大学院医学系研究科
医学専攻
English
更新日：2024/05/16
准教授
ｷﾀﾞﾆ　ﾃﾙｷ
木谷　彰岐

学位

  1. 博士(医学）整形外科愛媛大学2002/03/25

研究分野

  1. ライフサイエンス病態医化学骨軟部腫瘍

共同研究・競争的資金等の研究課題

  1. 愛媛大学Span80ベシクルを用いた悪性骨・軟部腫瘍治療の萌芽的研究萌芽研究
  2. 愛媛大学スパン８０ベシクルによるＤＤＳを用いた骨腫瘍に対するカフェイン療法の開発基盤研究(C)
  3. スパン８０ベシクルによるＤＤＳを用いた骨腫瘍に対するカフェイン療法の開発基盤研究(C)競争的資金
  4. 愛媛大学老人性骨粗鬆症の病態解析：加齢モデルにおける破骨細胞分化因子発現制御基盤研究(C)2019/04/01-2022/03/01
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論文

  1. Molecular profiling of bone remodeling occurring in musculoskeletal tumors.2020/10/09Nakajima Kosei,Kidani Teruki,Miura HiromasaJournal of orthopaedic research : official publication of the Orthopaedic Research Society10.1002/jor.24879Musculoskeletal malignancy is often accompanied by aberrant bone remodeling, leading to tumor cell invasion into skeletal tissues and causing severe pain. BMPs, FGF-2, and RANKL have been identified as promising regulators in physiological bone remodeling. In this study, we explored the expressional profile of BMPs, FGF-2, and RANKL in 1361 patients with 22 varieties of musculoskeletal tumors. Notably, the expression of FGF-2 and RANKL was under detected in all patients. Among BMP-1 to BMP-15, we found that BMP-1, -2, -4, -5, -6, and -7 were prevalent. In comparison with normal bones, osteosarcoma highly expressed BMP-1, -2, -4, and -7 with statistical significance. Synovial sarcoma upregulated BMP-4, -5, and -7; rhabdomyosarcoma increased BMP-1 and -4; and alveolar soft part sarcoma upregulated BMP-1, -4, and -7. To visualize the BMP-oriented interactions in a bone tumor microenvironment, we have developed novel software that analyzes numerous cell-to-cell and ligand-to-receptor interactions, i.e., Environmentome, delineating that osteosarcoma-secreted BMP-4 and synovial sarcoma-secreted BMP-7 potently interact with osteoblasts, osteocytes, osteoclast precursors, and mature osteoclasts. Specifically, quantification analysis revealed that the relationship between osteosarcoma and mature osteoclast/precursor, BMP4-BMPR2 and BMP4-ACVR2A interactions were most potent. Regarding the association between osteosarcoma and osteocyte/osteoblast, BMP4-ACVR1 and BMP4-BMPR2 were the key interactions. In the connection between synovial sarcoma and mature osteoclast/precursor, BMP7-ACVR2A and BMP7-BMPR2 interactions were most remarkable. With regard to the cellular link between synovial sarcoma and osteocyte/osteoblast, BMP7-BMPR2 was identified as a potent interaction. In conclusion, our new outlook suggests delivering the pathological events clinically underlie behind severe skeletal pain or fracture in musculoskeletal tumors. This article is protected by copyright. All rights reserved.
  2. Prediction of Soft Tissue Sarcoma from Clinical Characteristics and Laboratory Data.2020/03/13Fujibuchi Taketsugu,Miyawaki Joji,Kidani Teruki,Imai Hiroshi,Miura HiromasaCancers12/ 310.3390/cancers12030679The accurate diagnosis of soft tissue tumors may be difficult. Simple clinical characteristics or laboratory data that can predict tumor malignancy can be useful tools for diagnosing soft tissue tumors. Between 2003 and 2018, 588 patients with primary soft tissue tumors were retrospectively reviewed. Their clinical characteristics and laboratory data were evaluated to determine their association with the diagnosis of benign, intermediate, or malignant tumor. Multivariable analysis revealed that tumor size ≥ 5.6 cm (odds ratio (OR), 6.15; < 0.001), white blood cell (WBC) count ≥ 5700/µL (OR, 2.49; = 0.002), hemoglobin (Hb) count ≤ 12.4 g/dL (OR, 2.56; = 0.004), C-reactive protein (CRP) level ≥ 0.17 mg/dL (OR, 2.64; < 0.001), and lactate dehydrogenase (LDH) level ≥ 240 IU/L (OR, 4.94; < 0.001) were significant predictive factors for sarcoma. The sensitivity and specificity in the presence of three or more predictive factors for detecting malignant tumors were 0.58 and 0.90 respectively, and it was an appropriate threshold with the maximum Youden's index of 0.49. Simple clinical and laboratory data were useful tools for predicting whether the tumor is malignant. Patients with soft tissue tumors that meet any three or more predictive factors should be referred to a specialist.
  3. Progressive Aortic Calcification as a Complication of Dermatomyositis.2019/08/23Miyoshi Seigo,Matsumoto Takuya,Kidani Teruki,Sugimoto Eiji,Nakamura Yukihiro,Yamamoto Tetsuya,Kato Takahide,Yamamoto Shoicihiro,Hamada Chizuru,Hamaguchi Naohiko,Hamaguchi Yasuhito,Yamaguchi OsamuCirculation journal : official journal of the Japanese Circulation Society83/ 9, 197210.1253/circj.CJ-18-1249
  4. Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature.2019/02/01Fujibuchi Taketsugu,Miyawaki Joji,Kidani Teruki,Imai Hiroshi,Kiyomatsu Hiroshi,Kitazawa Riko,Miura HiromasaBMC cancer19/ 1, 11610.1186/s12885-019-5325-xSynovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. However, only few studies have been reported on intraosseous synovial sarcoma, and reports on cases with cytogenetic or molecular confirmation are even rarer. We report a case of intraosseous synovial sarcoma of the distal ulna that has been confirmed using histopathological examination and molecular analysis.A 77-year-old female was referred to our hospital with a 1-month history of right wrist pain after housework. Clinical and imaging findings suggested a benign bone tumor that was enhanced by Gd-DTPA. It was thought that the tumor was possibly an enchondroma. Initially, we planned to evaluate the benignancy of the tumor with intraoperative frozen section, followed by curettage and bone graft at one stage However, when considering carefully, characteristics of the tumor did not perfectly match those of any diagnostic categories including enchondroma. Therefore, an incisional biopsy was performed and revealed that the tumor was synovial sarcoma. Following an elaborate plan, the patient underwent a wide resection of the tumor at the distal part of the right ulna. Reverse transcription-polymerase chain reaction (RT-PCR) from the resected specimen and sequencing of RT-PCR products demonstrated a chimeric SYT-SSX1 transcript, confirming the diagnosis of synovial sarcoma.Synovial sarcoma is seldom considered in differential diagnosis of bone tumors because it is difficult to line up such an unusual diagnosis as a differential diagnosis. When the lesion does not perfectly fit into any diagnostic category, when the initial image diagnosis appears unconvincing, biopsy and pathology are indicated, recalling Jaffe's triangle. According to these diagnostic processes, the patient successfully completed the treatment for this rare intraosseous synovial sarcoma, following a careful plan based on the preoperative diagnosis.
  5. 両側重度扁平足に対して手術療法を行った1例2019村上 聡, 清水 晃, 山本 晴康, 渡邊 誠治, 木谷 彰岐, 三浦 裕正中国・四国整形外科学会雑誌31/ 1, 119-126URL中国・四国整形外科学会
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担当授業科目

  1. 2024整形外科学
  2. 2024整形外科学 講義・演習・実習
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