Graduate School of Medicine
医学専攻
日本語
Update date：2025/01/09
Senior Assistant Professor
Omori-Miyake Miyuki

Degree

  1. 医学博士千葉大学大学院

Research Areas

  1. epigenetics
  2. T lymphocyte
  3. Allergic dermatitis

Research Interests

  1. T lymphocyte
  2. dendritic cell
  3. allergic dermatitis
  4. keratinocyte
  5. cytokine
  6. epigenetics
  7. 細胞内代謝

Subject of Research

  1. Roles of thymic stromal lymphopoietin in the development of atopy-like dermatitis2004/01/15-2007/01/31
  2. Induction of Th1 cytokine production in NKT cells by a neoglycolipid, alpha-carba-GalCer2007/02/14-2008/03/31
  3. Effects of Th2 cytokines on the structural molecule expressions in epidermal keratinocytes2008/04/01-2015/03/31
  4. Identification of thymic stromal lymphopoietin-responsive subsets of dendritic cells2015/04/01-2018/09/30
  5. Molecular mechanisms of chronic inflammatory skin diseases2018/10/01-2023/04

Books and Other Publications

  1. 高齢者の免疫機能と食品大森深雪、山下政克9章-19朝倉書店2021/11/01978-4-254-43126-1
View details...

Papers

  1. The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice2023/10Michiko Okamoto, Miyuki Omori-Miyake, Makoto Kuwahara, Masataka Okabe, Mariko Eguchi, Masakatsu YamashitaJournal of Investigative Dermatology143/ 10, 1973-1982Research paper (scientific journal)10.1016/j.jid.2023.03.1667
  2. The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis2021/09/29Takashi Inoue, Miyuki Omori-Miyake, Saho Maruyama, Masataka Okabe, Makoto Kuwahara, Hiroaki Honda, Hiromasa Miura and Masakatsu YamashitaThe Journal of Immunology207/ 9, 2223-2234Research paper (scientific journal)10.4049/jimmunol.2001160The American Association of Immunologists, Inc.The pathogenesis of allergic contact dermatitis (ACD) requires the activation of Ag-specific T cells, including effector and regulatory T cells. The differentiation and function of these T cells is epigenetically regulated through DNA methylation and histone modifications. However, the roles of altered histone H3K27 methylation in T cells in the development of ACD remain unknown. Two types of histone H3K27 demethylases, Utx and Jmjd3, have been reported in mammals. To determine the role of the histone H3K27 demethylase expression of T cells in the development of ACD, we generated T cell-specific, Utx-deficient (Utx KO) mice or Jmjd3-deficient (Jmjd3 KO) mice. Unlike control mice, Utx KO mice had severer symptoms of ACD, whereas Jmjd3 KO mice showed symptoms identical to those in control mice. In Utx KO mice with ACD, the massive infiltration of myeloid cells, including neutrophils and dendritic cells, has been observed. In addition, the expression of proinflammatory cytokines in CD4+ T cells of the draining lymph nodes (LNs) and in CD8+ T cells of the skin was increased in Utx KO mice, whereas the ratio of Foxp3+ regulatory CD4+ T cells to Foxp3- conventional CD4+ T cells was decreased in both the draining LNs and the skin of Utx KO mice with ACD. Furthermore, Foxp3+ regulatory CD4+ T cells of Utx KO mice with ACD expressed a decreased level of CCR4 (a skin-tropic chemokine receptor) in comparison with control. Thus, in CD4+ T cells, Utx could potentially be involved in the regulation of the pathogenesis of ACD.
  3. An accumulation of two populations of dendritic cells in skin-draining lymph nodes in response to the expression of thymic stromal lymphopoietin in the skin2020/07/01Miyuki Omori-Miyake, Hiroshi Watarai, Kayoko Sato, Steven F. Ziegler, Junji YagiCellular Immunology353, 104116Research paper (scientific journal)
  4. Hepato-entrained B220+CD11c+NK1.1+cellsregulate pre-metastatic niche formation inthe lung2018/06/21Sachie Hiratsuka, Takeshi Tomita, Taishi Mishima, Yuta Matsunaga, Tsutomu Omori, Sachie Ishibashi, Satoshi Yamaguchi, Tsuyoshi Hosogane, Hiroshi Watarai, Miyuki Omori-Miyake, Tomoko Yamamoto, Noriyuki Shibata, Akira Watanabe, Hiroyuki Aburatani, Michio Tomura, Katherine A High, Yoshiro MaruEMBO Molecular Medicine10, e8643Research paper (scientific journal)
  5. アトピー性皮膚炎の表皮における構造の質的変化2018/01/31Changes of structures and functions in the epidermis of atopic dermatitisJournal of Cutaneous Immunology and Allergy1/ 1, 35-45(MISC) Introduction and explanation (scientific journal)
View details...

Allotted Class

  1. 2024Micro pathobiology
  2. 2024Lecture, seminar and practical training of Infections and Host Defenses
View details...

Teaching Achievements

  1. 病原生物学　実習Other achievement about your educational practices (except for the above-mentioned)2023/01/30-2023/02/08
  2. 病原生物学　講義Other achievement about your educational practices (except for the above-mentioned)2022/11/15-2023/01/27
  3. 基礎研究方法論 講義 抗原提示細胞の解析法Other achievement about your educational practices (except for the above-mentioned)2022/08/30
  4. Practice for medical microbiologyOther achievement about your educational practices (except for the above-mentioned)2022/01/28-2022/02/04
  5. Lecture for medical microbiologyOther achievement about your educational practices (except for the above-mentioned)2021/11/09-2022/01/21
View details...

Professional Memberships

  1. The American Association of Immunologists
  2. The Molecular Biology Society of Japan
  3. Japanese Society for Immunology
View details...