Graduate School of Medicine
医学専攻
日本語
Update date：2025/01/06
Associate Professor
Yano Hajime
  • Birth:1966

Education

  1. Osaka University1989
  2. Osaka University1989
  3. Osaka University1991
  4. Osaka University1991
  5. Osaka University1995
  6. Osaka University1995

Degree

  1. Ph.DOsaka University
  2. Master Degree of Medical ScienceOsaka University
  3. Bachelor's Degree of Social ScienceOsaka University

Research Areas

  1. Molecular and Cellular Physiology

Research Interests

  1. Cell physiology
  2. Cell migration
  3. Cancer invasion
  4. mechanotrunsduction
  5. 細胞生理学
  6. 細胞運動
  7. 癌浸潤
  8. メカノトランスダクション

Subject of Research

  1. Elucidation of the mechanism controls various cellular functions by mechanotransduction.2008/01/01-2020/12/31Addition to soluble bioactive substrates such as cytokines, cellular regulations mediated by physical force such as tension called mechanotransduction is also known. However, despite its importance and advances in molecular mechanisms of soluble factors, the progresses of study for mechanotransduction is historically and technologically not enough. We are studying the entity of cellular regulations mediated by physical force focusing on metabolic change as well as gene expression regulation as read out.
  2. Prevention of cancer metastasis focusing on the premetastatic niche formation2012/04/01-2020/12/31Premetastatic niche is known as a critical phenomena for cancer metastasis which act to cultivate metastatic target organ precede to the arrival of cancer cell to the target. We have found factors participate in this step, and furthermore, have confirmed that the factors really act in human cancer metastasis as risk factors. Now we are on the way to utilize these factors for diagnostic as well as therapeutic target.
  3. Control of neuroinflammation by focusing on a transcription factor Nrf2.2019/12/01-2020/12/31Aberrant neuroinflammation is known to participate in various neurodegenerative diseases. Cellular entities for this inflammation are microglia and bone marrow derived cells. Nrf2 is known as a cellular protective transcription factor which induces cells into anti-oxidant as well as anti inflammatory. The aim of this project is to control the neuroinflammation by regulating Nrf2.

Research Projects

  1. 愛媛大学ブロムワレリル尿素の抗炎症性作用機序の解明による新規 NSAID 開発愛媛大学研究活性化事業 産業シーズ育成2020/04/01-2021/03/31Principal investigator
  2. 日本学術振興会Development of a multidisciplinary anti-metastasis treatment against lymph node metastasis of head and neck squamous cell carcinomas基盤研究(C)2018/04/01-2020/03/31Principal investigator
  3. 愛媛大学新規炎症治療薬としての認可および企業化をめざしたブロモワレリル尿素の抗炎症効果の作用機序解析愛媛大学研究活性化事業 産業シーズ育成2018/04/01-2019/03/31Principal investigator
  4. 愛媛大学頭頸部扁平上皮がんの転移危険性診断系の開発愛媛大学産学連携推進事業 産業シーズ育成2017/04/01-2018/03/31Principal investigator
  5. 日本学術振興会The effect of LOXL2 in head and neck squamous cell carcinoma lymph node metastasis基盤研究(C)2016/04/01-2018/03/31Principal investigator
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Papers

  1. Berberine as a potential enhancer for 5-ALA-mediated fluorescence in glioblastoma: increasing detectability of infiltrating glioma stem cells to optimize 5-ALA-guided surgery. 2024 Mar Online ahead of print.2024/03Ohtsuka Y, Suehiro S, Inoue A, Ohnishi T, Nishikawa M, Yamashita D, Yano H, Choudhury ME, Ozaki S, Sampetrean O, Saya H, Watanabe H, Tanaka J, Kunieda T.J Neurosurg.8, 1-11Research paper (scientific journal)10.3171/2023.12.JNS231506.
  2. Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma.2024/03/22Hayashi Y, Miyoshi S, Watanabe I, Yano N, Nagashio K, Kaneko M, Kaminota T, Sanada T, Hosokawa Y, Kitani T, Mitani S, Choudhury ME, Yano H, Tanaka J, Hato N.Auris Nasus Larynx.51/ 3, 472-480Research paper (scientific journal)10.1016/j.anl.2024.01.006.
  3. A Narrative Review on CD44's Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence. 2023 Oct 9;2023/10/09Inoue A, Ohnishi T, Nishikawa M, Ohtsuka Y, Kusakabe K, Yano H, Tanaka J, Kunieda T.Cancers (Basel).15/ 19, 4898(MISC) Introduction and explanation (scientific journal)10.3390/cancers15194898.
  4. Identification of CD44 as a Reliable Biomarker for Glioblastoma Invasion: Based on Magnetic Resonance Imaging and Spectroscopic Analysis of 5-Aminolevulinic Acid Fluorescence. 2023 Aug 24;2023/08/24Inoue A, Ohnishi T, Nishikawa M, Watanabe H, Kusakabe K, Taniwaki M, Yano H, Ohtsuka Y, Matsumoto S, Suehiro S, Yamashita D, Shigekawa S, Takahashi H, Kitazawa R, Tanaka J, Kunieda T.Biomedicines.11/ 9, 236910.3390/biomedicines11092369.
  5. The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. 2023 Jul 31;2023/07/31Takeda H, Nakajima Y, Yamaguchi T, Watanabe I, Miyoshi S, Nagashio K, Sekine H, Motohashi H, Yano H, Tanaka J.J Biochem.174/ 2, 131-142Research paper (scientific journal)10.1093/jb/mvad030.
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Presentations

  1. Roles of lysyl oxidase like 2 (LOXL2) in exosomal fraction on lymph node metastasis of head and neck squamous cell carcinomaISEV (International Society for Extracellular Vesicles) 20192019/04/28Oral presentation(general)
  2. 頭頸部扁平上皮がんのリンパ節転移における LOXL2 のエクソソームへの局在の意義第 41 回日本分子生物学会年会2018/11/30Oral presentation(general)
  3. Possible participation of the intra-cell collective pH distribution in the maintenance of direction of the metastatic tumor cell collective migration.The 95th Annual Meeting of the Physiological Society of Japan2018/03/28Symposium workshop panel(nominated)
  4. 転移性頭頸部扁平上皮がん細胞におけるリジルオキシダーゼ様因子２第39回日本分子生物学会2016/11/30Oral presentation(general)
  5. 遅延型 TGF beta の活性型変換機構におけるナトリウムイオン / プロトン交換輸送体１ (NHE1) の意義第92回日本生理学会大会2015/03/22Poster presentation
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Allotted Class

  1. 2024Lecture, seminar and practical training of Molecular and Cellular Physiology
  2. 2024Human Physiology
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Teaching Achievements

  1. Affairs for Entrance ExaminationsEvaluation of universities and on the ability of educational2009/01/01Generation of questions for entrance examinations 1. 2010 - 2020 Chemistry and Biology for Bachelor transfer 2. 2009 Chemistry for Whole Ehime University 3. 2012 - 2014 English for Graduate School of Medical School 4. 2011 Small article and English for Medical School
  2. 愛媛県消防学校救急科 (非常勤)　Other achievement about your educational practices (except for the above-mentioned)2008/01/01解剖生理学講義
  3. 国立病院機構愛媛医療センター附属看護学校 (非常勤)　Other achievement about your educational practices (except for the above-mentioned)2008/01/01解剖生理学講義
  4. Classes for Graduate School studentsEvaluation of universities and on the ability of educational2008/01/01Instructions for various technologies for Graduate School research.
  5. Perspective for basic medicine IIEvaluation of universities and on the ability of educational2008/01/01Prompting understanding of basic concepts for cells and genes in early education on the 1st grade students.
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Textbooks and Teaching Materials

  1. 出版物としてはなし2008/09/01
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Academic_Activities

  1. Organization of a Symposium on the 95th Japanese meeting for PhysiologyPlanning,management,etc.Japanese Society for Physiology2017/05/01-2018/03/28Takamatsu city, Kagawa Prefecture, JapanMolecular/Cellular Physiology and Pathology of the Collective cell migration
  2. Invitation of Foreign Researcher for the 95th Japanese Meeting for PhysiologyPanel moderator,session chair,etc.Japanese Society for Physiology2017/05/01-2018/03/28Takamatsu city, Kagawa Prefecture, JapanInvitation of Dr. Peter Friedl, to ask the talk entitled "Plasticity of cancer cell invasion and metastasis: cell-tissue interplays across scale.", and acted a chairman.
  3. 第25回日本病態生理学会大会 (松山市) 事務局長Planning,management,etc.日本病態生理学会2014/10/01-2015/09/30愛媛大学城北キャンパス
  4. 第60回日本生理学会中四国地方会 (松山市) 事務局長Planning,management,etc.日本生理学会2008/04/01-2008/11/28愛媛大学城北キャンパス
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Professional Memberships

  1. 2009/08/01日本神経科学会
  2. 2008/05/01日本病態生理学会
  3. 2008/04/01日本生理学会
  4. 1999/04/01日本癌学会
  5. 1998/08/01日本分子生物学会
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Committee Memberships

  1. 2016/10/01-present日本病態生理学会学会誌編集局事務局長
  2. 2010/09/01-present日本生理学会評議員
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Teaching Experience

  1. Practical lessens for medical chemistry the 1stDepartment of Medical Chemistry the 1st of Ehime University Medical School1996/06/01-1998/05/31学部専門科目日本Students experience the progression of purification together with transition of activities and purities through the purification of phosphorylase from rabbit back muscle, and learn the basic concepts for biochemistry such as the purification, the activity assay and the specific activity.
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