Kunisue Tatsuya

Update date：2024/12/04

Professor

Kunisue Tatsuya

Affiliation

Ehime University沿岸環境科学研究センター化学汚染・毒性解析部門教授・生物環境試料バンク長

Research History

2008/03-2012/03Wadsworth Center, New York State Department of Health, Research scientist
2012/04-2014/03Tottori UniversityFaculty of Agriculture教授
2014/04-presentEhime UniversityCenter for Marine Environmental Studies教授
2015/04-presentEhime UniversityCenter for Marine Environmental Studiesバンク長

Degree

博士（農学）愛媛大学

Research Areas

Research Interests

環境化学
機器分析化学

Research Projects

Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)化学分析とバイオアッセイの統合手法による核内受容体介在型残留性未知物質の探索Grant-in-Aid for Challenging Research (Exploratory)2019/06-2022/03
日本学術振興会基盤研究（A) 一般新規環境汚染物質の水圏生物濃縮機構・時空間トレンドの解明とリスク評価2019/04-2022/03Principal investigator
Biomagnification mechanism, spatiotemporal trend, and risk assessment of legacy and new environmental pollutants in various aquatic animal species基盤研究(A)2019/04-2022/03Principal investigator
Levels, fate, bioaccumulation, and risk assessment of harmful environmental chemicals derived from wastes and industrial and domestic drainage in Vietnam国際共同研究加速基金(国際共同研究強化(B))2018/04-2021/03Principal investigator
日本学術振興会国際共同研究加速基金（国際共同研究強化(B)）ベトナムの廃棄物および工業・生活排水に由来する有害化学物質の動態とリスク評価2018-2021/03Principal investigator

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Books and Other Publications

地球をめぐる不都合な物質－拡散する化学物質がもたらすもの田辺信介国末達也第1章世界に広がるPOPs汚染－海生哺乳動物の化学物質汚染と途上国のダイオキシン汚染ブルーバックス、日本環境化学会（著・編）講談社2019/069784065163931
The Handbook of Environmental ChemistryKunisue T Tanabe SDioxin and Related Compounds - Contamination issues in Asian developing countriesvol 49. Springer20169783319238883

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Papers

Bioaccessibility of halogenated flame retardants and organophosphate esters in settled dust: Influences of specific dust matrices from informal e-waste and end-of-life vehicle processing areas in Vietnam.2024/05/20Hoang Anh Quoc,Tue Nguyen Minh,Goto Akitoshi,Karyu Ryogo,Tuyen Le Huu,Viet Pham Hung,Matsukami Hidenori,Suzuki Go,Takahashi Shin,Kunisue TatsuyaThe Science of the total environment926, 17204510.1016/j.scitotenv.2024.172045Bioaccessibility of halogenated flame retardants (HFRs) and organophosphorus esters (OPEs) is necessarily investigated to provide more accurate risk assessment and information about absorption behavior of these pollutants. In this study, total and bioaccessible concentrations of HFRs (including legacy and alternative substances) and OPEs were determined in settled dust samples collected from Vietnamese e-waste and end-of-life vehicle (ELV) processing areas. Concentrations of both HFRs and OPEs were significantly higher in the e-waste dust than ELV dust. Bioavailability of HFRs and OPEs in dust was determined by using an in vitro assay with human-simulated digestive fluids, dialysis membrane, and Tenax® TA sorptive sink. Bioaccessibility of HFRs was markedly lower than that of OPEs, which could be largely due to higher hydrophobicity of HFRs compared to OPEs. Bioaccessibility of almost hydrophobic compounds were markedly lower in the e-waste dust (containing micronized plastic debris) than in the ELV dust (containing oily materials), suggesting the influence of specific dust matrices on pollutant bioaccessibility. Although the daily uptake doses of selected HFRs and OPEs from dust were markedly higher in the e-waste sites compared to the ELV sites, the direct exposure risk was not significant. Our results suggest that bioaccessibility can partly explain the differences between dust and uptake profiles, which may relate to accumulation profiles of HFRs and OPEs in human samples.
Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay.2024/04/10Behnisch Peter,Besselink Harrie,Suzuki Go,Buchinger Sebastian,Reifferscheid Georg,Lukas Marcus,Wollenweber Marc,Wollenweber Simone,Hollert Henner,Kunisue Tatsuya,Tue Nguyen Minh,Alijagic Andi,Larsson Maria,Engwall Magnus,Ohno Kayo,Brouwer AbrahamThe Science of the total environment920, 17075910.1016/j.scitotenv.2024.170759Aquatic animals and consumers of aquatic animals are exposed to increasingly complex mixtures of known and as-yet-unknown chemicals with dioxin-like toxicities in the water cycle. Effect- and cell-based bioanalysis can cover known and yet unknown dioxin and dioxin-like compounds as well as complex mixtures thereof but need to be standardized and integrated into international guidelines for environmental testing. In an international laboratory testing (ILT) following ISO/CD 24295 as standard procedure for rat cell-based DR CALUX un-spiked and spiked extracts of drinking-, surface-, and wastewater were validated to generate precision data for the development of the full ISO-standard. We found acceptable repeatability and reproducibility ranges below 36 % by DR CALUX bioassay for the tested un-spiked and spiked water of different origins. The presence of 17 PCDD/Fs and 12 dioxin-like PCBs was also confirmed by congener-specific GC-HRMS analysis. We compared the sum of dioxin-like activity levels measured by DR CALUX bioassay (expressed in 2,3,7,8-TCDD Bioanalytical Equivalents, BEQ; ISO 23196, 2022) with the obtained GC-HRMS chemical analysis results converted to toxic equivalents (TEQ; van den Berg et al., 2013).
Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults.2024/02Nguyen Hue T,Isobe Tomohiko,Iwai-Shimada Miyuki,Takagi Mai,Ueyama Jun,Oura Kana,Tanoue Rumi,Kunisue Tatsuya,Nakayama Shoji FChemosphere349, 14092010.1016/j.chemosphere.2023.140920Environmental phenols are widely distributed in the environment and human samples, suggesting potential exposure to these chemicals. We designed an intervention trial with 30 participants over 6 days to assess the urinary concentrations and half-lives of environmental phenols in Japanese young people. The target environmental phenols include three parabens (methyl paraben, ethyl paraben, and propyl paraben), two benzophenones (benzophenone 1 and 3), two bisphenols (bisphenol F and bisphenol S), and triclosan. Throughout the intervention, the participants consumed the same food and drinks and used personal care products provided by the project. The target phenols were measured in urine from the participants using a liquid chromatography-tandem mass spectrometer. We compared the measured concentrations between the study periods to better understand the exposure tendency. Some statistically significant differences were observed. All target analytes were detected in more than 50% of samples collected on Day 0 (the day before the intervention). Methyl paraben was the dominant phenol detected in urine (1640 μg/g-creatinine), followed by ethyl paraben (119 μg/g-creatinine). Downward trends in creatinine-corrected concentrations were observed for all target analytes in some instances. Non-compartment analysis was performed to estimate urinary excretion parameters. The estimated half-lives ranged from 7.69 to 20.3 h. Use of paraben-free products during the intervention period reduced the body burden.
化学物質による水生生物の汚染の現状と今後2024/01国末達也化学物質と環境 : 化学物質と環境との調和をめざす情報誌183, 7-9URL横浜 : エコケミストリー研究会
Multi-level assessment of the origin, feeding area and organohalogen contamination on salmon from the Baltic Sea.2023/10/01Kanerva Mirella,Tue Nguyen Minh,Kunisue Tatsuya,Vuori Kristiina Am,Iwata HisatoEcotoxicology and environmental safety264, 11542410.1016/j.ecoenv.2023.115424The Atlantic salmon (Salmo salar) population in the Baltic Sea consists of wild and hatchery-reared fish that have been released into the sea to support salmon stocks. During feeding migration, salmon migrate to different parts of the Baltic Sea and are exposed to various biotic and abiotic stressors, such as organohalogen compounds (OHCs). The effects of salmon origin (wild or hatchery-reared), feeding area (Baltic Main Basin, Bothnian Sea, and Gulf of Finland), and OHC concentration on the differences in hepatic proteome of salmon were investigated. Multi-level analysis of the OHC concentration, transcriptome, proteome, and oxidative stress biomarkers measured from the same salmon individuals were performed to find the key variables (origin, feeding area, OHC concentrations, and oxidative stress) that best account for the differences in the transcriptome and proteome between the salmon groups. When comparing wild and hatchery-reared salmon, differences were found in xenobiotic and amino acid metabolism-related pathways. When comparing salmon from different feeding areas, the amino acid and carbohydrate metabolic pathways were notably different. Several proteins found in these pathways are correlated with the concentrations of polychlorinated biphenyls (PCBs). The multi-level analysis also revealed amino acid metabolic pathways in connection with PCBs and oxidative stress variables related to glutathione metabolism. Other pathways found in the multi-level analysis included genetic information processes related to ribosomes, signaling and cellular processes related to the cytoskeleton, and the immune system, which were connected mainly to the concentrations of Polychlorinated biphenyls and Dichlorodiphenyltrichloroethane and their metabolites. These results suggest that the hepatic proteome of salmon in the Baltic Sea, together with the transcriptome, is more affected by the OHC concentrations and oxidative stress of the feeding area than the origin of the salmon.

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Presentations

Py-Tag誘導体化法を用いた脳中神経伝達物質とその関連物質の高感度分析法の開発とその応用第29回環境化学討論会2021/06Oral presentation(general)講演要旨集, WO-007
別府湾および琵琶湖底質柱状試料を用いたPCBs・POPs汚染の時系列評価第29回環境化学討論会2021/06講演要旨集, WO-015
ベトナムのe-waste・ELV解体処理場におけるハロゲン系およびリン酸エステル系難燃剤汚染第29回環境化学討論会2021/06講演要旨集, WO-026
瀬戸内海の二枚貝とマアジにおけるリン酸エステル系難燃剤汚染第29回環境化学討論会2021/06講演要旨集, WO-030
瀬戸内海の二枚貝と堆積物に残留する既知・未知有機ハロゲン化合物の生物濃縮性評価第29回環境化学討論会2021/06講演要旨集, WO-031