University Hospital
附属病院
日本語
Update date：2025/01/06
Senior Assistant Professor
Yamamoto Yasunori

Research History

  1. 2004/05-2006/03愛媛県立中央病院初期臨床研修医
  2. 2006/04-2008/03愛媛県立中央病院消化器内科専攻医
  3. 2008/04-2012/04Ehime UniversityHospital非常勤医員（大学院生）
  4. 2012/05-2015/06Ehime UniversityHospital助教
  5. 2015/07-2016/08Ehime UniversityHospital特任講師
  6. 2016/09-2017/03がん研有明病院消化器内科医員
  7. 2018/04-2018/05Ehime UniversityHospital助教
  8. 2018/06-presentEhime UniversityHospital特任講師

Education

  1. Ehime University1998/042004/03
  2. Ehime University2008/042012/04

Degree

  1. 博士愛媛大学

Research Areas

Research Interests

  1. PBC

Research Projects

  1. Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)Development of a novel treatment for nonalcoholic steatohepatitis by targeting small intestinal fatty acid transportersGrant-in-Aid for Scientific Research (C)2021/04-2024/03Principal investigator
  2. Ehime UniversityDevelopment of a novel treatment for nonalcoholic steatohepatitis by targeting small intestinal fatty acid transportersGrant-in-Aid for Scientific Research (C)2021/04/01-2024/03/01
  3. 日本学術振興会科学研究費助成事業｜日本学術振興会肝硬変の小腸脂質吸収障害に対するBCAA(分枝鎖アミノ酸)の保護作用の解明2015/04-2018/03Principal investigator
  4. 日本学術振興会科学研究費助成事業小腸脂肪酸吸収関連蛋白のNASH 病態へ与える影響と治療標的分子の解明2015/04-2017/03Principal investigator
  5. Ehime UniversityElucidation of the protection of BCAA( branched-chain amino acid) for lipid intestinal absorption disorder in patients with liver cirrhosis.Grant-in-Aid for Scientific Research (C)2015/04/01-2018/03/01
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Papers

  1. Association between nighttime urinary frequency and clinical outcomes in Japanese patients with ulcerative colitis.2024/11Kitahata Shogo,Furukawa Shinya,Miyake Teruki,Yoshida Osamu,Shiraishi Kana,Hashimoto Yu,Tange Kazuhiro,Sen Yagi,Hanayama Masakazu,Ninomiya Tomoyuki,Suzuki Seiyuu,Shibata Naozumi,Murakami Hidehiro,Ohashi Katsuhisa,Tomida Hideomi,Yamamoto Yasunori,Takeshita Eiji,Ikeda Yoshio,Hiasa YoichiNeurourology and urodynamics43/ 8, 2222-222810.1002/nau.25570Nocturia is a common symptom of lower urinary tract syndrome (LUTS). In previous studies, a close association between LUTS and colorectal inflammation has been reported. However, evidence regarding the association between nighttime urinary frequency and ulcerative colitis (UC) is limited. Herein, we investigated the association between nighttime urinary frequency and clinical outcomes of UC.We surveyed 287 Japanese patients with UC. A self-administered questionnaire was used to collect the information on the variables studied. Patients were divided into three groups based on nighttime urinary frequency: (1) no voids, (2) one void, and (3) two or more voids. The assessment of clinical outcomes was based on mucosal healing (MH) and clinical remission (CR). The association between nighttime urinary frequency and prevalence of MH and CR was evaluated using multivariate logistic regression analyses.The prevalence of one nighttime frequency and two or more nighttime frequency in this cohort was 35.5% and 26.8%, respectively. The percentage of MH and CR was 24.7% and 59.2%, respectively. Two or more nighttime frequency (adjusted odds ratio [OR]: 0.31, 95% confidence interval [CI]: 0.13-0.73) was independently and inversely associated with MH. In nonelderly patients (<70 years) and patients in CR, an association between two or more nighttime frequency and MH remained significant (non-elderly: adjusted OR: 0.27, 95% CI: 0.09-0.72 and only CR: adjusted OR: 0.34, 95% CI: 0.12-0.90).Nighttime urinary frequency was independently and inversely associated with MH in Japanese patients with UC. Nighttime urinary frequency may serve as a complementary physical sign of MH in patients with UC.
  2. Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan.2024/11Miyake Yoshihiro,Tanaka Keiko,Nagata Chisato,Furukawa Shinya,Andoh Akira,Yokoyama Tetsuji,Yoshimura Naoki,Mori Kenichiro,Ninomiya Tomoyuki,Yamamoto Yasunori,Takeshita Eiji,Ikeda Yoshio,Saito Mitsuru,Ohashi Katsuhisa,Imaeda Hirotsugu,Kakimoto Kazuki,Higuchi Kazuhide,Nunoi Hiroaki,Mizukami Yuji,Suzuki Seiyuu,Hiraoka Sakiko,Okada Hiroyuki,Kawasaki Keitarou,Higashiyama Masaaki,Hokari Ryota,Miura Hiromasa,Miyake Teruki,Kumagi Teru,Kato Hiromasa,Hato Naohito,Sayama Koji,Hiasa Yoichi,Cytokine183, 15674310.1016/j.cyto.2024.156743Interleukin (IL)-23 is involved in the pathogenesis of ulcerative colitis (UC). A genome-wide significant association between IL23R p.G149R (rs76418789) and UC was previously identified in Japan and Korea. This case-control study aims to examine this association within the Japanese population.The study included 384 cases diagnosed with UC within the past 4 years and 661 control subjects. Adjustment was made for sex, age, and smoking.The frequency of the AA genotype of rs76418789 was 0.0 % in cases and 0.5 % in control subjects. In comparison to study subjects with the GG genotype of rs76418789, those with the GA or AA genotype had a significantly reduced risk of UC, with an adjusted odds ratio of 0.67 (95 % confidence interval: 0.44-0.999). A significant multiplicative interaction was observed between rs76418789 and having ever smoked influencing UC (p for interaction = 0.03). A significant positive association was found between having ever smoked and UC in individuals with at least one A allele, while no such positive relationship was observed in those with the GG genotype.IL23R SNP rs76418789 showed a significant association with UC. This study provides new evidence regarding the interaction between rs76418789 and smoking in relation to UC.
  3. Exercise Habits, Including Exercising With Partners, and the Prevalence of Self-Reported Constipation in Young Japanese People: A Cross-Sectional Study.2024/11Watanabe Junichi,Furukawa Shinya,Yamamoto Yasunori,Kato Aki,Kusumoto Katsunori,Takeshita Eiji,Ikeda Yoshio,Yamamoto Naofumi,Saeki Yuka,Miyake Teruki,Yoshida Osamu,Hiasa YoichiCureus16/ 11, e7445510.7759/cureus.74455Constipation is a very common medical issue among the general population worldwide. However, the association between exercise habits and constipation is still not fully understood. Additionally, no evidence regarding the association between exercise partners and constipation exists. This study aimed to evaluate this issue in a young Japanese population, taking the presence or absence of an exercise partner as an additional variable.The study subjects consisted of 12,497 Japanese university students. Information on constipation, exercise frequency, exercise intensity, and exercise partners was obtained through a self-administered questionnaire. Constipation was defined as present if a student answered "Yes" to the question, "Have you been constipated often recently?"The prevalence of self-reported constipation was 6.5%. Frequency and intensity of exercise were independently inversely associated with constipation. After adjustment for age, body mass index, drinking, smoking, anemia, and sports injury, exercise with groups and friends was independently inversely associated with constipation (groups: adjusted odds ratio (OR) - 0.70 (95% confidence interval (CI): 0.53-0.90), friends: adjusted OR - 0.56 (95% CI: 0.42-0.74)). After further adjustment by adding intensity and frequency of exercise to confounding factors, only the association between exercise with friends and constipation was still significant (adjusted OR: 0.61 (95% CI: 0.39-0.96)).In this young Japanese population, the frequency and the intensity of exercise and the presence of exercise partners might be independently inversely associated with self-reported constipation. Exercising, especially exercising with others, may have a preventive effect on constipation, and opportunities to exercise with others should be provided.
  4. Association between serum remnant cholesterol level and metabolic dysfunction-associated steatotic liver histology.2024/08/28Miyake Teruki,Furukawa Shinya,Matsuura Bunzo,Yoshida Osamu,Kanamoto Ayumi,Miyazaki Masumi,Shiomi Akihito,Nakaguchi Hironobu,Okazaki Yuki,Nakamura Yoshiko,Imai Yusuke,Koizumi Mitsuhito,Watanabe Takao,Yamamoto Yasunori,Koizumi Yohei,Tokumoto Yoshio,Hirooka Masashi,Kumagi Teru,Abe Masanori,Hiasa YoichiThe Journal of clinical endocrinology and metabolism10.1210/clinem/dgae597Estimated remnant cholesterol (Rem-C) level, a risk factor for cardiovascular disease (CVD), is associated with metabolic dysfunction-associated steatotic liver disease (MASLD) diagnosed via ultrasonography. However, the relationship between accurate serum Rem-C level measurements and histological findings of MASLD remains unclear.We aimed to elucidate the relationship between accurately measured serum Rem-C levels and histological findings of MASLD.Cross-sectional single-center observational study.We assessed 222 patients (94 men and 128 women; age 20-80) who were diagnosed with MASLD via liver biopsy with available medical history, physical examination, and biochemical measurement data. Serum ester-type cholesterol and free cholesterol contents in the remnant lipoproteins were measured using an enzymatic method.Serum Rem-C levels were significantly higher in patients with NAFLD activity score (NAS) 5-8, ＞66% steatosis grade, lobular inflammation with ≥5 foci, and many cells/prominent ballooning cells (a contiguous patch of hepatocytes showing prominent ballooning injury) than in patients with NAS 1-4, <33% steatosis grade, lobular inflammation with <2 foci, and few ballooning cells (several scattered balloon cells), respectively. While univariate analysis revealed no significant association between Rem-C levels and advanced fibrosis, a significant association between Rem-C levels and NAS was evident. This relationship remained significant in multivariate analysis adjusted for confounders. Furthermore, in the analysis by sex, these relationships were significant for men but not for women.High serum Rem-C levels were associated with high NAS, but not with fibrosis stage, particularly in men. Controlling serum Rem-C level may improve MASLD activity.
  5. 上部消化管内視鏡検査を契機に診断された梅毒の1例2024/05/10久門 志敬, 竹下 英次, 橋本 悠, 白石 佳奈, 丹下 和洋, 富田 英臣, 山本 安則, 阿部 雅則, 池田 宜央, 日浅 陽一日本内科学会雑誌113/ 5, 842-846URL東京 : 日本内科学会
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Presentations

  1. 内視鏡治療および定型的胃切除術が困難な胃がん症例に対するLECSの安全性と有用性の検討日本消化器がん検診学会雑誌2018/09/15URL
  2. PBCにおける門脈圧亢進症性胃症合併の意義についての検討日本門脈圧亢進症学会雑誌2018/08/24URL
  3. 性差から見た便秘と身体活動性との関連性の検討日本高齢消化器病学会誌2018/07/01URL
  4. 高齢者の食道癌に対する根治的化学放射線療法の安全性と有効性についての検討日本高齢消化器病学会誌2018/07/01URL
  5. 食道表在癌における内臓脂肪および皮下脂肪量と脈管侵襲の関連についての検討日本食道学会学術集会プログラム・抄録集2018/06
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Awards

  1. 2019/05/25第６回肝臓と糖尿病研究会若手研究奨励賞
  2. 2015第二回肝臓と糖尿病研究会若手研究奨励賞
  3. 2014第一回肝臓と糖尿病研究会学術奨励賞
  4. 2014第61回米国肝臓学会Presidential Poster of Distinction賞
  5. 2010愛媛医学奨励賞
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Allotted Class

  1. 2024Lecture, seminar and practical training of Gastroenterology and Metabology
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Professional Memberships

  1. THE JAPANESE SOCIETY OF INTERNAL MEDICINE
  2. JAPANESE SOCIETY OF GASTROENTEROLOGY
  3. JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY
  4. 日本臨床腫瘍学会
  5. THE JAPAN SOCIETY OF HEPATOLOGY
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Committee Memberships

  1. -present日本肝臓学会西部肝評議員
  2. 2015/05-present日本消化器病学会四国支部評議員
  3. 2015/05-present日本消化器内視鏡学会四国支部評議員
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