田 希臣, 大谷 敬之, 鈴木 誠, 岡山 英樹, 竹崎 雅之, 阿部 充伯, 重松 裕二, 住元 巧, 日和田 邦男, Japanese circulation journal, 19911120
  • 肥大型心筋症の冠動脈の形態学的特徴, 鈴木 誠, 濱田 希臣, 重松 裕二, 大谷 敬之, 岡山 英樹, 小林 卓正, 阿部 充伯, 竹崎 雅之, 住元 巧, 藤原 康史, 日和田 邦男, Japanese circulation journal, 19911120
  • 僧帽弁閉鎖不全症患者の心エコー諸指標とタリウム心筋シンチグラムの関連性, 阿部 充伯, 濱田 希臣, 住元 巧, 重松 裕二, 藤原 康史, 日和田 邦男, Japanese circulation journal, 19911120
  • 本院における循環器疾患に対するMRIの応用 : シネMRIを中心にして, 松岡 宏, 仁井田 明, 三木 均, 重松 裕二, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19901220
  • 長期生存する完全大血管転位症の1例, 大谷 敬之, 竹崎 雅之, 向井 幹夫, 鶴岡 高志, 重松 裕二, 濱田 希臣, 日和田 邦男, 末田 章三, 松岡 宏, Japanese circulation journal, 19901220
  • 右胸心に重症冠動脈硬化症を合併した1症例, 加藤 市次郎, 太宰 康伸, 末田 章三, 佐々木 徹, 重松 裕二, 関谷 達人, 濱田 希臣, 日和田 邦男, Japanese circulation journal, 19901220
  • -0536-CLINICAL SIGNIFICANCE OF NEGATIVE T WAVE IN PRECORDEAL LEADS ON ELCTROCARDIOGRAM IN ESSENTIAL HYPERTENSIVES : WITH SPECIAL REFERENCE TO THE LEFT VENTRICULAR MASS, Ohtani Takashi, Hamada Mareomi, Suzuki Makoto, Shigematsu Yuji, Sumimoto Takumi, Fujiwara Yasushi, Hiwada Kunio, Japanese circulation journal, 19900720
  • -0299-PERSISTENT ELEVATIONS OF SERUM CARDIAC ENZYMES IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY, Hamada Mareomi, Ohtani Takashi, Shigematsu Yuji, Fujiwara Yasushi, Sumimoto Takumi, Hiwada Kunio, Japanese circulation journal, 19900720
  • STUDY OF AORTIC ANEURYSM BY CINE MAGNETIC RESONANCE IMAGING : CT, MRI : 53 Annual Scientific Meeting, Japanese Circulation Society, Matsuoka Hiroshi, Niida Akira, Miki Hitoshi, Shigematsu Yuji, Hamada Mareomi, Hiwada Kunio, Japanese circulation journal, 19890820
  • DISPARATE DIFFERENCE OF LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH ESSNTIAL HYPERTENSION AND HYPERTROPHIC CARDIOMYOPATHY : DOES DISPROPORTIONATE SEPTAL HYPERTROPHY EXIST IN ESSENTIAL HYPERTENSIVES? : Hypertension : 53 Annual Scientific Meeting, Japanes, Fujiwara Yasushi, Hamada Mareomi, Sekiya Michihito, Sumimoto Takumi, Tsuruoka Takashi, Shigematsu Yuji, Mukai Mikio, Kodama Koji, Hiwada Kunio, Kokubu Tatsuo, Japanese circulation journal, 19890820
  • SPECIFIC DIASTOLIC FILLING PATTERN IN CORONARY ARTERY DISEASE WITH SEVERELY DEPRESSED LEFT VENTRICULAR FUNCTION : Ischemic Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society, Sekiya Michihito, Kodama Koji, Mukai Mikio, Tsuruoka Takashi, Shigematsu Yuji, Sumimoto Takumi, Fujiwara Yashushi, Hamada Mareomi, Hiwada Kunio, Kokubo Tatsuo, Japanese circulation journal, 19890820
  • Abnormal blood pressure response to atrial pacing in patients with hypertrophic cardiomyopathy., HAMADA M., Mukai Mikio, Kodama Koji, Tsuruoka Takashi, Shigematsu Yuji, Fujiwara Yasushi, Sumimoto Takumi, Sekiya Michihito, Hiwada Kunio, Kokubu Tatsuo, Jpn.Circ.J., 19890000
  • 24)右心負荷時の左心機能評価 : 日本循環器学会第48回中国・四国地方会, 向井 幹夫, 重松 裕二, 風谷 幸男, 関谷 達人, 土井内 純治, 西谷 晃二, 浜田 希臣, 国府 達郎, Japanese circulation journal, 19880930
  • 42)開心術後に心房粗動を呈した閉塞性肥大型心筋症の3例 : 日本循環器学会第47回中国・四国地方会, 末田 章三, 重松 裕二, 関谷 達人, 風谷 幸男, 西谷 晃二, 土井内 純治, 浜田 希臣, 国府 達郎, Japanese circulation journal, 19880210
  • 41)持続的な心筋逸脱酵素の上昇を認めた若年者肥大型心筋症の1症例 : 日本循環器学会第47回中国・四国地方会, 重松 裕二, 浜田 希臣, 国府 達郎, 鈴木 俊二, 高橋 貢, 宮崎 正章, Japanese circulation journal, 19880210
  • 26)心エコーでcystを同定し得た左房粘液腫の1例 : 日本循環器学会第47回中国・四国地方会, 西谷 晃二, 重松 裕二, 土井内 純治, 浜田 希臣, 国府 達郎, 石川 和彦, Japanese circulation journal, 19880210
  • 8)興味ある進展を認めた冠動脈硬化症の2例 : 日本循環器学会第47回中国・四国地方会, 関谷 達人, 向井 幹夫, 重松 裕二, 風谷 幸男, 西谷 晃二, 土井内 純治, 浜田 希臣, 国府 達郎, Japanese circulation journal, 19880210
  • 34)虚血性心疾患患者の前負荷に及ぼすisosorbide dinitrate tapeの急性効果 : 日本循環器学会第46回中国・四国地方会, 風谷 幸男, 土井内 純治, 冨田 直明, 末田 章三, 重松 裕二, 関谷 達人, 西山 誠一, 浜田 希臣, 国府 達郎, 伊藤 武俊, Japanese circulation journal, 19871220
  • 4)腱索断裂による僧帽弁閉鎖不全症を合併した閉鎖性肥大型心筋症の1例 : 日本循環器学会第46回中国・四国地方会, 太宰 康伸, 重松 裕二, 土井内 純治, 関谷 達人, 風谷 幸男, 西谷 晃二, 浜田 希臣, 国府 達郎, 伊藤 武俊, 大須賀 洋, 伊藤 孝, 呉 聡栄, Japanese circulation journal, 19871220
  • 174)右心負荷疾患の左心機能評価 : 日本循環器学会第45回中・四国地方会, 重松 裕二, 風谷 幸男, 関谷 達人, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19861220
  • 172)左冠動脈近位部狭窄病変診断における収縮期時相分析の有用性 : 日本循環器学会第45回中・四国地方会, 関谷 達人, 浜田 希臣, 重松 裕二, 風谷 幸男, 越智 隆明, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19861220
  • 52)大動脈弁逸脱様の所見を呈した大動脈弁閉鎖不全症の2症例 : 日本循環器学会第45回中国・四国地方会, 長江 明宏, 重松 裕二, 末田 章三, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 鶴岡 高志, Japanese circulation journal, 19861220
  • 38)持続的ST上昇を伴った家族性肥大型心筋症の2症例 : 日本循環器学会第45回中国・四国地方会, 重松 裕二, 井上 義一, 高橋 克仁, 末田 章三, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19861220
  • MORPHOLOGICAL AND FUNCTIONAL IDENTIFICATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY ESTIMATED BY LEFT VENTRICULOGRAM AT THE RIGHT ANTERIOR OBLIQUE PROJECTION : Cardiomyopathy (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CI, Doiuchi Junji, Hamada Mareomi, Sigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Mukai Mikio, Nishitani Koji, Kokubu Tatsuo, Japanese circulation journal, 19860820
  • CLINICAL SIGNIFICANCE OF SYSTOLIC TIME INTERVALS IN DETECTING THE STENOSIS OF PROXIMAL LEFT CORONARY ARTERY : Ischemic Heart Disease (V) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Kazatani Yukio, Hamada Mareomi, Sekiya Michihito, Shigematsu Yuji, Nishiyama Seichi, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19850820
  • 94)左冠動脈-右室瘻閉鎖術後に続発した心筋梗塞の1症例 : 日本循環器学会第43回中国・四国地方会, 松岡 宏, 重松 裕二, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 久保 明義, 菅 拓也, Japanese circulation journal, 19850410
  • 82)心房粗動時,僧帽弁の拡張中期閉鎖を生じた原発性肺高血圧症の1例 : 日本循環器学会第43回中国・四国地方会, 関谷 達人, 風谷 幸男, 重松 裕二, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19850410
  • 左冠動脈近位部狭窄病変診断における収縮期時相分析の有用性, 風谷 幸男, 浜田 希臣, 関谷 達人, 重松 裕二, 西山 誠一, 越智 隆明, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19850301
  • 7) 肥大型心筋症の治療 : β遮断剤とCa拮抗剤との比較 : 心筋症をめぐる諸問題 : シンポジウム : 日本循環器学会第42回中国・四国地方会, 越智 隆明, 浜田 希臣, 重松 裕二, 風谷 幸男, 松崎 圭輔, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19840910
  • 4) 拡張早期動態よりみた肥大型心筋症とその他の心肥大との鑑別 : 心筋症をめぐる諸問題 : シンポジウム : 日本循環器学会第42回中国・四国地方会, 浜田 希臣, 重松 裕二, 風谷 幸男, 松崎 圭輔, 越智 隆明, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19840910
  • 34) 左室流出路狭窄を伴った褐色細胞腫の1症例 : 日本循環器学会第42回中国・四国地方会, 土岐 秀夫, 重松 裕二, 風谷 幸男, 松崎 圭輔, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 石川 賢二, Japanese circulation journal, 19840910
  • 33) 下壁梗塞を思わせる心電図変化を呈した肥大型心筋症6例の検討 : 日本循環器学会第42回中国・四国地方会, 重松 裕二, 風谷 幸男, 松崎 圭輔, 西谷 晃二, 加藤 正和, 土井内 純治, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19840910
  • 31) 肥大型心筋症に異型狭心症を合併した1症例 : 日本循環器学会第42回中国・四国地方会, 風谷 幸男, 重松 裕二, 有木 喜和, 関谷 達人, 今村 陽一, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19840910
  • NONINVASIVE EVALUATION OF LEFT VENTRICULAR FUNCTION AND THE EFFECTS OF Ca^<2+> ANTAGONIST IN HYPERTENSION WITH ANGINA PECTORIS : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society, Ochi Takaaki, Hamada Mareomi, Shigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19840820
  • CALCIUM-CHANNEL BLOCKERS AND BETA-ADRENERGIC BLOCKER : THE DIFFERENCE EFFECTS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society, Doiuchi Junji, Hamada Mareomi, Shigematsu Yuji, Kazatani Yukio, Sekiya Michihito, Ochi Takaaki, Ito Taketoshi, Tatsuo Kokubu, Japanese circulation journal, 19840820
  • 47)冠動脈硬化症における全収縮期時間・拡張時間比の検討 : 日本循環器学会第41回中国・四国地方会, 松崎 圭輔, 重松 裕二, 風谷 幸男, 今村 陽一, 越知 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 土井内 純二, Japanese circulation journal, 19831201
  • 24)肥大型心筋症と心電図所見(第1報) : 心電図所見と臨床症状 : 日本循環器学会第41回中国・四国地方会, 加藤 正和, 重松 裕二, 風谷 幸男, 松崎 圭輔, 有木 喜和, 越知 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19831201
  • 23)愛媛県下における肥大型心筋症の疫学的検討(第1報) : 日本循環器学会第41回中国・四国地方会, 重松 裕二, 風谷 幸男, 土岐 秀夫, 松崎 圭輔, 加藤 正和, 今村 陽一, 越知 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, Japanese circulation journal, 19831201
  • TIME ANALYSIS: MORE SENSITIVE TECHNIQUE IN THE EVALUATION OF THE LEFT VENTRICULAR FUNCTION IN ESSENTIAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension, Ochi Takaaki, Shigematsu Yuji, Kazatani Yukio, Matsuzaki Keisuke, Nishitani Koji, Toki Hideo, Hamada Mareomi, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820
  • ABNORMAL BLOOD PRESSURE RESPONSE OF VALSALVA MANEUVER IN ESSENTIAL HYPERTENSIVES WITH PAROXYSMAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension, Kazatani Yukio, Hamada Mareomi, Shigematsu Yuji, Matsuzaki Keisuke, Ariki Kiwa, Kan Takuya, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820
  • DIFFERENCE IN MYOCARDIAL CHARACTERISTICS BETWEEN HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL HYPERTROPHY DUE TO ESSENTIAL HYPERTENSION USING THE EARLY DIASTOLIC TIME INTERVALS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION , Hamada Mareomi, Matsuzaki Keisuke, Shigematsu Yuji, Kazatani Yukio, Kato Masakazu, Doiuchi Junji, Ochi Takaaki, Ito Taketoshi, Kokubu Tatsuo, Japanese circulation journal, 19830820

MISC

  • 経皮的冠動脈形成術後4年を経過して多枝に冠攣縮を認めた1例, 原 裕二, 大島 清孝, 大塚 知明, 池田 俊太郎, 橋田 英俊, 桑原 大志, 児玉 光司, 重松 裕二, 濱田 希臣, 大谷 敬之, Japanese journal of interventional cardiology, Japanese journal of interventional cardiology, 13, 5, 467, 472, 19981010, 09148922, http://ci.nii.ac.jp/naid/10008359902
  • 高血圧と心疾患 (5月第5土曜特集 高血圧のすべて) -- (高血圧の病型・診断・合併症), 濱田 希臣, 重松 裕二, 医学のあゆみ, 医歯薬出版, 医学のあゆみ, 189, 9, 638, 641, 19990529, 00392359, http://ci.nii.ac.jp/naid/40000119578
  • 発作性心房細動により脾梗塞を合併した心室中部閉塞性肥大型心筋症, 徳安 一樹, 原 裕二, 松本 有司, 橋田 英俊, 池田 俊太郎, 大塚 知明, 日浅 豪, 北見 裕, 重松 裕二, 濱田 希臣, 日和田 邦男, Journal of cardiology, Journal of cardiology, 34, 5, 273, 277, 19991115, 09145087, http://ci.nii.ac.jp/naid/10005540365
  • Relative Wall Thickness Is an Independent Predictor of Left Ventricular Systolic and Diastolic Dysfunctions in Essential Hypertension., LI Liqi, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Hypertension Research, 日本高血圧学会, Hypertension Research, 24, 5, 493, 499, 20010000, 0916-9636, http://ci.nii.ac.jp/naid/130004436923, The objective of this study was to elucidate the relationship between left ventricular geometry and left ventricular (LV) function in patients with untreated essential hypertension. We evaluated LV systolic and diastolic functions by M-mode echocardiography in 24 normotensive control subjects (NC) and 129 patients with essential hypertension. Patients were divided into four groups according to the relative wall thickness and LV mass index: a normal left ventricle (n=57), a concentric remodeling (n=7), a concentric hypertrophy (n=31), and an eccentric hypertrophy (n=34) group. LV systolic function as measured by midwall fractional shortening (FS) was significantly decreased in both the concentric remodeling and concentric hypertrophy groups; no differences were observed for endocardial FS. LV diastolic function as measured by isovolumic relaxation time (IRT) was also decreased in both the concentric remodeling and concentric hypertrophy groups. In multivariate analysis, relative wall thickness (p<0.0001), end-systolic wall stress (p<0.0001), and systolic blood pressure (p=0.002) were independently associated (r2=0.72) with midwall FS in a model including age, LV mass index, body mass index, diastolic blood pressure and IRT. In addition, relative wall thickness (p=0.0008) and age (p<0.0001) were independently associated (r2=0.31) with IRT in a model including LV mass index, end-systolic wall stress, body mass index, systolic and diastolic blood pressures and midwall FS. We conclude that LV geometry as evaluated by relative wall thickness may provide a further independent stratification of LV systolic and diastolic functions in essential hypertension.
    (Hypertens Res 2001; 24:493-499)
  • Antiarrhythmic drug, cibenzoline, can directly improve the left ventricular diastolic function in patients with hypertrophic cardiomyopathy., HAMADA M, SHIGEMATSU Y, HARA Y, SUZUKI M, OHTSUKA T, HIASA G, OGIMOTO A, SAEKI H, HIWADA K, The Japanese Circultion SocietyJapanese Circulation Journal, 社団法人日本循環器学会, Japanese circulation journal, 65, 6, 531, 538, 20010520, 0047-1828|1347-4839, 10.1253/jcj.65.531, http://ci.nii.ac.jp/naid/110002625713, The effect of cibenzoline on left ventricular diastolic function was investigated in patients with hypertrophic cardiomyopathy (HCM). Before and 2 h after an oral administration of 200 mg of cibenzoline, echocardiographic, apexcardiographic and gated radionuclide angiographic studies were performed in 12 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 7 with hypertrophic nonobstructive cardiomyopathy (HNCM). After administration of cibenzoline, the left ventricular pressure gradient decreased from 96±33 mmHg to 29±22 mmHg (<0.0001). Fractional shortening decreased from 53.3±7.5 to 45.4±6.2% (p=0.0008) in patients with HOCM and from 49.9±8.7 to 40.9±7.5% (p=0.0039) in patients with HNCM. On the other hand, E-wave velocity increased and A-wave velocity decreased in both groups. The time between the second heart sound and O point was shortened from 253±53 to 176±21 ms (p<0.0001) in patients with HOCM and from 245±54 to 185±44 ms (p=0.0050) in patients with HNCM. The time to peak filling rate was shortened from 248±79 to 190±40ms (p=0.0072) in patients with HOCM and from 218±33 to 163±26ms (p=0.0052) in patients with HNCM. These results indicate that in patients with HCM, cibenzoline suppresses left ventricular systolic function, but can markedly improve left ventricular diastolic dysfunction through its direct action. (Jpn Circ J 2001; 65:531-538)
  • Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy., HARA Y, HAMADA M, OHTSUKA T, OGIMOTO A, SAEKI H, MATSUNAKA T, SUZUKI J, SHIGEMATSU Y, Springer TokyoHeart and Vessels, 17, 2, 53, 56, 20020000, 0910-8327, 10.1007/s003800200043
  • Use of thallium-201 myocardial scintigraphy for the prediction of the response to beta-blocker therapy in patients with dilated cardiomyopathy., HARA Y, HAMADA M, OHTSUKA T, OGIMOTO A, SAEKI H, SUZUKI J, MATSUNAKA T, NAKATA S, SHIGEMATSU Y, The Japanese Circulation SocietyCirculation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 66, 12, 1139, 1143, 20021120, 1346-9843|1347-4820, 10.1253/circj.66.1139, http://ci.nii.ac.jp/naid/110002666177, This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predict the usefulness of β-blocker therapy in patients with dilated cardiomyopathy (DCM). Tl-201 and MIBG were performed in 47 patients before β-blocker therapy. Patients were classified into group A, if their cardiac function improved, and group B, whose function remained unchanged. Two types of extent score (ES) by Tl-201 were proposed to quantitate myocardial damage, mean - 2SD (ES-2) and mean - 3SD (ES-3). The ES difference between ES-2 and ES-3 was calculated, and according to ES and ES difference, DCM cases were classified into 3 groups: mild-defect type (mild-type), moderate-defect type (moderate-type) and severe-defect type (severe-type). The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated, and the percent washout ratio of myocardial MIBG was obtained from these data. Group A comprised 18 mild-type, 14 moderate-type and 1 severe-type cases, and group B comprised 5 mild-type, 4 moderate-type and 5 severe-type cases. A significant relation was observed between the defect type on Tl-201 and the response to β-blocker therapy (p=0.0090). Both H/M MIBG uptake ratios and washout ratio were not significantly different in the 2 groups. Tl-201 may be useful for predicting the response to β-blocker therapy in patients with DCM. (Circ J 2002; 66: 1139 - 1143)
  • Attenuation of Biventricular Pressure Gradients by Cibenzoline in an 18-Year-Old Patient With Hypertrophic Obstructive Cardiomyopathy, HIASA Go, HAMADA Mareomi, SHIGEMATSU Yuji, HARA Yuji, OHTSUKA Tomoaki, OGIMOTO Akiyoshi, SAEKI Hideyuki, SUZUKI Jun, MATSUNAKA Tsuyoshi, HAMADA Hironobu, OKURA Takafumi, HIWADA Kunio, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 66, 12, 1173, 1175, 20021120, 13469843, http://ci.nii.ac.jp/naid/110002666183, An 18-year-old male patient with biventricular hypertrophic obstructive cardiomyopathy (HOCM) had successful reduction of the pressure gradients by cibenzoline. At 11 months after birth, he was first diagnosed with cardiac murmurs and by the age of 5 years, he was diagnosed with subpulmonic infundibular stenosis with a pressure gradient of 10 mmHg by cardiac catheterization. At the age of 14, re-catherterization revealed hypertrophic cardiomyopathy with isolated obstruction of the right ventricular outflow tract, with a pressure gradient of 70 mmHg, but no obstruction in the left ventricle. He began daily treatment with 30 mg propranolol. At the age of 18, he was admitted for cardiac evaluation. An echocardiogram revealed left mid-ventricular and subpulmonic obstructions associated with pressure gradients of 88 mmHg and 65 mmHg, respectively. A single oral dose of 200 mg of cibenzoline decreased the pressure gradients in the left and right ventricles (38 mmHg and 36 mmHg, respectively). He was then given 300 mg daily of cibenzoline, and both pressure gradients remained low without any complications 8 months later at the time of discharge. (Circ J 2002; 66: 1173 -1175)
  • Diagnostic usefulness of carotid pulse tracing in patients with hypertrophic obstructive cardiomyopathy due to midventricular obstruction: a comparison with idiopathic hypertrophic subaortic stenosis., The American College of Chest PhysiciansChest, 124, 4, 1275, 1283, 20030000, 10.1378/chest.124.4.1275
  • Effect of the addition of a beta-blocker on left ventricular remodeling and prognosis in patients with dilated cardiomyopathy treated with angiotensin-converting enzyme inhibitor., Lippincott Williams & WilkinsJournal of Cardiovascular Pharmacology, 41, Suppl 1, S5-S10, 20030000
  • 特発性間質性肺炎を伴った肥大型閉塞性心筋症に対して Cibenzoline が有効であった1症例, 齋藤 実, 原 裕二, 重松 裕二, 大塚 知明, 佐伯 秀幸, 大木元 明義, 横山 彰仁, 濱田 希臣, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 40, 1, 62, 64, 20030125, 03009173, http://ci.nii.ac.jp/naid/10010526910, 症例は72歳, 女性. 主訴は全身倦怠感. 平成12年より特発性間質性肺炎と診断され, 当科外来で経過観察されていた. 平成13年7月頃より全身倦怠感の増悪を認めたため精査加療目的で8月17日当科に入院した. 胸骨左縁第3肋間に収縮期雑音を認め, 心エコー図検査にて, 僧帽弁収縮期前方運動及び左室流出路圧較差52mmHgを認め, 肥大型閉塞性心筋症と診断した. 特発性間質性肺炎を伴っており, β遮断薬の使用は呼吸器症状の悪化が考えられるため, シベンゾリンにて加療した. 僧帽弁収縮期前方運動は消退し, 左室流出路圧較差は10mmHgと低下したが, 呼吸器症状の悪化は認めなかった. 呼吸器疾患を伴う肥大型心筋症の治療として, シベンゾリンが有用であることを経験したので報告する.
  • Effect of beta-blockers on insulin resistance in patients with dilated cardiomyopathy., HARA Y, HAMADA M, SHIGEMATSU Y, OHTSUKA T, OGIMOTO A, HIGAKI J, The Japanese Circulation SocietyCirculation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 8, 701, 704, 20030720, 1346-9843|1347-4820, 10.1253/circj.67.701, http://ci.nii.ac.jp/naid/110002666385, The aim of this study was to evaluate the effect of β-blockers on insulin resistance in patients with dilated cardiomyopathy (DCM). A secondary aim was to determine the effect of this treatment on plasma concentrations of tumor necrosis factor-α (TNF-α) and to investigate the relationships between this adipocytokine and insulin resistance. Insulin resistance determined using the Homeostatic Model Assessment (HOMA), echocardiographic measurements and analysis of plasma TNF-α concentration were carried out in 47 patients with DCM without diabetes mellitus before and after 6 months of β-blocker therapy. A reduction in left ventricular dimensions and an associated increase in ejection fraction occurred with β-blocker. The treatment resulted in a significant decrease in insulin resistance (HOMA index: Baseline, 2.73±3.36 vs, Month 6, 1.58±1.33, p=0.0347). Beta-blockade was also associated with a decrease in plasma TNF-α concentration although no significant relationship between this change and the improvement in insulin resistance was observed. Beta-blocker therapy in patients with DCM improved not only cardiac function, but also insulin resistance. The mechanism of the change in insulin function remains unclear, but may be related to improvements in left ventricular function or an attenuation of the inhibitory effect of reduction in TNF-α on insulin signaling. (Circ J 2003; 67: 701 - 704)
  • Rapid Progression of Primary Cardiac Leiomyosarcoma with Obstruction of the Left Ventricular Outflow Tract and Mitral Stenosis, Ogimoto Akiyoshi, Hamada Mareomi, Ohtsuka Tomoaki, HARA Yuji, SHIGEMATSU Yuji, YOKOYAMA Akihito, IMAGAWA Hiroshi, KAWACHI Kanji, KITO Katsumi, HIGAKI Jitsuo, Internal medicine, Japanese Society of Internal Medicine, Internal medicine, 42, 9, 827, 830, 20030901, 09182918, http://ci.nii.ac.jp/naid/50000297093
  • Effect of beta-blocker therapy in elderly patients with dilated cardiomyopathy., HARA Y, HAMADA M, SHIGEMATSU Y, OHTSUKA T, OGIMOTO A, SUZUKI J, HIGAKI J, The Japanese Circulation SocietyCirculation Journal, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 10, 826, 829, 20030920, 1346-9843|1347-4820, 10.1253/circj.67.826, http://ci.nii.ac.jp/naid/110002666223, The aim of this study was to evaluate whether β-blocker therapy can be safely administered to and improve cardiac function of elderly patients with dilated cardiomyopathy (DCM). Echocardiography and measurement of the concentrations of natriuretic peptides were carried out in 67 patients with DCM before and after 6 months of β-blocker therapy: 20 patients ≥65 years of age (older group); 47 <65 years of age (younger group). In all patients, β-blocker was safely administered and well tolerated. There was no significant difference in the dose of β-blocker between 2 groups. A reduction in the left ventricular dimensions and an associated increase in ejection fraction occurred in both treatment groups. The β-blocker treatment resulted in a significant decrease in the concentrations of natriuretic peptides in both groups. In conclusion, β-blocker therapy is well-tolerated and has similar effects on cardiac function in older and younger patients with DCM. (Circ J 2003; 67: 826 - 829)
  • Ischemia in the Territory of the First Major Septal Perfurator Branch Anomalously Originating From the First Diagonal Branch Leads to a Transient Leftward Shift of the QRS Axis in the Frontal Plane : A Case Report, KODAMA-TAKAHASHI Koji, SUZUKI Jun, WATANABE Akira, OHTSUKA Tomoaki, HASHIDA Hidetoshi, IKEDA Shutaro, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HAMADA Mareomi, HIWADA Kunio, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 67, 10, 885, 888, 20030920, 13469843, http://ci.nii.ac.jp/naid/110002666235, A patient with non-Q wave myocardial infarction had severe luminal narrowing in the first major septal perforator branch, which arose anomalously from the first diagonal branch. In this case, an exercise ECG showed a transient leftward QRS axis shift. (Circ J 2003; 67: 885 - 888)
  • Cardiac sympathetic nerve activity can detect congestive heart failure sensitively in patients with hypertrophic cardiomyopathy., The American College of Chest PhysiciansChest, 126, 3, 679, 686, 20040000, 10.1378/chest.126.3.679
  • 発作性心房粗動で発症し,抗結核薬が効果的であった心タンポナーデの1例, 大木元 明義, 濱田 希臣, 重松 裕二, 原 裕二, 佐伯 秀幸, 片山 均, 濱田 泰伸, 檜垣 實男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 41, 1, 112, 116, 20040000, 0300-9173, http://ci.nii.ac.jp/naid/130003652929, 症例は83歳男性. 自宅で失神しているところを発見され, 当院に緊急入院した. 来院時, 意識清明, 血圧90/68mmHg, 心拍数130/分の心房粗動, 心エコーで多量の心嚢液貯留と右心系の虚脱を認めた. 経過中, 失神, 血圧低下が出現したため心嚢穿刺を施行した. 少量の心嚢液を排液したのみで正常洞調律に回復した. 心嚢液は血性の滲出液で, 細胞診は Class III, 細菌培養陰性であった. 全身精査を行ったが悪性疾患の証拠は得られなかった. 心嚢液中のアデノシンデアミナーゼが118IU/Lと高値であったこと, 結核の既往があったことから, 結核性心膜炎・胸膜炎と診断し, エタンブトール, イソニアジド, リファンピシンの3者併用療法を開始した. その後, 経過順調であり, 治療開始3年経過したが心嚢液の再貯留は認めていない. 発作性心房粗動による失神で発症した心タンポナーデに対して抗結核薬が効果的であった1例を経験したので報告する.
  • 17-Year Follow-up Study of a Patient With Obstructive Hypertrophic Cardiomyopathy With a Deletion Mutation in the Cardiac Myosin Binding Protein C Gene, OGIMOTO Akiyoshi, HAMADA Mareomi, NAKURA Jun, SHIGEMATSU Yuji, HARA Yuji, OHTSUKA Tomoaki, MORISHIMA Atsuyuki, KIMURA Akinori, MIKI Tetsuro, HIWADA Kunio, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 68, 2, 174, 177, 20040120, 13469843, http://ci.nii.ac.jp/naid/110002667503, A 60-year-old Japanese man with obstructive hypertrophic cardiomyopathy was found to have a mutation in the cardiac myosin binding protein C gene: a single base deletion of a thymidine residue at nucleotide 11645 (codon 593) in exon 18. He was diagnosed at the age of 43 and has been followed for 17 years. During this follow-up period, echocardiograms and mechanocardiograms revealed progressive hypertrophy until the age of 54, then gradual dilation of the left ventricle associated with a decrease in the obstruction. Paroxysmal atrial fibrillation occurred at the age of 52 and progressed to chronic atrial fibrillation at the age of 53. He had congestive heart failure at the age of 58. (Circ J 2004; 68: 174 - 177)
  • 発作性心房粗動で発症し, 抗結核薬が効果的であった心タンポナーデの1例, 大木元 明義, 濱田 希臣, 重松 裕二, 原 裕二, 佐伯 秀幸, 片山 均, 濱田 泰伸, 檜垣 實男, 日本老年医学会雑誌, 日本老年医学会, 日本老年医学会雑誌, 41, 1, 112, 116, 20040125, 03009173, http://ci.nii.ac.jp/naid/10012898734
  • Insulin Resistance in Patients With Hypertrophic Cardiomyopthy, MURAKAMI Kazuo, SHIGEMATSU Yuji, HAMADA Mareomi, HIGAKI Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 68, 7, 650, 655, 20040620, 13469843, http://ci.nii.ac.jp/naid/110002692173, Background The aim of the present study was to investigate whether or not insulin resistance is present in hypertrophic cardiomyopathy (HCM), and also whether it is related to the clinical manifestations of HCM. Methods and Results The study group comprised 55 patients with HCM, 35 with essential hypertension (EHT) and 15 normotensive control subjects (NC). An insulin resistance index was estimated using the homeostasis model assessment (HOMA-IR) of fasting insulin - glucose interactions. In patients with HCM, prognosis and cardiovascular events were also checked. The HOMA-IR values in the HCM group (2.90±1.22) were significantly higher than those in the EHT (1.69±0.77) and NC groups (0.91±0.24). The HOMA-IR values in the EHT group were significantly higher than those in the NC group. Multiple regression analyses determined that left ventricular pressure gradient without provocation (p<0.0001), interventricular septal thickness (p=0.0143) and body mass index (p=0.0412) were independent determinants of insulin resistance in patients with HCM. During a mean follow-up of 105±50 months, 4 patients with HCM died suddenly and all of them had high HOMA-IR values. Conclusions The results suggest that patients with HCM without apparent diabetes mellitus or hypertension have insulin resistance and that insulin resistance may be related to the manifestations of HCM. (Circ J 2004; 68: 650 - 655)
  • 心疾患を合併する高血圧の治療, 濱田 希臣, 重松 裕二, 循環制御 = CIRCULATION CONTROL, 循環制御 = CIRCULATION CONTROL, 25, 2, 124, 129, 20040630, 03891844, http://ci.nii.ac.jp/naid/10013304098
  • Angiotensin-converting enzyme inhibitors as a new therapy for atrial fibrillation? Controversy. (Letter), American Heart Journal, 149, 3, e19, 20050000, 10.1016/j.ahj.2004.09.020
  • Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina., Springer-Verlag GmbHJournal of Molecular Medicine, 83, 8, 619, 625, 20050000, 10.1007/s00109-005-0641-9
  • Black pearl in the LIFE study: angiotensin II receptor blockade on atrial fibrillation for future personalized medicine. (Letter), American College of CardiologyJournal of the American College of Cardiology, 46, 8, 1585, 20050000, 10.1016/j.jacc.2005.07.035
  • Antiarrhythmic drug cibenzoline attenuates left ventricular pressure gradient and improves transmitral Doppler flow pattern in patients with hypertrophic obstructive cardiomyopathy caused by midventricular obstruction., HAMADA Mareomi, SHIGEMATSU Yuji, INABA Shinji, AONO Jun, IKEDA Shuntaro, WATANABE Kouki, OGIMOTO Akiyoshi, OHTSUKA Tomoaki, HARA Yuji, HIGAKI Jitsuo, The Japanese Circulation SocietyCirculation Journal, 社団法人日本循環器学会, 日本循環器學誌, 69, 8, 940, 945, 20050000, 1346-9843|1347-4820, 10.1253/circj.69.940, http://ci.nii.ac.jp/naid/110002696205, Background Recent interventional and surgical therapies to attenuate left ventricular pressure gradient (LVPG) can be difficult to perform in patients with hypertrophic obstructive cardiomyopathy (HOCM) cuased by midventricular obstruction (MVO), owing to the risk of inducing or deteriorating mitral regurgitation. Methods and Results The effects of the antiarrhythmic drug, cibenzoline, on LVPG and left ventricular (LV) diastolic function estimated by the change in the transmitral Doppler flow pattern were examined in 23 patients with HOCM and MVO. Hemodynamic changes 2 h after a single dose of 200 mg of cibenzoline and 3 months after oral administration of 300-450 mg of cibenzoline per day were examined. At 2 h after the treatment, LVPG decreased from 79±37 mmHg to 24±21 mmHg (p<0.0001). E-wave velocity significantly increased and A-wave velocity significantly decreased, and thus the E/A ratio increased from 0.83±0.39 to 1.36±0.50 (p<0.0001). After 3 months of treatment, LVPG remained decreased, and the E-wave and A-wave velocities and the E/A ratio remained improved. Conclusions Cibenzoline can attenuate LVPG and ameliorate LV diastolic dysfunction in patients with HOCM caused by MVO, which suggests a new strategy for the management of this condition. (Circ J 2005; 69: 940 - 945)
  • Effect of beta-blocker therapy on myocardial perfusion defects in thallium-201 scintigraphy in patients with dilated cardiomyopathy., Karger, International Journal of Cardiovascular Medicine, Surgery and PathologyCardiology, 104, 1, 16, 21, 20050000, 10.1159/000086048
  • 高齢男性に発症した原発性肺高血圧症の1例, 河野 珠美, 大木元 明義, 重松 裕二, 原 裕二, 大蔵 隆文, 井上 勝次, 檜垣 實男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 42, 1, 116, 120, 20050000, 0300-9173, http://ci.nii.ac.jp/naid/130003444606, 症例は73歳男性. 67歳時に狭心症と診断し, 経皮的冠動脈形成術を施行した. 再狭窄をくりかえすため, 69歳時に冠動脈バイパス術を施行し, 以後経過順調であった. 5カ月前より労作時の息切れ,胸痛が出現し, 食欲低下, 体重減少も出現したため入院した. 入院時, PaO255.9mmHgと低酸素血症を認め, 胸部X線写真では両側肺動脈の拡張を認めた. 心エコーでは右室腔の拡大と左室腔の狭小化, 心室中隔右室側から左室側への圧排がみられ, 三尖弁逆流波形では82.1mmHgの圧較差を認めた. 右心カテーテル検査で肺動脈圧は67/25 (41) mmHgと上昇していたが, 肺動脈楔入圧は4mmHgと正常であった. 精査を行った結果, 二次性肺高血圧症を示唆する所見はなく, 原発性肺高血圧症と診断し治療を開始した. 原発性肺高血圧症は高齢男性では極めてまれであり, 文献的考察を加えて報告する.
  • たこつぼ型心筋障害によると思われる心電図変化を繰り返した肥大型非閉塞性心筋症の1例, 三好 誠吾, 原 裕二, 大木元 明義, 重松 裕二, 大蔵 隆文, 檜垣 實男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 42, 1, 112, 115, 20050000, 0300-9173, http://ci.nii.ac.jp/naid/130003444605, 症例は67歳, 女性. 平成12年10月の健康診断時に心電図においてI・aVL・V1~V4誘導に陰性T波を認めたため, 精査加療目的で, 11月10日に当科外来を受診した. 諸検査の結果, 肥大型非閉塞性心筋症と診断し, 以後当科外来で経過観察していた. 外来受診時には, すでに陰性T波は改善していた. 平成15年9月上旬に, 胸部不快感を自覚した. 平成15年9月29日の心電図において, I・II・III・aVL・aVF・V2~V6誘導で陰性T波を認めた. 虚血性変化を疑い, 10月7日に当科へ入院した. 心臓カテーテル検査では, 冠動脈に有意な狭窄は認められなかった. MIBG心筋シンチにおいて, 心尖部を中心に集積の低下を認めたため, たこつぼ型心筋障害による心電図変化所見と判断した. その後の経過で陰性T波はほぼ消失した. 今回, たこつぼ型心筋障害によると思われる心電図変化を繰り返した肥大型非閉塞性心筋症の1例を経験したので報告する.
  • 高齢男性に発症した原発性肺高血圧症の1例, 河野 珠美, 大木元 明義, 重松 裕二, 原 裕二, 大蔵 隆文, 井上 勝次, 檜垣 實男, 日本老年医学会雑誌, 日本老年医学会, 日本老年医学会雑誌, 42, 1, 116, 120, 20050125, 03009173, http://ci.nii.ac.jp/naid/10015425536
  • たこつぼ型心筋障害によると思われる心電図変化を繰り返した肥大型非閉塞性心筋症の1例, 三好 誠吾, 原 裕二, 大木元 明義, 重松 裕二, 大蔵 隆文, 檜垣 實男, 日本老年医学会雑誌, 日本老年医学会, 日本老年医学会雑誌, 42, 1, 112, 115, 20050125, 03009173, http://ci.nii.ac.jp/naid/10015425526
  • Sex-Related Differences in Relations of Uric Acid to Left Ventricular Hypertrophy and Remodeling in Japanese Hypertensive Patients, KURATA Akira, SHIGEMATSU Yuji, HIGAKI Jitsuo, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 28, 2, 133, 139, 20050201, 09169636, http://ci.nii.ac.jp/naid/10016430657
  • Myocardial Perfusion Imaging Using Adenosine Triphosphate Stress Multi-Slice Spiral Computed Tomography : Alternative to Stress Myocardial Perfusion Scintigraphy, KURATA Akira, MOCHIZUKI Teruhito, KOYAMA Yasushi, HARAIKAWA Toyoaki, SUZUKI Jun, SHIGEMATSU Yuji, HIGAKI Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 69, 5, 550, 557, 20050420, 13469843, http://ci.nii.ac.jp/naid/110002696139, Background The present study was designed to: (i) detect myocardial ischemia in contrast enhanced multi-slice spiral computed tomography (CE-MSCT) using adenosine triphosphate (ATP) pharmacological stress test; and (ii) evaluate the potential of ATP stress CE-MSCT in a clinical setting. Methods and Results Twelve patients underwent ATP stress CE-MSCT and stress thallium-201 myocardial perfusion scintigraphy (MPS) and 9 of the patients received conventional coronary angiography (CAG). Dual CE-MSCT scans were performed for stress and rest images, with and without intravenous infusion of ATP (0.16 mg · kg-1 · min-1) at intervals of 20 min. Myocardial perfusion and coronary artery were visually evaluated using MSCT and compared the results obtained from MPS and CAG. Of 36 territories, stress images of CE-MSCT described 26 hypo-perfusion areas and MPS described 22 redistributions. The agreement between MSCT and MPS was 83% (30/36, p<0.05). In 141 coronary artery segments of 9 patients undergoing CAG, rest images of CE-MSCT, which had significantly higher assessability than stress images (89% vs 48%, p<0.05), described 76% (13/17) of culprit coronary stenoses. Conclusions Although CT-angiography should be currently assessed using rest images, ATP stress CE-MSCT can describe both ATP-induced myocardial ischemia and coronary artery stenoses in patients with coronary artery disease. (Circ J 2005; 69: 550 - 557)
  • 心肥大合併高血圧の治療 (第5土曜特集 高血圧UPDATE) -- (エビデンスに基づく高血圧の治療とあらたな展開), 重松 裕二, 檜垣 實男, 医学のあゆみ, 医歯薬出版, 医学のあゆみ, 214, 5, 400, 404, 20050730, 00392359, http://ci.nii.ac.jp/naid/40006774340
  • Sex-Related Differences in the Relations of Insulin Resistance and Obesity to Left Ventricular Hypertrophy in Japanese Hypertensive Patients, SHIGEMATSU Yuji, NORIMATSU Sadako, OHTSUKA Tomoaki, OKAYAMA Hideki, HIGAKI Jitsuo, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 29, 7, 499, 504, 20060701, 09169636, http://ci.nii.ac.jp/naid/10018346770
  • Effect of Intravenous Administration of Cibenzoline on Left Ventricular Diastolic Pressures in Patients With Hypertrophic Cardiomyopathy : Its Relationship to Transmitral Doppler Flow Profiles, HAMADA Mareomi, AONO Jun, IKEDA Shuntaro, WATANABE Kouki, INABA Shinji, SUZUKI Jun, OHTSUKA Tomoaki, SHIGEMATSU Yuji, Circulation journal : official journal of the Japanese Circulation Society, 社団法人日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 71, 10, 1540, 1544, 20070920, 13469843, http://ci.nii.ac.jp/naid/110006391128, Background Cibenzoline is able to improve left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), but the exact mechanism remains to be determined. Methods and Results The present study was designed to elucidate the effect of intravenous administration of 1.4 mg/kg of cibenzoline on aortic and LV pressures, and transmitral Doppler flow pattern in 7 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with hypertrophic nonobstructive cardiomyopathy (HNCM). Before and at the end of the administration, aortic and LV pressures, LV pressure gradient (LVPG) and transmitral Doppler velocity profiles were examined. After the administration of cibenzoline, LV minimal and end-diastolic pressures decreased from 9±4 mmHg to 1±5 mmHg (p=0.0049) and from 22±7 mmHg to 14±5 mmHg (p=0.0106) in patients with HOCM, and from 9±5 mmHg to 5±3 mmHg (p=0.0036) and from 20±6 mmHg to 14±3 mmHg (p=0.0033) in patients with HNCM. LVPG decreased in all patients with HOCM. E-wave velocity increased, A-wave velocity decreased, and thus the E/A ratio increased from 0.77±0.29 to 1.20±0.48 (p=0.0004). Conclusions Reduction of LV diastolic pressures by intravenous administration of cibenzoline may be related to an improvement in the E/A ratio in patients with HCM. (Circ J 2007; 71: 1540 - 1544)
  • メタボリックシンドロームの主要因子であるインスリン抵抗性および高尿酸血症と肥満の関連, 蘇 静, 重松 裕二, 日本体質医学会雑誌, 日本体質医学会, 日本体質医学会雑誌, 70, 1, 16, 22, 20080200, 13477137, http://ci.nii.ac.jp/naid/40015920350
  • 肥大型心筋症の臨床, 濱田 希臣, 泉 直樹, 山根 健一, 大島 弘世, 石橋 堅, 大島 清孝, 池田 俊太郎, 重松 裕二, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 日本心臓病学会, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 4, 1, 1, 19, 20090715, 18824501, http://ci.nii.ac.jp/naid/10025349988
  • β遮断薬(αβ遮断薬を含む) (特集 高血圧治療薬--降圧薬の上手な使い方), 重松 裕二, 檜垣 實男, レジデント, 医学出版, レジデント, 3, 3, 50, 56, 20100300, http://ci.nii.ac.jp/naid/40017285686
  • 高血圧が主体のメタボリックシンドロームの薬物療法 ARB介入試験による高血圧発症・進展制御のエビデンス (メタボリックシンドローム(第2版)--基礎・臨床の最新知見) -- (予防・管理・治療), 重松 裕二, 檜垣 實男, 日本臨床, 日本臨床社, 日本臨床, 69, 0, 597, 600, 20110100, 00471852, http://ci.nii.ac.jp/naid/40018269708
  • Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy : Association with insulin resistance, SHIGEMATSU Yuji, HAMADA Mareomi, NAGAI Takayuki, NISHIMURA Kazuhisa, INOUE Katsuji, SUZUKI Jun, OGIMOTO Akiyoshi, HIGAKI Jitsuo, Journal of cardiology, Journal of cardiology, 58, 1, 18, 25, 20110715, 09145087, http://ci.nii.ac.jp/naid/10031159569
  • Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients With Dilated Cardiomyopathy, OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SHIGEMATSU Yuji, TABARA Yasuharu, MIKI Tetsuro, HIGAKI Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 一般社団法人 日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 76, 8, 2003, 2008, 20120725, 13469843, http://ci.nii.ac.jp/naid/10030505036, Background: Sustained cardiac adrenergic stimulation has been implicated in the progression of cardiovascular events in patients with dilated cardiomyopathy (DCM). Our group hypothesized that a combination of polymorphisms that result in increased synaptic norepinephrine release and enhanced receptor function would predispose patients with DCM to cardiovascular events. The effect of polymorphisms in adrenergic receptor-related genes on cardiovascular event-free survival in patients with idiopathic DCM was evaluated. Methods and Results: Genotyping at 3 loci (ADRB1 Ser49Gly and Arg389Gly, and NET T-182C) was performed in 83 patients with DCM. Patients were followed prospectively to the endpoint of cardiovascular events (mean follow-up, 45 months). Cardiovascular events were defined as cardiac death and emergent hospitalization as a result of congestive heart failure, arrhythmia, and cerebrovascular events. Analyses were conducted based on the number of predicted risk genotypes a patient carried. The ADRB1 Ser49 allele carrier, ADRB1 Arg389 allele carrier, and NET-182CC genotype were defined as the predicted risk genotypes. Cardiovascular event-free survival was compared based on the number of predicted risk genotypes. Cardiovascular event-free survival was significantly better in patients with fewer than 3 predicted risk genotypes than in those with 3 predicted risk genotypes. Conclusions: Genotyping at these 3 loci might be a useful approach for identification of patients with DCM at risk for cardiovascular events.  (Circ J 2012; 76: 2003–2008)
  • 食塩による昇圧機序 (特集 高血圧における生活習慣修正とエビデンス), 重松 裕二, 循環器内科, 科学評論社, 循環器内科, 72, 2, 161, 165, 20120800, 1884-2909, http://ci.nii.ac.jp/naid/40019426470
  • Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy, INOUE Katsuji, OKAYAMA Hideki, NISHIMURA Kazuhisa, NAGAI Takayuki, SUZUKI Jun, OGIMOTO Akiyoshi, SAITO Makoto, YOSHII Toyofumi, HIASA Go, SUMIMOTO Takumi, FUNADA Jun-ichi, SHIGEMATSU Yuji, HAMADA Mareomi, HIGAKI Jitsuo, Circulation journal : official journal of the Japanese Circulation Society, 一般社団法人 日本循環器学会, Circulation journal : official journal of the Japanese Circulation Society, 77, 4, 1040, 1045, 20130325, 13469843, http://ci.nii.ac.jp/naid/10031139009, Background: The interventricular septum in hypertrophic cardiomyopathy (HC) has a unique shape, which is characterized by the convex curvature toward the left ventricle (LV). The aim of this study was to examine the relationship between curvature of the LV wall and regional myocardial strain. Methods and Results: Fifty-six patients with HC (mean age, 55±12 years) and 20 age- and sex-matched control subjects (mean age, 56±8 years) were enrolled. The curvature index (1/radius) was measured by drawing along the endocardial surface from the apical 4-chamber and short axis views. Peak systolic strain was calculated in the septal and lateral walls using 2-D speckle tracking echocardiography. The septal curvature index and septal longitudinal strain were significantly lower in the HC group than in the control group. A multivariate model using the HC patient data showed that the septal curvature index and septal thickness were the independent determinants of septal longitudinal strain (septal curvature index: β=–0.421, P<0.001; septal thickness: β=0.401, P=0.002). In addition, global longitudinal strain and E/e’ were worse in the lower septal curvature index group compared with the higher group. Conclusions: Septal longitudinal strain is associated with the degree of septal curvature. This indicates a possible link between LV wall configuration and regional myocardial function.  (Circ J 2013; 77: 1040–1045)
  • 80歳を超える高齢者に対するダビガトランによる抗凝固療法の検討, 河野 珠美, 大木元 明義, 青野 潤, 大藏 隆文, 重松 裕二, 檜垣 實男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 51, 4, 350, 355, 20140000, 0300-9173, http://ci.nii.ac.jp/naid/130004699378, 目的:心房細動患者では,脳梗塞の発症リスクが高く,高齢者においても塞栓症予防のための抗凝固療法が推奨されている.直接トロンビン阻害薬であるダビガトランは,ワルファリンにかわる新規抗凝固薬として期待されているが,高齢者や腎機能障害者での重篤な出血性副作用の報告により,特に80歳以上の高齢者での使用例が激減し,その効果・副作用についての報告は少ない.2011年8月の安全性速報(ブルーレター)が発行される以前にダビガトランによる抗凝固療法を開始した80歳を超える高齢者症例の臨床背景や内服後の経過とその安全性について報告する.方法:当科の関連病院で心房細動のため抗凝固療法を施行された80歳以上の患者28人(男性17人,女性11人)を対象とした.平均年齢は86.6±3.9歳(81~95歳)であった.ワルファリンによる抗凝固療法を施行しているのは19症例(68%)で,ダビガトランを内服した症例は9症例であった.CHADS2スコア,HAS-BLEDスコア,腎機能,出血性合併症の有無について検討した.結果:全例でダビガトランの処方量は220 mg/日であり,抗血小板薬は併用されていなかった.ダビガトラン内服中の症例で,クレアチニンクリアランス30 ml/min(クレアチニン1.55 mg/dl)と腎機能に注意が必要な症例を認めた.ダビガトランを継続している症例は全例で活性化部分トロンボプラスチン時間(APTT)は施設基準の2倍以内でコントロールされており,出血性合併症や塞栓症も認められなかった.2症例でAPTTの延長を認めたためワルファリンに変更したが,ダビガトラン内服中に出血性合併症は認められなかった.結論:80歳以上の心房細動患者でダビガトランによる抗凝固療法を行ったが,出血性合併症や新たな脳梗塞の発症は認められなかった.高齢者においても,出血の危険性,腎機能,併用薬など合併症発症のリスクを評価し,処方開始後は慎重に経過観察を行うことで,ダビガトランを安全に使用することが可能であった.
  • Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy, Iio Chiharuko, Shigematsu Yuji, Tabara Yasuharu, Kohara Katsuhiko, Miki Tetsuro, Hamada Mareomi, Higaki Jitsuo, Ogimoto Akiyoshi, Nagai Takayuki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Uetani Teruyoshi, Okayama Hideki, Okura Takafumi, International Heart Journal, 一般社団法人 インターナショナル・ハート・ジャーナル刊行会, International Heart Journal, 56, 4, 421, 427, 20150000, 1349-2365, http://ci.nii.ac.jp/naid/130005087577, Arrhythmias are associated with reduced quality of life and poor prognosis in patients with hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the SCN10A gene was associated with the PR interval. We examined whether the PR prolonging allele (A allele) in the SCN10A gene may be associated with cardiac conduction abnormalities in HCM patients.
    We genotyped the polymorphism in 149 HCM patients. Conduction abnormalities were defined as first-degree heart block, bundle-branch block, and bifascicular heart block. Patients were divided into two groups: group A consisted of 122 patients (82%) without a conduction abnormality; and group B consisted of 27 patients (18%) with one or more cardiac conduction abnormalities. The frequency distribution of the SCN10A genotypes (G/G, G/A, and A/A) among the patients with HCM was 71%, 26%, and 3%, respectively. A cardiac conduction abnormality was documented in 9% with G/G and 40% with G/A or A/A. There was a significant difference in the genotype distribution between the two groups (P = 0.0002). In the dominant A allele model, there was a significant difference in genotypes between the two groups (P < 0.0001). In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).
    The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.
  • Elevated Cardiac Enzymes in Hypertrophic Cardiomyopathy Patients With Heart Failure – A 20-Year Prospective Follow-up Study –, Hamada Mareomi, Shigematsu Yuji, Ohtani Takashi, Ikeda Shuntaro, 日本循環器學誌, 一般社団法人 日本循環器学会, 日本循環器學誌, 80, 1, 218, 226, 20160000, 1346-9843, http://ci.nii.ac.jp/naid/130005116989, Background:To better understand the evolution of typical hypertrophic cardiomyopathy (HCM) to heart failure (HF), we investigated the relationship between serum biochemical abnormalities and changes in left ventricular (LV) remodeling.Methods and Results:Seventy-seven HCM patients were followed for 20 years. Creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), LDH-1, troponin T and myosin light chain-1 (MLC-1) were measured. Abnormal CK-MB elevation was observed in 64% of HCM patients. LDH-1 was not significantly different compared with the control subjects. Troponin T elevation was observed in 3 HCM patients and MLC-1 elevation was not observed. According to median CK-MB, HCM patients were divided into 2 groups: group H (CK-MB ≥2.5%, n=33) and group L (CK-MB <2.5%, n=44). During the follow-up period in group H, LV end-diastolic dimension increased (P<0.0001), fractional shortening decreased (P<0.0004), and left atrial dimension increased (P<0.0001). The markers reflecting LV hypertrophy were significantly decreased. In group L, LV end-diastolic dimension increased (P<0.02) and left atrial dimension increased (P<0.0001). HF was observed in 18 patients in group H and in 4 in group L. There were 14 HF deaths in group H and 2 in group L, and 3 sudden cardiac deaths in group H.Conclusions:Persistent elevation of cardiac enzymes in HCM patients indicates ongoing myocardial injury, ultimately resulting in death by HF. (Circ J 2016; 80: 218–226)
  • Transmitral Doppler Flow Pattern in Left Atrial Myxoma, Hamada Mareomi, Ogimoto Akiyoshi, Shigematsu Yuji, Internal Medicine, 一般社団法人 日本内科学会, Internal Medicine, 57, 14, 2093, 2094, 20180000, 0918-2918, http://ci.nii.ac.jp/naid/130007404896
  • 僧帽弁置換術後, 2度にわたる再発性人口弁心内膜炎のため, 6年間に3度の弁置換術を施行した1例, 橋田 英俊, 濱田 希臣, 池田 俊太郎, 桑原 大志, 岡山 英樹, 原 裕二, 児玉 光司, 重松 裕二, 風谷 幸男, 富野 哲夫, 佐藤 晴瑞, 日和田 邦男, Journal of cardiology, Journal of cardiology, 29, 137, 141, 19970610, 09145087, http://ci.nii.ac.jp/naid/10006347940
  • Effect of patency from coronary angioplasty during acute myocardial infarction on left ventricular remodeling and levels of natriuretic peptides later., ELSEVIERThe American Journal of Cardiology, 88, 6, 683, 685, 20010000, 10.1016/S0002-9149(01)01817-3
  • Myocardial Ischemia Induced by Anomalous Aortic Origin of the Right Coronary Artery in a Patient with Atrial Septal Defect., Maki Fumie, Ohtsuka Tomoaki, Suzuki Makoto, Hara Yuji, Shigematsu Yuji, Hamada Mareomi, Kawachi Kanji, Hiwada Kunio, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 3, 371, 376, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070726, A 27-year-old woman with atrial septal defect (ASD) and a sensation of squeezing in the anterior chest by effort was admitted to our hospital. In addition to the ASD, the coronary angiogram showed an abnormal anomalous position of the right coronary artery. Exercise thallium (Tl)-201 cardiac scintigram with an electrocardiogram clearly detected myocardial ischemia in the inferior area. In the operative findings, the orifice of the right coronary artery was positioned high above the commissure between the right and left sinuses of Valsalva, and it ran between the aorta and pulmonary trunk. Considering myocardial ischemia possibly caused by the anomalous origin of the right coronary artery, a coronary artery bypass graft (CABG) was simultaneously performed to the right coronary artery with direct closure of ASD. The myocardial ischemic finding in the inferior area disappeared after the operation, and she was also relieved from the chest pain. In view of these findings, we suggest that an active combination treatment such as CABG and ASD closure is highly successful in a patient with a threatening coronary anomaly and congenital heart disease.
  • Congenitally Corrected Transposition of the Great Arteries in a 65-Year-Old Woman., Sasaki Osamu, Hiwada Kunio, Hamada Mareomi, Hiasa Go, Ogimoto Akiyoshi, Ohtsuka Tomoaki, Suzuki Makoto, Hara Yuji, Shigematsu Yuji, Araki Shuhei, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 5, 645, 649, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070778, A 65-year-old Japanese woman was admitted to hospital because of exertional dyspnea. Transthoracic echocardiography showed diffuse hypokinesis of the left-sided ventricular wall, but was not clear enough to provide useful information because of the rotation of the cardiac apex and the presence of lung tissue. Systemic ventriculography showed that the left-sided ventricle with heavy trabeculations was morphologically similar to a normal right ventricle. Magnetic resonance imaging (MRI) clearly revealed corrected transposition of the great arteries. Because this patient had no severe associated cardiac anomalies, systemic ventricular dysfunction is thought to be the major cause of exertional dyspnea. MRI is a useful non-invasive method for the rapid evaluation of cardiac morphology.
  • Hypoglycemic Syncope Induced by a Combination of Cibenzoline and Angiotensin Converting Enzyme Inhibitor., Ogimoto Akiyoshi, Hiwada Kunio, Hamada Mareomi, Saeki Hideyuki, Hiasa Go, Ohtsuka Tomoaki, Hashida Hidetoshi, Hara Yuji, Okura Takafumi, Shigematsu Yuji, Japanese Heart Journal, International Heart Journal刊行会, Japanese Heart Journal, 42, 2, 255, 259, 20010000, 0021-4868, http://ci.nii.ac.jp/naid/130000070739, A 65-year-old Japanese woman with dilated cardiomyopathy, hypothyroidism and refractory sustained ventricular tachycardia experienced a near-death hypoglycemic syncope. The attack seemed to be induced by a high level of serum insulin, probably due to cibenzoline and by concomitant use of an angiotensin converting enzyme inhibitor (ACEI). Additionally, decreased food intake because of a severe toothache may have contributed to the deterioration of her condition. This case warns cardiologists that a combined cibenzoline and ACEI therapy can provoke serious adverse effects such as hypoglycemic syncope in the elderly. Therefore, the possibility of a hypoglycemic attack associated with these drugs should be explained to patients who are in poor condition.
  • Comparison of effects of carvedilol versus metoprolol on cytokine levels in patients with idiopathic dilated cardiomyopathy., ELSEVIERThe American Journal of Cardiology, 89, 8, 996, 999, 20020000, 10.1016/S0002-9149(02)02258-0
  • Serum levels of matrix metalloproteinases and tumor necrosis factor-alpha in patients with idiopathic dilated cardiomyopathy and effect of carvedilol on these levels., ELSEVIERThe American Journal of Cardiology, 91, 8, 1024, 1027, 20030000, 10.1016/S0002-9149(03)00133-4
  • Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy., OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, OHTSUKA Tomoaki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SHIGEMATSU Yuji, TABARA Yasuharu, KOHARA Katsuhiko, MIKI Tetsuro, HIGAKI Jitsuo, Japanese College of CardiologyJournal of Cardiology, Journal of cardiology, 54, 1, 66, 70, 20090815, 0914-5087, 10.1016/j.jjcc.2009.04.001, http://ci.nii.ac.jp/naid/10025184385
  • 17年間の経過観察中肺高血圧の進展を認めなかった高齢者動脈管開存症の1例, 松中 豪, 原 裕二, 池田 俊太郎, 橋田 英俊, 桑原 大志, 川上 秀生, 岡山 英樹, 林 豊, 児玉 光司, 重松 裕二, 小原 克彦, 濱田 希臣, 日和田 邦男, 日本老年医学会雑誌, 日本老年医学会雑誌, 33, 9, 697, 701, 19960925, 03009173, http://ci.nii.ac.jp/naid/10013851975
  • Relation of circulating interleukin-6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction., Clinical Cardiology, 27, 7, 417, 420, 20040000
  • The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients, SHIGEMATSU Yuji, NORIMATSU Sadako, OGIMOTO Akiyoshi, OHTSUKA Tomoaki, OKAYAMA Hideki, HIGAKI Jitsuo, Hypertension Research, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 32, 6, 500, 504, 20090601, 0916-9636|1348-4214, 10.1038/hr.2009.41, http://ci.nii.ac.jp/naid/10024831267
  • 17年間の経過観察中肺高血圧の進展を認めなかった高齢者動脈管開存症の1例, 松中 豪, 重松 裕二, 小原 克彦, 濱田 希臣, 日和田 邦男, 原 裕二, 池田 俊太郎, 橋田 英俊, 桑原 大志, 川上 秀生, 岡山 英樹, 林 豊, 児玉 光司, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 33, 9, 697, 701, 19960000, 0300-9173, http://ci.nii.ac.jp/naid/130003444332, 症例は66歳, 女性. 1978年頃より労作時の動悸, 胸部不快感が出現するようになり, 1978年10月17日, 自覚症状の原因精査目的で当科へ入院した. 心臓カテーテル検査にて動脈管開存症と診断された. 左右短絡率は15%と少なく, また肺動脈圧は30/18mmHgと高値を認めないため手術は施行されなかった. 1995年2月, 起床時に左側半盲を認めた. 頭部CT検査にて脳梗塞と診断され原因精査のため8月21日, 当科へ再入院した. 心房細動を認めたが, 肺動脈圧は27/14mmHgであり肺高血圧は認めなかった. 血管内超音波検査により評価した動脈管の直径は4.4mmであり石灰化は認められなかった. 今回, 動脈管の性状に対する血管内超音波検査による評価に加え, 長期の経過観察にて肺高血圧への進展を認めなかった高齢者動脈管開存症の症例を報告した.
  • 高齢にて著しい左室内圧較差の出現をみた家族性肥大型心筋症患者の1例, 濱田 希臣, 重松 裕二, 小林 卓正, 児玉 光司, 林 豊, 原 裕二, 岡山 英樹, 川上 秀生, 桑原 大志, 池田 俊太郎, 橋田 英俊, 日和田 邦男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 33, 4, 284, 292, 19960425, 03009173, http://ci.nii.ac.jp/naid/10013851445, 患者は84歳女性. 1988年 (78歳), 顔面骨折の術前検査の心電図でIII, aVF の QS パターンを指摘され当科へ紹介された. 心エコー図検査により, 僧帽弁の収縮期前方運動 (SAM) は認めなかったが非対称性中隔肥大 (ASH: 心室中隔厚, 21mm, 左室後壁厚, 10mm) を認め, 肥大型非閉塞性心筋症と診断し, 以後β遮断薬とCa拮抗薬で治療していた.
    1992年末よりSAM及び左室内圧較差の出現を認め, 同時に労作時の息切れを認めるようになった. 左室内圧較差の増大, 左室駆出時間係数の延長が徐々に進展し, それぞれ, 1992年12月の46mmHg, 369msecから1994年5月の131mmHg, 459msecへと変化した. 1994年夏頃より, 著しい全身倦怠感が出現し9月28日, 当科へ入院した. ジソピラミド150ms/日の投与により, 左室内圧較差は180mmHgから76mmHgへと減少, 左室駆出時間係数も485msecから419msecへと短縮し, 左室駆出様式の改善と共に自覚症状も著しく改善した. 超高齢での左室内圧較差の出現と急激な進展を示す症例は稀であり, ジソピラミドの治療効果とともに報告した.
  • Serum Creatinine Level Underestimates Hypertensive Renal Involvement in Elderly Patients with Essential Hypertension, SHIGEMATSU Yuji, HAMADA Mareomi, HIASA Go, SASAKI Osamu, OHTSUKA Tomoaki, HASHIDA Hidetoshi, IKEDA Shuntaro, SUZUKI Makoto, HARA Yuji, HIWADA Kunio, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 22, 4, 297, 301, 19991101, 09169636, http://ci.nii.ac.jp/naid/10008737177
  • Apical Hypertrophic Cardiomyopathy Associated With Life-Threatening Paroxysmal Atrial Flutter With a Slow Ventricular Response:- A Case Report -, Hiasa Go, Shigematsu Yuji, Hiwada Kunio, Hamada Mareomi, Kodama Koji, Watanabe Sanae, Ohtsuka Tomoaki, Ikeda Shuntaro, Hashida Hidetoshi, Kuwahara Taishi, Hara Yuji, JAPANESE CIRCULATION JOURNAL, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 64, 3, 225, 228, 20000000, 0047-1828, http://ci.nii.ac.jp/naid/130004427688, A 58-year-old male patient had apical hypertrophic cardiomyopathy (HCM) associated with a life-threatening tachycardia due to atrial flutter. Following palpitation and dyspnea for 2-3h, he became unconscious because of circulatory catastrophe, but was fully resuscitated. An electrocardiogram recorded just before the loss of consciousness revealed atrial flutter at a rate of 260 beats/min with a 2:1 ventricular response. He was diagnosed as having apical HCM based on the echocardiographic and left ventriculographic findings. Atrial stimulation at a rate of 150 pacings/min for 1 min caused a marked drop in systemic systolic blood pressure from 170 to 120 mmHg. The patient was treated with 150 mg of cibenzoline per day to prevent supraventricular tachyarrhythmias and to improve left ventricular diastolic function. At the time of the recent follow-up at 2 and a half years, he felt quite well.
  • Apical Hypertrophic Cardiomyopathy Associated With Life - Threatening Paroxysmal Atrial Flutter With a Slow Ventricular Response - A Case Report -, HIASA Go, HAMADA Mareomi, KODAMA Koji, WATANABE Sanae, OHTSUKA Tomoaki, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 64, 3, 225, 228, 20000220, 00471828, http://ci.nii.ac.jp/naid/110002571798, A 58-year-old male patient had apical hypertrophic cardiomyopathy(HCM) associated with a life-threatening tachycardia due to atrial flutter. Following palpitation and dyspnea for 2-3 h, he became unconscious because of circulatory catastrophe, but was fully resuscitated. An electrocardiogram recorded just before the loss of consciousness revealed atrial flutter at a rate of 260 beats/min with a 2:1 ventricular response. He was diagnosed as having apical HCM based on the echocardiographic and left ventriculographic findings. Atrial stimulation at a rate of 150 pacings/min for 1 min caused a marked drop in systemic systolic blood pressure from 170 to 120 mmHg. The patient was treated with 150 mg of cibenzoline per day to prevent supraventricular tachyarrhythmias and to improve left ventricular diastolic function. At the time of the recent follow-up at 2 and a half years, he felt quite well.
  • Effect of Beta - Blocker on Left Ventricular Function and Natriuretic Peptides in Patients, With Chronic Heart Failure Treated With Angiotensin - Converting Enzyme Inhibitow, HARA Yuji, HAMADA Mareomi, SHIGEMATSU Yuji, SUZUKI Makoto, KODAMA Koji, KUWAHARA Taishi, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, HIASA Go, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 64, 5, 365, 369, 20000420, 00471828, http://ci.nii.ac.jp/naid/110002571823, To evaluate whether or not β-blockers can improve the condition of patients with heart failure treated with a combination of diuretics, digitalis and angiotensin-converting enzyme inhibitor (ACEI), 52 patients with chronic heart failure who have been treated with ACEI for more than 6 months were enrolled. They were divided into 2 groups: 26 patients continued the same therapy another 6 months or more (group A), and 26 patients were given oral metoprolol for 6 months or more, in addition to the ACEI (group B). Echocardiographic parameters and atrial and brain natriuretic peptides (ANP, BNP) were measured. The left ventricular dimensions at end-diastole and end-systole were significantly decreased and fractional shortening was significantly increased in group B after 6 months’ treatment with the β-blocker, but these parameters remained unchanged in group A. Plasma levels of both ANP and BNP were significantly decreased in group B, but remained unchanged in group A. These results indicate that concomitant β-blocker therapy can improve left ventricular function and attenuate plasma ANP and BNP levels in patients with chronic heart failure treated with ACEI.
  • Time-Course Changes in Left Ventricular Geometry and Function during the Development of Hypertension in Dahl Salt-Sensitive Rats, QU Peng, HAMADA Mareomi, IKEDA Shuntaro, HIASA Go, SHIGEMATSU Yuji, HIWADA Kunio, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 23, 6, 613, 623, 20001101, 09169636, http://ci.nii.ac.jp/naid/10008740952
  • Serum markers of angiogenesis and myocardial ultrasonic tissue characterization in patients with dilated cardiomyopathy., European Society of CardiologyThe European Journal of Heart Failure, 7, 4, 689, 695, 20050000, 10.1016/j.ejheart.2004.09.011
  • Relation of genetic predisposition and insulin resistance to left ventricular hypertrophy in hypertension., ELSEVIERThe American Journal of Hypertension, 18, 4 Pt 1, 457, 463, 20050000, 10.1016/j.amjhyper.2004.10.027
  • Dopamine agonists and valvular heart disease in Japanese patients with Parkinson’s disease., J Neurol, 254, S4, 54, 57, 20070000, 10.1007/s00415-007-4009-7
  • Pharmacogenetic interactions between angiotensin-converting enzyme insertion/deletion polymorphism and response to cibenzoline in patients with hypertrophic obstructive cardiomyopathy., OGIMOTO Akiyoshi, OKAYAMA Hideki, NAGAI Takayuki, OHTSUKA Tomoaki, SUZUKI Jun, INOUE Katsuji, NISHIMURA Kazuhisa, SAITO Makoto, SHIGEMATSU Yuji, HAMADA Mareomi, MIKI Tetsuro, HIGAKI Jitsuo, Journal of Cardiovascular Pharmacology, 55, 5, 506, 510, 20100000, 0160-2446, 10.1097/FJC.0b013e3181d8bc4b
  • The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease., ElsevierInternational Journal of Cardiology, Epub ahead of print, 20100000, 10.1016/j.ijcard.2010.04.040
  • Usefulness of the MOSAIC (measurement of stenosis by aliasing coronary flow) method using transthoracic color Doppler echocardiography in unstable angina patients., ElsevierInternational Journal of Cardiology, Epub ahead of print, 20100000, 10.1016/j.ijcard.2010.05.007
  • 成人型心房中隔欠損症の根治手術に伴う自覚症状,心拡大改善度に及ぼす加齢の影響, 重松 裕二, 濱田 希臣, 岡山 英樹, 原 裕二, 林 豊, 児玉 光司, 日和田 邦男, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 32, 11, 736, 740, 19950000, 0300-9173, http://ci.nii.ac.jp/naid/130003652088, 高齢者心房中隔欠損症 (ASD) の自然予後や手術至適時期については現在統一した見解が得られていない. そこで, ASD根治術の効果が手術施行年齢により如何なる修飾を受けるかを明らかにするため, 高齢者ASD群と若年者ASD群との術前血行動態諸指標および術後経過を比較検討した. 対象は50歳以上でASDの根治術を受けた11名 (高齢者ASD群) [男性5名, 女性6名, 平均年齢58±5歳] であり, 50歳未満でASDの根治術を受けた8名 (若年者ASD群) [男性5名, 女性3名, 平均年齢38±6歳] を対照とした. 術前の血行動態諸指標として, 収縮期肺動脈圧, 左→右シャント率, 肺体血流比, 肺体血管抵抗比および欠損孔サイズを計測した. 自覚症状, 心胸郭比の変化は術前と術後3カ月の時点で比較した. その結果, 1) 高齢者ASD群では若年者ASD群に比し, 心房細動の合併頻度 (27%対0%) が高率であった. 2) 血行動態諸指標および欠損孔サイズは両群間で差を認めず, 年齢との間には相関はなかった. 3) 手術死亡は両群とも認めなかった. 術後自覚症状は全例で改善を示したが, 術前心房細動を合併しでいた高齢者ASD 3症例では労作時の息切れなどの症状が術後も残存した. 4) 高齢者ASD群の心胸郭比は術前高値 (58±4%) を示し, 60歳以上で根治術を受けた3例では術後3カ月の時点でも縮小を認めなかった. 術前の心胸郭比は両群間に有意差を認めず, 術後3カ月の心胸郭比は若年者ASD群で高齢者ASD群に比較し有意に小さかった.
    高齢者心房中隔欠損症の中には根治術にもかかわらず術後の自覚症状, 心拡大の改善度が小さい症例が認められた. したがって, できる限り若年での根治術の施行が望ましいと考えられた.
  • ドパミン投与により心室内圧較差の増大と僧帽弁前方運動(SAM)を呈した高齢者の1例, 岡山 英樹, 濱田 希臣, 重松 裕二, 阿部 充伯, 向井 幹夫, 松岡 宏, 住元 巧, 日和田 邦男, 村上 凡平, 日本老年医学会雑誌, 一般社団法人 日本老年医学会, 日本老年医学会雑誌, 31, 3, 244, 248, 19940000, 0300-9173, http://ci.nii.ac.jp/naid/130003652035, 症例は91歳女性. 顔面腫瘍の切除術後血圧低下により呼吸困難・全身倦怠感を訴えたため, 昇圧目的でドパミンを投与したが血圧は改善しなかった. 心エコー上, 心尖部に心室瘤を認め, 心室中部の34.6mmHgの圧較差および僧帽弁前方運動 (SAM) を認めた. 心エコー図による経過観察で, ドパミンの中止および輸液により圧較差は減少し, SAMは消失した. このことから, SAMの発生にはβ刺激による心筋の hypercontraction が重要な因子の一つであることが示唆され, 興味深い症例と思われたので文献的考察を加えて報告した.
  • Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy, Kawakami Hideo, Shigematsu Yuji, Ohtsuka Tomoaki, Okayama Hideki, Hayashi Yutaka, Hara Yuji, Kodama Koji, Hamada Mareomi, Hiwada Kunio, JAPANESE CIRCULATION JOURNAL, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 62, 12, 873, 876, 19980000, 0047-1828, http://ci.nii.ac.jp/naid/130004427432, To examine the prognostic role of the circulating soluble form of Fas (sFas), circulating sFas levels were measured in 33 patients with dilated cardiomyopathy (DCM) and 12 age-matched normal control subjects (NC) using an enzyme-linked immunosorbent assay (ELISA). Circulating sFas levels in DCM were significantly higher than those in NC (2.42±1.02 vs 1.66±0.20 ng/ml, p=0.015). Patients with DCM were stratified into 2 groups [group I (n=15): sFas ≥2.06 ng/ml; group II (n=18): sFas <2.06 ng/ml] on the basis of the mean value plus 2SD of circulating sFas level in NC. The circulating sFas level was significantly increased in relation to the severity of heart failure and correlated positively to left ventricular end-diastolic pressure in DCM. However, there were no significant differences in left ventricular dimension between the 2 groups. There were 5 deaths from worsening heart failure in group II, but there were no deaths in group I during the follow-up period. In conclusion, circulating sFas levels were increased in patients with DCM. Circulating sFas levels are increased in proportion to the severity of heart failure and may provide prognostic information independent of left ventricular geometry. (Jpn Circ J 1998; 62: 873 - 876)
  • An Early Systolic Sound Associated With Midventricular Obstruction in a Patient With Hypertrophic Cardiomyopathy, OHTSUKA Tomoaki, HAMADA Mareomi, HARA Yuji, KUWAHARA Taishi, KODAMA Koji, SHIGEMATSU Yuji, IWATA Takeru, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 62, 5, 385, 388, 19980420, 00471828, http://ci.nii.ac.jp/naid/110002561018, A 57-year-old woman was admitted for examination because of chest discomfort. Transthoracic echocardiography was performed and she was diagnosed as having hypertrophic cardiomyopathy. An echocardiogram also revealed that she had midventricular obstruction with a pressure gradient of 125 mmHg determined by Doppler echocardiography. A phonocardiogram showed an early systolic sound and the beginning of the sound coincided with the time of septal-posterior wall contact. In addition, the timing also corresponded to the sudden obstruction of blood flow in the region of the midventricular narrowing. Furthermore, this sound markedly decreased with the reduction in pressure gradient caused by cibenzoline treatment. Thus, it was concluded that the early systolic sound was associated with midventricular obstruction and produced by a rapid deceleration of the interventricular flow caused by midventricular obstruction. (Jpn Circ J 1998; 62: 385-388)
  • Marked Attenuation of Mitral Regurgitation by Stent Implantation : A Patient With Unstable Angina, OHTSUKA Tomoaki, HAMADA Mareomi, KODAMA Koji, IKEDA Shuntaro, HASHIDA Hidetoshi, KUWAHARA Taishi, HARA Yuji, SHIGEMATSU Yuji, HIWADA Kunio, Journal of cardiology, Journal of cardiology, 31, 91, 95, 19980610, 09145087, http://ci.nii.ac.jp/naid/10006348116
  • Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy, KAWAKAMI Hideo, SHIGEMATSU Yuji, OHTSUKA Tomoaki, OKAYAMA Hideki, HAYASHI Yutaka, HARA Yuji, KODAMA Koji, HAMADA Mareomi, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 62, 12, 873, 876, 19981120, 00471828, http://ci.nii.ac.jp/naid/110002561127, To examine the prognostic role of the circulating soluble form of Fas(sFas), circulating sFas levels were measured in 33 patients with dilated cardiomyopathy(DCM)and 12 age-matched normal control subjects(NC)using an enzyme-linked immunosorbent assay(ELISA). Circulating sFas levels in DCM were significantly higher than those in NC(2.42±1.02 vs 1.66±0.20ng/ml, p=0.015). Patients with DCM were stratified into 2 groups[group I(n=15) : sFas32.06ng/ml ; group II(n=18) : sFas<2.06ng/ml]on the basis of the mean value plus 2SD of circulating sFas level in NC. The circulating sFas level was significantly increased in relation to the severity of heart failure and correlated positively to left ventricular end-diastolic pressure in DCM. However, there were no significant differences in left ventricular dimension between the 2 groups. There were 5 deaths from worsening heart failure in group II, but there were no deaths in group I during the follow-up period. In conclusion, circulating sFas levels were increased in patients with DCM. Circulating sFas levels are increased in proportion to the severity of heart failure and may provide prognostic information independent of left ventricular geometry.
  • Relation between Coronary Blood Flow and Left Ventriculaar Mass in Hypertension : Noninvasive Quantification of Coronary Blood Flow by Thallium-201 Myocardial Scintigraphy, HAMADA Mareomi, KUWAHARA Taishi, SHIGEMATSU Yuji, KODAMA Koji, HARA Yuji, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, NAKATA Shigeru, HIWADA Kunio, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 日本高血圧学会, Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension, 21, 4, 227, 234, 19981201, 09169636, http://ci.nii.ac.jp/naid/10009563564, This study was conducted to quantify coronary blood flow (CBF) noninvasively according to the fractionation principle and to elucidate the relation between CBF and left ventricular hypertrophy. CBF/cardiac output (CO), estimated on the basis of the ratio of myocardial uptake/total injected dose of thallium-201(% cardiac uptake), was determined in 14 control subjects and 40 patients with essential hypertension. CBF and CBF per 100g of myocardium (unit CBF) were calculated according to the following formulas: CBF=% cardiac uptake×CO, and unit CBF=(CBF/LVM)×100, where CO and left ventricular mass (LVM) are echocardiographically determined. There was good reproducibility of % cardiac uptake (r=0.983, p<0.0001). Percent cardiac uptake was greater in hypertensive patients (4.65±1.44%) than in control subjects (3.64±0.64%), and there was a positive correlation between % cardiac uptake and LVM. CBF (ml/min) was greater in hypertensive patients (240.7±80.5) than in control subjects (194.9±36.9), but unit CBF (ml/min/100g) was less in hypertensive patients (102.2± 26.7) than in control subjects (150.3±30.5). Multiple regression analyses showed that LVM was the most potent independent predictor of resting CBF in hypertension. Our results indicate that CBF, determined by thallium-201 myocardial scintigraphy, increases parallel to the increase in LVM, but unit CBF decreases even in the resting condition in patients with essential hypertension. (Hypertens Res 1998; 21: 227-234)
  • Serum Creatinine Level Underestimates Hypertensive Renal Involvement in Elderly Patients with Essential Hypertension., Shigematsu Yuji, Hiwada Kunio, Hamada Mareomi, Hiasa Go, Sasaki Osamu, Ohtsuka Tomoaki, Hashida Hidetoshi, Ikeda Shuntaro, Suzuki Makoto, Hara Yuji, Hypertension Research, 日本高血圧学会, Hypertension Research, 22, 4, 297, 301, 19990000, 0916-9636, http://ci.nii.ac.jp/naid/130003456407, It is well recognized that serum creatinine level provides a quick general assessment of renal function. However, we frequently encounter elderly hypertensive patients with renal involvement whose serum creatinine levels are within normal limits. The aim of this study was thus to determine whether serum creatinine level is a sensitive indicator of renal function in elderly hypertensive patients. Study groups were classified according to age: 82 elderly patients (aged 65 yr or older) and 98 middle-aged patients (aged 40-65 yr) with essential hypertension. To assess hypertensive renal involvement, serum creatinine and serum uric acid levels were measured. We also measured the left ventricular mass (LVM) index by using echocardiography as a marker of hypertensive target organ damage. There was no age-related difference in the LVM index, but the serum creatinine level in elderly hypertensive patients was significantly lower than that in middle-aged hypertensive patients. There was no significant difference in serum uric acid level between the two groups. In addition, the LVM index was correlated with the serum uric acid level (r=0.46, p=0.0001) but not with the serum creatinine level in elderly hypertensive patients. In middle-aged hypertensive patients, the LVM index was related to both serum uric acid level (r=0.41, p=0.007) and serum creatinine level (r=0.43, p=0.003). In conclusion, serum creatinine level may underestimate hypertensive renal involvement in elderly hypertensive patients. In contrast, serum uric acid level may be a sensitive indicator of hypertensive target organ damage irrespective of age. (Hypertens Res 1999; 22: 297-301)
  • 原発性肺高血圧症の姉弟例, 児玉 光司, 重松 裕二, 濱田 希臣, 日和田 邦男, 橋本 博之, 橋本 治久, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 54, 0, 201, 202, 19901220, 00471828, http://ci.nii.ac.jp/naid/110002616459
  • Systolic Time Intervals Can Detect Patients with Angina Pectoris at High-Risk, HAMADA Mareomi, SHIGEMATSU Yuji, KODAMA Kouji, HARA Yuji, KUWAHARA Taishi, HASHIDA Hidetoshi, IKEDA Shuntaro, OHTSUKA Tomoaki, SASAKI Osamu, HIWADA Kunio, 日本臨床生理学会雑誌 = Japanese journal of applied physiology, 日本臨床生理学会雑誌 = Japanese journal of applied physiology, 27, 1, 51, 60, 19970201, 02867052, http://ci.nii.ac.jp/naid/10008697739
  • 症例 数年間で正常T波から漸次陰性T波へ移行した心尖部肥大型心筋症の2症例, 松岡 宏, 重松 裕二, 西谷 晃二, 関谷 達人, 風谷 幸男, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 心臓, 心臓, 心臓, 17, 8, 886, 892, 19850000, 0586-4488, http://ci.nii.ac.jp/naid/130004411506, 肥大型心筋症の心電図変化は多彩である.胸部誘導の深い陰性T波もその1つであり,高頻度に認められる変化であるが,正常T波から陰性T波への自然経過を観察し得た症例はまれである.今回,われわれは数年間の経過で正常T波から漸次陰性T波へと移行した心尖部肥大型心筋症を2症例経験した.症例1は54歳,男性.胸痛精査の目的で入院した.心電図は左軸偏位と陰性T波を認めた.この陰性T波は最近の約4年間で正常T波から移行したものであった.症例2は49歳,男性.胸痛および失神の精査目的で入院した.心電図では左室側高電位と巨大陰性T波を認めた.この症例においても最近の約2年半で正常T波から巨大陰性T波へ移行していた.症例1,2ともに右前斜位の左室造影において,スペード型を呈した.冠動脈造影では有意狭窄を認めず,心尖部肥大型心筋症と診断した.心電図検査は肥大型心筋症の診断上,重要な役割を演じている.しかし,今回報告したごとく,短期間で著明な経時的心電図変化を呈する症例も認められ,本症の診断には慎重を要するものと考えられた.
  • 症例 持続性ST上昇を示した家族性肥大型心筋症の2症例, 重松 裕二, 浜田 希臣, 土井内 純治, 井上 義一, 藤原 康史, 越智 隆明, 伊藤 武俊, 国府 達郎, 心臓, 心臓, 心臓, 18, 5, 561, 566, 19860000, 0586-4488, http://ci.nii.ac.jp/naid/130004135496, 肥大型心筋症の心電図変化は多彩であるが,ST上昇を示す症例の報告はまれである.われわれは持続性ST上昇を示した家族性肥大型心筋症2症例を経験した.
    症例1は41歳,男性.主訴;前胸部痛およびフラツキ感.血圧108/74mmHg.心電図所見;V1-4誘導でST上昇およびI,II,III,aVF,V5,6誘導で陰性T波を認めた.症例2は36歳,男性.主訴;労作時の動悸およびフラツキ感.症例1の従兄弟である.心電図所見;I, V5誘導でST およびII, III, aVF ,V3,4,6誘導で陰性T波を認めた.2症例とも,心エコー図でASH , 左室流出路狭窄所見を示した. また,症例1では主要冠動脈に有意狭窄を認めず,左室造影で著明な心室中隔肥厚を示した.家族歴も濃厚であり,肥大型心筋症と診断した.
    主要冠動脈が正常な肥大型心筋症に心筋梗塞の合併することはすでに報告されている.われわれの2症例においても心電図上持続性ST上昇が認められ,心筋障害の関与が示唆された.肥大型心筋症の心電図を評価する際,心筋肥厚に加え心筋障害による変化を考慮する必要があると思われた.
  • 臨床 左房内可動血栓を有する僧帽弁狭窄症の3例と,その発生機序についての検討, 石丸 真由美, 松崎 圭輔, 重松 裕二, 末田 章三, 風谷 幸男, 関谷 達人, 越智 隆明, 浜田 希臣, 伊藤 武俊, 国府 達郎, 心臓, 心臓, 心臓, 17, 6, 615, 622, 19850000, 0586-4488, http://ci.nii.ac.jp/naid/130004411484, 左房内可動血栓は,全身への塞栓あるいは僧帽弁口への嵌頓のため,突然死の原因ともなりうる.われわれは,心エコー図により発見された,左房内可動血栓を有する僧帽弁狭窄症患者3例を経験したので,その発生因子および発生機序について検討した.3例中,2例は球状浮遊血栓であり,1例は有茎性可動血栓であったが,3例とも塞栓症を合併しており,左房内可動血栓においては塞栓症が頻発する可能性の高いことを示唆していた.さらにワーファリンコントロール中に左房内浮遊血栓が僧帽弁口を通過し,塞栓症を起こした症例もあるため,僧帽弁狭窄症における抗凝固療法は,症状,心エコー図所見などに注意を払い,慎重に開始すべきであると思われた.また,上記3例と,壁在血栓を有する患者5例および血栓を有さない僧帽弁狭窄症患者7例の心エコー図上の特徴を比較検討したが,左房径,僧帽弁口面積および左心機能に差は認められず,可動血栓の成因としては心房細動以外に所見は得られなかった.しかし,われわれの症例および文献的考察より,この可動血栓は短期間で発生,発育する可能性が示唆されるため,頻回に心エコー図をとり,その有無を確認すべきであると思われた.
  • 肥大型心筋症と高血圧心における拡張早期時相分析からみた心肥大の特性, 浜田 希臣, 松崎 圭輔, 風谷 幸男, 重松 裕二, 加藤 正和, 土井内 純治, 越智 隆明, 伊藤 武俊, 国府 達郎, 日本内科学会雑誌, 一般社団法人 日本内科学会, 日本内科学会雑誌, 72, 8, 1013, 1019, 19830000, 0021-5384, http://ci.nii.ac.jp/naid/130000891698, 肥大型心筋症(HCM)と高血圧心(HT)を鑑別する目的でHCM群35名(閉塞型10名,非閉塞型25名), HT群22名,健常対照群(N群)22名に拡張早期時相分析を行ない検討した.拡張早期時相は心エコー図,心尖拍動図,心音図を同時記録し, (1) IIA-O時間(IIA音から心尖拍動図のO点まで), (2) IIA-MVO時間(IIAから僧帽弁開放点まで), (3) MVO-O時間および, (4) MVO-O/IIA-MVO比を測定した.結果: (1)IIA-O時間はN群119±9msec, HT群170±20 (p<0.001, VS N),閉塞型171±34 (NS, VS HT),非閉塞型276±73 (p<0.001, VS HT)であつた. (2) IIA-MVO時間はN群66±11msec, HT群103±13 (p<0.001, VS N),閉塞型83±13 (p<0.001, VS HT),非閉塞型100±18 (NS, VS HT)であつた. (3) MVO-O時間はN群53±9msec, HT群67±14 (p<0.001, VS N),閉塞型89±24 (p<0.01, VS HT),非閉塞型175±68 (p<0.001, VS HT)であつた. (4) MVO-O/IIA-MVO比はN群0.89±0.32, HT群0.66±0.16 (p<0.01, VSN),閉塞型1.08±0.24 (p<0.001, VS HT),非閉塞型1.79±0.71 (p<0.001, VS HT)であつた.以上の結果より, HCM, HT両群とも等容拡張期であるIIA-MVO時間の延長を認めるが, HCMではさらに血液流入時相であるMVO-0時相により著明な延長を認め,このことが両者の重要な鑑別点であることが判明した. MVO-O/IIA-MVO比がN群に比しHT群は低値を, HCM群は逆に高値を示し,特にこれまで鑑別が極めて困難とされてきたHT群と非閉塞型を明瞭に区別し得たことは,本指標が今後両者の鑑別に極めて有用であるものと考えられた.
  • Mechanism of Atrial Fibrillation and Increased Incidence of Thromboembolism in Patients With Hypertrophic Cardiomyopathy, SHIGEMATSU Yuji, HAMADA Mareomi, MUKAI Mikio, MATSUOKA Hiroshi, SUMIMOTO Takumi, HIWADA Kunio, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 59, 6, 329, 336, 19950520, 00471828, http://ci.nii.ac.jp/naid/110002564915, To elucidate the morphologic characteristics of the left ventricle in patients with hypertrophic cardiomyopathy who developed atrial fibrillation, we studied left ventricular geometry by two-dimensional echocardiography in 92 patients with hypertrophic cardiomyopathy. These patients were divided into two groups; 24 patients with transient or persistent atrial fibrillation (group I) and 68 patients with sinus rhythm (group II). Left ventricular chamber size in group I was significantly smaller than that in group II. Left ventricular chamber size was correlated positively with stroke volume, and was correlated negatively with left ventricular end-diastolic pressure. The incidence of systemic thromboembolism in group I was 7.1% per patient year. In hypertrophic cardiomyopathy, the size of the left ventricle appears to have major pathophysiologic significance in the development of atrial fibrillation. In addition, since patients with hypertrophic cardiomyopathy who develop atrial fibrillation have a potential risk of systemic thromboembolism, prophylactic anticoagulant therapy should be performed in these patients.
  • Clinical Significance of Negative T Wave on Electrocardiogram in Patients with Essential Hypertension: Its Relation with Left Ventricular Mass., Ohtani Takashi, Hamada Mareomi, Matsuoka Hiroshi, Shigematsu Yuji, Sumimoto Takumi, Hiwada Kunio, Hypertension Research, 日本高血圧学会, Hypertension Research, 16, 3, 191, 195, 19930000, 0916-9636, http://ci.nii.ac.jp/naid/130003456152, To elucidate the clinical significance of negative T wave on electrocardiogram in patients with essential hypertension, the relation between negative T wave and left ventricular mass (LVM) was studied in 89 patients with essential hypertension. Left ventricular hypertrophy was defined as an LVM index of equal to or greater than 125g/m2. Essential hypertensive patients were classified into the following three groups: Group I (n=46) with neither left ventricular hypertrophy nor a history of hypertensive heart failure, Group II (n=33) with left ventricular hypertrophy and without a history of hypertensive heart failure, and Group III (n=10) with both left ventricular hypertrophy and a history of hypertensive heart failure. Negative T waves in essential hypertensive patients were observed in 4.3% of Group I, 51.5% of Group II and 100% of Group III. LVM indices in Groups I, II and III were 97±18(g/m2), 151±20 (p<0.01vs. I) and 238±23 (p<0.01vs. II), respectively. There was a significant relationship between the depth of negative T wave and LVM index (r=0.61, p<0.001). However, there was no significant difference in LVM index between Group II with negative T wave and without negative T wave. Essential hypertensive patients with more than 190g/m2 of LVM index developed hypertensive heart failure. These findings indicate that the negative T wave and its depth in patients with essential hypertension correlate well with LVM, but myocardial injury and ischemia associated with ventricular hypertrophy also have some influences on the appearance of negative T wave. (Hypertens Res 1993;16: 191-195)
  • Fatal Pulmonary Hypertension in a Patient with Mixed Connective Tissue Disease: Report of an Autopsy Case., SUZUKI Makoto, HAMADA Mareomi, SEKIYA Michihito, SHIGEMATSU Yuji, GO Soei, HIWADA Kunio, Internal Medicine, 一般社団法人 日本内科学会, Internal Medicine, 31, 1, 74, 77, 19920000, 0918-2918, http://ci.nii.ac.jp/naid/130000770364, A 34-yr-old woman with mixed connective tissue disease (MCTD) who died of heart failure due to pulmonary hypertension (PH) is reported. She showed various symptoms and signs over the previous 8 yr, including lymphadenopathy, Raynaud's phenomenon, polyarthralgia, sclerodactylia, esophageal disturbance, PH, Sjören's syndrome and renal tubular acidosis. Autopsy findings revealed severe intimal proliferation with marked luminal narrowing of the small arteries in the lung. Echocardiographic and mechanocardiographic methods were very useful for assessment of the degree of right ventricular dysfunction associated with PH on the early stage of MCTD.
    (Internal Medicine 31 : 74-77, 1992)
  • Familial Primary Pulmonary Hypertension. Report of Two Siblings., KODAMA Koji, HAMADA Mareomi, SHIGEMATSU Yuji, SUZUKI Makoto, HIWADA Kunio, HAYASHI Yutaka, HASHIMOTO Hiroyuki, HASHIMOTO Haruhisa, SUGITA Atsuro, Japanese Journal of Medicine, 社団法人 日本内科学会, Japanese Journal of Medicine, 30, 3, 273, 277, 19910000, 0021-5120, http://ci.nii.ac.jp/naid/130003514427, Familial primary pulmonary hypertension was found in two siblings (sister and brother). The woman noted exertional dyspnea at the age of 28 yr. The younger brother noticed exertional dyspnea, cough with bloody sputum and pretibial edema at the age of 38 yr. We diagnosed them as primary pulmonary hypertension as based on hemodynamicand histopathological findings. Regardless of the treatment, both patients died of right-sided heart failure with a short time course. We examined their family members, but there were no other members with primary pulmonary hypertension.
  • Persistent elevation of cardiac enzymes in a patient with hypertrophic cardiomyopathy. With special reference to electrocardiographic, echocardiographic and 201-thallium myocardial scintigraphic findings., HAMADA MAREOMI, SHIGEMATSU YUJI, FUJIWARA YASUSHI, SUMIMOTO TAKUMI, HIWADA KUNIO, KOKUBU TATSUO, JAPANESE CIRCULATION JOURNAL, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 54, 4, 354, 360, 19900000, 0047-1828, http://ci.nii.ac.jp/naid/130003547963, A 17-year-old female patient with hypertrophic cardiomyopathy whose serum cardiac enzymes (creatine phosphokinase = CPK, lactic dehydrogenase = LDH) showed persistent elevation was presented. Percent of CPK-MB and LDHl in 6-year-follow-up period ranged from 3.2% to 8.5%, and 58.0% to 63.2%, respectively. This finding strongly suggests the existence of a small amount of continuous myocardial necrosis for a long time. The influence of cardiac enzyme release on the heart was assessed by serial checks of electrocardiogram, echocardiogram and 201-thallium myocardial scintigram. In serial checks of electrocardiograms, markedly decreased R wave amplitude ranging between 31% and 47% was observed in II, III, aVF and V3-6. On echocardiograms, asymmetric septal hypertrophy and a narrow left ventricular cavity were observed in all echocardiograms through the follow-up period. But, in most recent apical two-dimensional echocardiograms, hourglass appearance of the left ventricle due to a distinct cavity-formation at the apex was observed. In 201-thallium single photon emission computed tomogram, hypoperfusion area markedly extended in anterior and lateral parts. These changes in electrocardiograms, echocardiograms and 201-thallium myocardial scintigrams seemed to reflect myocardial necrosis. Our case points to a mechanism for hypertrophic cardiomyopathy to change, over time, to dilated cardiomyopathy-like features.
  • Difference in myocardial characteristics between hypertrophic cardiomyopathy and myocardial hypertrophy due to essential hypertension., HAMADA MAREOMI, MATSUZAKI KEISUKE, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKIYA MICHIHITO, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, JAPANESE CIRCULATION JOURNAL, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 49, 3, 267, 275, 19850000, 0047-1828, http://ci.nii.ac.jp/naid/130003547367, To investigate the qualitative difference in myocardial hypertrophy that exists between hypertrophic cardiomyopathy (HCM) and essential hypertension (HT), we measured the mean wall thickness (MWT), the early diastolic time intervals (IIA-MVO time: from the second heart sound to the point of mitral valve opening, MVO-O time: from MVO to the O point of apexcardiogram) and the MVO-O/IIA-MVO ratio. The MWT in HCM and HT was measured by biventriculogram and echocardiogram, respectively. The MWT showed no significant difference between HT (1.31±3.0 mm) and non-obstructive type of HCM (14.8±3.7), but the MWT in obstructive type (1.08±0.24) was significantly thinner than that in HT. As the MWT increased, both IIA-MVO and MVO-O time were prolonged in both groups. But the mode of prolongation was quite different. In HT, the prolongation of the IIA-MVO time was almost always greater than that of MVO-O time. In HCM, the prolongation of the latter was greater than that of the former. The MVO-O/IIA-MVO ratio in HT was significantly greater. These findings suggest that the differences in the early diastolic time intervals between HCM and HT are not due to the magnitude of the left ventricular hypertrophy, but due to myocardial characteristics.
  • Difference in myocardial characteristics between hypertrophic cardiomyopathy and myocardial hypertrophy due to essential hypertension., HAMADA M., MATSUZAKI KEISUKE, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKIYA MICHIHITO, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, Jpn.Circ.J., 社団法人日本循環器学会, Jpn.Circ.J., 49, 267, 275, 19850000, 00471828, http://ci.nii.ac.jp/naid/110002579972, To investigate the qualitative difference in myocardial hypertrophy that exists between hypertrophic cardiomyopathy (HCM) and essential hypertension (HT), we measured the mean wall thickness (MWT), the early diastolic time intervals (II_A-MVO time: from the second heart sound to the point of mitral valve opening, MVO-O time: from MVO to the O point of apexcardiogram) and the MVO-O/II_A-MVO ratio. The MWT in HCM and HT was measured by biventriculogram and echocardiogram, respectively. The MWT showed no significant difference between HT (1.31±3.0 mm) and non-obstructive type of HCM (14.8±3.7), but the MWT in obstructive type (1.08±0.24) was significantly thinner than that in HT. As the MWT increased, both II_A-MVO and MVO-O time were prolonged in both groups. But the mode of prolongation was quite different. In HT, the prolongation of the II_A-MVO time was almost always greater than that of MVO-O time. In HCM, the prolongation of the latter was greater than that of the former. The MVO-O/II_A-MVO ratio in HT was significantly greater. These findings suggest that the differences in the early diastolic time intervals between HCM and HT are not due to the magnitude of the left ventricular hypertrophy, but due to myocardial characteristics.
  • NONINVASIVE EVALUATION OF LEFT VENTRICULAR FUNCTION BY SYSTOLIC TIME INTERVALS IN ESSENTIAL HYPERTENSION WITH ANGINA PECTORIS, OCHI TAKAAKI, HAMADA MAREOMI, KAZATANI YUKIO, SHIGEMATSU YUJI, SEKITA MICHIHITO, ITO TAKETOSHI, KOKUBU TATSUO, Japanese circulation journal, 社団法人日本循環器学会, Japanese circulation journal, 48, 12, 1299, 1305, 19841220, 00471828, http://ci.nii.ac.jp/naid/110002578185, In order to clarify the hemodynamic characteristics in essential hypertension (HT) with angina pectoris (AP), systolic time intervals (STIs) were measured in 13 normal subjects (N), 23 patients with AP, 43 HT (WHO stage I: 13, WHO stage II: 23, WHO stage III: 7) and 19 HT with AP (WHO I: 9, WHO II: 10). The ET/PEP ratio was 2.41±0.24 in N, 2.70±0.34 in AP (p<0.02, vs N), 2.25±0.29 in WHO I, 2.13±0.25 in WHO II (p<0.01, vs N), 1.54±0.37 in WHO III (p<0.001, vs N), 2.68±0.32 in WHO I with AP (p<0.05 vs N: p<0.005, vs HT) and 2.71±0.30 in WHO II with AP (p<0.02, vs N: p<0.001, vs HT). Ejection time index (ETI) was 385±15 msec in N, 399±16 in AP (p<0.05, vs N), 387±13 in WHO I, 385±15 in WHO II, 363±25 in WHO III (p<0.05, vs N), 393±16 in WHO I with AP and 402±15 in WHO II with AP (p<0.05, vs N: p<0.01, vs HT). Pre-ejection period index (PEPI) was 142±10 msec in N, 135±11 in AP, 148±12 in WHO I, 156±13 in WHO II (p<0.005, vs N), 192±24 in WHO III (p<0.001, vs N), 134±13 in WHO I with AP (p<0.05, vs HT) and 136±9 in WHO II with AP (p<0.001, vs HT). These results showed that the ET/PEP ratio in HT with AP was significantly higher than that in HT alone, and this increase in ET/PEP ratio was mainly due to the shortening of PEP interval in WHO stage I and the lengthening of ET in addition to it in WHO stage II. Thus, the changes of STIs in essential hypertension, but identical with those in patients with angina pectoris.
  • Clinical significance of systolic time intervals for the evaluation of left ventricular function in patients with coronary artery disease., HAMADA MAREOMI, KAZATANI YUKIO, SHIGEMATSU YUJI, MATSUZAKI KEISUKE, IMAMURA YOICHI, OCHI TAKAAKI, ITO TAKETOSHI, KOKUBU TATSUO, JAPANESE CIRCULATION JOURNAL, 社団法人 日本循環器学会, JAPANESE CIRCULATION JOURNAL, 47, 7, 810, 816, 19830000, 0047-1828, http://ci.nii.ac.jp/naid/130003547134, Systolic time intervals and cardiac output were measured in 10 normal subjects (group I), 25 patients with angina pectoris (group II) and 32 patients with old myocardial infarction who were subdivided into 3 groups (group III : ejection fraction (EF) ⩾50% without congestive heart failure (CHF), group IV : EF < 50% without CHF and group V with CHF irrespective of the level of EF). Because the number of the patients of group V was too small and only this group was undergoing treatment during the study, the results obtained from this group were used for comparison only. The ET/PEP ratio was 2.41 ± 0.28 in group I, 2.70 ± 0.34 in group II (p < 0.02 as compared with group I), 2.35 ± 0.30 in group III and 2.11 ± 0.18 in group IV (p < 0.01 as compared with group I). The ejection time (ET) showed no significant difference between group I and group III or IV. The pre-ejection period (PEP) showed no significant difference between groups I and II. In groups III and IV, the PEP was prolonged as the EF decreased. These results indicate that the increase of the ET/PEP ratio in group II was mainly due to the prolongation of the ET, and the decrease of the ET/PEP ratio in group IV was not directly related to the ET but to the PEP prolongation. Both the stroke index (SI) and the mean systolic ejection rate (MSER) in groups III and IV were significantly low as compared with those in group I, but those in group II showed no significant difference as compared with those in group I. These findings suggest that the prolongation of ET in groups II, III and IV indicates a compensatory mechanism to maintain the SI.
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