大学院農学研究科
食料生産学専攻
日本語
English
更新日:2024/12/27
教授
タチバナ テツヤ
橘 哲也
個人ウェブサイトはこちら
経歴
2002/04/01-2006/03/31
九州大学大学院
農学研究院
助手
2006/04/01-2007/03/31
愛媛大学
農学部
助教授
2007/04/01-2021/09/30
愛媛大学
農学部
准教授
2021/10/01-現在
愛媛大学
農学部
教授
学歴
宇都宮大学
1993/04/01
1997/03/31
卒業
宇都宮大学
1997/04/01
1999/03/31
修了
東京農工大学
1999/04/01
2002/03/31
修了
学位
博士(農学)
東京農工大学
2002/03/31
研究分野
ライフサイエンス
動物生産科学
家禽生産学、家禽栄養学、家禽生理学、家禽行動学
ライフサイエンス
動物生産科学
家禽生産学、家禽栄養学、家禽生理学、家禽行動学
研究キーワード
ホルモン
神経伝達物質
ストレス
脳
摂食行動
ニワトリ
消化管機能
感染
chickens
共同研究・競争的資金等の研究課題
愛媛大学
プロラクチン放出ペプチドによるニワトリ独自の新規脳内摂食促進機構の解明
若手研究(B)
愛媛大学
ニワトリヒナの右利き・左利きに関する研究
萌芽研究
愛媛大学
ソマトスタチンによるニワトリヒナ独自の脳内摂食促進機構の解明
若手研究(B)
宇都宮大学
トリプトファンの肝タンパク質合成促進機能の解析と摂取の有効性・安全性の評価
基盤研究(B)
セキショクヤケイを利用したブロイラーヒナの脳内摂食調節機構の解明
特別研究員奨励費
競争的資金
詳細表示...
論文
Effect of lithium chloride on food intake, cloacal temperature, voluntary activity, and crop-emptying rate in chicks.
2022/11
Tachibana Tetsuya,Nakatani Ai,Khan Sakirul,Makino Ryosuke,Cline Mark A
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
273, 111284
研究論文(学術雑誌)
10.1016/j.cbpa.2022.111284
Infections frequently accompany with non-specific symptoms such as anorexia and hyperthermia. In addition, there may be unpleasant sensations such as visceral discomfort during infection. Lipopolysaccharide (LPS), a Gram-negative bacteria cell wall component, is known to induce the unpleasant sensation of conditioned taste aversion in mammals. However, the relationship between unpleasant sensations and changes in behavior and physiological conditions has not been investigated extensively in birds. Lithium chloride (LiCl) is a compound that induces unpleasant sensations, including visceral discomfort, although its effects on behavior and physiological conditions have also not been investigated extensively in birds. Thus, the present study was aimed to investigate the effect of an intraperitoneal (IP) injection of LiCl on conditioned visual aversion, food intake, cloacal temperature, voluntary activity, crop-emptying rate, and blood constituents in chicks (Gallus gallus). We also examined the effect of IP injections of LPS and zymosan, a cell wall component of fungus, on conditioned visual aversion formation. First, IP injection of LiCl was confirmed to induce conditioned visual aversion in chicks. An IP injection of LiCl significantly decreased food intake, voluntary activity, and crop-emptying rate but did not affect the temperature. In addition, the injection of LiCl significantly increased plasma corticosterone concentration, indicating that LiCl serves as a stressor in chicks. Finally, IP injections of LPS and zymosan were found to induce conditioned visual aversion in chicks. Collectively, these results suggest that LiCl induces conditioned aversion, anorexia, hypoactivity, and inhibition of crop-emptying in chicks. In addition, LPS and zymosan would induce unpleasant sensations in chicks.
Effect of ornithokinin on feeding behavior, cloacal temperature, voluntary activity and crop emptying rate in chicks.
2022/11/01
Tachibana Tetsuya,Asaka Tadaki,Khan Sakirul,Makino Ryosuke,Cline Mark A
General and comparative endocrinology
328, 114101
研究論文(学術雑誌)
10.1016/j.ygcen.2022.114101
Bradykinin is a well-studied bioactive peptide associated with several physiological functions, including vasodilation and inflammation, in mammals. However, its avian homolog, ornithokinin, has received less research attention in birds. Therefore this study aimed to investigate the effect of intraperitoneal (IP) and intracerebroventricular (ICV) injections of ornithokinin on feeding behavior, cloacal temperature, voluntary activity, crop emptying rate, and blood constituents in chicks (Gallus gallus). We also investigated the effect of lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria, on ornithokinin-associated gene expression was also investigated to determine whether activation of the ornithokinin system is induced by bacterial infection. Both IP and ICV injections of ornithokinin significantly decreased feed intake, cloacal temperature, voluntary activity, and crop emptying rate in chicks, but they did not affect the plasma concentration of corticosterone. Additionally, LPS significantly increased the expression of ornithokinin B2 receptor mRNA in several organs. Hence, ornithokinin is associated with a range of physiological responses in chicks and may be related to their response to bacterial infection.
Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks.
2022/07
Tachibana Tetsuya,Takahashi Maki,Khan Sakirul,Makino Ryosuke,Cline Mark A
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
269, 111211
研究論文(学術雑誌)
10.1016/j.cbpa.2022.111211
Nitric oxide (NO) is a gaseous bioactive molecule associated with many physiological functions including vasodilation and neurotransmission. NO also plays an important role in immune responses during viral infections in mammals. However, there is a paucity of knowledge regarding the involvement of NO in viral infections in birds. Therefore, the purpose of the present study was to determine if intraperitoneal (IP) injection of poly I:C and R848 (resiquimod), which are analogues of virus component, affects NO production in chicks (Gallus gallus) as a bird model. The involvement of inducible NO synthase (iNOS) in poly I:C- and R848-induced anorexia and corticosterone release was also investigated. These virus analogues significantly increased plasma NO metabolites (NOx) concentrations. IP injection of poly I:C and R848 significantly increased iNOS mRNA expression in several organs including the liver. On the other hand, poly I:C and R848 significantly decreased mRNA expressions of endothelial NOS and neural NOS in several organs, indicating that induction of iNOS might be responsible for increased NOx levels in plasma. This finding was further confirmed by using a selective iNOS inhibitor, S-methylisothiourea sulfate (SMT), which abolished the poly I:C- and R848-induced increase in plasma NOx concentration. In addition, SMT partly attenuated the poly I:C- and R848-induced increase in plasma corticosterone concentration, suggesting that corticosterone release induced by these virus analogues may be partly mediated by iNOS. Collectively, the present results suggest that viral infections facilitate NO production by inducing iNOS. The liver would play an important role in the NO production because the response in iNOS mRNA expression to poly I:C and R848 was remarkable. The present results also suggest that NO is associated with corticosterone release in birds under viral infection.
Effect of sodium nitroprusside on feeding behavior, voluntary activity, and cloacal temperature in chicks.
2022/07/01
Takahashi Maki,Sengan Akira,Khan Sakirul,Makino Ryosuke,Cline Mark A,Tachibana Tetsuya
Physiology & behavior
251, 113805
研究論文(学術雑誌)
10.1016/j.physbeh.2022.113805
Nitric oxide (NO) is a well-known gaseous signaling molecule that is involved in a variety of physiological and pathological processes in vertebrates. The role of NO in physiological responses of birds has been investigated primarily using NOS inhibitors. Therefore, the effect of the absence of NO is well characterized. However, there is little knowledge on the effects of abundant NO in birds, which is the case in birds that have infections. Therefore, the purpose of the present study was to determine if intraperitoneal (IP) and intracerebroventricular (ICV) injections of sodium nitroprusside (SNP), a NO donor, affected feed intake, voluntary activity, cloacal temperature, crop emptying rate, and blood constituents in domesticated chicks (Gallus gallus) as model birds. We found that both IP and ICV injections of SNP significantly decreased feed intake while there was little effect on voluntary activity. Cloacal temperature was temporarily, but significantly, decreased by both types of injection of SNP. Additionally, both IP and ICV injections of SNP significantly decreased the crop emptying rate. The IP injection of SNP significantly increased the plasma concentrations of NO/NO, which are metabolites of NO, and corticosterone, and decreased the plasma glucose concentrations, while the ICV injection had no effect. The IP injection of SNP also showed the tendency to increase the nitrotyrosine level, to increase superoxide dismutase activity, and to decrease catalase activity in the plasma. These results suggest that under specific situations which produce abundant NO such as infection, NO would induce anorexia, hypothermia, inhibition of feed passage, and activation of the hypothalamus-pituitary-adrenal axis in chicks.
Role of nitric oxide on zymosan-induced inhibition of crop emptying in chicks.
2021/11
Takahashi M, Khan MSI, Makino R, Cline MA, Tachibana T.
Comp Biochem Physiol A Mol Integr Physiol
261, 111057
研究論文(学術雑誌)
10.1016/j.cbpa.2021.111057.
詳細表示...
講演・口頭発表等
落下麦麹添加飼料がブロイラーの成長成績および腸内細菌叢に与える影響
第72回関西畜産学会岡山大会
2022/10/16
口頭発表(一般)
血小板活性化因子がニワトリヒナの行動と生理反応に与える影響
第72回関西畜産学会岡山大会
2022/10/16
口頭発表(一般)
LPSはニワトリヒナの神経型一酸化窒素合成酵素の遺伝子発現量を低下させる
第72回関西畜産学会岡山大会
2022/10/16
口頭発表(一般)
低タンパク質飼料へのメトホルミン添加がブロイラーの生産性に与える影響
第72回関西畜産学会岡山大会
2022/10/16
口頭発表(一般)
ジカルボニル化合物がニワトリ筋芽細胞の細胞生存能に与える影響
第72回関西畜産学会岡山大会
2022/10/16
口頭発表(一般)
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担当授業科目
2024
生物学入門
2024
生物学入門
2024
動物飼養学特論
2024
動物飼養学特論
2024
医学統計学概論
詳細表示...