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河田 美幸カワダ ミユキ

所属部署
大学院農学研究科 生命機能学専攻
職名准教授
メールアドレスkawada.miyuki.my[at]ehime-u.ac.jp ※[at]を@に書き換えて送信して下さい
ホームページURL
生年月日
Last Updated :2017/08/18

研究者基本情報

所属学協会

  • 日本農芸化学会
  • 日本分子生物学会
  • 日本生化学会

研究活動情報

研究分野

  • 分子生物学

研究キーワード

    トランスポーター, 液胞型ATPase

論文

  • The amino-terminal hydrophilic region of the vacuolar transporter Avt3p is dispensable for the vacuolar amino acid compartmentalization of Schizosaccharomyces pombe.
    Kawano-Kawada M, Chardwiriyapreecha S, Manabe K, Sekito T, Akiyama K, Takegawa K, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 80, (12) 2291 - 2297,   2016年12月
  • Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae.
    Manabe K, Kawano-Kawada M, Ikeda K, Sekito T, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 80, (6) 1125 - 1130,   2016年06月
  • Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae.
    Kawano-Kawada M, Pongcharoen P, Kawahara R, Yasuda M, Yamasaki T, Akiyama K, Sekito T, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 80, (2) 279 - 287,   2016年
  • A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae.
    Tone J, Yamanaka A, Manabe K, Murao N, Kawano-Kawada M, Sekito T, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 79, (2) 190 - 195,   2015年
  • Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae.
    Tone J, Yoshimura A, Manabe K, Murao N, Sekito T, Kawano-Kawada M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 79, (5) 782 - 789,   2015年
  • Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae.
    Lunprom S, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Akiyama K, Bioscience, biotechnology, and biochemistry, 79, (12) 1972 - 1979,   2015年
  • Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae.
    Chardwiriyapreecha S, Manabe K, Iwaki T, Kawano-Kawada M, Sekito T, Lunprom S, Akiyama K, Takegawa K, Kakinuma Y, PloS one, 10, (6) ,   2015年
  • Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.
    Kumagai K, Kawano-Kawada M, Hanada K, The Journal of biological chemistry, 289, (15) 10748 - 10760,   2014年04月
  • Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae.
    Sekito T, Sugimoto N, Ishimoto M, Kawano-Kawada M, Akiyama K, Nishimoto S, Sugahara T, Kakinuma Y, The Journal of toxicological sciences, 39, (2) 311 - 317,   2014年04月
  • Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae.
    Sekito T, Chardwiriyapreecha S, Sugimoto N, Ishimoto M, Kawano-Kawada M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 78, (6) 969 - 975,   2014年
  • Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1∆ mutant.
    Sekito T, Nakamura K, Manabe K, Tone J, Sato Y, Murao N, Kawano-Kawada M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 78, (7) 1199 - 1202,   2014年
  • Functional expression of Schizosaccharomyces pombe Vba2p in the vacuolar membrane of Saccharomyces cerevisiae.
    Pongcharoen P, Kawano-Kawada M, Iwaki T, Sugimoto N, Sekito T, Akiyama K, Takegawa K, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 77, (9) 1988 - 1990,   2013年
  • Mutagenesis of the residues forming an ion binding pocket of the NtpK subunit of Enterococcus hirae V-ATPase.
    Kawano-Kawada M, Iwaki T, Hosaka T, Murata T, Yamato I, Homma M, Kakinuma Y, Journal of bacteriology, 194, (17) 4546 - 4549,   2012年09月
  • Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
    Watanabe S, Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y, The Journal of biological chemistry, 287, (39) 32674 - 32688,   2012年09月
  • ATP-dependent export of neutral amino acids by vacuolar membrane vesicles of Saccharomyces cerevisiae.
    Ishimoto M, Sugimoto N, Sekito T, Kawano-Kawada M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 76, (9) 1802 - 1804,   2012年
  • Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae.
    Shimazu M, Itaya T, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 76, (10) 1993 - 1995,   2012年
  • Significance of the glutamate-139 residue of the V-type Na+-ATPase NtpK subunit in catalytic turnover linked with salt tolerance of Enterococcus hirae.
    Kawano-Kawada M, Takahashi H, Igarashi K, Murata T, Yamato I, Homma M, Kakinuma Y, Journal of bacteriology, 193, (14) 3657 - 3661,   2011年07月
  • Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
    AKIYAMA Koichi, IWAKI Tomoko, SUGIMOTO Naoko, CHARDWIRIYAPREECHA Soracom, KAWANO Miyuki, NISHIMOTO Sogo, SUGAHARA Takuya, SEKITO Takayuki, KAKINUMA Yoshimi, J Toxicol Sci, 36, (1) ,   2011年
  • Atg22p, a Vacuolar Membrane Protein Involved in the Amino Acid Compartmentalization of Schizosaccharomyces pombe
    SUGIMOTO Naoko, IWAKI Tomoko, CHARDWIRIYAPREECHA Soracom, SHIMAZU Masamitsu, KAWANO Miyuki, SEKITO Takayuki, TAKEGAWA Kaoru, KAKINUMA Yoshimi, Biosci Biotechnol Biochem, 75, (2) ,   2011年
  • Mutations in the lipid A deacylase PagL which release the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide in Salmonella enterica serovar Typhimurium
    MANABE Takayuki, KAWANO Miyuki, KAWASAKI Kiyoshi, Biochem Biophys Res Commun, 396, (4) 812 - 816,   2010年06月11日
  • Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages
    KAWANO Miyuki, MANABE Takayuki, KAWASAKI Kiyoshi, FEBS Lett, 584, (1) 207 - 212,   2010年01月04日
  • Decreased Ceramide Transport Protein (CERT) Function Alters Sphingomyelin Production following UVB Irradiation
    CHARRUYER Alexandra, BELL Sean M., KAWANO Miyuki, DOUANGPANYA Sounthala, YEN Ten‐Yang, MACHER Bruce A., KUMAGAI Keigo, HANADA Kentaro, HOLLERAN Walter M., UCHIDA Yoshikazu, J Biol Chem, 283, (24) 16682 - 16692,   2008年06月13日
  • Protein Phosphatase 2C.EPSILON. Is an Endoplasmic Reticulum Integral Membrane Protein That Dephosphorylates the Ceramide Transport Protein CERT to Enhance Its Association with Organelle Membranes
    SAITO Satoko, MATSUI Hiroyuki, KAWANO Miyuki, KUMAGAI Keigo, TOMISHIGE Nario, HANADA Kentaro, ECHIGO Seishi, TAMURA Shinri, KOBAYASHI Takayasu, J Biol Chem, 283, (10) 6584 - 6593,   2008年03月07日
  • Interorganelle Trafficking of Ceramide Is Regulated by Phosphorylation-dependent Cooperativity between the PH and START Domains of CERT
    KUMAGAI Keigo, KAWANO Miyuki, SHINKAI‐OUCHI Fumiko, NISHIJIMA Masahiro, HANADA Kentaro, J Biol Chem, 282, (24) 17758 - 17766,   2007年06月15日
  • CERT and intracellular trafficking of ceramide
    HANADA Kentaro, KUMAGAI Keigo, TOMISHIGE Nario, KAWANO Miyuki, Biochim Biophys Acta, 1771, (6) 644 - 653,   2007年06月
  • Efficient Trafficking of Ceramide from the Endoplasmic Reticulum to the Golgi Apparatus Requires a VAMP-associated Protein-interacting FFAT Motif of CERT
    KAWANO Miyuki, KUMAGAI Keigo, NISHIJIMA Masahiro, HANADA Kentaro, J Biol Chem, 281, (40) 30279 - 30288,   2006年10月06日
  • Molecular machinery for non-vesicular trafficking of ceramide.
    Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M, Nature, 426, (6968) 803 - 809,   2003年12月
  • Arginine residue at position 573 in Enterococcus hirae vacuolar-type ATPase NtpI subunit plays a crucial role in Na+ translocation.
    Kawano M, Igarashi K, Yamato I, Kakinuma Y, The Journal of biological chemistry, 277, (27) 24405 - 24410,   2002年07月
  • Isolation of Enterococcus hirae mutant deficient in low-affinity potassium uptake at alkaline pH.
    Kawano M, Igarashi K, Kakinuma Y, Bioscience, biotechnology, and biochemistry, 66, (7) 1597 - 1600,   2002年07月
  • Catalytic properties of Na(+)-translocating V-ATPase in Enterococcus hirae.
    Murata T, Kawano M, Igarashi K, Yamato I, Kakinuma Y, Biochimica et biophysica acta, 1505, (1) 75 - 81,   2001年05月
  • Potassium uptake with low affinity and high rate in Enterococcus hirae at alkaline pH.
    Kawano M, Abuki R, Igarashi K, Kakinuma Y, Archives of microbiology, 175, (1) 41 - 45,   2001年01月
  • Evidence for Na(+) influx via the NtpJ protein of the KtrII K(+) uptake system in Enterococcus hirae.
    Kawano M, Abuki R, Igarashi K, Kakinuma Y, Journal of bacteriology, 182, (9) 2507 - 2512,   2000年05月
  • Enterococcus hirae vacuolar ATPase is expressed in response to pH as well as sodium.
    Ikegami M, Kawano M, Takase K, Yamato I, Igarashi K, Kakinuma Y, FEBS letters, 454, (1-2) 67 - 70,   1999年07月
  • The Na+-responsive ntp operon is indispensable for homeostatis of K+ and Na+ in Enterococcus hirae at limited proton potential.
    Kawano M, Igarashi K, Kakinuma Y, Journal of bacteriology, 180, (18) 4942 - 4945,   1998年09月

MISC

講演・口頭発表等

  • 出芽酵母におけるリジンに応答したTORC1活性の変化
    山口翔吾, 國米春香, 兵頭美波, 村尾奈美, 河田美幸, 河田美幸, 関藤孝之, 柿沼喜己, 日本農芸化学会大会講演要旨集(Web),   2016年03月05日
  • 出芽酵母液胞膜タンパク質Ypq3のアミノ酸輸送活性及び発現調節
    池田紘一, 真鍋邦男, 山縣里奈, 河田美幸, 河田美幸, 関藤孝之, 柿沼喜己, 日本農芸化学会大会講演要旨集(Web),   2016年03月05日
  • Identification of vacuolar amino acid transporter from Fusarium oxysporum
    LUNPROM Siriporn, PONGCHAROEN Pongsanat, KAWADA‐KAWANO Miyuki, SEKITO Takayuki, AKIYAMA Koichi, KAKINUMA Yoshimi, 日本農芸化学会大会講演要旨集(Web),   2014年03月05日
  • Novel vacuolar membrace proteins, Atg22p and Vba2p, involved in amino acid transport by Schizosaccharomyces pombe
    SUGIMOTO Naoko, IWAKI Tomoko, CHARDWIRIYAPREECHA Soracom, SHIMAZU Masamitsu, KAWANO Miyuki, SEKITO Takayuki, TAKEGAWA Kaoru, KAKINUMA Yoshimi, 日本農芸化学会大会講演要旨集,   2011年03月05日
  • Inter-Organelle Trafficking of Ceramide is Regulated by Phosphorylation-Dependent Co-Operativity between the PH and START Domains of CERT
    KUMAGAI Keigo, KAWANO Miyuki, OUCHI Fumiko, NISHIJIMA Masahiro, HANADA Kentaro, 生化学,   2007年
  • Interaction between CERT and VAP at the ER is required for efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus.
    KAWANO Miyuki, KUMAGAI Keigo, NISHIJIMA Masahiro, HANADA Kentaro, 生化学,   2006年
  • Regulation of ER-to-Golgi trafficking of ceramide by phosphorylation of CERT and its molecular mechanism
    KUMAGAI Keigo, KAWANO Miyuki, OHUCHI Fumiko, NISHIJIMA Masahiro, HANADA Kentaro, 生化学,   2006年
  • The FFAT motif of CERT is required for an interaction with VAP-A and efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus.
    KAWANO Miyuki, KUMAGAI Keigo, NISHIJIMA Masahiro, HANADA Kentaro, 生化学,   2005年08月25日
  • Multiple phosphorylation of the ceramide transfer protein CERT
    KUMAGAI Keigo, KAWANO Miyuki, OHUCHI Fumiko, NISHIJIMA Masahiro, HANADA Kentaro, 生化学,   2005年08月25日


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